Redirecting to http://dergipark.org.tr/_fragment?_hash=vD18bvrWhONqw7NaG6qeiMGm1cHkNsG1LqJ02DT_qSg&_path=id%3D350977%26_format%3Dhtml%26_locale%3Den%26_controller%3DApp%255CController%255CSite%255CArticleController%253A%253AesiArticleStats.
Review
BibTex RIS Cite

IMMUNOTHERAPY AND POTENTIAL USE OF PROPOLIS IN CANCER IMMUNOTHERAPY

Year 2018, Volume: 4 Issue: 4, 231 - 246, 01.10.2018

Elif Onur , Ayşe Nalbantsoy , Duygu Kışla

https://doi.org/10.3153/FH18023

Abstract

In recent years cancer incidence has increased.
Innovative studies have been carried out on the treatment methods of cancer, a
major threat to public health. Immunotherapy is the treatment of the disease
with therapeutic agents that increase or decrease immune responses.
Immunotherapy is known to be effective in the treatment of cancer. A bee
product, propolis that has been investigated for its availability in this
respect draws attention because of its antitumor effects. In addition,
immunomodulatory effects of propolis, which is known to have antibacterial,
antimicrobial, antifungal, antiviral and cytotoxic effects, have been
investigated in recent years. According to researchers, propolis is a promising
compound in cancer immunotherapy. In this review, it is aimed to give
information about immunotherapy and the use of propolis in cancer
immunotherapy.

Keywords

Immunotherapy Propolis Cancer Immunomodulator

References

  • Akramiené, D., Kondrotas, A., Didžiapetriené, J., Kévelaitis, E. (2007). Effects of β-glucans on the Immune System. Medicisa (Kaunas), 43(8), 597-606.
  • Arda, M., Minbay, A., Aydın, N., Akay, Ö., İzgür, M., Diker, S. (1998). İmmunoloji. Ankara: Medisan Yayınevi, p. 20-31.
  • Atayoğlu, T. (2012). Apiterapi Açısından Arı Ürünlerinin Kalite Kriterleri ve Standardizasyonu. Standard Ekonomik ve Teknik Dergi, 601, 68-73.
  • Awale, S., Li, F., Onozuku, H., Esumi, H., Tezuka, Y., Kadota, S. (2008). Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorganic and Medicinal Chemistry, 16, 181-189.
  • Bankova, V. (2005). Recent trends and important developments in propolis research. Evidence-based Complementary and Alternative Medicine, 2, 29-32.
  • Banskota, A. H., Tezuka, Y., Kadota, S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research,, 15, 561-571.
  • Barbaros, B., Dikmen, M. (2015). Kanser İmmünoterapisi. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 31(4), 177-181.
  • Barnes, S. (1997). The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Research Treament (46), 169–179.
  • Bazo, A.P., Rodrigues, M.A.M., Sforcin, J.M., Camargo, J.L.V., Ribeiro, L.R., Salvadori, D.M.F. (2002). Protective action of propolis on the rat colon carcinogenesis. Teratogenesis, Carcinogenesis and Mutagenesis, 22, 183-194.
  • Boudourova-Krasteva, G., Bankova, V., Sforcin, J. M., Nikolova, N., Popov, S. (1997). Phenolics from Brazilian propolis. Zeitschrift für Naturforschung 52, 676-679.
  • Burdock, G.A. (1998). Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36, 347–363.
  • Carvalho, A.A., Finger, D., Machado, C.S., Schmidt, E.M., Costa, P.M., Alves, A.P.N.N., Morais, T.M.F., Queiroz, M.G.R., Quináia, S.P., Rosa, M.R., Santos, J.M.T., Pessoa, C., Moraes, M.O., Lotufo, L.V.C., Sawaya, A.C.H.F., Eberlin, M.N., Torres, Y.R. (2011). In vivo antitumoural activity and composition of an oil extract of Brazilian propolis. Food Chemistry, 126, 1239-1245.
  • Chan, G.C., Chan, W.K., Sze, D.M. (2009). The Effects of β-Glucan on Human, Immune and Cancer Cells. Journal of Hematology and Oncology, 25(2), 1-11. Chen, C.N., Weng, M.S., Wu, C.L., Lin, J.K. (2014). Comparison of Radical Scavenging Activity, Cytotoxic Effects and Apoptosis Induction in Human Melanoma Cells by Taiwanese Propolis from Different Sources. Evidenced-based Complementary and Alternative Medicine, 1(2), 175-185.
  • Choudhari, M.K., Haghniaz, R., Rajwade, J.M., Paknikar, K. (2013). Anticancer Activity of Indian Stingless Bee Propolis: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine, Volume 2013, 1-10.
  • Cuesta, A., Rodriguez, A., Angeles, M. (2005). In vivo effects of propolis, a honeybee product, on gilthead seabream innate immune responses. Fish and Selfish Immun, 18(1), 71-80.
  • DeCastro, S.L. (2001). Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product. Annual Review of Biomedical Science (3), 49-83.
  • DeSantes, K.B., Sondel P.M., Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., Nathan, D.G. (2009). Immunotherapy of Cancer, Oncology of Infancy and Childhood, 209-241.
  • Doğan, N., Hayoğlu, İ. (2012). Propolis ve kullanım alanları, Harran Üniversitesi, Ziraat Fakültesi Dergisi, 16(3), 39-48.
  • Dudov, I.A., Morenets, A.A., Artiukh, V.P., Starodub, N. F. (1994). Immunomodulatory effect of honeybee flower pollen load, Ukrainskii Biokhimicheskii Zhurnal, 66(6), 91-93.
  • Filho, R.N.P., Batista, F.S., Ribeiro, D.R., Melo, G.C., Reis, F.P., Melo, A.U.C., Gomes, M.Z., Cardoso, J.C., Albuquerque, R.L.C. (2014). Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model. International Journal of Morphology, 32(2), 522-530.
  • Gardana, C., Barbieri, A., Simonetti, P., Guglielmetti, S. (2012). Biotransformation strategy to reduce allergens in propolis. Applied and Environmental Microbiology, 78(13), 4654-4658.
  • Ghisalberti, E.L. (1979). Propolis: a review. Bee World, 60, 59–84.
  • Göç, D. (2015). Tümörlere ve Nakil Dokularına Karşı İmmün Yanıtlar. In Y. Camcıoğlu ve G. Deniz (Eds.), Temel İmmünoloji, İmmün Sistemin İşlevleri ve Bozuklukları. (p. 189-205). Ankara, Güneş Tıp Kitapevi.
  • Grunberger, D., Banerjee, R., Eisinger, K., Oltz, E.M., Efros, L., Caldwell, M., Estevez, V., Nakanishi, K. (1988). Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis, Experientia, 44, 230-232.
  • Hausen, B. M. (2005). Evaluation of the main contact allergens in propolis. Dermatitis, 16(3), 127-129.
  • Hepşen, İ.F. Tilgen, F., Er, H. (1996). Propolis: Tıbbi ve Oftalmolojik Kullanımı. Turgut Özal Tıp Merkezi Dergisi 3(4), 386-391.
  • Herbert, T.B. Cohen, S. (1993). Stress and Immunity in Humans: A Meta-Analytic Review, Psychosomatic Medicine, 55, 364-379.
  • Holick, M.F., Garabedian, M. (2006). Vitamin D photobiology, metabolism, mechanism of action and clinical application. Washington, p. 106-114.
  • Huang, S., Zhang, C.P., Wang, K., Li, G.Q., Hu, F.L. (2014). Recent Advances in the Chemical Composition of Propolis. Molecules, 19(12), 19610-19632.
  • Inoue, K., Saito, M., Kanai, T., Kawata, T., Shigematsu, N., Uno, T., Isobe, K., Liu, C. H., Ito, H. (2008). Anti-Tumor Effects of Water-Soluble Propolis on a Mouse Sarcoma Cell Line In Vivo and In Vitro. The American Journal of Chinese Medicine, 36 (3), 625-634.
  • Jantan, I., Ahmad, W., Bukhari, S.N.A. (2015). Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Frontiers in Plant Science, 6, 1-18.
  • Jasprica, I., Mornar, A. Debeljak, Z., Bubalo, A.A., Sari´c, M., Mayerc, L., Romi´c, Z., Bucan, K., Balog, T., Sobocanec, S., Sverko, V. (2007). In vivo study of propolis supplementation effects on antioxidative status and red blood cells. Journal of Ethnopharmacology 110, 548-554.
  • Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., Forman, D. (2011). Global Cancer Statistic. Cancer Journal for Clinicians, 61, 69-90.
  • Jones, A., McAdam, M., Rayter. Z., Mansi, J. (2003). Medical Therapy of Advanced Disease. Medical Therapy of Breast Cancer, 283-308.
  • Jutel, M., Pichler, W.J., Skrbic, D., Urwyler, A., Dahinden, C., Müller, U. R. (1995). Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. Journal of Immunol, 154(8), 4187-4194.
  • Kaneno, R. (2005). Role of natural killer cells in antitumor resistance. Annual Review of Biomedical Sciences, 7, 127–148.
  • Kimoto, T., Arai, S., Kohguchi, M., Aga, M., Nomura, Y., Micallef, M. J., Kurimoto, M., Mito, K. (1998). Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. Cancer Detection and Prevention, 22, 506-515.
  • Kumova, U., Korkmaz, A., Avcı, B.C., Ceyran, G. (2002). Önemli bir arı ürünü: Propolis, Uludağ Arıcılık Dergisi, 22-28.
  • Kundu, J. K., Surh, Y. J. (2008). Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Letters, 269, 243-261.
  • Lee, Y.T., Don, M.J., Hung, P.S., Shen, Y.C., Lo, Y.S., Chang, K.W., Chen, C.F., Ho, L.K. (2005). Cytotoxic of phenolic acid phenethyl esters on oral cancer cells. Cancer Letters, 223, 19-25.
  • Li, Y., Sarkar, F.H. (2002). Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Letters, 186, 157-164.
  • Liao, H.F., Chen, Y.Y., Liu, J.J., Hsu, M.L., Shieh, H.J., Liao, H.J., Shieh, C.J., Shiao, M.S., Chen,Y.J. (2003). Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. Journal of Agricultural and Food Chemistry, 51, 7907–7912.
  • Lisicic, D., Benkovic, V., Dikic, D, Blazevic, A.S., Mihaljevic, J., Orsolic, N., Knezevic, A.H. (2014), Addition of Propolis to Irinotecan Therapy Prolongs Survival in Ehrlich Ascites Tumor-Bearing Mice. Cancer Bıotherapy and Radıopharmaceutıcals, 29(2), 62-69.
  • Maksimova-Todorova, V., Manolova, N., Gegova, G. (1985). Antiviral action of some fractions isolated from propolis. Acta Microbiologica Bulgarica, 17, 79-84.
  • Marcucci, M.C. (1995). Propolis: chemical composition, biological properties and therapeutic activity. Apidologie (26), 83-99.
  • Markham, K.R., Mitchel, K.A., Wilkins, A.L., Daldy, J.A., Lu, Y. (1995). HPLC and GS-MS Identification of the Major Organic Constituents in New Zeland Propolis. Phytochemisty, 42(1), 205-211.
  • Matsuno, T. (1995). A new clerodane diterpenoid isolated from propolis. Zeitschrift für Naturforschung, 50, 93-97.
  • Matsuno, T., Chen, C., Basnet, P. (1997). A tumoricidal and antioxidant compound isolated from an aqueous extract of propolis. Medical Science Research, 25, 583-584.
  • Spesifik immün yanıtta hücre-hücre etkileşimleri, (31 Mart 2016) http://www.microbiologybook.org/Turkish-immunol/immunolchapter12turk.htm (Erişim tarihi: 24.08.2017)
  • Muehlbauer, P., Burke, M., Wilkes, G. (2006). Biologic Therapy for Cancer Treatments. Cancer Therapies, 117-180.
  • Mukhopadhyay, A., Bueso-Ramos, C., Chatterjee, D., Pantazis, P., Aggarwal, B.B. (2001). Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene, 20, 7597-7609.
  • Ning, Y., Xu, D., Zhang, X., Bai, Y., Ding, J., Feng, T., Wang, S., Xu, N., Qian, K., Wang, Y., Qi, C. (2016). β-Glucan Restores Tumor-Educated Dendritic Cell Maturation to Enhance Antitumor Immune Responses. International Journal of Cancer, 138, 2713-2723.
  • Niraula, N. P., Kim, S. H., Sohng, J. K., Kim, E. S. (2010). Biotechnological doxorubicin production: pathway and regulation engineering of strains for enhanced production. Applied Microbiology and Biotechnology, 87(4), 1187-1194.
  • Novak, E.M., Silva, M.S.C., Marcucci, M.C., Sawaya, A. C.H.F., López, B.G.C., Fortes, M.A.H.Z., Giorgi, R.R., Marumo, K.T., Rodrigues, R.F., Maria, D.A. (2014). Antitumoural activity of Brazilian red propolis fraction enriched with xanthochymol and formononetin: An in vitro and in vivo study. Journal of Functional Foods, 11, 91-102.
  • Orsolic, N., Knezevic, A.H., Sver, L., Terzic, S., Basic, I. (2004). Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds. Journal of Ethnopharmacology, 94, 307–315.
  • Orsolic, N., Terzic, S., Mihaljevic, Z., Sver, L., Basic, I. (2005). Effects of Local Administration of Propolis and Its Polyphenolic Compounds on Tumor Formation and Growth. Biological Pharmaceutical Bulletin, 28(10), 1928-1933.
  • Orsolić, N., Basić, I. (2005). Antitumor, hematostimulative and radioprotective action of water-soluble derivative of propolis (WSDP). Biomedicine and Pharmacotherapy, 59, (10), 561-570.
  • Osésa, S.M., Pascual-Matéa, A., Fernández-Muiño, M.A., López-Díaz, T.M., Sancho, M.T. (2016). Bioactive properties of honey with propolis. Food Chemistry, 196, 1215-1223.
  • Özbal, Y. (2000). Temel İmmünoloji. İstanbul: Nobel Tıp Kitabevleri, p. 18-110. ISBN: 9789752775602
  • Özverel, C.S., Karaboz, İ., Nalbantsoy, A. (2017). Novel treatment strategies in cancer immunotherapy. Acta Biologica Turcica, 30(2), 36-51.
  • Park, J.H., Leea, J.K., Kima, H.S., Chunga, S.T., Eoma, J.H., Kima, K.A., Chunga, S.J., Paikb, S.Y., Oha, H.Y. (2004). Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. International Immunopharmacology, 4, 429-436.
  • Patel, S. (2016). Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. Journal of Dietary Supplements. 13(3), 245-268.
  • Pehlivan, T., Şahinler, N., Gül, A. (2012). Doğal bir ürün propolis; yapısı ve kullanım alanları, Arıcılık Araştırma Dergisi, 4(7), 9-13.
  • Pohorska, J., Richter, J., Kral, V., Dobiasova, L.R., Stiborova, I., Vetvicka, V. (2016). Reconstruction of NK Cells During Complex Cancer Treatment. Journal of Tumor, 4(2), 398-402.
  • Popovic, S., Baskic, D., Zelen, I., Djurdjevic, P., Zaric, M., Avramovic, D., Arsenijevic, N. (2012). The Cytotoxicity of Korbazol Against Murine Cancer Cell Lines. Serbian Journal of Experimental and Clinical Research, 13 (2), 62-67.
  • Rao, C. V., Desai, D., Rivenson, A., Simi, B., Amin, S., Reddy, B. S. (1995). Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. Cancer Research, 55, 2310-2315.
  • Salatino, A., Teixeira, E.W., Negri, G., Message, D. (2005). Origin and chemical variation of Brazilian propolis. Evidence-based Complementary and Alternative Medicine, 2, 33-38.
  • Schenk, D. (2002). Amyloid-β immunotherapy for Alzheimer’s disease: the end of the beginning. Nature Reviews, 3, 824-828.
  • Sforcin, J.M. (2007). Propolis and the immune system: a review. Journal of Ethnopharmacology, 113, 1-14.
  • Sforcin, J.M., Funari, S.R.C., Novelli, E.L.B. (1995). Serum biochemical determinations of propolis-treated rats. The Journal of Venomous Animals and Toxins, 1, 31-37.
  • Sforcin, J. M., Kaneno, R., Funari, S. R. C. (2002). Absence of seasonal effect on the immunomodulatory action of Brazilian propolis on natural killer activity. The Journal of Venomous Animals and Toxins, 8, 19-29.
  • Singh, B. N., Shankar, S., and Srivastava, R. K. (2011). Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochemical. Pharmacology, 82, 1807–1821.
  • Şengül, A. (2008). Hücresel İmmün Yanıt. Türkiye Klinikleri Enfeksiyon Hastalıkları Özel Dergisi, 1(2), 19-22.
  • Suzuki, I., Hayashi, I., Takaki, T., Groveman, D.S., Fujimiya, Y. (2002). Antitumor and anticytopenic effects of aqueous extracts of propolis in combination with chemotherapeutic agents. Cancer Biotherapy and Radiopharmaceuticals. 17(5), 553-562.
  • TS 12910 Arıcılık-Arı Tutkalı (Propolis), (14 Nisan 2003) https://intweb.tse.org.tr/standard/standard/Standard.aspx?053107106111065067115113049116090107100056052055108081090071086075069085047110067109075073081116103090081086073108065117084119102117080049106055054100083122117081090120069083101065078105117047 (Erişim tarihi: 10.07.2017)
  • Vagish Kumar, L.S. (2014). Propolis in Dentistry and Oral Cancer Management. North American Journal of Medical Sciences, 6(6), 250–259.
  • Van Etten, E., Mathieu, C. (2005). Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. The Journal of Steroid Biochemistry and Molecular Biology, 97, 93-101.
  • Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Álvarez, J.A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science, 73(9), 117-124.
  • Walgrave, S.E., Warshaw, E.M., Glesne, L.A. (2005). Allergic contact dermatitis from propolis. Dermatitis, 16, 209-215.
  • Wang, M., Yin, B., Wang, H.Y., Wang, R. (2014). Current Advances in T-Cell Based Cancer Immunotherapy, Future Medicine. Immunotherapy, 6(12), 1265-1278.
  • Whyte, L., Huang, Y.Y., Torres, K., Mehta, R.G. (2007). Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Research, 67, 12007-120017.
  • Yamaguchi, Y. (2016). Immunotherapy of Cancer: Overview of Current Cancer Immunotherapy. p. 3-21. Online ISBN 978-4-431-55031-0, ISBN 978-4-431-55030-3
  • Yılmaz, L., Yılsay, T.Ö., Bayizit, A.A. (2004). Propolisin Kimyasal Bileşimi, Biyolojik Özellikleri ve İnsan Sağlığı Üzerine Etkileri, Gıda ve Yem Bilimi Teknolojisi, 6, 34-38.

İMMÜNOTERAPİ VE PROPOLİSİN KANSER İMMÜNOTERAPİSİNDE KULLANIM POTANSİYELİ

Year 2018, Volume: 4 Issue: 4, 231 - 246, 01.10.2018

Elif Onur , Ayşe Nalbantsoy , Duygu Kışla

https://doi.org/10.3153/FH18023

Abstract

Son yıllarda kanser hastalığı oldukça yaygın olarak
görülmektedir. Halk sağlığı için büyük tehlike oluşturan kanser hastalığının
tedavi yöntemleri üzerinde yenilikçi araştırmalar yapılmaktadır. İmmünoterapi immün yanıtları artıran veya azaltan
terapötik ajanlar ile ortaya çıkan hastalığın tedavisidir. İmmünoterapinin
kanser tedavisinde etkili olduğu bilinmektedir. Bu amaç doğrultusunda
kullanılabilirliği araştırılan, bir arı ürünü olan propolis antitümör etkiler
göstermesi ile dikkat çekmektedir. Bunun yanı sıra antibakteriyel,
antimikrobiyal, antifungal, antiviral ve sitotoksik etkileri olduğu bilinmekte
olan propolisin son yıllarda immünomodülatör etkileri incelenmektedir.
Araştırmacılara göre propolis kanser immünoterapisinde umut vadeden bir
bileşendir. Bu derlemede immünoterapi ve propolisin kanser immünoterapisinde
kullanımı hakkında bilgi verilmesi amaçlanmaktadır.

Keywords

İmmünoterapi Propolis Kanser İmmünomodulatör

References

  • Akramiené, D., Kondrotas, A., Didžiapetriené, J., Kévelaitis, E. (2007). Effects of β-glucans on the Immune System. Medicisa (Kaunas), 43(8), 597-606.
  • Arda, M., Minbay, A., Aydın, N., Akay, Ö., İzgür, M., Diker, S. (1998). İmmunoloji. Ankara: Medisan Yayınevi, p. 20-31.
  • Atayoğlu, T. (2012). Apiterapi Açısından Arı Ürünlerinin Kalite Kriterleri ve Standardizasyonu. Standard Ekonomik ve Teknik Dergi, 601, 68-73.
  • Awale, S., Li, F., Onozuku, H., Esumi, H., Tezuka, Y., Kadota, S. (2008). Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Bioorganic and Medicinal Chemistry, 16, 181-189.
  • Bankova, V. (2005). Recent trends and important developments in propolis research. Evidence-based Complementary and Alternative Medicine, 2, 29-32.
  • Banskota, A. H., Tezuka, Y., Kadota, S. (2001). Recent progress in pharmacological research of propolis. Phytotherapy Research,, 15, 561-571.
  • Barbaros, B., Dikmen, M. (2015). Kanser İmmünoterapisi. Erciyes Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 31(4), 177-181.
  • Barnes, S. (1997). The chemopreventive properties of soy isoflavonoids in animal models of breast cancer. Breast Cancer Research Treament (46), 169–179.
  • Bazo, A.P., Rodrigues, M.A.M., Sforcin, J.M., Camargo, J.L.V., Ribeiro, L.R., Salvadori, D.M.F. (2002). Protective action of propolis on the rat colon carcinogenesis. Teratogenesis, Carcinogenesis and Mutagenesis, 22, 183-194.
  • Boudourova-Krasteva, G., Bankova, V., Sforcin, J. M., Nikolova, N., Popov, S. (1997). Phenolics from Brazilian propolis. Zeitschrift für Naturforschung 52, 676-679.
  • Burdock, G.A. (1998). Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36, 347–363.
  • Carvalho, A.A., Finger, D., Machado, C.S., Schmidt, E.M., Costa, P.M., Alves, A.P.N.N., Morais, T.M.F., Queiroz, M.G.R., Quináia, S.P., Rosa, M.R., Santos, J.M.T., Pessoa, C., Moraes, M.O., Lotufo, L.V.C., Sawaya, A.C.H.F., Eberlin, M.N., Torres, Y.R. (2011). In vivo antitumoural activity and composition of an oil extract of Brazilian propolis. Food Chemistry, 126, 1239-1245.
  • Chan, G.C., Chan, W.K., Sze, D.M. (2009). The Effects of β-Glucan on Human, Immune and Cancer Cells. Journal of Hematology and Oncology, 25(2), 1-11. Chen, C.N., Weng, M.S., Wu, C.L., Lin, J.K. (2014). Comparison of Radical Scavenging Activity, Cytotoxic Effects and Apoptosis Induction in Human Melanoma Cells by Taiwanese Propolis from Different Sources. Evidenced-based Complementary and Alternative Medicine, 1(2), 175-185.
  • Choudhari, M.K., Haghniaz, R., Rajwade, J.M., Paknikar, K. (2013). Anticancer Activity of Indian Stingless Bee Propolis: An In Vitro Study. Evidence-Based Complementary and Alternative Medicine, Volume 2013, 1-10.
  • Cuesta, A., Rodriguez, A., Angeles, M. (2005). In vivo effects of propolis, a honeybee product, on gilthead seabream innate immune responses. Fish and Selfish Immun, 18(1), 71-80.
  • DeCastro, S.L. (2001). Propolis: biological and pharmacological activities. Therapeutic uses of this bee-product. Annual Review of Biomedical Science (3), 49-83.
  • DeSantes, K.B., Sondel P.M., Orkin, S.H., Fisher, D.E., Look, A.T., Lux, S.E., Ginsburg, D., Nathan, D.G. (2009). Immunotherapy of Cancer, Oncology of Infancy and Childhood, 209-241.
  • Doğan, N., Hayoğlu, İ. (2012). Propolis ve kullanım alanları, Harran Üniversitesi, Ziraat Fakültesi Dergisi, 16(3), 39-48.
  • Dudov, I.A., Morenets, A.A., Artiukh, V.P., Starodub, N. F. (1994). Immunomodulatory effect of honeybee flower pollen load, Ukrainskii Biokhimicheskii Zhurnal, 66(6), 91-93.
  • Filho, R.N.P., Batista, F.S., Ribeiro, D.R., Melo, G.C., Reis, F.P., Melo, A.U.C., Gomes, M.Z., Cardoso, J.C., Albuquerque, R.L.C. (2014). Chemopreventive Effect of Brazilian Green Propolis on Experimental Dermal Carcinogenesis in Murine Model. International Journal of Morphology, 32(2), 522-530.
  • Gardana, C., Barbieri, A., Simonetti, P., Guglielmetti, S. (2012). Biotransformation strategy to reduce allergens in propolis. Applied and Environmental Microbiology, 78(13), 4654-4658.
  • Ghisalberti, E.L. (1979). Propolis: a review. Bee World, 60, 59–84.
  • Göç, D. (2015). Tümörlere ve Nakil Dokularına Karşı İmmün Yanıtlar. In Y. Camcıoğlu ve G. Deniz (Eds.), Temel İmmünoloji, İmmün Sistemin İşlevleri ve Bozuklukları. (p. 189-205). Ankara, Güneş Tıp Kitapevi.
  • Grunberger, D., Banerjee, R., Eisinger, K., Oltz, E.M., Efros, L., Caldwell, M., Estevez, V., Nakanishi, K. (1988). Preferential cytotoxicity on tumor cells by caffeic acid phenethyl ester isolated from propolis, Experientia, 44, 230-232.
  • Hausen, B. M. (2005). Evaluation of the main contact allergens in propolis. Dermatitis, 16(3), 127-129.
  • Hepşen, İ.F. Tilgen, F., Er, H. (1996). Propolis: Tıbbi ve Oftalmolojik Kullanımı. Turgut Özal Tıp Merkezi Dergisi 3(4), 386-391.
  • Herbert, T.B. Cohen, S. (1993). Stress and Immunity in Humans: A Meta-Analytic Review, Psychosomatic Medicine, 55, 364-379.
  • Holick, M.F., Garabedian, M. (2006). Vitamin D photobiology, metabolism, mechanism of action and clinical application. Washington, p. 106-114.
  • Huang, S., Zhang, C.P., Wang, K., Li, G.Q., Hu, F.L. (2014). Recent Advances in the Chemical Composition of Propolis. Molecules, 19(12), 19610-19632.
  • Inoue, K., Saito, M., Kanai, T., Kawata, T., Shigematsu, N., Uno, T., Isobe, K., Liu, C. H., Ito, H. (2008). Anti-Tumor Effects of Water-Soluble Propolis on a Mouse Sarcoma Cell Line In Vivo and In Vitro. The American Journal of Chinese Medicine, 36 (3), 625-634.
  • Jantan, I., Ahmad, W., Bukhari, S.N.A. (2015). Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Frontiers in Plant Science, 6, 1-18.
  • Jasprica, I., Mornar, A. Debeljak, Z., Bubalo, A.A., Sari´c, M., Mayerc, L., Romi´c, Z., Bucan, K., Balog, T., Sobocanec, S., Sverko, V. (2007). In vivo study of propolis supplementation effects on antioxidative status and red blood cells. Journal of Ethnopharmacology 110, 548-554.
  • Jemal, A., Bray, F., Center, M. M., Ferlay, J., Ward, E., Forman, D. (2011). Global Cancer Statistic. Cancer Journal for Clinicians, 61, 69-90.
  • Jones, A., McAdam, M., Rayter. Z., Mansi, J. (2003). Medical Therapy of Advanced Disease. Medical Therapy of Breast Cancer, 283-308.
  • Jutel, M., Pichler, W.J., Skrbic, D., Urwyler, A., Dahinden, C., Müller, U. R. (1995). Bee venom immunotherapy results in decrease of IL-4 and IL-5 and increase of IFN-gamma secretion in specific allergen-stimulated T cell cultures. Journal of Immunol, 154(8), 4187-4194.
  • Kaneno, R. (2005). Role of natural killer cells in antitumor resistance. Annual Review of Biomedical Sciences, 7, 127–148.
  • Kimoto, T., Arai, S., Kohguchi, M., Aga, M., Nomura, Y., Micallef, M. J., Kurimoto, M., Mito, K. (1998). Apoptosis and suppression of tumor growth by artepillin C extracted from Brazilian propolis. Cancer Detection and Prevention, 22, 506-515.
  • Kumova, U., Korkmaz, A., Avcı, B.C., Ceyran, G. (2002). Önemli bir arı ürünü: Propolis, Uludağ Arıcılık Dergisi, 22-28.
  • Kundu, J. K., Surh, Y. J. (2008). Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives. Cancer Letters, 269, 243-261.
  • Lee, Y.T., Don, M.J., Hung, P.S., Shen, Y.C., Lo, Y.S., Chang, K.W., Chen, C.F., Ho, L.K. (2005). Cytotoxic of phenolic acid phenethyl esters on oral cancer cells. Cancer Letters, 223, 19-25.
  • Li, Y., Sarkar, F.H. (2002). Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein. Cancer Letters, 186, 157-164.
  • Liao, H.F., Chen, Y.Y., Liu, J.J., Hsu, M.L., Shieh, H.J., Liao, H.J., Shieh, C.J., Shiao, M.S., Chen,Y.J. (2003). Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis. Journal of Agricultural and Food Chemistry, 51, 7907–7912.
  • Lisicic, D., Benkovic, V., Dikic, D, Blazevic, A.S., Mihaljevic, J., Orsolic, N., Knezevic, A.H. (2014), Addition of Propolis to Irinotecan Therapy Prolongs Survival in Ehrlich Ascites Tumor-Bearing Mice. Cancer Bıotherapy and Radıopharmaceutıcals, 29(2), 62-69.
  • Maksimova-Todorova, V., Manolova, N., Gegova, G. (1985). Antiviral action of some fractions isolated from propolis. Acta Microbiologica Bulgarica, 17, 79-84.
  • Marcucci, M.C. (1995). Propolis: chemical composition, biological properties and therapeutic activity. Apidologie (26), 83-99.
  • Markham, K.R., Mitchel, K.A., Wilkins, A.L., Daldy, J.A., Lu, Y. (1995). HPLC and GS-MS Identification of the Major Organic Constituents in New Zeland Propolis. Phytochemisty, 42(1), 205-211.
  • Matsuno, T. (1995). A new clerodane diterpenoid isolated from propolis. Zeitschrift für Naturforschung, 50, 93-97.
  • Matsuno, T., Chen, C., Basnet, P. (1997). A tumoricidal and antioxidant compound isolated from an aqueous extract of propolis. Medical Science Research, 25, 583-584.
  • Spesifik immün yanıtta hücre-hücre etkileşimleri, (31 Mart 2016) http://www.microbiologybook.org/Turkish-immunol/immunolchapter12turk.htm (Erişim tarihi: 24.08.2017)
  • Muehlbauer, P., Burke, M., Wilkes, G. (2006). Biologic Therapy for Cancer Treatments. Cancer Therapies, 117-180.
  • Mukhopadhyay, A., Bueso-Ramos, C., Chatterjee, D., Pantazis, P., Aggarwal, B.B. (2001). Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines. Oncogene, 20, 7597-7609.
  • Ning, Y., Xu, D., Zhang, X., Bai, Y., Ding, J., Feng, T., Wang, S., Xu, N., Qian, K., Wang, Y., Qi, C. (2016). β-Glucan Restores Tumor-Educated Dendritic Cell Maturation to Enhance Antitumor Immune Responses. International Journal of Cancer, 138, 2713-2723.
  • Niraula, N. P., Kim, S. H., Sohng, J. K., Kim, E. S. (2010). Biotechnological doxorubicin production: pathway and regulation engineering of strains for enhanced production. Applied Microbiology and Biotechnology, 87(4), 1187-1194.
  • Novak, E.M., Silva, M.S.C., Marcucci, M.C., Sawaya, A. C.H.F., López, B.G.C., Fortes, M.A.H.Z., Giorgi, R.R., Marumo, K.T., Rodrigues, R.F., Maria, D.A. (2014). Antitumoural activity of Brazilian red propolis fraction enriched with xanthochymol and formononetin: An in vitro and in vivo study. Journal of Functional Foods, 11, 91-102.
  • Orsolic, N., Knezevic, A.H., Sver, L., Terzic, S., Basic, I. (2004). Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds. Journal of Ethnopharmacology, 94, 307–315.
  • Orsolic, N., Terzic, S., Mihaljevic, Z., Sver, L., Basic, I. (2005). Effects of Local Administration of Propolis and Its Polyphenolic Compounds on Tumor Formation and Growth. Biological Pharmaceutical Bulletin, 28(10), 1928-1933.
  • Orsolić, N., Basić, I. (2005). Antitumor, hematostimulative and radioprotective action of water-soluble derivative of propolis (WSDP). Biomedicine and Pharmacotherapy, 59, (10), 561-570.
  • Osésa, S.M., Pascual-Matéa, A., Fernández-Muiño, M.A., López-Díaz, T.M., Sancho, M.T. (2016). Bioactive properties of honey with propolis. Food Chemistry, 196, 1215-1223.
  • Özbal, Y. (2000). Temel İmmünoloji. İstanbul: Nobel Tıp Kitabevleri, p. 18-110. ISBN: 9789752775602
  • Özverel, C.S., Karaboz, İ., Nalbantsoy, A. (2017). Novel treatment strategies in cancer immunotherapy. Acta Biologica Turcica, 30(2), 36-51.
  • Park, J.H., Leea, J.K., Kima, H.S., Chunga, S.T., Eoma, J.H., Kima, K.A., Chunga, S.J., Paikb, S.Y., Oha, H.Y. (2004). Immunomodulatory effect of caffeic acid phenethyl ester in Balb/c mice. International Immunopharmacology, 4, 429-436.
  • Patel, S. (2016). Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents. Journal of Dietary Supplements. 13(3), 245-268.
  • Pehlivan, T., Şahinler, N., Gül, A. (2012). Doğal bir ürün propolis; yapısı ve kullanım alanları, Arıcılık Araştırma Dergisi, 4(7), 9-13.
  • Pohorska, J., Richter, J., Kral, V., Dobiasova, L.R., Stiborova, I., Vetvicka, V. (2016). Reconstruction of NK Cells During Complex Cancer Treatment. Journal of Tumor, 4(2), 398-402.
  • Popovic, S., Baskic, D., Zelen, I., Djurdjevic, P., Zaric, M., Avramovic, D., Arsenijevic, N. (2012). The Cytotoxicity of Korbazol Against Murine Cancer Cell Lines. Serbian Journal of Experimental and Clinical Research, 13 (2), 62-67.
  • Rao, C. V., Desai, D., Rivenson, A., Simi, B., Amin, S., Reddy, B. S. (1995). Chemoprevention of colon carcinogenesis by phenylethyl-3-methylcaffeate. Cancer Research, 55, 2310-2315.
  • Salatino, A., Teixeira, E.W., Negri, G., Message, D. (2005). Origin and chemical variation of Brazilian propolis. Evidence-based Complementary and Alternative Medicine, 2, 33-38.
  • Schenk, D. (2002). Amyloid-β immunotherapy for Alzheimer’s disease: the end of the beginning. Nature Reviews, 3, 824-828.
  • Sforcin, J.M. (2007). Propolis and the immune system: a review. Journal of Ethnopharmacology, 113, 1-14.
  • Sforcin, J.M., Funari, S.R.C., Novelli, E.L.B. (1995). Serum biochemical determinations of propolis-treated rats. The Journal of Venomous Animals and Toxins, 1, 31-37.
  • Sforcin, J. M., Kaneno, R., Funari, S. R. C. (2002). Absence of seasonal effect on the immunomodulatory action of Brazilian propolis on natural killer activity. The Journal of Venomous Animals and Toxins, 8, 19-29.
  • Singh, B. N., Shankar, S., and Srivastava, R. K. (2011). Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. Biochemical. Pharmacology, 82, 1807–1821.
  • Şengül, A. (2008). Hücresel İmmün Yanıt. Türkiye Klinikleri Enfeksiyon Hastalıkları Özel Dergisi, 1(2), 19-22.
  • Suzuki, I., Hayashi, I., Takaki, T., Groveman, D.S., Fujimiya, Y. (2002). Antitumor and anticytopenic effects of aqueous extracts of propolis in combination with chemotherapeutic agents. Cancer Biotherapy and Radiopharmaceuticals. 17(5), 553-562.
  • TS 12910 Arıcılık-Arı Tutkalı (Propolis), (14 Nisan 2003) https://intweb.tse.org.tr/standard/standard/Standard.aspx?053107106111065067115113049116090107100056052055108081090071086075069085047110067109075073081116103090081086073108065117084119102117080049106055054100083122117081090120069083101065078105117047 (Erişim tarihi: 10.07.2017)
  • Vagish Kumar, L.S. (2014). Propolis in Dentistry and Oral Cancer Management. North American Journal of Medical Sciences, 6(6), 250–259.
  • Van Etten, E., Mathieu, C. (2005). Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. The Journal of Steroid Biochemistry and Molecular Biology, 97, 93-101.
  • Viuda-Martos, M., Ruiz-Navajas, Y., Fernández-López, J., Pérez-Álvarez, J.A. (2008). Functional properties of honey, propolis, and royal jelly. Journal of Food Science, 73(9), 117-124.
  • Walgrave, S.E., Warshaw, E.M., Glesne, L.A. (2005). Allergic contact dermatitis from propolis. Dermatitis, 16, 209-215.
  • Wang, M., Yin, B., Wang, H.Y., Wang, R. (2014). Current Advances in T-Cell Based Cancer Immunotherapy, Future Medicine. Immunotherapy, 6(12), 1265-1278.
  • Whyte, L., Huang, Y.Y., Torres, K., Mehta, R.G. (2007). Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Research, 67, 12007-120017.
  • Yamaguchi, Y. (2016). Immunotherapy of Cancer: Overview of Current Cancer Immunotherapy. p. 3-21. Online ISBN 978-4-431-55031-0, ISBN 978-4-431-55030-3
  • Yılmaz, L., Yılsay, T.Ö., Bayizit, A.A. (2004). Propolisin Kimyasal Bileşimi, Biyolojik Özellikleri ve İnsan Sağlığı Üzerine Etkileri, Gıda ve Yem Bilimi Teknolojisi, 6, 34-38.
There are 83 citations in total.

Details

Primary Language Turkish
Subjects Food Engineering
Journal Section Articles
Authors

Elif Onur 0000-0002-5880-1340

Ayşe Nalbantsoy 0000-0002-3852-1974

Duygu Kışla 0000-0002-6993-3883

Publication Date October 1, 2018
Submission Date November 10, 2017
Published in Issue Year 2018 Volume: 4 Issue: 4

Cite

APA Onur, E., Nalbantsoy, A., & Kışla, D. (2018). İMMÜNOTERAPİ VE PROPOLİSİN KANSER İMMÜNOTERAPİSİNDE KULLANIM POTANSİYELİ. Food and Health, 4(4), 231-246. https://doi.org/10.3153/FH18023
 Download Cover Image

16339

Journal is licensed under a

CreativeCommons Attribtion-ShareAlike 4.0 International Licence  14627 1331027042
Diamond Open Access refers to a scholarly publication model in which journals and platforms do not charge fees to either authors or readers.

Open Access Statement:

This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

Archiving Policy:

27222

Archiving is done according to ULAKBİM "DergiPark" publication policy (LOCKSS).