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IMMUNOTHERAPY AND POTENTIAL USE OF PROPOLIS IN CANCER IMMUNOTHERAPY

Year 2018, Volume: 4 Issue: 4, 231 - 246, 01.10.2018

Elif Onur , Ayşe Nalbantsoy , Duygu Kışla

https://doi.org/10.3153/FH18023

Abstract

In recent years cancer incidence has increased.
Innovative studies have been carried out on the treatment methods of cancer, a
major threat to public health. Immunotherapy is the treatment of the disease
with therapeutic agents that increase or decrease immune responses.
Immunotherapy is known to be effective in the treatment of cancer. A bee
product, propolis that has been investigated for its availability in this
respect draws attention because of its antitumor effects. In addition,
immunomodulatory effects of propolis, which is known to have antibacterial,
antimicrobial, antifungal, antiviral and cytotoxic effects, have been
investigated in recent years. According to researchers, propolis is a promising
compound in cancer immunotherapy. In this review, it is aimed to give
information about immunotherapy and the use of propolis in cancer
immunotherapy.

Keywords

Immunotherapy Propolis Cancer Immunomodulator

References

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İMMÜNOTERAPİ VE PROPOLİSİN KANSER İMMÜNOTERAPİSİNDE KULLANIM POTANSİYELİ

Year 2018, Volume: 4 Issue: 4, 231 - 246, 01.10.2018

Elif Onur , Ayşe Nalbantsoy , Duygu Kışla

https://doi.org/10.3153/FH18023

Abstract

Son yıllarda kanser hastalığı oldukça yaygın olarak
görülmektedir. Halk sağlığı için büyük tehlike oluşturan kanser hastalığının
tedavi yöntemleri üzerinde yenilikçi araştırmalar yapılmaktadır. İmmünoterapi immün yanıtları artıran veya azaltan
terapötik ajanlar ile ortaya çıkan hastalığın tedavisidir. İmmünoterapinin
kanser tedavisinde etkili olduğu bilinmektedir. Bu amaç doğrultusunda
kullanılabilirliği araştırılan, bir arı ürünü olan propolis antitümör etkiler
göstermesi ile dikkat çekmektedir. Bunun yanı sıra antibakteriyel,
antimikrobiyal, antifungal, antiviral ve sitotoksik etkileri olduğu bilinmekte
olan propolisin son yıllarda immünomodülatör etkileri incelenmektedir.
Araştırmacılara göre propolis kanser immünoterapisinde umut vadeden bir
bileşendir. Bu derlemede immünoterapi ve propolisin kanser immünoterapisinde
kullanımı hakkında bilgi verilmesi amaçlanmaktadır.

Keywords

İmmünoterapi Propolis Kanser İmmünomodulatör

References

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  • Arda, M., Minbay, A., Aydın, N., Akay, Ö., İzgür, M., Diker, S. (1998). İmmunoloji. Ankara: Medisan Yayınevi, p. 20-31.
  • Atayoğlu, T. (2012). Apiterapi Açısından Arı Ürünlerinin Kalite Kriterleri ve Standardizasyonu. Standard Ekonomik ve Teknik Dergi, 601, 68-73.
  • Awale, S., Li, F., Onozuku, H., Esumi, H., Tezuka, Y., Kadota, S. (2008). Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorganic and Medicinal Chemistry, 16, 181-189.
  • Bankova, V. (2005). Recent trends and important developments in propolis research. Evidence-based Complementary and Alternative Medicine, 2, 29-32.
  • Banskota, A. H., Tezuka, Y., Kadota, S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research,, 15, 561-571.
  • Barbaros, B., Dikmen, M. (2015). Kanser İmmünoterapisi. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 31(4), 177-181.
  • Barnes, S. (1997). The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Research Treament (46), 169–179.
  • Bazo, A.P., Rodrigues, M.A.M., Sforcin, J.M., Camargo, J.L.V., Ribeiro, L.R., Salvadori, D.M.F. (2002). Protective action of propolis on the rat colon carcinogenesis. Teratogenesis, Carcinogenesis and Mutagenesis, 22, 183-194.
  • Boudourova-Krasteva, G., Bankova, V., Sforcin, J. M., Nikolova, N., Popov, S. (1997). Phenolics from Brazilian propolis. Zeitschrift für Naturforschung 52, 676-679.
  • Burdock, G.A. (1998). Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36, 347–363.
  • Carvalho, A.A., Finger, D., Machado, C.S., Schmidt, E.M., Costa, P.M., Alves, A.P.N.N., Morais, T.M.F., Queiroz, M.G.R., Quináia, S.P., Rosa, M.R., Santos, J.M.T., Pessoa, C., Moraes, M.O., Lotufo, L.V.C., Sawaya, A.C.H.F., Eberlin, M.N., Torres, Y.R. (2011). In vivo antitumoural activity and composition of an oil extract of Brazilian propolis. Food Chemistry, 126, 1239-1245.
  • Chan, G.C., Chan, W.K., Sze, D.M. (2009). The Effects of β-Glucan on Human, Immune and Cancer Cells. Journal of Hematology and Oncology, 25(2), 1-11. Chen, C.N., Weng, M.S., Wu, C.L., Lin, J.K. (2014). Comparison of Radical Scavenging Activity, Cytotoxic Effects and Apoptosis Induction in Human Melanoma Cells by Taiwanese Propolis from Different Sources. Evidenced-based Complementary and Alternative Medicine, 1(2), 175-185.
  • Choudhari, M.K., Haghniaz, R., Rajwade, J.M., Paknikar, K. (2013). Anticancer Activity of Indian Stingless Bee Propolis: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine, Volume 2013, 1-10.
  • Cuesta, A., Rodriguez, A., Angeles, M. (2005). In vivo effects of propolis, a honeybee product, on gilthead seabream innate immune responses. Fish and Selfish Immun, 18(1), 71-80.
  • DeCastro, S.L. (2001). Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product. Annual Review of Biomedical Science (3), 49-83.
  • DeSantes, K.B., Sondel P.M., Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., Nathan, D.G. (2009). Immunotherapy of Cancer, Oncology of Infancy and Childhood, 209-241.
  • Doğan, N., Hayoğlu, İ. (2012). Propolis ve kullanım alanları, Harran Üniversitesi, Ziraat Fakültesi Dergisi, 16(3), 39-48.
  • Dudov, I.A., Morenets, A.A., Artiukh, V.P., Starodub, N. F. (1994). Immunomodulatory effect of honeybee flower pollen load, Ukrainskii Biokhimicheskii Zhurnal, 66(6), 91-93.
  • Filho, R.N.P., Batista, F.S., Ribeiro, D.R., Melo, G.C., Reis, F.P., Melo, A.U.C., Gomes, M.Z., Cardoso, J.C., Albuquerque, R.L.C. (2014). Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model. International Journal of Morphology, 32(2), 522-530.
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Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Articles
Authors

Elif Onur 0000-0002-5880-1340

Ayşe Nalbantsoy 0000-0002-3852-1974

Duygu Kışla 0000-0002-6993-3883

Publication Date October 1, 2018
Submission Date November 10, 2017
Published in Issue Year 2018Volume: 4 Issue: 4

Cite

APA Onur, E., Nalbantsoy, A., & Kışla, D. (2018). İMMÜNOTERAPİ VE PROPOLİSİN KANSER İMMÜNOTERAPİSİNDE KULLANIM POTANSİYELİ. Food and Health, 4(4), 231-246. https://doi.org/10.3153/FH18023
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