Food and Health
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BLACK CUMIN (Nigella sativa) AND ITS ACTIVE COMPONENT OF THYMOQUINONE: EFFECTS ON HEALTH

Year 2017, Volume 3, Issue 4, 170 - 183, 22.09.2017

Merve Şeyda Karaçil Ermumcu Nevin Şanlıer

https://doi.org/10.3153/JFHS17020

Abstract

Nigella sativa has the richest historical past of plants in the healthcare field. It has been used as a food preservative and to enhance flavour in many countries of the world for thousands of years and has also been used as a spice, and Nigella sativa seed and oil has been consumed for the treatment of many diseases in the world for many years. Today, it is believed to have antihypertensive, antihyperlipidemic, antidiabetic, anticancer, antioxidant, antimicrobial, antitumour, antibacterial, anti-inflammtory and immune-system effects through its components. And therefore Nigella sativa and its effects on health are discussed in this review.

Keywords

Nigella sativa, Black cumin, Thymoquinone, Nutrition, Health

References

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  • Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A.K., Siddique, N. A., . . . Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337-352.
  • Ahmad, S., & Beg, Z.H. (2013). Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chemistry,138(2), 1116-1124.
  • Ait Mbarek, L., Ait Mouse, H., Elabbadi, N., Bensalah, M., Gamouh, A., Aboufatima, R., . . . Dalal, A. (2007). Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Brazilian Journal of Medical and Biological Research, 40(6), 839-847.
  • Akash, M., Rehman, K., Rasool, F., Sethi, A., Abrar, M., Irshad, A., . . . Murtaza, G. (2011). Alternate therapy of type 2 diabetes mellitus (T2DM) with Nigella (Ranunculaceae). Journal of Medicinal Plants Research, 5(31), 6885-6889.
  • Al-Naqeep, G., Al-Zubairi, A.S., Ismail, M., Amom, Z.H., & Esa, N.M. (2011). Antiatherogenic potential of Nigella sativa seeds and oil in diet-induced hypercholesterolemia in rabbits. Evidence-Based Complementary and Alternative Medicine, 2011, 1-8.
  • Al‐Mahasneh, M.A., Ababneh, H.A., & Rababah, T. (2008). Some engineering and thermal properties of black cumin (Nigella sativa L.) seeds. International Journal of Food Science & Technology, 43(6), 1047-1052.
  • Ali, B., & Blunden, G. (2003). Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research, 17(4), 299-305.
  • Badary, O.A., Taha, R.A., Gamal El-Din, A.M., & Abdel-Wahab, M.H. (2003). Thymoquinone is a potent superoxide anion scavenger. Drug and Chemical Toxicology, 26(2), 87-98.
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  • Bamosa, A.O., Ali, B.A., & al-Hawsawi, Z.A. (2002). The effect of thymoquinone on blood lipids in rats. Indian Journal of Physiology and Pharmacology, 46(2), 195-201.
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  • Benhaddou-Andaloussi, A., Martineau, L. C., Spoor, D., Vuong, T., Leduc, C., Joly, E., . . . Arnason, J.T. (2008). Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic β-cells, skeletal muscle cells, and adipocytes. Pharmaceutical Biology, 46(1-2), 96-104.
  • Botnick, I., Xue, W., Bar, E., Ibdah, M., Schwartz, A., Joel, D. M., . . . Lewinsohn, E. (2012). Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. Molecules, 17(9), 10159-10177.
  • Bourgou, S., Ksouri, R., Bellila, A., Skandrani, I., Falleh, H., & Marzouk, B. (2008). Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots. Comptes Rendus Biologies, 331(1), 48-55.
  • Bourgou, S., Pichette, A., Marzouk, B., & Legault, J. (2010). Bioactivities of black cumin essential oil and its main terpenes from Tunisia. South African Journal of Botany, 76(2), 210-216.
  • Bourgou, S., Pichette, A., Marzouk, B., & Legault, J. (2012). Antioxidant, anti‐inflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (black cumin) plant parts. Journal of Food Biochemistry, 36(5), 539-546.
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  • Darakhshan, S., Pour, A.B., Colagar, A.H., & Sisakhtnezhad, S. (2015). Thymoquinone and its therapeutic potentials. Pharmacological Research, 95, 138-158.
  • Datau, E., Surachmanto, E., Pandelaki, K., & Langi, J. (2010). Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Medica Indonesiana, 42(3), 130-134.
  • Dehkordi, F.R., & Kamkhah, A.F. (2008). Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology, 22(4), 447-452.
  • El-Mahmoudy, A., Matsuyama, H., Borgan, M., Shimizu, Y., El-Sayed, M., Minamoto, N., & Takewaki, T. (2002). Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. International Immunopharmacology, 2(11), 1603-1611.
  • El‐Mahdy, M.A., Zhu, Q., Wang, Q.E., Wani, G., & Wani, A.A. (2005). Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells. International Journal of Cancer, 117(3), 409-417.
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  • Fallah Huseini, H., Amini, M., Mohtashami, R., Ghamarchehre, M., Sadeqhi, Z., Kianbakht, S., & Fallah Huseini, A. (2013). Blood Pressure Lowering Effect of Nigella sativa L. Seed Oil in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐controlled Clinical Trial. Phytotherapy Research, 27(12), 1849-1853.
  • Farah, I.O., & Begum, R.A. (2002). Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomedical Sciences Instrumentation, 39, 359-364.
  • Fararh, K.M., Ibrahim, A.K., & Elsonosy, Y.A. (2010). Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats. Research in Veterinary Science, 88(3), 400-404.
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Year 2017, Volume 3, Issue 4, 170 - 183, 22.09.2017

Merve Şeyda Karaçil Ermumcu Nevin Şanlıer

https://doi.org/10.3153/JFHS17020

Abstract

References

  • Abukhader, M. (2012). The effect of route of administration in thymoquinone toxicity in male and female rats. Indian Journal of Pharmaceutical Sciences, 74(3), 195.
  • Ahmad, A., Husain, A., Mujeeb, M., Khan, S. A., Najmi, A.K., Siddique, N. A., . . . Anwar, F. (2013). A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pacific Journal of Tropical Biomedicine, 3(5), 337-352.
  • Ahmad, S., & Beg, Z.H. (2013). Hypolipidemic and antioxidant activities of thymoquinone and limonene in atherogenic suspension fed rats. Food Chemistry,138(2), 1116-1124.
  • Ait Mbarek, L., Ait Mouse, H., Elabbadi, N., Bensalah, M., Gamouh, A., Aboufatima, R., . . . Dalal, A. (2007). Anti-tumor properties of blackseed (Nigella sativa L.) extracts. Brazilian Journal of Medical and Biological Research, 40(6), 839-847.
  • Akash, M., Rehman, K., Rasool, F., Sethi, A., Abrar, M., Irshad, A., . . . Murtaza, G. (2011). Alternate therapy of type 2 diabetes mellitus (T2DM) with Nigella (Ranunculaceae). Journal of Medicinal Plants Research, 5(31), 6885-6889.
  • Al-Naqeep, G., Al-Zubairi, A.S., Ismail, M., Amom, Z.H., & Esa, N.M. (2011). Antiatherogenic potential of Nigella sativa seeds and oil in diet-induced hypercholesterolemia in rabbits. Evidence-Based Complementary and Alternative Medicine, 2011, 1-8.
  • Al‐Mahasneh, M.A., Ababneh, H.A., & Rababah, T. (2008). Some engineering and thermal properties of black cumin (Nigella sativa L.) seeds. International Journal of Food Science & Technology, 43(6), 1047-1052.
  • Ali, B., & Blunden, G. (2003). Pharmacological and toxicological properties of Nigella sativa. Phytotherapy Research, 17(4), 299-305.
  • Badary, O.A., Taha, R.A., Gamal El-Din, A.M., & Abdel-Wahab, M.H. (2003). Thymoquinone is a potent superoxide anion scavenger. Drug and Chemical Toxicology, 26(2), 87-98.
  • Bamosa, A.O. (2015). A review on the hypoglycemic effect of Nigella sativa and thymoquinone. Saudi Journal of Medicine and Medical Sciences, 3(1), 2.
  • Bamosa, A.O., Ali, B.A., & al-Hawsawi, Z.A. (2002). The effect of thymoquinone on blood lipids in rats. Indian Journal of Physiology and Pharmacology, 46(2), 195-201.
  • Bamosa, A.O., Kaatabi, H., Lebda, F.M., Elq, A.-M.A., & Al-Sultan, A. (2010). Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian Journal of Physiology and Pharmacology, 54(4), 344-54.
  • Bayram, U.Ö.İ. (2012). Çörek Otunun (Nigella sativa) Kuzularda Besi Performansı, Bazı Kan ve Rumen sıvısı Parametreleri Üzerine Etkisi. Kocatepe Veteriner Dergisi, 5(2), 27-33.
  • Benhaddou-Andaloussi, A., Martineau, L. C., Spoor, D., Vuong, T., Leduc, C., Joly, E., . . . Arnason, J.T. (2008). Antidiabetic activity of Nigella sativa seed extract in cultured pancreatic β-cells, skeletal muscle cells, and adipocytes. Pharmaceutical Biology, 46(1-2), 96-104.
  • Botnick, I., Xue, W., Bar, E., Ibdah, M., Schwartz, A., Joel, D. M., . . . Lewinsohn, E. (2012). Distribution of primary and specialized metabolites in Nigella sativa seeds, a spice with vast traditional and historical uses. Molecules, 17(9), 10159-10177.
  • Bourgou, S., Ksouri, R., Bellila, A., Skandrani, I., Falleh, H., & Marzouk, B. (2008). Phenolic composition and biological activities of Tunisian Nigella sativa L. shoots and roots. Comptes Rendus Biologies, 331(1), 48-55.
  • Bourgou, S., Pichette, A., Marzouk, B., & Legault, J. (2010). Bioactivities of black cumin essential oil and its main terpenes from Tunisia. South African Journal of Botany, 76(2), 210-216.
  • Bourgou, S., Pichette, A., Marzouk, B., & Legault, J. (2012). Antioxidant, anti‐inflammatory, anticancer and antibacterial activities of extracts from Nigella sativa (black cumin) plant parts. Journal of Food Biochemistry, 36(5), 539-546.
  • Bulca, S. (2015). Çörek otunun bileşenleri ve bu yağın ve diğer bazı uçucu yağların antioksidan olarak gıda teknolojisinde kullanımı. Journal of Adnan Menderes University, Agricultural Faculty, 11(2), 29-36.
  • Burits, M., & Bucar, F. (2000). Antioxidant activity of Nigella sativa essential oil. Phytotherapy Research, 14(5), 323-328. Chehl, N., Chipitsyna, G., Gong, Q., Yeo, C.J., & Arafat, H.A. (2009). Anti‐inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB, 11(5), 373-381.
  • Darakhshan, S., Pour, A.B., Colagar, A.H., & Sisakhtnezhad, S. (2015). Thymoquinone and its therapeutic potentials. Pharmacological Research, 95, 138-158.
  • Datau, E., Surachmanto, E., Pandelaki, K., & Langi, J. (2010). Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Medica Indonesiana, 42(3), 130-134.
  • Dehkordi, F.R., & Kamkhah, A.F. (2008). Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundamental & Clinical Pharmacology, 22(4), 447-452.
  • El-Mahmoudy, A., Matsuyama, H., Borgan, M., Shimizu, Y., El-Sayed, M., Minamoto, N., & Takewaki, T. (2002). Thymoquinone suppresses expression of inducible nitric oxide synthase in rat macrophages. International Immunopharmacology, 2(11), 1603-1611.
  • El‐Mahdy, M.A., Zhu, Q., Wang, Q.E., Wani, G., & Wani, A.A. (2005). Thymoquinone induces apoptosis through activation of caspase‐8 and mitochondrial events in p53‐null myeloblastic leukemia HL‐60 cells. International Journal of Cancer, 117(3), 409-417.
  • Entok, E., Ustuner, M.C., Ozbayer, C., Tekin, N., Akyuz, F., Yangi, B., . . . Gunes, H. V. (2014). Anti-inflammatuar and anti-oxidative effects of Nigella sativa L.: 18FDG-PET imaging of inflammation. Molecular Biology Reports, 41(5), 2827-2834.
  • Fallah Huseini, H., Amini, M., Mohtashami, R., Ghamarchehre, M., Sadeqhi, Z., Kianbakht, S., & Fallah Huseini, A. (2013). Blood Pressure Lowering Effect of Nigella sativa L. Seed Oil in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐controlled Clinical Trial. Phytotherapy Research, 27(12), 1849-1853.
  • Farah, I.O., & Begum, R.A. (2002). Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomedical Sciences Instrumentation, 39, 359-364.
  • Fararh, K.M., Ibrahim, A.K., & Elsonosy, Y.A. (2010). Thymoquinone enhances the activities of enzymes related to energy metabolism in peripheral leukocytes of diabetic rats. Research in Veterinary Science, 88(3), 400-404.
  • Forouzanfar, F., Bazzaz, B. S.F., & Hosseinzadeh, H. (2014). Black cumin (Nigella sativa) and its constituent (thymoquinone): A review on antimicrobial effects. Iranian Journal of Basic Medical Sciences, 17(12), 929.
  • Güllü, E.B., & Gülcan, A. (2013). Timokinon: Nigella sativa’ nın Biyoaktif Komponenti. Kocatepe Veterinary Journal, 6(1), 51-61.
  • Hasani-Ranjbar, S., Jouyandeh, Z., & Abdollahi, M. (2013). A systematic review of anti-obesity medicinal plants-an update. Journal of Diabetes & Metabolic Disorders, 12(1), 28.
  • Heshmati, J., & Namazi, N. (2015). Effects of black seed (Nigella sativa) on metabolic parameters in diabetes mellitus: A systematic review. Complementary Therapies in Medicine, 23(2), 275-282.
  • Heshmati, J., Namazi, N., Memarzadeh, M.-R., Taghizadeh, M., & Kolahdooz, F. (2015). Nigella sativa oil affects glucose metabolism and lipid concentrations in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial. Food Research International, 70, 87-93.
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Details

Subjects Medicine
Journal Section Articles
Authors

Merve Şeyda Karaçil Ermumcu>
Gazi University, Faculty of Health Sciences, Nutrition and Dietetics Department, Ankara
0000-0002-2023-8433
Türkiye

Nevin Şanlıer>
Biruni University, Faculty of Health Sciences, Nutrition and Dietetics Department, lstanbul, Turkey
0000-0001-5937-0485
Türkiye

Publication Date September 22, 2017
Submission Date April 18, 2017
Acceptance Date June 23, 2017
Published in Issue Year 2017, Volume 3Issue 4

Cite

APA Karaçil Ermumcu, M. Ş. & Şanlıer, N. (2017). BLACK CUMIN (Nigella sativa) AND ITS ACTIVE COMPONENT OF THYMOQUINONE: EFFECTS ON HEALTH . Food and Health , 3 (4) , 170-183 . DOI: 10.3153/JFHS17020
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