A
natural agent that, promotes osteogenic differentiation of dental pulp
mesenchymal stem cells (DP-MSCs) could achieve success in regeneration during
healing and may also prevent bone resorption and improve regeneration. We aimed
to demonstrate that a Nigella sativa
oil could induce differentiation of DP-MSCs. DP-MSCs were isolated from 3.
molars and identified with flow cytometer. Osteogenic differentiation was
conducted, and calcium granules were showed by typical Alizarin Red dying and
calcium concentration were determined by DICA 500. Identification results
showed that the cells are mesenchymal stem cells. Alizarin Red dying signed the
calcium granules and DICA 500 showed that calcium concentrations were higher
than the Control Group. This preliminary study shows for the first time the
inductive potential of N. sativa oil
for osteogenic differentiation in DP-MSCs. The mechanism should be investigated
in further studies.
Subjects | Clinical Sciences |
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Journal Section | Articles |
Authors | |
Publication Date | January 1, 2018 |
Submission Date | March 20, 2017 |
Published in Issue | Year 2018Volume: 4 Issue: 1 |
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