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PROBİYOTİK- İNSAN BAĞIŞIKLIK SİSTEMİ ETKİLEŞİMLERİ

Year 2019, Volume: 5 Issue: 4, 265 - 280, 01.10.2019

Dicle Dilara Akpınar , Burcu Kaplan Türköz

https://doi.org/10.3153/FH19027

Abstract

Probiyotikler
yeterli miktarda tüketildiklerinde sağlık üzerine yararlı etkiler gösteren
canlı mikroorganizmalardır. Bu mikroorganizmalar, patojenlerle mücadele, epitel
hücre kararlılığını sağlama ve bağışıklık sistemini düzenleyebilmeleri ile
sağlık üzerine olumlu etkiler göstermektedirler. Bağışıklık düzenleyici,
anti-inflamatuar, anti-mikrobiyal, anti-oksidan etkilerini, açığa çıkardıkları
metabolitleriyle, ürettikleri moleküllerle ve hücre yapı bileşenleriyle
sağlamaktadırlar. Peptidoglikan, teikoik asit, lipoteikoik asit, hücre yüzey
polisakkaritleri, salgılanan proteinler ve yüzey proteinleri gibi probiyotik
etken molekülleri doğal bağışıklıkta görevli reseptörler tarafından tanınarak
bağışıklık sistemini harekete geçirmektedir. Yapılan çalışmalarla bu etken
moleküllerinden bazılarının etki mekanizmaları aydınlatılmıştır.Bu derlemede
probiyotiklerin, probiyotik-konak etkileşimleri için kullandıkları bilinen
etken molekülleri hakkında ve etkileri üzerine bilgi verilmesi amaçlanmıştır.

Keywords

Probiyotikler Sağlık etkileri Probiyotik-konak etkileşimleri Bağışıklık düzenleme Etken moleküller

Thanks

Bu derlemedeki bilgi birikiminin oluşmasına katkı sağlayan TÜBİTAK-KBAG (Proje No: 116Z299) ve Ege Üniversitesi Bilimsel Araştırma Projesi (Proje No: 16-Müh-083) desteklerine teşekkür ederiz.

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PROBIOTIC-HUMAN IMMUNE SYSTEM INTERACTIONS

Year 2019, Volume: 5 Issue: 4, 265 - 280, 01.10.2019

Dicle Dilara Akpınar , Burcu Kaplan Türköz

https://doi.org/10.3153/FH19027

Abstract

Probiotics are
live microorganisms which when administered in adequate amounts confer a health
benefit on the host. These microorganisms are known to provide beneficial
health effects by competing with pathogens, providing epithelial cell stability
and showing regulatory effects on the immune system. They provide
immunomodulatory, anti-inflammatory, anti-microbial, antioxidant effects with
their released metabolites, produced molecules and cell structure components.
Effector molecules of probiotics such as peptidoglycan, teichoic acid,
lipoteichoic acid, cell surface polysaccharides, secreted proteins and surface
proteins are recognized by innate immunity receptors and activate the immune
system. The mechanisms of some effector molecules of probiotics have been
elucidated. The aim of this review is to give information on the effects of
probiotics and their active molecules known to be used for probiotic-host
interactions.

Keywords

Probiotics Health Effects Probiotic-host interactions Immunomodulation Effector molecules

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Details

Primary Language Turkish
Subjects Structural Biology, Food Engineering
Journal Section Review Articles
Authors

Dicle Dilara Akpınar 0000-0002-8318-169X

Burcu Kaplan Türköz 0000-0003-3040-3321

Publication Date October 1, 2019
Submission Date February 6, 2019
Published in Issue Year 2019Volume: 5 Issue: 4

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APA Akpınar, D. D., & Kaplan Türköz, B. (2019). PROBİYOTİK- İNSAN BAĞIŞIKLIK SİSTEMİ ETKİLEŞİMLERİ. Food and Health, 5(4), 265-280. https://doi.org/10.3153/FH19027
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