Ak, T., Gülçin, İ. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interactions, 174, 27-37. https://doi.org/10.1016/j.cbi.2008.05.003
Aksoy, A. (2018). Determination of the DNA damage levels in patients with chronic renal failure using 8-hydroxy-2’-deoxyguanosine biomarker. Fresenius Environmental Bulletin, 27(12a), 9308-9314.
Antiga, E., Bonciolini, V., Volpi, W., Del Bianco, E., Caproni, M. (2015). Oral curcumin (meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with Psoriasis vulgaris. BioMed Research International, 1-7. https://doi.org/10.1155/2015/283634
Asouri, M., Ataee, R., Ahmadi, A.A., Amini, A., Rezaei Moshaei, M. (2013). Antioxidant and free radical scavenging activities of curcumin. Asian Journal of Chemistry, 25(13), 7593-7595. https://doi.org/10.14233/ajchem.2013.15308
Atakan, A. (2017). Kilolu ve obez bireylerde zerdeçal tüketiminin ağırlık kaybı ve kan lipid düzeyleri üzerindeki etkisinin değerlendirilmesi. Doğu Akdeniz Üniversitesi, Lisansüstü Eğitim, Öğretim ve Araştırma Enstitüsü, Yüksek Lisans Tezi, Gazimağusa.
Belviranlı, M., Okudan, N., Nurullahoğlu, Atalık. K.E. (2012). Yaşlı sıçanlarda kurkumin takviyesinin kalp dokusunun oksidan/antioksidan durumu üzerine etkileri. Genel Tıp Dergisi, 22(2), 61-66.
Chandran, B., Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research, 26(11), 1719-1725. https://doi.org/10.1002/ptr.4639
Chin, D., Huebbe, P., Pallauf, K., Rimbach, G. (2013). Neuroprotective properties of curcumin in Alzheimer’s disease-merits and limitations. Current Medicinal Chemistry, 20(32), 3955-3985. https://doi.org/10.2174/09298673113209990210
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., Jirawatnotal, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35, 2121-2127. https://doi.org/10.2337/dc12-0116
Dai, C., Li, D., Gong, L., Xiao, X., Tang, S. (2016). Curcumin ameliorates furazolidone-induced DNA damage and apoptosis in human hepatocyte L02 cells by inhibiting ROS production and mitochondrial pathway. Molecules, 21(8), E1061. https://doi.org/10.3390/molecules21081061
Deniz, R., Gürateş, B., Aydın, S., Çelik, H., Sahin, İ., Baykuş, Y., Çatak, Z., Aksoy, A., Çitil, C., Güngör, S. (2012). Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine, 42, 694-699. https://doi.org/10.1007/s12020-012-9638-7
Ghosh, S., Banerjee, S., Sil, P.C. (2015). The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chemical Toxicology, 83, 111-124. https://doi.org/10.1016/j.fct.2015.05.022
Harish, G., Venkateshappa, C., Mythri, R.B., Dubey, S.K., Mishra, K., Singh, N., Vali, S., Bharath, M.M. (2010). Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease. Bioorganic & Medicinal Chemistry, 18(7), 2631-2638. https://doi.org/10.1016/j.bmc.2010.02.029
Jaggi, M., Du, C., Zhang, W., Balaji, K.C. (2007). Protein kinase D1: A protein of emerging translational interest. Frontiers in Bioscience, 12, 3757-3767. https://doi.org/10.2741/2349
Jamilian, M., Foroozanfard, F., Kavossian, E., Aghadavod, E., Shafabakhsh, R., Hoseini, A., Asemi, Z. (2020). Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. European Society for Clinical Nutrition and Metabolism, 36, 128-133. https://doi.org/10.1016/j.clnesp.2020.01.005
Kumar, A., Sharma, N. (2015). Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pesticide Biochemistry and Physiology, 119(1), 16-27. https://doi.org/10.1016/j.pestbp.2015.03.003
Lang, A., Salomon, N., Wu, J.C., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J.Y., Cheong, P.K., Avidan, B., Gamus, D., Kaimakliotis, I., Eliakim, R., Ng, S.C., Ben-Horin, S. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology Hepatology, 13(8), 1444-1449. https://doi.org/10.1016/j.cgh.2015.02.019
Laveti, D., Kumar, M., Hemalatha, R., Sistla, R., Naidu, V.G., Talla, V., Verma, V., Kaur, N., Nagpal, R. (2013). Anti-inflammatory treatments for chronic diseases: A review. Inflammation & Allergy - Drug Targets, 12(5), 349–361. https://doi.org/10.2174/18715281113129990053
McFadden, R.T., Larmonier, C.B., Shehab, K.W., Midura-Kiela, M., Ramalingam, R., Harrison, C.A., Besselsen, D.G., Chase, J.H., Caporaso, J.G., Jobin, C., Ghishan, F.K., Kiela, P.R. (2015). The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory Bowel Diseases, 21(11), 2483-2494. https://doi.org/10.1097/MIB.0000000000000522
Mohammadi, S., Kayedpoor, P., Karimzadeh-Bardei, L., Nabiuni, M. (2017). The effect of curcumin on TNF-α, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state. Journal of Reproduction & Infertility, 18(4), 352-360.
Neeraj, J.P., Singh S, Singh J. (2008). Role of free radicals and antioxidants in human health and disease. International Journal of Current Research and Review, 5(19), 14-22.
Oyetayo, B.O., Amos, O., Abolaji, A.O., Fasae, K.D., Aderibigbe, A. (2020). Ameliorative role of diets fortified with curcumin in a Drosophila Melanogaster model of aluminum chloride-induced neurotoxicity. Journal of Functional Foods, 71, 1-7. https://doi.org/10.1016/j.jff.2020.104035
Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S.M., Keshavarz, S.A. (2016). Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepatitis Monthyl, 16(1), 1-5. https://doi.org/10.5812/hepatmon.34897
Sak, M.E., Soydinc, H.E., Sak, S., Evsen, M.S., Alabalik, U., Akdemir, F., Gul, T. (2013). The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. International Journal of Surgery, 11(9), 967-970. https://doi.org/10.1016/j.ijsu.2013.06.007
Seyithanoğlu, M., Tanrıkulu Küçük, S., Öner İyidoğan, Y., Koçak, H., Mikailova, P., Aydın, A.F. (2020). Kurkumin uygulamasının yüksek yağlı diyetle beslenen sıçanların testis dokusunda oksidanantioksidan sistem üzerine etkisi. İstanbul Tıp Fakültesi Dergisi, 83(3), 247-253. https://doi.org/10.26650/IUITFD.2019.0049
Sharma, R.A., Gescher, A.J., Steward, W.P. (2005). Curcumin: The story so far. European Journal of Cancer, 41(3), 1955-1968. https://doi.org/10.1016/j.ejca.2005.05.009
Sundram, V., Chauhan, S.C., Ebeling, M., Jaggi, M. (2012). Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1. PLoS One, 7(4), 1-13. https://doi.org/10.1371/journal.pone.0035368
Tanvir, E.M., Hossen, M.S., Hossain, M.F., Afroz, R., Hua Gan, S., Khalil, M.I., Karim, N. (2017). Antioxidant properties of popular turmeric (curcuma longa) varieties from Bangladesh. Journal of Food Quality, 8471785, 1-8. https://doi.org/10.1155/2017/8471785
Turgut, M. (2019). Deneysel akut pankretit’te kaempferol ve kurkumin’in etkilerinin araştırılması. Pamukkale Üniversitesi, Tıp Fakültesi, Uzmanlık Tezi, Denizli.
Wongcharoen, W., Jai-Aue, S., Phrommintikul, A., Nawarawong, W., Woragidpoonpol, S., Tepsuwan, T., Sukonthasarn, A., Apaijai, N., Chattpakorn, N. (2012). Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. American Journal of Cardiology, 110, 40-44. https://doi.org/10.1016/j.amjcard.2012.02.043
WHO (2000). Evaluation of certain food additives: Fifty-first report of the joint FAO/WHO expert committee on food additives. World Health Organization & Food and Agriculture Organization of The United Nations.
Yang, Y.S., Su, Y.F., Yang, H.W., Lee, Y.H., Chou, J.I., Ueng, K.C. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytotheraop Research, 28, 1770-1777. https://doi.org/10.1002/ptr.5197
Yeh, C.H., Chen, T.P., Wu, Y.C., Lin, Y.M., Jing Lin, P. (2005). Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. Journal of Surgical Research, 125(1), 109-116. https://doi.org/10.1016/j.jss.2004.11.009
Curcumin's antioxidant effects on inflammatory diseases
Year 2021,
Volume: 7 Issue: 1, 45 - 53, 03.12.2020
There are similar inflammatory reasons behind non-contagious chronic diseases. The prevalence of these diseases increases everyday both in our country and around the world. That's why scientists have begun looking for strong antioxidants that could help prevent and treat such inflammatory diseases. Curcumin is one of those antioxidants. Curcumin is one of the components of turmeric, which belongs to the ginger family. Many studies showed that the curcuminoids in turmeric can be used to prevent and treat cardiovascular, autoimmune and endocrine diseases, cancer as well as various inflammatory diseases. With this study, we aim to interpret these recent studies conducted with curcumin.
Ak, T., Gülçin, İ. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interactions, 174, 27-37. https://doi.org/10.1016/j.cbi.2008.05.003
Aksoy, A. (2018). Determination of the DNA damage levels in patients with chronic renal failure using 8-hydroxy-2’-deoxyguanosine biomarker. Fresenius Environmental Bulletin, 27(12a), 9308-9314.
Antiga, E., Bonciolini, V., Volpi, W., Del Bianco, E., Caproni, M. (2015). Oral curcumin (meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with Psoriasis vulgaris. BioMed Research International, 1-7. https://doi.org/10.1155/2015/283634
Asouri, M., Ataee, R., Ahmadi, A.A., Amini, A., Rezaei Moshaei, M. (2013). Antioxidant and free radical scavenging activities of curcumin. Asian Journal of Chemistry, 25(13), 7593-7595. https://doi.org/10.14233/ajchem.2013.15308
Atakan, A. (2017). Kilolu ve obez bireylerde zerdeçal tüketiminin ağırlık kaybı ve kan lipid düzeyleri üzerindeki etkisinin değerlendirilmesi. Doğu Akdeniz Üniversitesi, Lisansüstü Eğitim, Öğretim ve Araştırma Enstitüsü, Yüksek Lisans Tezi, Gazimağusa.
Belviranlı, M., Okudan, N., Nurullahoğlu, Atalık. K.E. (2012). Yaşlı sıçanlarda kurkumin takviyesinin kalp dokusunun oksidan/antioksidan durumu üzerine etkileri. Genel Tıp Dergisi, 22(2), 61-66.
Chandran, B., Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research, 26(11), 1719-1725. https://doi.org/10.1002/ptr.4639
Chin, D., Huebbe, P., Pallauf, K., Rimbach, G. (2013). Neuroprotective properties of curcumin in Alzheimer’s disease-merits and limitations. Current Medicinal Chemistry, 20(32), 3955-3985. https://doi.org/10.2174/09298673113209990210
Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., Jirawatnotal, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35, 2121-2127. https://doi.org/10.2337/dc12-0116
Dai, C., Li, D., Gong, L., Xiao, X., Tang, S. (2016). Curcumin ameliorates furazolidone-induced DNA damage and apoptosis in human hepatocyte L02 cells by inhibiting ROS production and mitochondrial pathway. Molecules, 21(8), E1061. https://doi.org/10.3390/molecules21081061
Deniz, R., Gürateş, B., Aydın, S., Çelik, H., Sahin, İ., Baykuş, Y., Çatak, Z., Aksoy, A., Çitil, C., Güngör, S. (2012). Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine, 42, 694-699. https://doi.org/10.1007/s12020-012-9638-7
Ghosh, S., Banerjee, S., Sil, P.C. (2015). The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chemical Toxicology, 83, 111-124. https://doi.org/10.1016/j.fct.2015.05.022
Harish, G., Venkateshappa, C., Mythri, R.B., Dubey, S.K., Mishra, K., Singh, N., Vali, S., Bharath, M.M. (2010). Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease. Bioorganic & Medicinal Chemistry, 18(7), 2631-2638. https://doi.org/10.1016/j.bmc.2010.02.029
Jaggi, M., Du, C., Zhang, W., Balaji, K.C. (2007). Protein kinase D1: A protein of emerging translational interest. Frontiers in Bioscience, 12, 3757-3767. https://doi.org/10.2741/2349
Jamilian, M., Foroozanfard, F., Kavossian, E., Aghadavod, E., Shafabakhsh, R., Hoseini, A., Asemi, Z. (2020). Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. European Society for Clinical Nutrition and Metabolism, 36, 128-133. https://doi.org/10.1016/j.clnesp.2020.01.005
Kumar, A., Sharma, N. (2015). Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pesticide Biochemistry and Physiology, 119(1), 16-27. https://doi.org/10.1016/j.pestbp.2015.03.003
Lang, A., Salomon, N., Wu, J.C., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J.Y., Cheong, P.K., Avidan, B., Gamus, D., Kaimakliotis, I., Eliakim, R., Ng, S.C., Ben-Horin, S. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology Hepatology, 13(8), 1444-1449. https://doi.org/10.1016/j.cgh.2015.02.019
Laveti, D., Kumar, M., Hemalatha, R., Sistla, R., Naidu, V.G., Talla, V., Verma, V., Kaur, N., Nagpal, R. (2013). Anti-inflammatory treatments for chronic diseases: A review. Inflammation & Allergy - Drug Targets, 12(5), 349–361. https://doi.org/10.2174/18715281113129990053
McFadden, R.T., Larmonier, C.B., Shehab, K.W., Midura-Kiela, M., Ramalingam, R., Harrison, C.A., Besselsen, D.G., Chase, J.H., Caporaso, J.G., Jobin, C., Ghishan, F.K., Kiela, P.R. (2015). The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory Bowel Diseases, 21(11), 2483-2494. https://doi.org/10.1097/MIB.0000000000000522
Mohammadi, S., Kayedpoor, P., Karimzadeh-Bardei, L., Nabiuni, M. (2017). The effect of curcumin on TNF-α, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state. Journal of Reproduction & Infertility, 18(4), 352-360.
Neeraj, J.P., Singh S, Singh J. (2008). Role of free radicals and antioxidants in human health and disease. International Journal of Current Research and Review, 5(19), 14-22.
Oyetayo, B.O., Amos, O., Abolaji, A.O., Fasae, K.D., Aderibigbe, A. (2020). Ameliorative role of diets fortified with curcumin in a Drosophila Melanogaster model of aluminum chloride-induced neurotoxicity. Journal of Functional Foods, 71, 1-7. https://doi.org/10.1016/j.jff.2020.104035
Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S.M., Keshavarz, S.A. (2016). Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepatitis Monthyl, 16(1), 1-5. https://doi.org/10.5812/hepatmon.34897
Sak, M.E., Soydinc, H.E., Sak, S., Evsen, M.S., Alabalik, U., Akdemir, F., Gul, T. (2013). The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. International Journal of Surgery, 11(9), 967-970. https://doi.org/10.1016/j.ijsu.2013.06.007
Seyithanoğlu, M., Tanrıkulu Küçük, S., Öner İyidoğan, Y., Koçak, H., Mikailova, P., Aydın, A.F. (2020). Kurkumin uygulamasının yüksek yağlı diyetle beslenen sıçanların testis dokusunda oksidanantioksidan sistem üzerine etkisi. İstanbul Tıp Fakültesi Dergisi, 83(3), 247-253. https://doi.org/10.26650/IUITFD.2019.0049
Sharma, R.A., Gescher, A.J., Steward, W.P. (2005). Curcumin: The story so far. European Journal of Cancer, 41(3), 1955-1968. https://doi.org/10.1016/j.ejca.2005.05.009
Sundram, V., Chauhan, S.C., Ebeling, M., Jaggi, M. (2012). Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1. PLoS One, 7(4), 1-13. https://doi.org/10.1371/journal.pone.0035368
Tanvir, E.M., Hossen, M.S., Hossain, M.F., Afroz, R., Hua Gan, S., Khalil, M.I., Karim, N. (2017). Antioxidant properties of popular turmeric (curcuma longa) varieties from Bangladesh. Journal of Food Quality, 8471785, 1-8. https://doi.org/10.1155/2017/8471785
Turgut, M. (2019). Deneysel akut pankretit’te kaempferol ve kurkumin’in etkilerinin araştırılması. Pamukkale Üniversitesi, Tıp Fakültesi, Uzmanlık Tezi, Denizli.
Wongcharoen, W., Jai-Aue, S., Phrommintikul, A., Nawarawong, W., Woragidpoonpol, S., Tepsuwan, T., Sukonthasarn, A., Apaijai, N., Chattpakorn, N. (2012). Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. American Journal of Cardiology, 110, 40-44. https://doi.org/10.1016/j.amjcard.2012.02.043
WHO (2000). Evaluation of certain food additives: Fifty-first report of the joint FAO/WHO expert committee on food additives. World Health Organization & Food and Agriculture Organization of The United Nations.
Yang, Y.S., Su, Y.F., Yang, H.W., Lee, Y.H., Chou, J.I., Ueng, K.C. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytotheraop Research, 28, 1770-1777. https://doi.org/10.1002/ptr.5197
Yeh, C.H., Chen, T.P., Wu, Y.C., Lin, Y.M., Jing Lin, P. (2005). Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. Journal of Surgical Research, 125(1), 109-116. https://doi.org/10.1016/j.jss.2004.11.009
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