Food and Health
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A1 Milk and Beta-casomorphin-7

Yıl 2021, Cilt 7, Sayı 2, 128 - 137, 09.03.2021

Seval ANDİÇ Rozelin Münevver AYAZ Şehriban OĞUZ

https://doi.org/10.3153/FH21014

Öz

Milk is composed of water, proteins, lipids, lactose, vitamins, and minerals. More than 80% of most mammals’ milk proteins are constituted by caseins. Casein is a group of proteins and they are sub-divided into αs1-, αs2-, β- and β-casein families. Among these casein families, -casein is the second most abundant protein. Different mutations in the cow milk β-casein gene led to 12 genetic variants and most common of these are genetic variants A1 and A2. The A1 and A2 variants differ only at amino acid position 67, which is histidine in A1 or proline in A2 milk. This difference in amino acid sequence suggests a conformational change in the secondary structure of the expressed β-casein. Milk that contains A1 β-casein and A2 β-casein are known as A1 milk and A2 milk, respectively. A1 β-casein milk releases an amino acid bioactive peptide called beta-casomorphin-7 (βCM-7) in small intestine. Beta-casomorphin-7 released from A1 β-casein is responsible for many human disorders like type-1 diabetes, autism, schizophrenia, alzheimer’s disease (AD), attention deficit hyperactivity disorder (ADHD), multiple sclerosis (MS) and heart diseases.

Anahtar Kelimeler

A1 Milk, A2 Milk, βCM-7, Casein, Health

Kaynakça

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Yıl 2021, Cilt 7, Sayı 2, 128 - 137, 09.03.2021

Seval ANDİÇ Rozelin Münevver AYAZ Şehriban OĞUZ

https://doi.org/10.3153/FH21014

Öz

Kaynakça

  • Abrahams, B.S., Geschwind, D.H. (2008). Advances in autism genetics: on the thresholdof a new neurobiology. Nature Reviews Genetics, 9(5), 341-55. https://doi.org/10.1038/nrg2346
  • Anthony, M.S., Clarkson, T.B., Williams, J.K. (1998). Effects of soy isoflavones on atherosclerosis: potential mechanisms. American Journal of Clinical Nutrition, 68, 1390-1393. https://doi.org/10.1093/ajcn/68.6.1390S
  • Banerjee, S. (2018). A2 Milk: The unknown story about a milk protein. Acta Scientific Nutritional Health, 2(3), 28-31.
  • Barnett, M. P., McNabb, W. C., Roy, N. C., Woodford, K. B., Clarke, A. J. (2014). Dietary A1 β-casein affects gastrointestinal transit time, dipeptidyl peptidase-4 activity, and inflammatory status relative to A2 β-casein in Wistar rats. International Journal of Food Sciences and Nutrition, 65, 720-727. https://doi.org/10.3109/09637486.2014.898260
  • Boro, P., Naha, B.C., Saikia, D.P., Prakash, C. (2016). A1 and A2 milk & its impact on human health. International Journal of Science and Nature, 7(1), 01-05.
  • Brambilla, F., Guareschi-Cazzullo, A., Tacchini, C., Musetti, C., Panerai, A.E., Sacerdote, P. (1997). Beta endorphin and cholecystokinin-8 concentrations in peripheral bloodmononuclear cells of autistic children. Neuropsychobiology, 35(1), 1-4. https://doi.org/10.1159/000119322
  • Buchberger, J. (1995). Genetic polymorphism of milk proteins: Differences between breeds. Bulletin IDF, 304, 5-6.
  • Cade, R., Wagemaker, H., Privette, R.M., Fregly, M.S., Rogers, J., Orlando, J. (1990). The effect of dialysis and diet on schizophrenia. Psychiatry: A World Perspective, 3, 494-500.
  • Chia, J. S. J., McRae, J. L., Kukuljan, S., Woodford, K., Elliott, R.B., Swinburn, B., Dwyer, K. M. (2017). A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes. Nutrition & Diabetes, 1(7), 1-7. https://doi.org/10.1038/nutd.2017.16
  • Chia, J.S.J., McRae, J.L., Enjapoori, A.K., Lefèvre, C.M., Kukuljan, S., Dwyer, K.M. (2018). Dietary Cows’ Milk Protein A1 Beta-Casein Increases the Incidence of T1D in NOD Mice. Nutrients, 10(9), 1291. https://doi.org/10.3390/nu10091291
  • Crane, L., Chester, J.W., Goddard, L., Henry, L.A., Hill, E. (2016). Experiences of autism diagnosis: A survey of over 1000 parents in the United Kingdom. Autism, 20(2), 153-162. https://doi.org/10.1177/1362361315573636
  • Damodaran, S. (1996). Amino Acids, peptides, and proteins. In Fennema, O. R. (Ed.), Food Chemistry (p. 321-425). Marcel Dekker, Inc. New York. ISBN: 0849384737, 9780849384738
  • Davoodi, S. H., Shahbazi, R., Esmaeili, S., Sohrabvandi, S., Mortazavian, A.M., Jazayeri, S., Taslimi, A. (2016). Health-Related Aspects of Milk Proteins. Iranian Journal of Pharmaceutical Research, 15(3), 573-591, 2016. https://doi.org/10.22037/IJPR.2016.1897
  • Elliott, R.B., M. Martin, J.M. (1984). Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia, 26(4), 297-299. https://doi.org/10.1007/BF00283653
  • Elliott, R.B., Wasmuth, W.H., Bibby, N.J., Hill, J.P. (1997). The role of β-casein variants in the induction of insulin-dependent diabetes in the non-obese diabetic mouse and humans. Food and Agriculture Organization, Brussels, Belgium, IDF Special Issue, No. 9702, 445-453. https://doi.org/10.1007/s001250051
  • Fox, P.F., Uniacke-Lowe, T., McSweeney, P.L.H., O’Mahony, J.A. (2015). Dairy Chemistry and Biochemistry (p. 584). Second Edition, Switzerland: Springer, Cham. ISBN: 978-3-319-14892-2. https://doi.org/10.1007/978-3-319-14892-2
  • Fox, P.F., Guinee, T.P., Cogan, T.M., McSweeney, P.L.H. (2017). Fundamentals of cheese science (p. 799). Boston: Springer, US. ISBN: 978-1-4899-7681-9 https://doi.org/10.1007/978-1-4899-7681-9
  • Gimeno, S.G., de Souza, J.M. (1997). IDDM and milk consumption. A case-control study in Sao Paulo, Brazil. Diabetes Care, 20(8), 1256–1260. https://doi.org/10.2337/diacare.20.8.1256
  • Jaiswal, K.P., De, S., Sarsavan, A. (2014). Review on bovine beta-casein (A1, A2) gene polymorphism and their potentially hazardous on human health. International Journal of Environment & Animal Conservation, 3(1), 1-12.
  • Jarmołowska, B., Sidor, K., Iwan, M., Bielikowicz, K., Kaczmarski, M., Kostyra, E., Kostyra, H. (2007). Changes of -casomorphin content in human milk during Lactation. Peptides, 28, 1982-1986. https://doi.org/10.1016/j.peptides.2007.08.002
  • Kadam, B.R., Ambadkar, R.K., Rathod, K.S., Pandiyan, C. (2017). A1/A2 milk and human health: A brief review. Journal of Environment and Bio-Sciences, 31(2), 357-362.
  • Kamiński, S., Kamiński, A., Kostyra, E. (2007). Polymorphism of bovine beta-casein and its potential effect on human health. Journal of Applied Genetics, 48(3), 189-198. https://doi.org/10.1007/BF03195213
  • Knip, M., Virtanen, S.M., Seppa, K., Ilonen, J., Savilahti, E., Vaarala, O., Reunanen, A., Teramo, K., Hämäläinen, A.M., Paronen, J., Dosch, H.M., Hakulinen, T., Akerblom, H.K. (2010a). Dietary intervention in infancy and later signs of beta-cell autoimmunity. New England Journal of Medicine, 363(20), 1900-1908. https://doi.org/10.1056/NEJMoa1004809
  • Knip, M., Virtanen, S.M., Akerblom,, H.K. (2010b). Infant feeding and the risk of type 1 diabetes. American Journal of Clinical Nutrition, 91(5), 1506S-1513S. https://doi.org/10.3945/ajcn.2010.28701C
  • Knip, M., Akerblom, H.K., Becker, D., Dosch, H.M., Dupre, J., Fraser, W., Howard, N., Ilonen, J., Krischer, J.P., Kordonouri, O., Lawson, M.L., Palmer, J.P., Savilahti, E., Vaarala, O., Virtanen, S.M. (2014). Hydrolyzed infant formula and early beta-cell autoimmunity: a randomized clinical trial. Journal of the American Medical Association, 311, 2279-2287. https://doi.org/10.1001/jama.2014.5610
  • Kost, N.V., Sokolov, O.Y., Kurasova, O.B., Dmitriev, A.D., Tarakanova, J.N., Gabaeva, M.V., Zolotarev, Y.A., Dadayan, A.K., Grachev, S.A., Korneeva, E.V., Mikheeva, I.G., Zozulya, A.A. (2009). β-Casomorphins-7 in infants on different type of feeding and different levels of psychomotor development. Peptides, 30, 1854-1860. https://doi.org/10.1016/j.peptides.2009.06.025
  • Lamb, M.M., Miller, M., Seifert, J.A., Frederiksen, B., Kroehl, M., Rewers, M., Norris, J.M. (2015). The effect of childhood cow's milk intake and HLA-DR genotype on risk of islet autoimmunity and type 1 diabetes: The Diabetes Autoimmunity Study in the Young. Pediatr Diabetes, 16(1), 31-38. https://doi.org/10.1111/pedi.12115
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Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Bilimi ve Teknolojisi
Bölüm Review Articles
Yazarlar

Seval ANDİÇ (Sorumlu Yazar)
VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, GIDA MÜHENDİSLİĞİ BÖLÜMÜ
0000-0002-8306-0222
Türkiye

Rozelin Münevver AYAZ Bu kişi benim
VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, FEN BİLİMLERİ ENSTİTÜSÜ
0000-0002-8818-9850
Türkiye

Şehriban OĞUZ
VAN YÜZÜNCÜ YIL ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, GIDA MÜHENDİSLİĞİ BÖLÜMÜ
0000-0001-6889-9487
Türkiye

Yayımlanma Tarihi 9 Mart 2021
Başvuru Tarihi 25 Mayıs 2020
Kabul Tarihi 4 Ekim 2020
Yayınlandığı Sayı Yıl 2021, Cilt 7, Sayı 2

Kaynak Göster

Bibtex @İnceleme makalesi { jfhs742564, journal = {Food and Health}, issn = {}, eissn = {2602-2834}, address = {Vidin Caddesi No:28 D:4 Kocamustafapaşa 34107 Fatih İstanbul}, publisher = {Özkan ÖZDEN}, year = {2021}, volume = {7}, pages = {128 - 137}, doi = {10.3153/FH21014}, title = {A1 Milk and Beta-casomorphin-7}, key = {cite}, author = {Andiç, Seval and Ayaz, Rozelin Münevver and Oğuz, Şehriban} }
APA Andiç, S. , Ayaz, R. M. & Oğuz, Ş. (2021). A1 Milk and Beta-casomorphin-7 . Food and Health , 7 (2) , 128-137 . DOI: 10.3153/FH21014
MLA Andiç, S. , Ayaz, R. M. , Oğuz, Ş. "A1 Milk and Beta-casomorphin-7" . Food and Health 7 (2021 ): 128-137 <http://jfhs.scientificwebjournals.com/tr/pub/issue/58210/742564>
Chicago Andiç, S. , Ayaz, R. M. , Oğuz, Ş. "A1 Milk and Beta-casomorphin-7". Food and Health 7 (2021 ): 128-137
RIS TY - JOUR T1 - A1 Milk and Beta-casomorphin-7 AU - Seval Andiç , Rozelin Münevver Ayaz , Şehriban Oğuz Y1 - 2021 PY - 2021 N1 - doi: 10.3153/FH21014 DO - 10.3153/FH21014 T2 - Food and Health JF - Journal JO - JOR SP - 128 EP - 137 VL - 7 IS - 2 SN - -2602-2834 M3 - doi: 10.3153/FH21014 UR - https://doi.org/10.3153/FH21014 Y2 - 2020 ER -
EndNote %0 Food and Health A1 Milk and Beta-casomorphin-7 %A Seval Andiç , Rozelin Münevver Ayaz , Şehriban Oğuz %T A1 Milk and Beta-casomorphin-7 %D 2021 %J Food and Health %P -2602-2834 %V 7 %N 2 %R doi: 10.3153/FH21014 %U 10.3153/FH21014
ISNAD Andiç, Seval , Ayaz, Rozelin Münevver , Oğuz, Şehriban . "A1 Milk and Beta-casomorphin-7". Food and Health 7 / 2 (Mart 2021): 128-137 . https://doi.org/10.3153/FH21014
AMA Andiç S. , Ayaz R. M. , Oğuz Ş. A1 Milk and Beta-casomorphin-7. Food Health. 2021; 7(2): 128-137.
Vancouver Andiç S. , Ayaz R. M. , Oğuz Ş. A1 Milk and Beta-casomorphin-7. Food and Health. 2021; 7(2): 128-137.
IEEE S. Andiç , R. M. Ayaz ve Ş. Oğuz , "A1 Milk and Beta-casomorphin-7", Food and Health, c. 7, sayı. 2, ss. 128-137, Mar. 2021, doi:10.3153/FH21014

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