Research Article
Year 2019,
Volume: 5 Issue: 1, 39 - 47, 01.01.2019
Abstract
The
aim of this study was to determine total phenolic and total flavonoid contents,
antioxidant and anticholinesterase activities of the hexane, acetone and
ethanol extracts prepared from mantle, rosemary, thistle, mallow and nettle
commonly consumed for medicinal and nutraceutical purposes in Turkey and all
around the world. DPPH free radical, ABTS cation radical and superoxide anion
radical scavenging assays, and Ellman method were used to establish the antioxidant
and anticholinesterase potential of the extracts, respectively. Total phenolic
and total flavonoid contents of the mantle ethanol extract were found to be the
richest extract among the others. Mantle ethanol and thistle hexane extracts in
DPPH free radical scavenging method (88.03% and 88.07%, respectively), and acetone and ethanol extracts of mantle and
rosemary in ABTS cation radical scavenging assay showed the highest
inhibition (88.60% and 89.73%, respectively)
at 100 μg/mL concentration. None of the
extracts exhibited superoxide anion radical scavenging activity. Nettle ethanol
extract indicated higher butyrylcholinesterase inhibitory activity (92.68%)
than galanthamine, mallow acetone extract as galanthamine, mantle hexane,
mallow hexane and ethanol, and nettle acetone extracts almost as galanthamine.
To our knowledge, ABTS cation radical and superoxide anion radical scavenging
activities, and anticholinesterase potential of the extracts prepared from
mantle leaves and flowers, anticholinesterase effect of thistle seeds extracts,
ABTS cation radical scavenging activity and butyrylcholinesterase inhibitory
activity of the extracts prepared from mallow leaves and flowers were investigated
for the first time in this study.
References
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- Boğa, M., Hacıbekiroğlu, I., Kolak, U. (2011). Antioxidant and anticholinesterase activities of eleven edible plants. Pharmaceutical Biology, 49, 290-295.
- Boğa, M., Ertaş, A., Yılmaz, M.B., Kızıl, M., Çeken, B., Haşimi, N., Yılmaz Özden, T., Demirci, S., Yener, İ., Deveci, Ö. (2016). UHPLC-ESI-MS/MS and GC-MS analyses on phenolic, fatty acid and essential oil of Verbascum pinetorum with antioxidant, anticholinesterase, antimicrobial and DNA damage protection effects. Iranian Journal of Pharmaceutical Research, 15, 393-405.
- Craft, B.D., Kerrihard, A.L., Amarowicz, R., Pegg, R.B. (2012). Phenol-based antioxidants and the in vitro methods used for their assessment. Comprehensive Reviews in Food Science and Food Safety, 11, 148-173.
- Dudonné, S., Vitrac, X., Coutière, P., Woilllez, M., Mérillon, J-M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Food Chemistry, 57, 1768-1774.
- Ellman, G.L., Courtney, K.D., Andres, V., Featherston, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7, 88-95.
- Ertaş, A., Boğa, M., Haşimi, N., Yeşil, Y., Gören, A.C., Topçu, G., Kolak, U. (2014). Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm. Turkish Journal of Chemistry, 38, 592-599.
- Ferreira, A., Proenca, C., Serralheiro, M.L.M., Araujo, M.E.M. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal of Ethnopharmacology, 108, 7-31.
- Gholamhoseinian, A., Moradi, M.N., Sharifi-Far, F. (2009). Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in Pharmaceutical Sciences, 4, 105-112.
- Gülçin, İ., Küfrevioğlu, Ö.İ., Oktay, M., Büyükokuroğlu, M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). Journal of Ethnopharmacology, 90, 205-215.
- Hamad, İ., Erol-Dayi, Ö., Pekmez, M., Önay-Uçar, E., Arda, N. (2010). Antioxidant and cytotoxic activities of Aphanes arvensis extracts. Plant Foods for Human Nutrition, 65, 45-49.
- Hartman, R.E. (2009). Phytochemicals in cell function and Alzheimer’s disease pathology. In L. Packer, H. Sies, M. Eggersdorfer & E. Cadenas (Eds.) Micronutrients and Brain Health (p. 225-241). New York, NY: CRC press. ISBN 9781420073515
- Howes, M-J.R., Perry, N.S.L., Houghton, P.F. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotherapy Research, 17, 1-18.
- Keskin, C., Aktepe, N., Yükselten, Y., Sunguroğlu, A., Boğa, M. (2017). In-vitro antioxidant, cytotoxic, cholinesterase ınhibitory activities and anti-genotoxic effects of Hypericum retusum Aucher flowers, fruits and seeds methanol extracts in human mononuclear leukocytes. Iranian Journal of Pharmaceutical Research, 16, 210-220.
- Liang, N., Kitts, D.D. (2014). Antioxidant property of coffee components: Assessment of methods that define mechanisms of action. Molecules, 19, 19180-19208.
- Nasri, H., Baradaran, A., Shirzad, H., Rafieian-Kopaei, M. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine, 5, 1487-1499.
- Nishikimi, M., Rao, N.A., Yagi, K. (1972). The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and moleculer oxygen. Biochemical and Biophysical Research Communications, 46, 849-854.
- Oh, J., Jo, H., Cho, A.R., Kim, S-J., Han, J. (2012). Antioxidant and antimicrobial activities of various leafy herbal teas. Food Control, 31, 403-409.
- Orhan, İ., Aslan, S., Kartal, M., Şener, B., Başer, K.H.C. (2008). Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chemistry, 108, 663-668.
- Park, Y.K., Koo, M.H., Ikegaki, M., Contado, J.L. (1997). Comparison of the flavonoid aglycone contents of Apis mellifera propolis from various regions of Brazil. Brazilian Archives of Biology and Technology, 40, 97-106.
- Piazzi, L., Cavalli, A., Colizzi, F., Belluti, F., Bartolini, M., Mancini, F., Recanatini, M., Andrisano, V., Rampa, A. (2008). Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorganic & Medicinal Chemistry Letters, 18, 423-426.
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology & Medicine, 26, 1231-1237.
- Reische, D.W., Lillard, D.A., Eitenmiller, R.R. (2002). Antioxidants. In C.C. Akoh & D.B. Min (Eds.), Food Lipids: Chemistry, Nutrition, and Biotechnology (p. 489-516). New York, NY: Marcel Dekker Inc. ISBN 0-8247-0749-4
- Samuelsson, G., Bohlin L. (1999). Drugs of natural origin: a text book of pharmacognosy. Stockholm: Swedish P’ceutical Press, ISBN 9789186274818
- Slinkard, K., Singleton, V.L. (1977). Total phenol analysis automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55.
- Wong, S.P., Leong, L.P., Koh, J.H.W. (2006). Antioxidant activities of aqueous extracts of selected plants. Food Chemistry, 99, 775-783.
Year 2019,
Volume: 5 Issue: 1, 39 - 47, 01.01.2019
Abstract
References
- Baytop, T. (1984). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün). İstanbul: İstanbul University Press, p. 184, 221-2, 226, 258-9, 417, ISBN 9789754200218
- Benso, B., Franchin, M., Massarioli, A.P., Paschoal, J.A.R., Alencar, S.M., Franco, G.C.N., Rosalen, P.L. (2016). Anti-inflammatory, antiosteoclastogenic and antioxidant effects of Malva sylvestris extract and fractions: in vitro and in vivo studies. PLoS One 11(9), e0162728. Blois, M.S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200.
- Boğa, M., Hacıbekiroğlu, I., Kolak, U. (2011). Antioxidant and anticholinesterase activities of eleven edible plants. Pharmaceutical Biology, 49, 290-295.
- Boğa, M., Ertaş, A., Yılmaz, M.B., Kızıl, M., Çeken, B., Haşimi, N., Yılmaz Özden, T., Demirci, S., Yener, İ., Deveci, Ö. (2016). UHPLC-ESI-MS/MS and GC-MS analyses on phenolic, fatty acid and essential oil of Verbascum pinetorum with antioxidant, anticholinesterase, antimicrobial and DNA damage protection effects. Iranian Journal of Pharmaceutical Research, 15, 393-405.
- Craft, B.D., Kerrihard, A.L., Amarowicz, R., Pegg, R.B. (2012). Phenol-based antioxidants and the in vitro methods used for their assessment. Comprehensive Reviews in Food Science and Food Safety, 11, 148-173.
- Dudonné, S., Vitrac, X., Coutière, P., Woilllez, M., Mérillon, J-M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Food Chemistry, 57, 1768-1774.
- Ellman, G.L., Courtney, K.D., Andres, V., Featherston, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7, 88-95.
- Ertaş, A., Boğa, M., Haşimi, N., Yeşil, Y., Gören, A.C., Topçu, G., Kolak, U. (2014). Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm. Turkish Journal of Chemistry, 38, 592-599.
- Ferreira, A., Proenca, C., Serralheiro, M.L.M., Araujo, M.E.M. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal of Ethnopharmacology, 108, 7-31.
- Gholamhoseinian, A., Moradi, M.N., Sharifi-Far, F. (2009). Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in Pharmaceutical Sciences, 4, 105-112.
- Gülçin, İ., Küfrevioğlu, Ö.İ., Oktay, M., Büyükokuroğlu, M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). Journal of Ethnopharmacology, 90, 205-215.
- Hamad, İ., Erol-Dayi, Ö., Pekmez, M., Önay-Uçar, E., Arda, N. (2010). Antioxidant and cytotoxic activities of Aphanes arvensis extracts. Plant Foods for Human Nutrition, 65, 45-49.
- Hartman, R.E. (2009). Phytochemicals in cell function and Alzheimer’s disease pathology. In L. Packer, H. Sies, M. Eggersdorfer & E. Cadenas (Eds.) Micronutrients and Brain Health (p. 225-241). New York, NY: CRC press. ISBN 9781420073515
- Howes, M-J.R., Perry, N.S.L., Houghton, P.F. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotherapy Research, 17, 1-18.
- Keskin, C., Aktepe, N., Yükselten, Y., Sunguroğlu, A., Boğa, M. (2017). In-vitro antioxidant, cytotoxic, cholinesterase ınhibitory activities and anti-genotoxic effects of Hypericum retusum Aucher flowers, fruits and seeds methanol extracts in human mononuclear leukocytes. Iranian Journal of Pharmaceutical Research, 16, 210-220.
- Liang, N., Kitts, D.D. (2014). Antioxidant property of coffee components: Assessment of methods that define mechanisms of action. Molecules, 19, 19180-19208.
- Nasri, H., Baradaran, A., Shirzad, H., Rafieian-Kopaei, M. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine, 5, 1487-1499.
- Nishikimi, M., Rao, N.A., Yagi, K. (1972). The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and moleculer oxygen. Biochemical and Biophysical Research Communications, 46, 849-854.
- Oh, J., Jo, H., Cho, A.R., Kim, S-J., Han, J. (2012). Antioxidant and antimicrobial activities of various leafy herbal teas. Food Control, 31, 403-409.
- Orhan, İ., Aslan, S., Kartal, M., Şener, B., Başer, K.H.C. (2008). Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chemistry, 108, 663-668.
- Park, Y.K., Koo, M.H., Ikegaki, M., Contado, J.L. (1997). Comparison of the flavonoid aglycone contents of Apis mellifera propolis from various regions of Brazil. Brazilian Archives of Biology and Technology, 40, 97-106.
- Piazzi, L., Cavalli, A., Colizzi, F., Belluti, F., Bartolini, M., Mancini, F., Recanatini, M., Andrisano, V., Rampa, A. (2008). Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorganic & Medicinal Chemistry Letters, 18, 423-426.
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology & Medicine, 26, 1231-1237.
- Reische, D.W., Lillard, D.A., Eitenmiller, R.R. (2002). Antioxidants. In C.C. Akoh & D.B. Min (Eds.), Food Lipids: Chemistry, Nutrition, and Biotechnology (p. 489-516). New York, NY: Marcel Dekker Inc. ISBN 0-8247-0749-4
- Samuelsson, G., Bohlin L. (1999). Drugs of natural origin: a text book of pharmacognosy. Stockholm: Swedish P’ceutical Press, ISBN 9789186274818
- Slinkard, K., Singleton, V.L. (1977). Total phenol analysis automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55.
- Wong, S.P., Leong, L.P., Koh, J.H.W. (2006). Antioxidant activities of aqueous extracts of selected plants. Food Chemistry, 99, 775-783.
There are 27 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Structural Biology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | January 1, 2019 |
| Submission Date | January 19, 2018 |
| Published in Issue | Year 2019Volume: 5 Issue: 1 |
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