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CURRENT APPROACHES: FOLIC ACID SUPPLEMENTATION FOR PREGNANT WOMEN

Year 2019, Volume: 5 Issue: 2, 128 - 138, 01.04.2019

Tagun Dayı , Gülden Pekcan

https://doi.org/10.3153/FH19014

Abstract

Folate belongs to B group of vitamins. It exists naturally in foods and
it is a water soluble vitamin. Folic acid is a synthetic form of folate and it
exists in food supplements and fortified foods. Folate has an important role in
pregnant women and fetus physiology. Only diet is not enough to supply required
amount of folate. There is an important relationship between folate and neural
tube defects, megaloblastic anemia, postpartum depression, birth weight,
childhood allergic disorders, congenital heart disorders, autism etc. So with a
planned pregnancy folic acid supplementation (400 µg/day) beginning before
pregnancy and continued during pregnancy is recommended to prevent neural tube
defects, anemia and other health problems.

Keywords

Folate Folic acid Preganancy Food supplement

References

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  • American Heart Association (2018). About congenital heart defects. Retrieved from http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/About-Congenital-Heart-Defects_UCM_001217_Article.jsp#.WlHq_VhG3IU (Erişim tarihi: 20.06.2018)
  • Anderson, G., Maes, M. (2013). Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatric Disease and Treatment, 9, 277-287.
  • Bailey, B.L., Hausman, B.D. (2017). Folate status in women of reproductive age as basis of neural tube defect risk assessment. Annals of The New York Academy of Sciences, 1414(1), 82/95.
  • Baohong, M., Jie, Q., Nan, Z., Yawen, S., Wei, D., Xiaochun, H., Hongmei, C., Xiaochun, H., Hongmei, C., Xiaojuan, L., Ling, L., Zhangfeng, T., Sijuan, X., Huang, H., Min, Z., Xiaoying, X., Weitao, Q., Quing, L., Zhang, Y. (2017). Maternal folic acid supplementation anddietary folate intake and congenital heart defects. Plos One, 12(11), 1-14.
  • Castellanos-Sinco, H.B., Ramos-Peἠafiel, C.O, Santoyo-Sἀnchez, A., Collazo-Jaloma, J., Martỉnez-Murillo, C., Montaἠo-Figueroa, E. Sinco-Angelas, A. (2015). Megaloblastic anaemia: folic acid and B12 metabolism. Revista Medica Del Hospital General De Mexico, 78(3), 135-143.
  • Chandra, J. (2010). Megaloblastic anemia: back in focus. Indian Journal of Pediatrics, 77(7), 795-799.
  • Chong, M.F, Wong, J.F., Colega, M., Chen, L.W., van Dam, RM., Tan, CS. Lim, A.L., Cai, S., Broekman, B.F., Lee, Y.S., Saw, S.M., Kwek, K., Godfrey, K.M., Chong, Y.S., Gluckman, P., Meaney, M.J., Chen, H. (2014). Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. Journal of Psychiartic Research, 55, 110-116.
  • Crider, S.K., Devine, O., Hao, L., Dowling, N.F., Li, S., Molloy, A.M. Li, Z., Zhu, J., Berry, R.J. (2014). Population red blood cell folate concentrations forprevention of neural tube defects: bayesian model. The BioMed Journal, 349, 1-12.
  • Czeizel, A.E., Dudἀs, I., Vereczkey, A., Bἀnhidy, F. (2013). Folate deficiency and folic acid supplementation: the prevention of neural tube defects and congenital heart defects. Nutrients, 5(11), 4760-4775.
  • Czeizel, A.E., Vereczkey, A., Szabỏ, I. (2015). Folic acid in pregnant women associated with reduced prevalence of severe congenital heart defects in their children: a national population-based case–control study. Europen Journal of Obstetrics & Gynecology and Reproductive Biology, 193(2015), 34-39.
  • da Silva Lopes, K., Ota, E., Shakya, P., Dagvadorj, A., Balogun, O.O., Peňa-Rosas, J. De-Regil, L.M., Mori, R. (2017). Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews. BMC Global Health Research and Policy, 2(3), 1-12.
  • Dietitians of Canada (2016). Food sources of folate. Retrieved from https://www.dietitians.ca/Your-Health/Nutrition-A-Z/Vitamins/Food-Sources-of-Folate.aspx (Erişim tarihi: 21.12.2017).
  • Dunstan, J.A., West, C., McCarthy, S., Metcalfe, J., Meldrum, S., Oddy, W.H., Tulic, M.K. (2012). The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. European Journal of Allergy and Clinical Immunology, 67(2012), 50-57.
  • Ebera, S. (2017). Nutritional role of folate. Congenital Anomalies, 57(5), 138-141.
  • EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). (2014). Scientific Opinion on Dietary Reference Values for Folate. EFSA Journal, 12(11), 1-59.
  • Europen Food Safety Authority (2017). Dietary reference values for nutrients summary report. EFSA, https://doi.org/10.2903/sp.efsa.2017.e15121
  • Fekete, K., Berti, C., Trovato, M., Lohner, S., Dullemeijer, C., Souverein, O.W. Cetin, I., Decsi, T. (2012). Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutrition Journal, 11(75), 1-8.
  • Fischer, M., Stronati, M., Lanari, M. (2017). Mediterranean diet, folic acid and neural tube defects. Journal of Pediatrics, 43(74), 1-8.
  • Frye, E.R. (2014). Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder. Epilepsy & Behavior, 47(2015), 147-157.
  • Greenberg, J.A., Bell, S.J., Guan, Y., Yu, Y.H. (2011). Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Reviews in Obstetrics and Gynecology, 4(2), 52-59.
  • Greene, N.D.E., Copp, A.J. (2014). Neural tube defects. Annu Rev Neurosci, 37(2014): 221-242.
  • Gropper, S., Smith, J. (2013). Vitamins. Peggy Williams & Elesha Weldman (Ed.), Advanced nutrition and human metabolism (s. 344). United States of America: Cengage Learning. ISBN 978-1-133-04877-0.
  • Hamishehkar, H., Ranjdoost, F., Asgharian, P., Mahmoodpoor, A., Sanaei, S. (2016). Vitamins, are they safe?. Advanced Pharmaceutical Bulletin, 6(4), 467-477.
  • Hoffbrand, A.V., Weir D.G. (2001). The history of Haematology. British Journal of Haematology, 113(3), 579-589.
  • Huhta, J.C., Linask, K. (2015). When should we prescribe high-dose folic acid to prevent congenital heart defects? Current Opinion in Cardiology, 30(1), 125-131.
  • Ja Hyeong, K., Kyoung-Sook, J., Eun-Hee, H., Hyesook, P., Mina, H., Yun-Chul, H. Soo-Young, B., Soo-Jeong, L., Kyung-Yeon, L., Seon-Ho, L., Yangho, K., Min-Ho, K., Namsoo, C. (2014). Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood. Pediatric Pulmonology, 50(2), 155-163.
  • Köksal, G., Gökmen, H. (2013). Çocuk Hastalıklarında Beslenme Tedavisi (3. bs.). Ankara: Hatiboğlu Yayınları, s. 95, ISBN 978-975-8322-05-3
  • Köksal, G., Gökmen, H. (2013). Çocuk Hastalıklarında Beslenme Tedavisi (3. bs.). Ankara: Hatiboğlu Yayınları, s. 67, ISBN 978-975-8322-05-3
  • Leirgul, E., Gildestad, T., Nilsen, R.M., Fomina, T., Brodwall, K., Greve, G. Vollset, S.E., Holmstrom, H., Tell, G.S., Qyen, N. (2015). Periconceptional folic acid supplementation and infant risk of congenital heart defects in Norway 1999-2009. Paediatrik Epidemiology, 29(5), 391-400.
  • Li, X., Li, S., Mu, D., Liu, Z., Li, Y., Chen, X. You, F., Li, N., Deng, K., Deng, Y., Wang, Y., Zhu, J. (2013). The association between periconceptional folic acid supplementation and congenital heart defects: A case–control study in China. Preventive Medicine, 56(6), 385-389.
  • Liu, J., Li, Z., Greene, N.D.E., Li, H., Ren, A. (2017). The recurrence risk of neural tube defects (NTDs) in population with high prevalence of NTDs in northern China. Oncotarget, 8(42), 72577-72583.
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GEBELERDE FOLİK ASİT DESTEĞİ VE GÜNCEL YAKLAŞIMLAR

Year 2019, Volume: 5 Issue: 2, 128 - 138, 01.04.2019

Tagun Dayı , Gülden Pekcan

https://doi.org/10.3153/FH19014

Abstract

Suda çözünen B grubu vitaminler içerisinde yer alan folat besinler
içerisinde doğal olarak bulunmaktadır. Folik asit vitaminin sentetik formudur, besin
desteklerinde ve zenginleştirilmiş besinler içerisinde yer almaktadır. Gebe ve
fetüs fizyolojisinde önemli bir role sahip olan folat gereksinmesinin gebe
kadınlarda tek başına diyet ile karşılanması mümkün değildir. Folat ile başta
nöral tüp defekti ve megaloblastik anemi olmak üzere, postpartum depresyon,
doğum ağırlığı, çocukluk çağı alerjik hastalıkları, konjenital kalp
hastalıkları, otizm vb. sağlık sorunları yakından ilişkilidir. Bu nedenle tüm
dünyada nöral tüp defekti, anemi vb. sağlık sorunlarını önlemek amacıyla planlı
bir gebelik ile gebelik öncesinde başlayan ve gebelik süresince devam edilen
folik asit desteği (400 µg/gün) yaygın olarak önerilmektedir. 

Keywords

Folat Folik asit Gebelik Besin desteği

References

  • Altaş, M., Aras, M., Altaş, Z. G., Aras, Z., Serarslan, Y., Yılmaz, N. (2012). Nöral tüp defektli hastalara retrospektif bakış. Mustafa Kemal Üniversitesi Tıp Fakültesi Dergisi, 3(9), 22-28.
  • American Heart Association (2018). About congenital heart defects. Retrieved from http://www.heart.org/HEARTORG/Conditions/CongenitalHeartDefects/AboutCongenitalHeartDefects/About-Congenital-Heart-Defects_UCM_001217_Article.jsp#.WlHq_VhG3IU (Erişim tarihi: 20.06.2018)
  • Anderson, G., Maes, M. (2013). Postpartum depression: psychoneuroimmunological underpinnings and treatment. Neuropsychiatric Disease and Treatment, 9, 277-287.
  • Bailey, B.L., Hausman, B.D. (2017). Folate status in women of reproductive age as basis of neural tube defect risk assessment. Annals of The New York Academy of Sciences, 1414(1), 82/95.
  • Baohong, M., Jie, Q., Nan, Z., Yawen, S., Wei, D., Xiaochun, H., Hongmei, C., Xiaochun, H., Hongmei, C., Xiaojuan, L., Ling, L., Zhangfeng, T., Sijuan, X., Huang, H., Min, Z., Xiaoying, X., Weitao, Q., Quing, L., Zhang, Y. (2017). Maternal folic acid supplementation anddietary folate intake and congenital heart defects. Plos One, 12(11), 1-14.
  • Castellanos-Sinco, H.B., Ramos-Peἠafiel, C.O, Santoyo-Sἀnchez, A., Collazo-Jaloma, J., Martỉnez-Murillo, C., Montaἠo-Figueroa, E. Sinco-Angelas, A. (2015). Megaloblastic anaemia: folic acid and B12 metabolism. Revista Medica Del Hospital General De Mexico, 78(3), 135-143.
  • Chandra, J. (2010). Megaloblastic anemia: back in focus. Indian Journal of Pediatrics, 77(7), 795-799.
  • Chong, M.F, Wong, J.F., Colega, M., Chen, L.W., van Dam, RM., Tan, CS. Lim, A.L., Cai, S., Broekman, B.F., Lee, Y.S., Saw, S.M., Kwek, K., Godfrey, K.M., Chong, Y.S., Gluckman, P., Meaney, M.J., Chen, H. (2014). Relationships of maternal folate and vitamin B12 status during pregnancy with perinatal depression: The GUSTO study. Journal of Psychiartic Research, 55, 110-116.
  • Crider, S.K., Devine, O., Hao, L., Dowling, N.F., Li, S., Molloy, A.M. Li, Z., Zhu, J., Berry, R.J. (2014). Population red blood cell folate concentrations forprevention of neural tube defects: bayesian model. The BioMed Journal, 349, 1-12.
  • Czeizel, A.E., Dudἀs, I., Vereczkey, A., Bἀnhidy, F. (2013). Folate deficiency and folic acid supplementation: the prevention of neural tube defects and congenital heart defects. Nutrients, 5(11), 4760-4775.
  • Czeizel, A.E., Vereczkey, A., Szabỏ, I. (2015). Folic acid in pregnant women associated with reduced prevalence of severe congenital heart defects in their children: a national population-based case–control study. Europen Journal of Obstetrics & Gynecology and Reproductive Biology, 193(2015), 34-39.
  • da Silva Lopes, K., Ota, E., Shakya, P., Dagvadorj, A., Balogun, O.O., Peňa-Rosas, J. De-Regil, L.M., Mori, R. (2017). Effects of nutrition interventions during pregnancy on low birth weight: an overview of systematic reviews. BMC Global Health Research and Policy, 2(3), 1-12.
  • Dietitians of Canada (2016). Food sources of folate. Retrieved from https://www.dietitians.ca/Your-Health/Nutrition-A-Z/Vitamins/Food-Sources-of-Folate.aspx (Erişim tarihi: 21.12.2017).
  • Dunstan, J.A., West, C., McCarthy, S., Metcalfe, J., Meldrum, S., Oddy, W.H., Tulic, M.K. (2012). The relationship between maternal folate status in pregnancy, cord blood folate levels, and allergic outcomes in early childhood. European Journal of Allergy and Clinical Immunology, 67(2012), 50-57.
  • Ebera, S. (2017). Nutritional role of folate. Congenital Anomalies, 57(5), 138-141.
  • EFSA NDA Panel (EFSA Panel on Dietetic Products, Nutrition and Allergies). (2014). Scientific Opinion on Dietary Reference Values for Folate. EFSA Journal, 12(11), 1-59.
  • Europen Food Safety Authority (2017). Dietary reference values for nutrients summary report. EFSA, https://doi.org/10.2903/sp.efsa.2017.e15121
  • Fekete, K., Berti, C., Trovato, M., Lohner, S., Dullemeijer, C., Souverein, O.W. Cetin, I., Decsi, T. (2012). Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutrition Journal, 11(75), 1-8.
  • Fischer, M., Stronati, M., Lanari, M. (2017). Mediterranean diet, folic acid and neural tube defects. Journal of Pediatrics, 43(74), 1-8.
  • Frye, E.R. (2014). Metabolic and mitochondrial disorders associated with epilepsy in children with autism spectrum disorder. Epilepsy & Behavior, 47(2015), 147-157.
  • Greenberg, J.A., Bell, S.J., Guan, Y., Yu, Y.H. (2011). Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Reviews in Obstetrics and Gynecology, 4(2), 52-59.
  • Greene, N.D.E., Copp, A.J. (2014). Neural tube defects. Annu Rev Neurosci, 37(2014): 221-242.
  • Gropper, S., Smith, J. (2013). Vitamins. Peggy Williams & Elesha Weldman (Ed.), Advanced nutrition and human metabolism (s. 344). United States of America: Cengage Learning. ISBN 978-1-133-04877-0.
  • Hamishehkar, H., Ranjdoost, F., Asgharian, P., Mahmoodpoor, A., Sanaei, S. (2016). Vitamins, are they safe?. Advanced Pharmaceutical Bulletin, 6(4), 467-477.
  • Hoffbrand, A.V., Weir D.G. (2001). The history of Haematology. British Journal of Haematology, 113(3), 579-589.
  • Huhta, J.C., Linask, K. (2015). When should we prescribe high-dose folic acid to prevent congenital heart defects? Current Opinion in Cardiology, 30(1), 125-131.
  • Ja Hyeong, K., Kyoung-Sook, J., Eun-Hee, H., Hyesook, P., Mina, H., Yun-Chul, H. Soo-Young, B., Soo-Jeong, L., Kyung-Yeon, L., Seon-Ho, L., Yangho, K., Min-Ho, K., Namsoo, C. (2014). Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood. Pediatric Pulmonology, 50(2), 155-163.
  • Köksal, G., Gökmen, H. (2013). Çocuk Hastalıklarında Beslenme Tedavisi (3. bs.). Ankara: Hatiboğlu Yayınları, s. 95, ISBN 978-975-8322-05-3
  • Köksal, G., Gökmen, H. (2013). Çocuk Hastalıklarında Beslenme Tedavisi (3. bs.). Ankara: Hatiboğlu Yayınları, s. 67, ISBN 978-975-8322-05-3
  • Leirgul, E., Gildestad, T., Nilsen, R.M., Fomina, T., Brodwall, K., Greve, G. Vollset, S.E., Holmstrom, H., Tell, G.S., Qyen, N. (2015). Periconceptional folic acid supplementation and infant risk of congenital heart defects in Norway 1999-2009. Paediatrik Epidemiology, 29(5), 391-400.
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There are 65 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Review
Authors

Tagun Dayı 0000-0003-2491-7609

Gülden Pekcan 0000-0002-2037-3037

Publication Date April 1, 2019
Submission Date February 12, 2018
Published in Issue Year 2019 Volume: 5 Issue: 2

Cite

APA Dayı, T., & Pekcan, G. (2019). GEBELERDE FOLİK ASİT DESTEĞİ VE GÜNCEL YAKLAŞIMLAR. Food and Health, 5(2), 128-138. https://doi.org/10.3153/FH19014
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