Review Article
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Year 2021, , 45 - 53, 03.12.2020

Halime Selen , Veysel Çomaklı

https://doi.org/10.3153/FH21006

Abstract

References

  • Ak, T., Gülçin, İ. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interactions, 174, 27-37. https://doi.org/10.1016/j.cbi.2008.05.003
  • Aksoy, A. (2018). Determination of the DNA damage levels in patients with chronic renal failure using 8-hydroxy-2’-deoxyguanosine biomarker. Fresenius Environmental Bulletin, 27(12a), 9308-9314.
  • Antiga, E., Bonciolini, V., Volpi, W., Del Bianco, E., Caproni, M. (2015). Oral curcumin (meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with Psoriasis vulgaris. BioMed Research International, 1-7. https://doi.org/10.1155/2015/283634
  • Asouri, M., Ataee, R., Ahmadi, A.A., Amini, A., Rezaei Moshaei, M. (2013). Antioxidant and free radical scavenging activities of curcumin. Asian Journal of Chemistry, 25(13), 7593-7595. https://doi.org/10.14233/ajchem.2013.15308
  • Atakan, A. (2017). Kilolu ve obez bireylerde zerdeçal tüketiminin ağırlık kaybı ve kan lipid düzeyleri üzerindeki etkisinin değerlendirilmesi. Doğu Akdeniz Üniversitesi, Lisansüstü Eğitim, Öğretim ve Araştırma Enstitüsü, Yüksek Lisans Tezi, Gazimağusa.
  • Belviranlı, M., Okudan, N., Nurullahoğlu, Atalık. K.E. (2012). Yaşlı sıçanlarda kurkumin takviyesinin kalp dokusunun oksidan/antioksidan durumu üzerine etkileri. Genel Tıp Dergisi, 22(2), 61-66.
  • Chandran, B., Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research, 26(11), 1719-1725. https://doi.org/10.1002/ptr.4639
  • Chen, Q.Y., Lu, G.H., Wu, Y.Q., Zheng, Y., Xu, K., Wu, L.J., Jiang, Z.Y., Feng, R., Zhou, J.Y. (2010). Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells. Oncology Reports, 23(5), 1285-1292. https://doi.org/10.3892/or_00000762
  • Chin, D., Huebbe, P., Pallauf, K., Rimbach, G. (2013). Neuroprotective properties of curcumin in Alzheimer’s disease-merits and limitations. Current Medicinal Chemistry, 20(32), 3955-3985. https://doi.org/10.2174/09298673113209990210
  • Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., Jirawatnotal, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35, 2121-2127. https://doi.org/10.2337/dc12-0116
  • Dai, C., Li, D., Gong, L., Xiao, X., Tang, S. (2016). Curcumin ameliorates furazolidone-induced DNA damage and apoptosis in human hepatocyte L02 cells by inhibiting ROS production and mitochondrial pathway. Molecules, 21(8), E1061. https://doi.org/10.3390/molecules21081061
  • Deniz, R., Gürateş, B., Aydın, S., Çelik, H., Sahin, İ., Baykuş, Y., Çatak, Z., Aksoy, A., Çitil, C., Güngör, S. (2012). Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine, 42, 694-699. https://doi.org/10.1007/s12020-012-9638-7
  • Ghosh, S., Banerjee, S., Sil, P.C. (2015). The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chemical Toxicology, 83, 111-124. https://doi.org/10.1016/j.fct.2015.05.022
  • Harish, G., Venkateshappa, C., Mythri, R.B., Dubey, S.K., Mishra, K., Singh, N., Vali, S., Bharath, M.M. (2010). Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease. Bioorganic & Medicinal Chemistry, 18(7), 2631-2638. https://doi.org/10.1016/j.bmc.2010.02.029
  • Jaggi, M., Du, C., Zhang, W., Balaji, K.C. (2007). Protein kinase D1: A protein of emerging translational interest. Frontiers in Bioscience, 12, 3757-3767. https://doi.org/10.2741/2349
  • Jamilian, M., Foroozanfard, F., Kavossian, E., Aghadavod, E., Shafabakhsh, R., Hoseini, A., Asemi, Z. (2020). Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. European Society for Clinical Nutrition and Metabolism, 36, 128-133. https://doi.org/10.1016/j.clnesp.2020.01.005
  • Kumar, A., Sharma, N. (2015). Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pesticide Biochemistry and Physiology, 119(1), 16-27. https://doi.org/10.1016/j.pestbp.2015.03.003
  • Lang, A., Salomon, N., Wu, J.C., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J.Y., Cheong, P.K., Avidan, B., Gamus, D., Kaimakliotis, I., Eliakim, R., Ng, S.C., Ben-Horin, S. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology Hepatology, 13(8), 1444-1449. https://doi.org/10.1016/j.cgh.2015.02.019
  • Laveti, D., Kumar, M., Hemalatha, R., Sistla, R., Naidu, V.G., Talla, V., Verma, V., Kaur, N., Nagpal, R. (2013). Anti-inflammatory treatments for chronic diseases: A review. Inflammation & Allergy - Drug Targets, 12(5), 349–361. https://doi.org/10.2174/18715281113129990053
  • McFadden, R.T., Larmonier, C.B., Shehab, K.W., Midura-Kiela, M., Ramalingam, R., Harrison, C.A., Besselsen, D.G., Chase, J.H., Caporaso, J.G., Jobin, C., Ghishan, F.K., Kiela, P.R. (2015). The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory Bowel Diseases, 21(11), 2483-2494. https://doi.org/10.1097/MIB.0000000000000522
  • Mohamed, G.A., Ibrahim, S.R.M., Elkhayat, E.S., El Dine, R.S. (2014). Natural anti-obesity agents. Bulletin of Faculty Pharmaciy Cairo University, 52, 269-284. https://doi.org/10.1016/j.bfopcu.2014.05.001
  • Mohammadi, S., Kayedpoor, P., Karimzadeh-Bardei, L., Nabiuni, M. (2017). The effect of curcumin on TNF-α, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state. Journal of Reproduction & Infertility, 18(4), 352-360.
  • Nahar, P.P., Slitt, A.L., Seeram, N.P. (2015). Anti-inflammatory effects of novel standardized solid lipid curcumin formulations. Journal of Medicinal Food, 18(7), 786-792. https://doi.org/10.1089/jmf.2014.0053
  • Neeraj, J.P., Singh S, Singh J. (2008). Role of free radicals and antioxidants in human health and disease. International Journal of Current Research and Review, 5(19), 14-22.
  • Oyetayo, B.O., Amos, O., Abolaji, A.O., Fasae, K.D., Aderibigbe, A. (2020). Ameliorative role of diets fortified with curcumin in a Drosophila Melanogaster model of aluminum chloride-induced neurotoxicity. Journal of Functional Foods, 71, 1-7. https://doi.org/10.1016/j.jff.2020.104035
  • Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S.M., Keshavarz, S.A. (2016). Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepatitis Monthyl, 16(1), 1-5. https://doi.org/10.5812/hepatmon.34897
  • Sak, M.E., Soydinc, H.E., Sak, S., Evsen, M.S., Alabalik, U., Akdemir, F., Gul, T. (2013). The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. International Journal of Surgery, 11(9), 967-970. https://doi.org/10.1016/j.ijsu.2013.06.007
  • Seyithanoğlu, M., Tanrıkulu Küçük, S., Öner İyidoğan, Y., Koçak, H., Mikailova, P., Aydın, A.F. (2020). Kurkumin uygulamasının yüksek yağlı diyetle beslenen sıçanların testis dokusunda oksidanantioksidan sistem üzerine etkisi. İstanbul Tıp Fakültesi Dergisi, 83(3), 247-253. https://doi.org/10.26650/IUITFD.2019.0049
  • Sharma, R.A., Gescher, A.J., Steward, W.P. (2005). Curcumin: The story so far. European Journal of Cancer, 41(3), 1955-1968. https://doi.org/10.1016/j.ejca.2005.05.009
  • Sundram, V., Chauhan, S.C., Ebeling, M., Jaggi, M. (2012). Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1. PLoS One, 7(4), 1-13. https://doi.org/10.1371/journal.pone.0035368
  • Tanvir, E.M., Hossen, M.S., Hossain, M.F., Afroz, R., Hua Gan, S., Khalil, M.I., Karim, N. (2017). Antioxidant properties of popular turmeric (curcuma longa) varieties from Bangladesh. Journal of Food Quality, 8471785, 1-8. https://doi.org/10.1155/2017/8471785
  • Turgut, M. (2019). Deneysel akut pankretit’te kaempferol ve kurkumin’in etkilerinin araştırılması. Pamukkale Üniversitesi, Tıp Fakültesi, Uzmanlık Tezi, Denizli.
  • Wongcharoen, W., Jai-Aue, S., Phrommintikul, A., Nawarawong, W., Woragidpoonpol, S., Tepsuwan, T., Sukonthasarn, A., Apaijai, N., Chattpakorn, N. (2012). Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. American Journal of Cardiology, 110, 40-44. https://doi.org/10.1016/j.amjcard.2012.02.043 WHO (2000). Evaluation of certain food additives: Fifty-first report of the joint FAO/WHO expert committee on food additives. World Health Organization & Food and Agriculture Organization of The United Nations.
  • Yang, Y.S., Su, Y.F., Yang, H.W., Lee, Y.H., Chou, J.I., Ueng, K.C. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytotheraop Research, 28, 1770-1777. https://doi.org/10.1002/ptr.5197
  • Yeh, C.H., Chen, T.P., Wu, Y.C., Lin, Y.M., Jing Lin, P. (2005). Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. Journal of Surgical Research, 125(1), 109-116. https://doi.org/10.1016/j.jss.2004.11.009

Curcumin's antioxidant effects on inflammatory diseases

Year 2021, , 45 - 53, 03.12.2020

Halime Selen , Veysel Çomaklı

https://doi.org/10.3153/FH21006

Abstract

There are similar inflammatory reasons behind non-contagious chronic diseases. The prevalence of these diseases increases everyday both in our country and around the world. That's why scientists have begun looking for strong antioxidants that could help prevent and treat such inflammatory diseases. Curcumin is one of those antioxidants. Curcumin is one of the components of turmeric, which belongs to the ginger family. Many studies showed that the curcuminoids in turmeric can be used to prevent and treat cardiovascular, autoimmune and endocrine diseases, cancer as well as various inflammatory diseases. With this study, we aim to interpret these recent studies conducted with curcumin.

Keywords

Antioxidant Curcumin Health Inflammatory diseases

References

  • Ak, T., Gülçin, İ. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-Biological Interactions, 174, 27-37. https://doi.org/10.1016/j.cbi.2008.05.003
  • Aksoy, A. (2018). Determination of the DNA damage levels in patients with chronic renal failure using 8-hydroxy-2’-deoxyguanosine biomarker. Fresenius Environmental Bulletin, 27(12a), 9308-9314.
  • Antiga, E., Bonciolini, V., Volpi, W., Del Bianco, E., Caproni, M. (2015). Oral curcumin (meriva) is effective as an adjuvant treatment and is able to reduce IL-22 serum levels in patients with Psoriasis vulgaris. BioMed Research International, 1-7. https://doi.org/10.1155/2015/283634
  • Asouri, M., Ataee, R., Ahmadi, A.A., Amini, A., Rezaei Moshaei, M. (2013). Antioxidant and free radical scavenging activities of curcumin. Asian Journal of Chemistry, 25(13), 7593-7595. https://doi.org/10.14233/ajchem.2013.15308
  • Atakan, A. (2017). Kilolu ve obez bireylerde zerdeçal tüketiminin ağırlık kaybı ve kan lipid düzeyleri üzerindeki etkisinin değerlendirilmesi. Doğu Akdeniz Üniversitesi, Lisansüstü Eğitim, Öğretim ve Araştırma Enstitüsü, Yüksek Lisans Tezi, Gazimağusa.
  • Belviranlı, M., Okudan, N., Nurullahoğlu, Atalık. K.E. (2012). Yaşlı sıçanlarda kurkumin takviyesinin kalp dokusunun oksidan/antioksidan durumu üzerine etkileri. Genel Tıp Dergisi, 22(2), 61-66.
  • Chandran, B., Goel, A. (2012). A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytotherapy Research, 26(11), 1719-1725. https://doi.org/10.1002/ptr.4639
  • Chen, Q.Y., Lu, G.H., Wu, Y.Q., Zheng, Y., Xu, K., Wu, L.J., Jiang, Z.Y., Feng, R., Zhou, J.Y. (2010). Curcumin induces mitochondria pathway mediated cell apoptosis in A549 lung adenocarcinoma cells. Oncology Reports, 23(5), 1285-1292. https://doi.org/10.3892/or_00000762
  • Chin, D., Huebbe, P., Pallauf, K., Rimbach, G. (2013). Neuroprotective properties of curcumin in Alzheimer’s disease-merits and limitations. Current Medicinal Chemistry, 20(32), 3955-3985. https://doi.org/10.2174/09298673113209990210
  • Chuengsamarn, S., Rattanamongkolgul, S., Luechapudiporn, R., Phisalaphong, C., Jirawatnotal, S. (2012). Curcumin extract for prevention of type 2 diabetes. Diabetes Care, 35, 2121-2127. https://doi.org/10.2337/dc12-0116
  • Dai, C., Li, D., Gong, L., Xiao, X., Tang, S. (2016). Curcumin ameliorates furazolidone-induced DNA damage and apoptosis in human hepatocyte L02 cells by inhibiting ROS production and mitochondrial pathway. Molecules, 21(8), E1061. https://doi.org/10.3390/molecules21081061
  • Deniz, R., Gürateş, B., Aydın, S., Çelik, H., Sahin, İ., Baykuş, Y., Çatak, Z., Aksoy, A., Çitil, C., Güngör, S. (2012). Nesfatin-1 and other hormone alterations in polycystic ovary syndrome. Endocrine, 42, 694-699. https://doi.org/10.1007/s12020-012-9638-7
  • Ghosh, S., Banerjee, S., Sil, P.C. (2015). The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chemical Toxicology, 83, 111-124. https://doi.org/10.1016/j.fct.2015.05.022
  • Harish, G., Venkateshappa, C., Mythri, R.B., Dubey, S.K., Mishra, K., Singh, N., Vali, S., Bharath, M.M. (2010). Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson’s disease. Bioorganic & Medicinal Chemistry, 18(7), 2631-2638. https://doi.org/10.1016/j.bmc.2010.02.029
  • Jaggi, M., Du, C., Zhang, W., Balaji, K.C. (2007). Protein kinase D1: A protein of emerging translational interest. Frontiers in Bioscience, 12, 3757-3767. https://doi.org/10.2741/2349
  • Jamilian, M., Foroozanfard, F., Kavossian, E., Aghadavod, E., Shafabakhsh, R., Hoseini, A., Asemi, Z. (2020). Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. European Society for Clinical Nutrition and Metabolism, 36, 128-133. https://doi.org/10.1016/j.clnesp.2020.01.005
  • Kumar, A., Sharma, N. (2015). Comparative efficacy of piperine and curcumin in deltamethrin induced splenic apoptosis and altered immune functions. Pesticide Biochemistry and Physiology, 119(1), 16-27. https://doi.org/10.1016/j.pestbp.2015.03.003
  • Lang, A., Salomon, N., Wu, J.C., Kopylov, U., Lahat, A., Har-Noy, O., Ching, J.Y., Cheong, P.K., Avidan, B., Gamus, D., Kaimakliotis, I., Eliakim, R., Ng, S.C., Ben-Horin, S. (2015). Curcumin in combination with mesalamine induces remission in patients with mild-to-moderate ulcerative colitis in a randomized controlled trial. Clinical Gastroenterology Hepatology, 13(8), 1444-1449. https://doi.org/10.1016/j.cgh.2015.02.019
  • Laveti, D., Kumar, M., Hemalatha, R., Sistla, R., Naidu, V.G., Talla, V., Verma, V., Kaur, N., Nagpal, R. (2013). Anti-inflammatory treatments for chronic diseases: A review. Inflammation & Allergy - Drug Targets, 12(5), 349–361. https://doi.org/10.2174/18715281113129990053
  • McFadden, R.T., Larmonier, C.B., Shehab, K.W., Midura-Kiela, M., Ramalingam, R., Harrison, C.A., Besselsen, D.G., Chase, J.H., Caporaso, J.G., Jobin, C., Ghishan, F.K., Kiela, P.R. (2015). The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory Bowel Diseases, 21(11), 2483-2494. https://doi.org/10.1097/MIB.0000000000000522
  • Mohamed, G.A., Ibrahim, S.R.M., Elkhayat, E.S., El Dine, R.S. (2014). Natural anti-obesity agents. Bulletin of Faculty Pharmaciy Cairo University, 52, 269-284. https://doi.org/10.1016/j.bfopcu.2014.05.001
  • Mohammadi, S., Kayedpoor, P., Karimzadeh-Bardei, L., Nabiuni, M. (2017). The effect of curcumin on TNF-α, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state. Journal of Reproduction & Infertility, 18(4), 352-360.
  • Nahar, P.P., Slitt, A.L., Seeram, N.P. (2015). Anti-inflammatory effects of novel standardized solid lipid curcumin formulations. Journal of Medicinal Food, 18(7), 786-792. https://doi.org/10.1089/jmf.2014.0053
  • Neeraj, J.P., Singh S, Singh J. (2008). Role of free radicals and antioxidants in human health and disease. International Journal of Current Research and Review, 5(19), 14-22.
  • Oyetayo, B.O., Amos, O., Abolaji, A.O., Fasae, K.D., Aderibigbe, A. (2020). Ameliorative role of diets fortified with curcumin in a Drosophila Melanogaster model of aluminum chloride-induced neurotoxicity. Journal of Functional Foods, 71, 1-7. https://doi.org/10.1016/j.jff.2020.104035
  • Rahimlou, M., Yari, Z., Hekmatdoost, A., Alavian, S.M., Keshavarz, S.A. (2016). Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepatitis Monthyl, 16(1), 1-5. https://doi.org/10.5812/hepatmon.34897
  • Sak, M.E., Soydinc, H.E., Sak, S., Evsen, M.S., Alabalik, U., Akdemir, F., Gul, T. (2013). The protective effect of curcumin on ischemia-reperfusion injury in rat ovary. International Journal of Surgery, 11(9), 967-970. https://doi.org/10.1016/j.ijsu.2013.06.007
  • Seyithanoğlu, M., Tanrıkulu Küçük, S., Öner İyidoğan, Y., Koçak, H., Mikailova, P., Aydın, A.F. (2020). Kurkumin uygulamasının yüksek yağlı diyetle beslenen sıçanların testis dokusunda oksidanantioksidan sistem üzerine etkisi. İstanbul Tıp Fakültesi Dergisi, 83(3), 247-253. https://doi.org/10.26650/IUITFD.2019.0049
  • Sharma, R.A., Gescher, A.J., Steward, W.P. (2005). Curcumin: The story so far. European Journal of Cancer, 41(3), 1955-1968. https://doi.org/10.1016/j.ejca.2005.05.009
  • Sundram, V., Chauhan, S.C., Ebeling, M., Jaggi, M. (2012). Curcumin attenuates β-catenin signaling in prostate cancer cells through activation of protein kinase D1. PLoS One, 7(4), 1-13. https://doi.org/10.1371/journal.pone.0035368
  • Tanvir, E.M., Hossen, M.S., Hossain, M.F., Afroz, R., Hua Gan, S., Khalil, M.I., Karim, N. (2017). Antioxidant properties of popular turmeric (curcuma longa) varieties from Bangladesh. Journal of Food Quality, 8471785, 1-8. https://doi.org/10.1155/2017/8471785
  • Turgut, M. (2019). Deneysel akut pankretit’te kaempferol ve kurkumin’in etkilerinin araştırılması. Pamukkale Üniversitesi, Tıp Fakültesi, Uzmanlık Tezi, Denizli.
  • Wongcharoen, W., Jai-Aue, S., Phrommintikul, A., Nawarawong, W., Woragidpoonpol, S., Tepsuwan, T., Sukonthasarn, A., Apaijai, N., Chattpakorn, N. (2012). Effects of curcuminoids on frequency of acute myocardial infarction after coronary artery bypass grafting. American Journal of Cardiology, 110, 40-44. https://doi.org/10.1016/j.amjcard.2012.02.043 WHO (2000). Evaluation of certain food additives: Fifty-first report of the joint FAO/WHO expert committee on food additives. World Health Organization & Food and Agriculture Organization of The United Nations.
  • Yang, Y.S., Su, Y.F., Yang, H.W., Lee, Y.H., Chou, J.I., Ueng, K.C. (2014). Lipid-lowering effects of curcumin in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled trial. Phytotheraop Research, 28, 1770-1777. https://doi.org/10.1002/ptr.5197
  • Yeh, C.H., Chen, T.P., Wu, Y.C., Lin, Y.M., Jing Lin, P. (2005). Inhibition of NFκB activation with curcumin attenuates plasma inflammatory cytokines surge and cardiomyocytic apoptosis following cardiac ischemia/reperfusion. Journal of Surgical Research, 125(1), 109-116. https://doi.org/10.1016/j.jss.2004.11.009
There are 35 citations in total.

Details

Primary Language English
Subjects Food Engineering
Journal Section Review Articles
Authors

Halime Selen 0000-0002-3705-0875

Veysel Çomaklı 0000-0003-2109-6702

Publication Date December 3, 2020
Submission Date July 24, 2020
Published in Issue Year 2021

Cite

APA Selen, H., & Çomaklı, V. (2021). Curcumin’s antioxidant effects on inflammatory diseases. Food and Health, 7(1), 45-53. https://doi.org/10.3153/FH21006

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