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Aralıklı orucun bağırsak mikrobiyotası üzerine etkisi

Yıl 2023, Cilt: 9 Sayı: 1, 87 - 97, 01.01.2023
https://doi.org/10.3153/FH23008

Öz

Beslenme alışkanlıklarının bağırsak mikrobiyotasını etkilediği bilinmektedir. Son dönemlerde besin alımının çeşitliliğinden ziyade besin alınan zamanın mikrobiyota üzerine etkisine odaklanılmış ve bunun mikrobiyomu etkilediği görülmüştür. Aralıklı orucun mikrobiyotadaki yararlı mikroorganizmaları arttığı, patojen mikroorganizmaları azalttığı rapor edilmiş olsa da etki mekanizması tam olarak açıklanamamıştır. Bu derlemenin amacı aralıklı oruç ve mikrobiyota ilişkisini inceleyen güncel çalışmaları yorumlamaktır.

Kaynakça

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  • Deng, Y., Liu, W., Wang, J., Yu, J., Yang, L.Q. (2020). Intermittent fasting improves lipid metabolism through changes in gut microbiota in diet-induced obese mice. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e926789-1. https://dx.doi.org/10.12659%2FMSM.926789
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The Effect of Intermittent Fasting on Gut Microbiota

Yıl 2023, Cilt: 9 Sayı: 1, 87 - 97, 01.01.2023
https://doi.org/10.3153/FH23008

Öz

Nutritional habits are known to affect the gut microbiota. Recently, it has been focused on the effect of the time taken in food on the microbiota rather than the variety of food intake, and it has been seen that this affects the microbiome. Although it has been reported that intermittent fasting increases beneficial microorganisms in the microbiota and decreases pathogenic microorganisms, its mechanism of action has not been fully explained. The purpose of this review is to interpret current studies examining the relationship between intermittent fasting and microbiota.

Kaynakça

  • Abdelaal, M., le Roux, C.W., Docherty, N.G. (2017). Morbidity and mortality associated with obesity. Annals of Translational Medicine, 5(7), 161. https://doi.org/10.21037/atm.2017.03.107
  • Ajala, O., Mold, F., Boughton, C., Cooke, D., Whyte, M. (2017). Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta‐analysis. Obesity Reviews, 18(9), 1061-1070. https://doi.org/10.1111/obr.12561
  • Akanji, A.O., Mojiminiyi, O.A., Abdella, N. (2000). Beneficial changes in serum apo A-1 and its ratio to apo Band HDL in stable hyperlipidaemic subjects after Ramadan fasting in Kuwait. European Journal of Clinical Nutrition, 54, 508-513. https://doi.org/10.1038/sj.ejcn.1601047
  • Anonim. (2016). The Nobel Prize in Physiology or Medicine. https://www.nobelprize.org/prizes/medicine/2016/summary/ (Erişim Tarihi: 01.03.2022)
  • Aybak, M., Turkoglu, A., Sermet, A., Denli, O. (1996). Effect of Ramadan fasting on platelet aggregation in healthy male subjects. European Journal of Applied Physiology and Occupational Physiology, 73, 552-556. https://doi.org/10.1007/BF00357678
  • Aydın, Ü.F., Tuli, A. (2021). Bağırsak-beyin eksenine biyokimyasal bakış. Arşiv Kaynak Tarama Dergisi, 30(3), 137-143. https://doi.org/10.17827/aktd.910674
  • Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y. ve ark. (2018). Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice. Diabetes, 67(9), 1867-1879. https://doi.org/10.2337/db18-0158
  • Blum, H.E. (2017). The human microbiome. Advances in Medical Sciences, 62(2), 414-420. https://doi.org/10.1016/j.advms.2017.04.005
  • Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L. ve ark. (2018). Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Cell Metabolism, 27(6), 1222-1235. https://doi.org/10.1016/j.cmet.2018.05.006
  • Claesson, M.J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E. ve ark. (2011). Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proceedings of the National Academy of Sciences, 108(Supplement 1), 4586-4591. https://doi.org/10.1073/pnas.1000097107
  • Clemente, J.C., Pehrsson, E.C., Blaser, M.J., Sandhu, K., Gao, Z., Wang, B. ve ark. (2015). The microbiome of uncontacted Amerindians. Science Advances, 1(3), e1500183. https://doi.org/10.1126/sciadv.1500183
  • Clos-Garcia, M., Andrés-Marin, N., Fernández-Eulate, G., Abecia, L., Lavín, J.L., van Liempd, S. ve ark. (2019). Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia. EBioMedicine, 46, 499-511. https://doi.org/10.1016/j.ebiom.2019.07.031
  • Deng, Y., Liu, W., Wang, J., Yu, J., Yang, L.Q. (2020). Intermittent fasting improves lipid metabolism through changes in gut microbiota in diet-induced obese mice. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e926789-1. https://dx.doi.org/10.12659%2FMSM.926789
  • Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004). Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. International Journal of Systematic and Evolutionary Microbiology, 54(5), 1469-1476. https://doi.org/10.1099/ijs.0.02873-0
  • Di Daniele, N. (2019). The role of preventive nutrition in chronic non-communicable diseases. Nutrients, 11(5), 1074. https://doi.org/10.3390/nu11051074
  • Doifode, T., Giridharan, V.V., Generoso, J.S., Bhatti, G., Collodel, A., Schulz, P.E. ve ark. (2021). The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology. Pharmacological Research, 164, 105314. https://doi.org/10.1016/j.phrs.2020.105314
  • El Ati, J., Beji, C., Danguir, J. (1995). Increased fat oxidation during Ramadan fasting in healthy women: An adaptative mechanism for body-weight maintenance. American Journal of Clinical Nutrition, 62(2), 302-307. https://doi.org/10.1093/ajcn/62.2.302
  • Fernando, H.A., Zibellini, J., Harris, R.A., Seimon, R.V., Sainsbury, A. (2019). Effect of Ramadan fasting on weight and body composition in healthy non-athlete adults: A systematic review and meta-analysis. Nutrients, 11(2), 478. https://doi.org/10.3390/nu11020478
  • Festi, D., Schiumerini, R., Eusebi, L.H., Marasco, G., Taddia, M., Colecchia, A. (2014). Gut microbiota and metabolic syndrome. World Journal of Gastroenterology, 20(43), 16079. https://doi.org/10.3748/wjg.v20.i43.16079
  • Frank, D.N., St Amand, A.L., Feldman, R.A., Boedeker, E.C., Harpaz, N., Pace, N.R. (2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences of the USA, 104, 13780-13785. https://doi.org/10.1073/pnas.0706625104
  • GBD 2015 Obesity Collaborators. (2017). Health effects of overweight and obesity in 195 countries over 25 years. New England Journal of Medicine, 377(1), 13-27. https://doi.org/10.1056/NEJMoa1614362
  • Gill, S.R., Pop, M., DeBoy, R.T., Eckburg, P.B., Turnbaugh, P.J., Samuel, B.S. ve ark. (2006). Metagenomic analysis of the human distal gut microbiome. Science, 312(5778), 1355-1359. https://doi.org/10.1126/science.1124234
  • Guo, Y., Luo, S., Ye, Y., Yin, S., Fan, J., Xia, M. (2021). Intermittent fasting improves cardiometabolic risk factors and alters gut microbiota in metabolic syndrome patients. The Journal of Clinical Endocrinology & Metabolism, 106(1), 64-79. https://doi.org/10.1210/clinem/dgaa644
  • Harvie, M.N., Pegington, M., Mattson, M.P., Frystyk, J., Dillon, B., Evans, G. ve ark. (2011). The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. International Journal of Obesity, 35(5), 714-727. https://doi.org/10.1038/ijo.2010.171
  • Huang, F., Wu, X. (2021). Brain neurotransmitter modulation by gut microbiota in anxiety and depression. Frontiers in Cell and Developmental Biology, 9, 472. https://doi.org/10.3389/fcell.2021.649103
  • Human Microbiome Project Consortium. (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207-214. https://doi.org/10.1038/nature11234
  • Ichimura, Y., Kirisako T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N. ve ark. (2000). A ubiquitin-like system mediates protein lipidation. Nature, 408, 488-492. https://doi.org/10.1038/35044114
  • Kul, S., Savas, E., Ozturk, Z.A., Karadag, G. (2014). Does Ramadan fasting alter body weight and blood lipids and fasting blood glucose in a healthy population? A meta-analysis. Journal of Religion & Health, 53(3), 929-942. https://doi.org/10.1007/s10943-013-9687-0
  • Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L. ve ark. (2017). Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell Metabolism, 26(4), 672-685. https://doi.org/10.1016/j.cmet.2017.08.019
  • Li, L., Su, Y., Li, F., Wang, Y., Ma, Z., Li, Z., Su, J. (2020). The effects of daily fasting hours on shaping gut microbiota in mice. BMC Microbiology, 20(1), 1-8. https://doi.org/10.1186/s12866-020-01754-2
  • Li, T., Qi, M., Gatesoupe, F.J., Tian, D., Jin, W., Li, J. ve ark. (2019). Adaptation to fasting in crucian carp (carassius auratus): Gut microbiota and its correlative relationship with immune function. Microbial Ecology, 78(1), 6-19. https://doi.org/10.1007/s00248-018-1275-0
  • Liu, Y., Wang, H., Gui, S., Zeng, B., Pu, J., Zheng, P. ve ark. (2021). Proteomics analysis of the gut–brain axis in a gut microbiota-dysbiosis model of depression. Translational Psychiatry, 11(1), 1-8. https://doi.org/10.1038/s41398-021-01689-w
  • Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X. ve ark. (2020). Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications, 11(1), 1-14. https://doi.org/10.1038/s41467-020-14676-4
  • Longo, V.D., Mattson, M.P. (2014). Fasting: Molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-92. https://doi.org/10.1016/j.cmet.2013.12.008
  • Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V.D., Sokol, H., Doré, J. ve ark. (2009). The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiology, 9(1), 1-6. https://doi.org/10.1186/1471-2180-9-123
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  • Mirmiran, P., Bahadoran, Z., Gaeini, Z., Moslehi, N., Azizi F. (2019). Effects of Ramadan intermittent fasting on lipid and lipoprotein parameters: An updated meta-analysis. Nutrition, Metabolism & Cardiovascular Diseases, 29(9), 906–915. https://doi.org/10.1016/j.numecd.2019.05.056
  • Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J. (2008). Autophagy fights disease through cellular self-digestion. Nature, 451, 1069-1075. https://doi.org/10.1038/nature06639
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  • Morais, L.H., Schreiber, H.L., Mazmanian, S.K. (2021). The gut microbiota–brain axis in behaviour and brain disorders. Nature Reviews Microbiology, 19(4), 241-255. https://doi.org/10.1038/s41579-020-00460-0
  • Most, J., Tosti, V., Redman, L.M., Fontana, L. (2017). Calorie restriction in humans: an update. Ageing Research Reviews, 39, 36-45. https://doi.org/10.1016/j.arr.2016.08.005
  • Ohsumi, Y. (2001). Molecular dissection of autophagy: Two ubiquitin-like systems. Nature Reviews Molecular Cell Biology, 2(3), 211-216. https://doi.org/10.1038/35056522
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  • Takeshige, K., Baba, M., Tsuboi, S., Noda, T., Ohsumi, Y. (1992). Autophagy in Yeast Demonstrated with Proteinase-Deficient Mutants and Conditions for Its Induction. The Journal of Cell Biology, 119(2), 301-311. https://doi.org/10.1083/jcb.119.2.301
  • Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J.P. ve ark. (2009). Towards the human intestinal microbiota phylogenetic core. Environmental Microbiology, 11(10), 2574-2584. https://doi.org/10.1111/j.1462-2920.2009.01982.x
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  • Wei, S., Han, R., Zhao, J., Wang, S., Huang, M., Wang, Y. ve ark. (2018). Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutrition & Metabolism, 15(1), 1-12. https://doi.org/10.1186/s12986-018-0318-3
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  • Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z. (2022). Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and Therapeutic Medicine, 23(1), 1-10. https://doi.org/10.3892/etm.2021.10974
Toplam 60 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Review Articles
Yazarlar

Halime Selen 0000-0002-3705-0875

Aylin Seylam 0000-0003-4705-8042

Yayımlanma Tarihi 1 Ocak 2023
Gönderilme Tarihi 9 Mart 2022
Yayımlandığı Sayı Yıl 2023Cilt: 9 Sayı: 1

Kaynak Göster

APA Selen, H., & Seylam, A. (2023). Aralıklı orucun bağırsak mikrobiyotası üzerine etkisi. Food and Health, 9(1), 87-97. https://doi.org/10.3153/FH23008

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