Review Article
BibTex RIS Cite

Aralıklı orucun bağırsak mikrobiyotası üzerine etkisi

Year 2023, , 87 - 97, 01.01.2023

Halime Selen , Aylin Seylam

https://doi.org/10.3153/FH23008

Abstract

Beslenme alışkanlıklarının bağırsak mikrobiyotasını etkilediği bilinmektedir. Son dönemlerde besin alımının çeşitliliğinden ziyade besin alınan zamanın mikrobiyota üzerine etkisine odaklanılmış ve bunun mikrobiyomu etkilediği görülmüştür. Aralıklı orucun mikrobiyotadaki yararlı mikroorganizmaları arttığı, patojen mikroorganizmaları azalttığı rapor edilmiş olsa da etki mekanizması tam olarak açıklanamamıştır. Bu derlemenin amacı aralıklı oruç ve mikrobiyota ilişkisini inceleyen güncel çalışmaları yorumlamaktır.

Keywords

Aralıklı oruç Bağırsak beyin ekseni Beslenme Mikrobiyota

References

  • Abdelaal, M., le Roux, C.W., Docherty, N.G. (2017). Morbidity and mortality associated with obesity. Annals of Translational Medicine, 5(7), 161. https://doi.org/10.21037/atm.2017.03.107
  • Ajala, O., Mold, F., Boughton, C., Cooke, D., Whyte, M. (2017). Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta‐analysis. Obesity Reviews, 18(9), 1061-1070. https://doi.org/10.1111/obr.12561
  • Akanji, A.O., Mojiminiyi, O.A., Abdella, N. (2000). Beneficial changes in serum apo A-1 and its ratio to apo Band HDL in stable hyperlipidaemic subjects after Ramadan fasting in Kuwait. European Journal of Clinical Nutrition, 54, 508-513. https://doi.org/10.1038/sj.ejcn.1601047
  • Anonim. (2016). The Nobel Prize in Physiology or Medicine. https://www.nobelprize.org/prizes/medicine/2016/summary/ (Erişim Tarihi: 01.03.2022)
  • Aybak, M., Turkoglu, A., Sermet, A., Denli, O. (1996). Effect of Ramadan fasting on platelet aggregation in healthy male subjects. European Journal of Applied Physiology and Occupational Physiology, 73, 552-556. https://doi.org/10.1007/BF00357678
  • Aydın, Ü.F., Tuli, A. (2021). Bağırsak-beyin eksenine biyokimyasal bakış. Arşiv Kaynak Tarama Dergisi, 30(3), 137-143. https://doi.org/10.17827/aktd.910674
  • Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y. ve ark. (2018). Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice. Diabetes, 67(9), 1867-1879. https://doi.org/10.2337/db18-0158
  • Blum, H.E. (2017). The human microbiome. Advances in Medical Sciences, 62(2), 414-420. https://doi.org/10.1016/j.advms.2017.04.005
  • Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L. ve ark. (2018). Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Cell Metabolism, 27(6), 1222-1235. https://doi.org/10.1016/j.cmet.2018.05.006
  • Claesson, M.J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E. ve ark. (2011). Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proceedings of the National Academy of Sciences, 108(Supplement 1), 4586-4591. https://doi.org/10.1073/pnas.1000097107
  • Clemente, J.C., Pehrsson, E.C., Blaser, M.J., Sandhu, K., Gao, Z., Wang, B. ve ark. (2015). The microbiome of uncontacted Amerindians. Science Advances, 1(3), e1500183. https://doi.org/10.1126/sciadv.1500183
  • Clos-Garcia, M., Andrés-Marin, N., Fernández-Eulate, G., Abecia, L., Lavín, J.L., van Liempd, S. ve ark. (2019). Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia. EBioMedicine, 46, 499-511. https://doi.org/10.1016/j.ebiom.2019.07.031
  • Deng, Y., Liu, W., Wang, J., Yu, J., Yang, L.Q. (2020). Intermittent fasting improves lipid metabolism through changes in gut microbiota in diet-induced obese mice. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e926789-1. https://dx.doi.org/10.12659%2FMSM.926789
  • Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004). Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. International Journal of Systematic and Evolutionary Microbiology, 54(5), 1469-1476. https://doi.org/10.1099/ijs.0.02873-0
  • Di Daniele, N. (2019). The role of preventive nutrition in chronic non-communicable diseases. Nutrients, 11(5), 1074. https://doi.org/10.3390/nu11051074
  • Doifode, T., Giridharan, V.V., Generoso, J.S., Bhatti, G., Collodel, A., Schulz, P.E. ve ark. (2021). The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology. Pharmacological Research, 164, 105314. https://doi.org/10.1016/j.phrs.2020.105314
  • El Ati, J., Beji, C., Danguir, J. (1995). Increased fat oxidation during Ramadan fasting in healthy women: An adaptative mechanism for body-weight maintenance. American Journal of Clinical Nutrition, 62(2), 302-307. https://doi.org/10.1093/ajcn/62.2.302
  • Fernando, H.A., Zibellini, J., Harris, R.A., Seimon, R.V., Sainsbury, A. (2019). Effect of Ramadan fasting on weight and body composition in healthy non-athlete adults: A systematic review and meta-analysis. Nutrients, 11(2), 478. https://doi.org/10.3390/nu11020478
  • Festi, D., Schiumerini, R., Eusebi, L.H., Marasco, G., Taddia, M., Colecchia, A. (2014). Gut microbiota and metabolic syndrome. World Journal of Gastroenterology, 20(43), 16079. https://doi.org/10.3748/wjg.v20.i43.16079
  • Frank, D.N., St Amand, A.L., Feldman, R.A., Boedeker, E.C., Harpaz, N., Pace, N.R. (2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences of the USA, 104, 13780-13785. https://doi.org/10.1073/pnas.0706625104
  • GBD 2015 Obesity Collaborators. (2017). Health effects of overweight and obesity in 195 countries over 25 years. New England Journal of Medicine, 377(1), 13-27. https://doi.org/10.1056/NEJMoa1614362
  • Gill, S.R., Pop, M., DeBoy, R.T., Eckburg, P.B., Turnbaugh, P.J., Samuel, B.S. ve ark. (2006). Metagenomic analysis of the human distal gut microbiome. Science, 312(5778), 1355-1359. https://doi.org/10.1126/science.1124234
  • Guo, Y., Luo, S., Ye, Y., Yin, S., Fan, J., Xia, M. (2021). Intermittent fasting improves cardiometabolic risk factors and alters gut microbiota in metabolic syndrome patients. The Journal of Clinical Endocrinology & Metabolism, 106(1), 64-79. https://doi.org/10.1210/clinem/dgaa644
  • Harvie, M.N., Pegington, M., Mattson, M.P., Frystyk, J., Dillon, B., Evans, G. ve ark. (2011). The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. International Journal of Obesity, 35(5), 714-727. https://doi.org/10.1038/ijo.2010.171
  • Huang, F., Wu, X. (2021). Brain neurotransmitter modulation by gut microbiota in anxiety and depression. Frontiers in Cell and Developmental Biology, 9, 472. https://doi.org/10.3389/fcell.2021.649103
  • Human Microbiome Project Consortium. (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207-214. https://doi.org/10.1038/nature11234
  • Ichimura, Y., Kirisako T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N. ve ark. (2000). A ubiquitin-like system mediates protein lipidation. Nature, 408, 488-492. https://doi.org/10.1038/35044114
  • Kul, S., Savas, E., Ozturk, Z.A., Karadag, G. (2014). Does Ramadan fasting alter body weight and blood lipids and fasting blood glucose in a healthy population? A meta-analysis. Journal of Religion & Health, 53(3), 929-942. https://doi.org/10.1007/s10943-013-9687-0
  • Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L. ve ark. (2017). Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell Metabolism, 26(4), 672-685. https://doi.org/10.1016/j.cmet.2017.08.019
  • Li, L., Su, Y., Li, F., Wang, Y., Ma, Z., Li, Z., Su, J. (2020). The effects of daily fasting hours on shaping gut microbiota in mice. BMC Microbiology, 20(1), 1-8. https://doi.org/10.1186/s12866-020-01754-2
  • Li, T., Qi, M., Gatesoupe, F.J., Tian, D., Jin, W., Li, J. ve ark. (2019). Adaptation to fasting in crucian carp (carassius auratus): Gut microbiota and its correlative relationship with immune function. Microbial Ecology, 78(1), 6-19. https://doi.org/10.1007/s00248-018-1275-0
  • Liu, Y., Wang, H., Gui, S., Zeng, B., Pu, J., Zheng, P. ve ark. (2021). Proteomics analysis of the gut–brain axis in a gut microbiota-dysbiosis model of depression. Translational Psychiatry, 11(1), 1-8. https://doi.org/10.1038/s41398-021-01689-w
  • Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X. ve ark. (2020). Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications, 11(1), 1-14. https://doi.org/10.1038/s41467-020-14676-4
  • Longo, V.D., Mattson, M.P. (2014). Fasting: Molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-92. https://doi.org/10.1016/j.cmet.2013.12.008
  • Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V.D., Sokol, H., Doré, J. ve ark. (2009). The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiology, 9(1), 1-6. https://doi.org/10.1186/1471-2180-9-123
  • Martin, C.R., Osadchiy, V., Kalani, A., Mayer, E.A. (2018). The brain-gut-microbiome axis. Cellular and Molecular Gastroenterology and Hepatology, 6(2), 133-148. https://doi.org/10.1016/j.jcmgh.2018.04.003
  • McCarroll, M.N., Gendelev, L., Kinser, R., Taylor, J., Bruni, G., Myers-Turnbull, D.ve ark. (2019). Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nature Communications, 10(1), 1-14. https://doi.org/10.1038/s41467-019-11936-w
  • Mirmiran, P., Bahadoran, Z., Gaeini, Z., Moslehi, N., Azizi F. (2019). Effects of Ramadan intermittent fasting on lipid and lipoprotein parameters: An updated meta-analysis. Nutrition, Metabolism & Cardiovascular Diseases, 29(9), 906–915. https://doi.org/10.1016/j.numecd.2019.05.056
  • Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J. (2008). Autophagy fights disease through cellular self-digestion. Nature, 451, 1069-1075. https://doi.org/10.1038/nature06639
  • Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D. ve ark. (1998). A protein conjugation system essential for autophagy. Nature, 395, 395-398. https://doi.org/10.1038/26506
  • Morais, L.H., Schreiber, H.L., Mazmanian, S.K. (2021). The gut microbiota–brain axis in behaviour and brain disorders. Nature Reviews Microbiology, 19(4), 241-255. https://doi.org/10.1038/s41579-020-00460-0
  • Most, J., Tosti, V., Redman, L.M., Fontana, L. (2017). Calorie restriction in humans: an update. Ageing Research Reviews, 39, 36-45. https://doi.org/10.1016/j.arr.2016.08.005
  • Ohsumi, Y. (2001). Molecular dissection of autophagy: Two ubiquitin-like systems. Nature Reviews Molecular Cell Biology, 2(3), 211-216. https://doi.org/10.1038/35056522
  • Özkul, C., Yalınay, M., Karakan, T. (2019). Islamic fasting leads to an increased abundance of Akkermansia muciniphila and Bacteroides fragilis group: A preliminary study on intermittent fasting. The Turkish Journal of Gastroenterology, 30(12), 1030. https://doi.org/10.5152/tjg.2019.19185
  • Patterson, R.E., Sears, D.D. (2017). Metabolic effects of intermittent fasting. Annual Review Of Nutrition, 37, 371-393. https://doi.org/10.1146/annurev-nutr-071816-064634
  • Qian, X.H., Song, X.X., Liu, X.L., Tang, H.D. (2021). Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota. Ageing Research Reviews, 68, 101317. https://doi.org/10.1016/j.arr.2021.101317
  • Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K.S., Manichanh, C. ve ark. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464, 59-65. https://doi.org/10.1038/nature08821
  • Ramakrishna, B., Krishnan, S. (2007). The normal bacterial flora of the human intestine and its regulation. Journal of Clinical Gastroenterology, 41, 2-6. https://doi.org/10.1097/MCG.0b013e31802fba68
  • Sekirov, I., Russell, S.L., Antunes, L.C., Finlay, B.B. (2010). Gut microbiota in health and disease. Physiological Reviews, 90, 859-904. https://doi.org/10.1152/physrev.00045.2009
  • Sender, R., Fuchs, S., Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS Biology, 14(8), e1002533. https://doi.org/10.1371/journal.pbio.1002533
  • Shi, H., Zhang, B., Abo-Hamzy, T., Nelson, J.W., Ambati, C.S.R., Petrosino, J.F. ve ark. (2021). Restructuring the gut microbiota by intermittent fasting lowers blood pressure. Circulation Research, 128(9), 1240-1254. https://doi.org/10.1161/CIRCRESAHA.120.318155
  • Shintani, T., Klionsky, D.J. (2004). Autophagy in health and disease: A double-edged sword. Science, 306(5698), 990-995. https://doi.org/10.1126/science.1099993
  • St Onge, M.P., Ard, J., Baskin, M.L., Chiuve, S.E., Johnson, H.M., Kris-Etherton, P. ve ark. (2017). Meal timing and frequency: Implications for cardiovascular disease prevention: A scientific statement from the American Heart Association. Circulation, 135(9), e96-e121. https://doi.org/10.1161/CIR.0000000000000476
  • Su, J., Wang, Y., Zhang, X., Ma, M., Xie, Z., Pan, Q. ve ark. (2021). Remodeling of the gut microbiome during Ramadan-associated intermittent fasting. The American Journal of Clinical Nutrition, 113(5), 1332-1342. https://doi.org/10.1093/ajcn/nqaa388
  • Takeshige, K., Baba, M., Tsuboi, S., Noda, T., Ohsumi, Y. (1992). Autophagy in Yeast Demonstrated with Proteinase-Deficient Mutants and Conditions for Its Induction. The Journal of Cell Biology, 119(2), 301-311. https://doi.org/10.1083/jcb.119.2.301
  • Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J.P. ve ark. (2009). Towards the human intestinal microbiota phylogenetic core. Environmental Microbiology, 11(10), 2574-2584. https://doi.org/10.1111/j.1462-2920.2009.01982.x
  • Tsukada, M., Ohsumi, Y. (1993). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Letters, 333(1-2), 169-174. https://doi.org/10.1016/0014-5793(93)80398-E
  • Wei, S., Han, R., Zhao, J., Wang, S., Huang, M., Wang, Y. ve ark. (2018). Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutrition & Metabolism, 15(1), 1-12. https://doi.org/10.1186/s12986-018-0318-3
  • Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D. ve ark. (2015). Obesity management task force of the european association for the study of obesity. European guidelines for obesity management in adults. Obes Facts, 8(6), 402-424. https://doi.org/10.1159/000442721
  • Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z. (2022). Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and Therapeutic Medicine, 23(1), 1-10. https://doi.org/10.3892/etm.2021.10974

The Effect of Intermittent Fasting on Gut Microbiota

Year 2023, , 87 - 97, 01.01.2023

Halime Selen , Aylin Seylam

https://doi.org/10.3153/FH23008

Abstract

Nutritional habits are known to affect the gut microbiota. Recently, it has been focused on the effect of the time taken in food on the microbiota rather than the variety of food intake, and it has been seen that this affects the microbiome. Although it has been reported that intermittent fasting increases beneficial microorganisms in the microbiota and decreases pathogenic microorganisms, its mechanism of action has not been fully explained. The purpose of this review is to interpret current studies examining the relationship between intermittent fasting and microbiota.

Keywords

Intermittent fasting Gut brain axis Nutrition Microbiota

References

  • Abdelaal, M., le Roux, C.W., Docherty, N.G. (2017). Morbidity and mortality associated with obesity. Annals of Translational Medicine, 5(7), 161. https://doi.org/10.21037/atm.2017.03.107
  • Ajala, O., Mold, F., Boughton, C., Cooke, D., Whyte, M. (2017). Childhood predictors of cardiovascular disease in adulthood. A systematic review and meta‐analysis. Obesity Reviews, 18(9), 1061-1070. https://doi.org/10.1111/obr.12561
  • Akanji, A.O., Mojiminiyi, O.A., Abdella, N. (2000). Beneficial changes in serum apo A-1 and its ratio to apo Band HDL in stable hyperlipidaemic subjects after Ramadan fasting in Kuwait. European Journal of Clinical Nutrition, 54, 508-513. https://doi.org/10.1038/sj.ejcn.1601047
  • Anonim. (2016). The Nobel Prize in Physiology or Medicine. https://www.nobelprize.org/prizes/medicine/2016/summary/ (Erişim Tarihi: 01.03.2022)
  • Aybak, M., Turkoglu, A., Sermet, A., Denli, O. (1996). Effect of Ramadan fasting on platelet aggregation in healthy male subjects. European Journal of Applied Physiology and Occupational Physiology, 73, 552-556. https://doi.org/10.1007/BF00357678
  • Aydın, Ü.F., Tuli, A. (2021). Bağırsak-beyin eksenine biyokimyasal bakış. Arşiv Kaynak Tarama Dergisi, 30(3), 137-143. https://doi.org/10.17827/aktd.910674
  • Beli, E., Yan, Y., Moldovan, L., Vieira, C. P., Gao, R., Duan, Y. ve ark. (2018). Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/db mice. Diabetes, 67(9), 1867-1879. https://doi.org/10.2337/db18-0158
  • Blum, H.E. (2017). The human microbiome. Advances in Medical Sciences, 62(2), 414-420. https://doi.org/10.1016/j.advms.2017.04.005
  • Cignarella, F., Cantoni, C., Ghezzi, L., Salter, A., Dorsett, Y., Chen, L. ve ark. (2018). Intermittent fasting confers protection in CNS autoimmunity by altering the gut microbiota. Cell Metabolism, 27(6), 1222-1235. https://doi.org/10.1016/j.cmet.2018.05.006
  • Claesson, M.J., Cusack, S., O'Sullivan, O., Greene-Diniz, R., de Weerd, H., Flannery, E. ve ark. (2011). Composition, variability, and temporal stability of the intestinal microbiota of the elderly. Proceedings of the National Academy of Sciences, 108(Supplement 1), 4586-4591. https://doi.org/10.1073/pnas.1000097107
  • Clemente, J.C., Pehrsson, E.C., Blaser, M.J., Sandhu, K., Gao, Z., Wang, B. ve ark. (2015). The microbiome of uncontacted Amerindians. Science Advances, 1(3), e1500183. https://doi.org/10.1126/sciadv.1500183
  • Clos-Garcia, M., Andrés-Marin, N., Fernández-Eulate, G., Abecia, L., Lavín, J.L., van Liempd, S. ve ark. (2019). Gut microbiome and serum metabolome analyses identify molecular biomarkers and altered glutamate metabolism in fibromyalgia. EBioMedicine, 46, 499-511. https://doi.org/10.1016/j.ebiom.2019.07.031
  • Deng, Y., Liu, W., Wang, J., Yu, J., Yang, L.Q. (2020). Intermittent fasting improves lipid metabolism through changes in gut microbiota in diet-induced obese mice. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e926789-1. https://dx.doi.org/10.12659%2FMSM.926789
  • Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004). Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium. International Journal of Systematic and Evolutionary Microbiology, 54(5), 1469-1476. https://doi.org/10.1099/ijs.0.02873-0
  • Di Daniele, N. (2019). The role of preventive nutrition in chronic non-communicable diseases. Nutrients, 11(5), 1074. https://doi.org/10.3390/nu11051074
  • Doifode, T., Giridharan, V.V., Generoso, J.S., Bhatti, G., Collodel, A., Schulz, P.E. ve ark. (2021). The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology. Pharmacological Research, 164, 105314. https://doi.org/10.1016/j.phrs.2020.105314
  • El Ati, J., Beji, C., Danguir, J. (1995). Increased fat oxidation during Ramadan fasting in healthy women: An adaptative mechanism for body-weight maintenance. American Journal of Clinical Nutrition, 62(2), 302-307. https://doi.org/10.1093/ajcn/62.2.302
  • Fernando, H.A., Zibellini, J., Harris, R.A., Seimon, R.V., Sainsbury, A. (2019). Effect of Ramadan fasting on weight and body composition in healthy non-athlete adults: A systematic review and meta-analysis. Nutrients, 11(2), 478. https://doi.org/10.3390/nu11020478
  • Festi, D., Schiumerini, R., Eusebi, L.H., Marasco, G., Taddia, M., Colecchia, A. (2014). Gut microbiota and metabolic syndrome. World Journal of Gastroenterology, 20(43), 16079. https://doi.org/10.3748/wjg.v20.i43.16079
  • Frank, D.N., St Amand, A.L., Feldman, R.A., Boedeker, E.C., Harpaz, N., Pace, N.R. (2007). Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences of the USA, 104, 13780-13785. https://doi.org/10.1073/pnas.0706625104
  • GBD 2015 Obesity Collaborators. (2017). Health effects of overweight and obesity in 195 countries over 25 years. New England Journal of Medicine, 377(1), 13-27. https://doi.org/10.1056/NEJMoa1614362
  • Gill, S.R., Pop, M., DeBoy, R.T., Eckburg, P.B., Turnbaugh, P.J., Samuel, B.S. ve ark. (2006). Metagenomic analysis of the human distal gut microbiome. Science, 312(5778), 1355-1359. https://doi.org/10.1126/science.1124234
  • Guo, Y., Luo, S., Ye, Y., Yin, S., Fan, J., Xia, M. (2021). Intermittent fasting improves cardiometabolic risk factors and alters gut microbiota in metabolic syndrome patients. The Journal of Clinical Endocrinology & Metabolism, 106(1), 64-79. https://doi.org/10.1210/clinem/dgaa644
  • Harvie, M.N., Pegington, M., Mattson, M.P., Frystyk, J., Dillon, B., Evans, G. ve ark. (2011). The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: A randomized trial in young overweight women. International Journal of Obesity, 35(5), 714-727. https://doi.org/10.1038/ijo.2010.171
  • Huang, F., Wu, X. (2021). Brain neurotransmitter modulation by gut microbiota in anxiety and depression. Frontiers in Cell and Developmental Biology, 9, 472. https://doi.org/10.3389/fcell.2021.649103
  • Human Microbiome Project Consortium. (2012). Structure, function and diversity of the healthy human microbiome. Nature, 486, 207-214. https://doi.org/10.1038/nature11234
  • Ichimura, Y., Kirisako T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N. ve ark. (2000). A ubiquitin-like system mediates protein lipidation. Nature, 408, 488-492. https://doi.org/10.1038/35044114
  • Kul, S., Savas, E., Ozturk, Z.A., Karadag, G. (2014). Does Ramadan fasting alter body weight and blood lipids and fasting blood glucose in a healthy population? A meta-analysis. Journal of Religion & Health, 53(3), 929-942. https://doi.org/10.1007/s10943-013-9687-0
  • Li, G., Xie, C., Lu, S., Nichols, R. G., Tian, Y., Li, L. ve ark. (2017). Intermittent fasting promotes white adipose browning and decreases obesity by shaping the gut microbiota. Cell Metabolism, 26(4), 672-685. https://doi.org/10.1016/j.cmet.2017.08.019
  • Li, L., Su, Y., Li, F., Wang, Y., Ma, Z., Li, Z., Su, J. (2020). The effects of daily fasting hours on shaping gut microbiota in mice. BMC Microbiology, 20(1), 1-8. https://doi.org/10.1186/s12866-020-01754-2
  • Li, T., Qi, M., Gatesoupe, F.J., Tian, D., Jin, W., Li, J. ve ark. (2019). Adaptation to fasting in crucian carp (carassius auratus): Gut microbiota and its correlative relationship with immune function. Microbial Ecology, 78(1), 6-19. https://doi.org/10.1007/s00248-018-1275-0
  • Liu, Y., Wang, H., Gui, S., Zeng, B., Pu, J., Zheng, P. ve ark. (2021). Proteomics analysis of the gut–brain axis in a gut microbiota-dysbiosis model of depression. Translational Psychiatry, 11(1), 1-8. https://doi.org/10.1038/s41398-021-01689-w
  • Liu, Z., Dai, X., Zhang, H., Shi, R., Hui, Y., Jin, X. ve ark. (2020). Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment. Nature Communications, 11(1), 1-14. https://doi.org/10.1038/s41467-020-14676-4
  • Longo, V.D., Mattson, M.P. (2014). Fasting: Molecular mechanisms and clinical applications. Cell Metabolism, 19(2), 181-92. https://doi.org/10.1016/j.cmet.2013.12.008
  • Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V.D., Sokol, H., Doré, J. ve ark. (2009). The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiology, 9(1), 1-6. https://doi.org/10.1186/1471-2180-9-123
  • Martin, C.R., Osadchiy, V., Kalani, A., Mayer, E.A. (2018). The brain-gut-microbiome axis. Cellular and Molecular Gastroenterology and Hepatology, 6(2), 133-148. https://doi.org/10.1016/j.jcmgh.2018.04.003
  • McCarroll, M.N., Gendelev, L., Kinser, R., Taylor, J., Bruni, G., Myers-Turnbull, D.ve ark. (2019). Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nature Communications, 10(1), 1-14. https://doi.org/10.1038/s41467-019-11936-w
  • Mirmiran, P., Bahadoran, Z., Gaeini, Z., Moslehi, N., Azizi F. (2019). Effects of Ramadan intermittent fasting on lipid and lipoprotein parameters: An updated meta-analysis. Nutrition, Metabolism & Cardiovascular Diseases, 29(9), 906–915. https://doi.org/10.1016/j.numecd.2019.05.056
  • Mizushima, N., Levine, B., Cuervo, A.M., Klionsky, D.J. (2008). Autophagy fights disease through cellular self-digestion. Nature, 451, 1069-1075. https://doi.org/10.1038/nature06639
  • Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D. ve ark. (1998). A protein conjugation system essential for autophagy. Nature, 395, 395-398. https://doi.org/10.1038/26506
  • Morais, L.H., Schreiber, H.L., Mazmanian, S.K. (2021). The gut microbiota–brain axis in behaviour and brain disorders. Nature Reviews Microbiology, 19(4), 241-255. https://doi.org/10.1038/s41579-020-00460-0
  • Most, J., Tosti, V., Redman, L.M., Fontana, L. (2017). Calorie restriction in humans: an update. Ageing Research Reviews, 39, 36-45. https://doi.org/10.1016/j.arr.2016.08.005
  • Ohsumi, Y. (2001). Molecular dissection of autophagy: Two ubiquitin-like systems. Nature Reviews Molecular Cell Biology, 2(3), 211-216. https://doi.org/10.1038/35056522
  • Özkul, C., Yalınay, M., Karakan, T. (2019). Islamic fasting leads to an increased abundance of Akkermansia muciniphila and Bacteroides fragilis group: A preliminary study on intermittent fasting. The Turkish Journal of Gastroenterology, 30(12), 1030. https://doi.org/10.5152/tjg.2019.19185
  • Patterson, R.E., Sears, D.D. (2017). Metabolic effects of intermittent fasting. Annual Review Of Nutrition, 37, 371-393. https://doi.org/10.1146/annurev-nutr-071816-064634
  • Qian, X.H., Song, X.X., Liu, X.L., Tang, H.D. (2021). Inflammatory pathways in Alzheimer’s disease mediated by gut microbiota. Ageing Research Reviews, 68, 101317. https://doi.org/10.1016/j.arr.2021.101317
  • Qin, J., Li, R., Raes, J., Arumugam, M., Burgdorf, K.S., Manichanh, C. ve ark. (2010). A human gut microbial gene catalogue established by metagenomic sequencing. Nature, 464, 59-65. https://doi.org/10.1038/nature08821
  • Ramakrishna, B., Krishnan, S. (2007). The normal bacterial flora of the human intestine and its regulation. Journal of Clinical Gastroenterology, 41, 2-6. https://doi.org/10.1097/MCG.0b013e31802fba68
  • Sekirov, I., Russell, S.L., Antunes, L.C., Finlay, B.B. (2010). Gut microbiota in health and disease. Physiological Reviews, 90, 859-904. https://doi.org/10.1152/physrev.00045.2009
  • Sender, R., Fuchs, S., Milo, R. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS Biology, 14(8), e1002533. https://doi.org/10.1371/journal.pbio.1002533
  • Shi, H., Zhang, B., Abo-Hamzy, T., Nelson, J.W., Ambati, C.S.R., Petrosino, J.F. ve ark. (2021). Restructuring the gut microbiota by intermittent fasting lowers blood pressure. Circulation Research, 128(9), 1240-1254. https://doi.org/10.1161/CIRCRESAHA.120.318155
  • Shintani, T., Klionsky, D.J. (2004). Autophagy in health and disease: A double-edged sword. Science, 306(5698), 990-995. https://doi.org/10.1126/science.1099993
  • St Onge, M.P., Ard, J., Baskin, M.L., Chiuve, S.E., Johnson, H.M., Kris-Etherton, P. ve ark. (2017). Meal timing and frequency: Implications for cardiovascular disease prevention: A scientific statement from the American Heart Association. Circulation, 135(9), e96-e121. https://doi.org/10.1161/CIR.0000000000000476
  • Su, J., Wang, Y., Zhang, X., Ma, M., Xie, Z., Pan, Q. ve ark. (2021). Remodeling of the gut microbiome during Ramadan-associated intermittent fasting. The American Journal of Clinical Nutrition, 113(5), 1332-1342. https://doi.org/10.1093/ajcn/nqaa388
  • Takeshige, K., Baba, M., Tsuboi, S., Noda, T., Ohsumi, Y. (1992). Autophagy in Yeast Demonstrated with Proteinase-Deficient Mutants and Conditions for Its Induction. The Journal of Cell Biology, 119(2), 301-311. https://doi.org/10.1083/jcb.119.2.301
  • Tap, J., Mondot, S., Levenez, F., Pelletier, E., Caron, C., Furet, J.P. ve ark. (2009). Towards the human intestinal microbiota phylogenetic core. Environmental Microbiology, 11(10), 2574-2584. https://doi.org/10.1111/j.1462-2920.2009.01982.x
  • Tsukada, M., Ohsumi, Y. (1993). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Letters, 333(1-2), 169-174. https://doi.org/10.1016/0014-5793(93)80398-E
  • Wei, S., Han, R., Zhao, J., Wang, S., Huang, M., Wang, Y. ve ark. (2018). Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores β cells and reconstructs gut microbiota in mice. Nutrition & Metabolism, 15(1), 1-12. https://doi.org/10.1186/s12986-018-0318-3
  • Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D. ve ark. (2015). Obesity management task force of the european association for the study of obesity. European guidelines for obesity management in adults. Obes Facts, 8(6), 402-424. https://doi.org/10.1159/000442721
  • Zhang, T., Wang, T., Chen, X., Zhao, Z., Chen, Z. (2022). Gut microbiota relieves inflammation in the substantia nigra of chronic Parkinson's disease by protecting the function of dopamine neurons. Experimental and Therapeutic Medicine, 23(1), 1-10. https://doi.org/10.3892/etm.2021.10974
There are 60 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Review Articles
Authors

Halime Selen 0000-0002-3705-0875

Aylin Seylam 0000-0003-4705-8042

Publication Date January 1, 2023
Submission Date March 9, 2022
Published in Issue Year 2023

Cite

APA Selen, H., & Seylam, A. (2023). Aralıklı orucun bağırsak mikrobiyotası üzerine etkisi. Food and Health, 9(1), 87-97. https://doi.org/10.3153/FH23008

ustresim_2021_1.png

Journal is licensed under a 

CreativeCommons Attribtion-ShareAlike 4.0 International Licence 146271331027042

Diamond Open Access refers to a scholarly publication model in which journals and platforms do not charge fees to either authors or readers.

Open Access Statement:
This is an open access journal which means that all content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author. This is in accordance with the BOAI definition of open access.

Archiving Policy:


Archiving is done according to ULAKBİM "DergiPark" publication policy (LOCKSS).