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Antioxidant and 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitory activities of some plant samples

Yıl 2023, Cilt: 9 Sayı: 4, 293 - 303, 08.10.2023

Elmas Irmak Çil Arslan Özlem Saçan

https://doi.org/10.3153/FH23026

Öz

The antioxidant activity capacities of some plants, and their inhibitory effects on the HMG-CoA reductase enzyme, the rate-determining enzyme of cholesterol synthesis, were investigated in our study. Antioxidant activity capacity and inhibitory effect of the HMG-CoA reductase enzyme were detected in all plant extracts used in our research. The results obtained determined that both antioxidant activity and % inhibition values of HMG-CoA reductase enzyme increased as the plant extracts concentration increased. The strongest ABTS and DPPH radical scavenging activities were exhibited by pomegranate fruit extract (IC50= 1.07 ±0.04 mg/mL and IC50= 0.39 ±0.01 mg/mL, respectively). At the same time, lemon had the strongest DMPD radical scavenging activity (IC50= 9×10-4 ±6×10-5 mg/mL). The best HMG-CoA reductase inhibitory activity was observed in persimmon fruit extract (IC50= 0.71 ±0.18 µg/mL). The inhibitory power of this extract was much higher than that of the enzyme’s standard inhibitor, Atorvastatin (IC50 = 1.76 ±0.12 µg/mL). The extracts' potent antioxidant and inhibitory properties can be attributed to the rich phytochemical composition of plant extracts. Thus, it may be a potential source of new bioactive compounds effective against oxidative stress, hypercholesterolemia and cardiovascular complications.

Anahtar Kelimeler

Antioxidant activity Enzyme HMG-CoA reductase Inhibition Plants

Destekleyen Kurum

The Scientific Research Project Coordination Unit of Istanbul University-Cerrahpaşa

Proje Numarası

Project No. 28070

Kaynakça

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Yıl 2023, Cilt: 9 Sayı: 4, 293 - 303, 08.10.2023

Elmas Irmak Çil Arslan Özlem Saçan

https://doi.org/10.3153/FH23026

Öz

Anahtar Kelimeler

Antioxidant activity Enzyme HMG-CoA reductase Inhibition Plants

Proje Numarası

Project No. 28070

Kaynakça

  • Afam, I.O.J., Henry S., Thakhani T., Adewale O.O., Henry O.U., Tonna A.A. (2021). Antioxidant-rich natural fruit and vegetable products and human health. International Journal of Food Properties, 24(1), 41-67. https://doi.org/10.1080/10942912.2020.1866597
  • Agudelo, C., Barros, L., Santos-Buelga, C., Martinez-Navarrete, N., Ferreira, I.C.F.R. (2017). Phytochemical content and antioxidant activity of grapefruit (Star Ruby): A comparison between fresh freeze-dried fruits and different powder formulations. LWT - Food Science and Technology, 80, 106-112. https://doi.org/10.1016/j.lwt.2017.02.006
  • Alagarsamy, S., Chellappan, P., Jesuraj, M.T., Mohan, M.S.G., Balakrishnan, R. (2018). Phytochemical analysis and antioxidant potential of the crude extract of Allium oschaninii scape. Oriental Pharmacy and Experimental Medicine, 18, 309-316. https://doi.org/10.1007/s13596-018-0339-5
  • Almeida, M.M.B., de Sousa, P.H.M., Arriaga, A.M.C., do Prado, G.M., de Carvalho Magalhaes, C.E., Maia, G.A., de Lemos, T.L.G. (2011). Bioactive compounds and antioxidant activity of fresh exotic fruits from northeastern Brazil. Food Research International, 44(7), 2155–2159. https://doi.org/10.1016/j.foodres.2011.03.051
  • Alrasheid, A.A., Mohamed, A.A., Mohieldin, E.G., Eldein, K.I., Yassin, L.F., Widdatallh, M.O., Alnour, M.I., Eltilib, S.H., Ahmed, S.A., Ayoub, S.M.H. (2019). Phytochemical investigation and assessment of antimicrobial, anti-inflammatory and antioxidant activities of Sudanese Citrus paradisi peel extract. Pharmacognosy and Phytotherapy, 11(1), 1-8. https://doi.org/10.5897/JPP2018.0531
  • Arnao, M.B., Cano, M., Acosta, M. (2001). The hydrophilic and lipophilic contribution to total antioxidant activity. Food Chemistry, 73, 239-244. https://doi.org/10.1016/S0308-8146(00)00324-1
  • Aruoma, O.I. (1994). Nutrition and health aspects of free radicals and antioxidants. Food and Chemical Toxicology, 32, 671–683. https://doi.org/10.1016/0278-6915(94)90011-6
  • Asale, Y., Dessalegn, E., Assefa, D., Abdisa, M. (2021). Phytochemicals and antioxidant activity of different apple cultivars grown in South Ethiopia: Case of the wolayta zone. International Journal of Food Properties, 24(1), 354-363. https://doi.org/10.1080/10942912.2021.1885440
  • Aydin, E. (2021). Attributes of total phenolic content, antioxidant capacity and in-vitro simulated bioaccessibility of astringent, non-astringent and wild (rootstock) persimmons. Gida, 46(3), 669-680. https://doi.org/10.15237/gida.GD21032
  • Baenas, N., Garcia-Viguera, C., Moreno, D.A. (2014). Biotic elicitors effectively increase the glucosinolates content in Brassicaceae sprouts. Journal of Agricultural and Food Chemistry, 62, 1881–1889. https://doi.org/10.1021/jf404876z
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  • Murathan, Z.T. (2020). Phytochemical screening and antioxidant activity of Diospyros lotus L. fruits grown in Turkey. Acta Scientiarum Polonorum Hortorum Cultus, 19(2), 49–55. https://doi.org/10.24326/asphc.2020.2.5
  • Muzykiewicz, A., Zielonka-Brzezicka, J., Klimowicz, A. (2018). Quince (Cydonia oblonga Mill.) as a useful source of antioxidants–antioxidant activity evaluation. Herba Polonica, 64(4), 23-33. https://doi.org/10.2478/hepo-2018-0020
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Toplam 71 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji , Kimya Mühendisliği (Diğer)
Bölüm Research Articles
Yazarlar

Elmas Irmak Çil Arslan 0000-0001-7888-5118

Özlem Saçan 0000-0001-6503-4613

Proje Numarası Project No. 28070
Erken Görünüm Tarihi 27 Temmuz 2023
Yayımlanma Tarihi 8 Ekim 2023
Gönderilme Tarihi 8 Şubat 2023
Yayımlandığı Sayı Yıl 2023Cilt: 9 Sayı: 4

Kaynak Göster

APA Çil Arslan, E. I., & Saçan, Ö. (2023). Antioxidant and 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitory activities of some plant samples. Food and Health, 9(4), 293-303. https://doi.org/10.3153/FH23026
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