Green tea extracts and substantial catechin derivatives: Evaluation of their potential against breast cancer

Nadire Özenver; Sıla Ünlü; Seren Gündoğdu; L. Ömür Demirezer

doi:10.3153/FH24008

EN

Green tea extracts and substantial catechin derivatives: Evaluation of their potential against breast cancer

Abstract

Breast cancer is one of the most predominant types of cancer. Although assorted treatment options are available to cope with breast cancer (e.g. chemotherapy, radiotherapy, surgery, hormone therapy, targeted therapy), chemotherapy regimens still hold vital importance. Studies on the discovery of drug-candidate molecules that can create an alternative in the treatment of breast cancer continue at full speed. At this point, nature has a substantial place offering great diversity. Natural products may exhibit anticancer properties directly through molecular targets such as genes or indirectly through metabolic pathways. Moreover, they may be adjuvant agents and contribute to conventional therapy, and thus, they can enhance the efficacy of chemotherapeutics or even ease their side effects. Green tea, a critical dietary source of polyphenols and flavonoids, is obtained from the minimally fermented or unfermented leaves of the Camellia sinensis L. plant and is used in traditional Chinese medicine for many important conditions, including cancer. The phytochemical content of green tea is extremely rich, including (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC); (-)-epicatechin-3-gallate (ECG) and (-)-epicatechin (EC) as the main catechins in the composition of green tea. Within the scope of our study, we proposed the cytotoxicity and toxicity comparison of the water and 80% ethanolic extract of the green tea extracts as well as of (-)-epicatechin (EC) and (-)-epigallocatechin (EGC) in terms of their cytotoxicity and toxicity based on the structure-activity relationship on breast cancer. Therefore, we tested aqueous and 80% ethanolic extracts of green tea and EGC and EC on MDA-MB-231, MDA-BMB-468, MCF-7 and SK-BR-3 breast cancer cells. Their toxicity on healthy rat myoblastoma H9c2 cells was further examined. Resazurin reduction assay was used to detect cytotoxicity and toxicity. Both water and 80% ethanolic extract of green tea exhibited remarkable cytotoxicity on MCF-7 cancer cells deserving further investigation, including phytochemical characterization of the extract. Epigallocatechin was also cytotoxic on MCF-7 cells with an IC50 value of 20.07 µM. The possible therapeutic potentials of green tea extracts and their substantial catechin derivatives were assessed for breast cancer therapy.

Keywords

Supporting Institution

TÜBİTAK

Project Number

1919B012211398

Ethical Statement

There is no ethical statement. Because our research does not require an ethical statement.

Thanks

This study was supported by TÜBİTAK 2209-A University Students Research Projects Support Program (Project No: 1919B012211398)

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Details

Primary Language

English

Subjects

Biochemistry and Cell Biology (Other) , Food Chemistry and Food Sensory Science , Food Sciences (Other)

Journal Section

Research Article

Authors

Nadire Özenver ^*
0000-0001-9561-8994
Türkiye

Sıla Ünlü
0009-0000-1007-1193
Türkiye

Seren Gündoğdu
0000-0003-4295-2520
Türkiye

L. Ömür Demirezer
0000-0002-5284-0744
Türkiye

Early Pub Date

December 30, 2023

Publication Date

January 3, 2024

Submission Date

September 9, 2023

Acceptance Date

November 24, 2023

Published in Issue

Year 1970 Volume: 10 Number: 1

DOI

https://doi.org/10.3153/FH24008

IZ

https://izlik.org/JA29UW83JL

Cite

RIS / Bibtex

APA

Özenver, N., Ünlü, S., Gündoğdu, S., & Demirezer, L. Ö. (2024). Green tea extracts and substantial catechin derivatives: Evaluation of their potential against breast cancer. Food and Health, 10(1), 85-95. https://doi.org/10.3153/FH24008

Green tea extracts and substantial catechin derivatives: Evaluation of their potential against breast cancer

Abstract

Keywords

Öz

Supporting Institution

Project Number

Ethical Statement

Thanks

References

Details

Primary Language

Subjects

Journal Section

Authors

Early Pub Date

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

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