Araştırma Makalesi
EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS
Yıl 2019, Cilt 5, Sayı 1, 39 - 47, 01.01.2019Öz
The aim of this study was to determine total phenolic and total flavonoid contents, antioxidant and anticholinesterase activities of the hexane, acetone and ethanol extracts prepared from mantle, rosemary, thistle, mallow and nettle commonly consumed for medicinal and nutraceutical purposes in Turkey and all around the world. DPPH free radical, ABTS cation radical and superoxide anion radical scavenging assays, and Ellman method were used to establish the antioxidant and anticholinesterase potential of the extracts, respectively. Total phenolic and total flavonoid contents of the mantle ethanol extract were found to be the richest extract among the others. Mantle ethanol and thistle hexane extracts in DPPH free radical scavenging method (88.03% and 88.07%, respectively), and acetone and ethanol extracts of mantle and rosemary in ABTS cation radical scavenging assay showed the highest inhibition (88.60% and 89.73%, respectively) at 100 μg/mL concentration. None of the extracts exhibited superoxide anion radical scavenging activity. Nettle ethanol extract indicated higher butyrylcholinesterase inhibitory activity (92.68%) than galanthamine, mallow acetone extract as galanthamine, mantle hexane, mallow hexane and ethanol, and nettle acetone extracts almost as galanthamine. To our knowledge, ABTS cation radical and superoxide anion radical scavenging activities, and anticholinesterase potential of the extracts prepared from mantle leaves and flowers, anticholinesterase effect of thistle seeds extracts, ABTS cation radical scavenging activity and butyrylcholinesterase inhibitory activity of the extracts prepared from mallow leaves and flowers were investigated for the first time in this study.
Anahtar Kelimeler
Medicinal Plant, Total Phenolic, Total Flavonoid, Antioxidant, Anticholinesterase
Kaynakça
- Baytop, T. (1984). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün). İstanbul: İstanbul University Press, p. 184, 221-2, 226, 258-9, 417, ISBN 9789754200218
- Benso, B., Franchin, M., Massarioli, A.P., Paschoal, J.A.R., Alencar, S.M., Franco, G.C.N., Rosalen, P.L. (2016). Anti-inflammatory, antiosteoclastogenic and antioxidant effects of Malva sylvestris extract and fractions: in vitro and in vivo studies. PLoS One 11(9), e0162728. Blois, M.S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200.
- Boğa, M., Hacıbekiroğlu, I., Kolak, U. (2011). Antioxidant and anticholinesterase activities of eleven edible plants. Pharmaceutical Biology, 49, 290-295.
- Boğa, M., Ertaş, A., Yılmaz, M.B., Kızıl, M., Çeken, B., Haşimi, N., Yılmaz Özden, T., Demirci, S., Yener, İ., Deveci, Ö. (2016). UHPLC-ESI-MS/MS and GC-MS analyses on phenolic, fatty acid and essential oil of Verbascum pinetorum with antioxidant, anticholinesterase, antimicrobial and DNA damage protection effects. Iranian Journal of Pharmaceutical Research, 15, 393-405.
- Craft, B.D., Kerrihard, A.L., Amarowicz, R., Pegg, R.B. (2012). Phenol-based antioxidants and the in vitro methods used for their assessment. Comprehensive Reviews in Food Science and Food Safety, 11, 148-173.
- Dudonné, S., Vitrac, X., Coutière, P., Woilllez, M., Mérillon, J-M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Food Chemistry, 57, 1768-1774.
- Ellman, G.L., Courtney, K.D., Andres, V., Featherston, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7, 88-95.
- Ertaş, A., Boğa, M., Haşimi, N., Yeşil, Y., Gören, A.C., Topçu, G., Kolak, U. (2014). Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm. Turkish Journal of Chemistry, 38, 592-599.
- Ferreira, A., Proenca, C., Serralheiro, M.L.M., Araujo, M.E.M. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal of Ethnopharmacology, 108, 7-31.
- Gholamhoseinian, A., Moradi, M.N., Sharifi-Far, F. (2009). Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in Pharmaceutical Sciences, 4, 105-112.
- Gülçin, İ., Küfrevioğlu, Ö.İ., Oktay, M., Büyükokuroğlu, M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). Journal of Ethnopharmacology, 90, 205-215.
- Hamad, İ., Erol-Dayi, Ö., Pekmez, M., Önay-Uçar, E., Arda, N. (2010). Antioxidant and cytotoxic activities of Aphanes arvensis extracts. Plant Foods for Human Nutrition, 65, 45-49.
- Hartman, R.E. (2009). Phytochemicals in cell function and Alzheimer’s disease pathology. In L. Packer, H. Sies, M. Eggersdorfer & E. Cadenas (Eds.) Micronutrients and Brain Health (p. 225-241). New York, NY: CRC press. ISBN 9781420073515
- Howes, M-J.R., Perry, N.S.L., Houghton, P.F. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotherapy Research, 17, 1-18.
- Keskin, C., Aktepe, N., Yükselten, Y., Sunguroğlu, A., Boğa, M. (2017). In-vitro antioxidant, cytotoxic, cholinesterase ınhibitory activities and anti-genotoxic effects of Hypericum retusum Aucher flowers, fruits and seeds methanol extracts in human mononuclear leukocytes. Iranian Journal of Pharmaceutical Research, 16, 210-220.
- Liang, N., Kitts, D.D. (2014). Antioxidant property of coffee components: Assessment of methods that define mechanisms of action. Molecules, 19, 19180-19208.
- Nasri, H., Baradaran, A., Shirzad, H., Rafieian-Kopaei, M. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine, 5, 1487-1499.
- Nishikimi, M., Rao, N.A., Yagi, K. (1972). The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and moleculer oxygen. Biochemical and Biophysical Research Communications, 46, 849-854.
- Oh, J., Jo, H., Cho, A.R., Kim, S-J., Han, J. (2012). Antioxidant and antimicrobial activities of various leafy herbal teas. Food Control, 31, 403-409.
- Orhan, İ., Aslan, S., Kartal, M., Şener, B., Başer, K.H.C. (2008). Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chemistry, 108, 663-668.
- Park, Y.K., Koo, M.H., Ikegaki, M., Contado, J.L. (1997). Comparison of the flavonoid aglycone contents of Apis mellifera propolis from various regions of Brazil. Brazilian Archives of Biology and Technology, 40, 97-106.
- Piazzi, L., Cavalli, A., Colizzi, F., Belluti, F., Bartolini, M., Mancini, F., Recanatini, M., Andrisano, V., Rampa, A. (2008). Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorganic & Medicinal Chemistry Letters, 18, 423-426.
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology & Medicine, 26, 1231-1237.
- Reische, D.W., Lillard, D.A., Eitenmiller, R.R. (2002). Antioxidants. In C.C. Akoh & D.B. Min (Eds.), Food Lipids: Chemistry, Nutrition, and Biotechnology (p. 489-516). New York, NY: Marcel Dekker Inc. ISBN 0-8247-0749-4
- Samuelsson, G., Bohlin L. (1999). Drugs of natural origin: a text book of pharmacognosy. Stockholm: Swedish P’ceutical Press, ISBN 9789186274818
- Slinkard, K., Singleton, V.L. (1977). Total phenol analysis automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55.
- Wong, S.P., Leong, L.P., Koh, J.H.W. (2006). Antioxidant activities of aqueous extracts of selected plants. Food Chemistry, 99, 775-783.
Yıl 2019, Cilt 5, Sayı 1, 39 - 47, 01.01.2019
Öz
Kaynakça
- Baytop, T. (1984). Türkiye’de Bitkilerle Tedavi (Geçmişte ve Bugün). İstanbul: İstanbul University Press, p. 184, 221-2, 226, 258-9, 417, ISBN 9789754200218
- Benso, B., Franchin, M., Massarioli, A.P., Paschoal, J.A.R., Alencar, S.M., Franco, G.C.N., Rosalen, P.L. (2016). Anti-inflammatory, antiosteoclastogenic and antioxidant effects of Malva sylvestris extract and fractions: in vitro and in vivo studies. PLoS One 11(9), e0162728. Blois, M.S. (1958). Antioxidant determinations by the use of a stable free radical. Nature, 181, 1199-1200.
- Boğa, M., Hacıbekiroğlu, I., Kolak, U. (2011). Antioxidant and anticholinesterase activities of eleven edible plants. Pharmaceutical Biology, 49, 290-295.
- Boğa, M., Ertaş, A., Yılmaz, M.B., Kızıl, M., Çeken, B., Haşimi, N., Yılmaz Özden, T., Demirci, S., Yener, İ., Deveci, Ö. (2016). UHPLC-ESI-MS/MS and GC-MS analyses on phenolic, fatty acid and essential oil of Verbascum pinetorum with antioxidant, anticholinesterase, antimicrobial and DNA damage protection effects. Iranian Journal of Pharmaceutical Research, 15, 393-405.
- Craft, B.D., Kerrihard, A.L., Amarowicz, R., Pegg, R.B. (2012). Phenol-based antioxidants and the in vitro methods used for their assessment. Comprehensive Reviews in Food Science and Food Safety, 11, 148-173.
- Dudonné, S., Vitrac, X., Coutière, P., Woilllez, M., Mérillon, J-M. (2009). Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. Food Chemistry, 57, 1768-1774.
- Ellman, G.L., Courtney, K.D., Andres, V., Featherston, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7, 88-95.
- Ertaş, A., Boğa, M., Haşimi, N., Yeşil, Y., Gören, A.C., Topçu, G., Kolak, U. (2014). Antioxidant, anticholinesterase, and antimicrobial activities and fatty acid constituents of Achillea cappadocica Hausskn. et Bornm. Turkish Journal of Chemistry, 38, 592-599.
- Ferreira, A., Proenca, C., Serralheiro, M.L.M., Araujo, M.E.M. (2006). The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal. Journal of Ethnopharmacology, 108, 7-31.
- Gholamhoseinian, A., Moradi, M.N., Sharifi-Far, F. (2009). Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity. Research in Pharmaceutical Sciences, 4, 105-112.
- Gülçin, İ., Küfrevioğlu, Ö.İ., Oktay, M., Büyükokuroğlu, M.E. (2004). Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.). Journal of Ethnopharmacology, 90, 205-215.
- Hamad, İ., Erol-Dayi, Ö., Pekmez, M., Önay-Uçar, E., Arda, N. (2010). Antioxidant and cytotoxic activities of Aphanes arvensis extracts. Plant Foods for Human Nutrition, 65, 45-49.
- Hartman, R.E. (2009). Phytochemicals in cell function and Alzheimer’s disease pathology. In L. Packer, H. Sies, M. Eggersdorfer & E. Cadenas (Eds.) Micronutrients and Brain Health (p. 225-241). New York, NY: CRC press. ISBN 9781420073515
- Howes, M-J.R., Perry, N.S.L., Houghton, P.F. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer’s disease and other cognitive disorders. Phytotherapy Research, 17, 1-18.
- Keskin, C., Aktepe, N., Yükselten, Y., Sunguroğlu, A., Boğa, M. (2017). In-vitro antioxidant, cytotoxic, cholinesterase ınhibitory activities and anti-genotoxic effects of Hypericum retusum Aucher flowers, fruits and seeds methanol extracts in human mononuclear leukocytes. Iranian Journal of Pharmaceutical Research, 16, 210-220.
- Liang, N., Kitts, D.D. (2014). Antioxidant property of coffee components: Assessment of methods that define mechanisms of action. Molecules, 19, 19180-19208.
- Nasri, H., Baradaran, A., Shirzad, H., Rafieian-Kopaei, M. (2014). New concepts in nutraceuticals as alternative for pharmaceuticals. International Journal of Preventive Medicine, 5, 1487-1499.
- Nishikimi, M., Rao, N.A., Yagi, K. (1972). The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and moleculer oxygen. Biochemical and Biophysical Research Communications, 46, 849-854.
- Oh, J., Jo, H., Cho, A.R., Kim, S-J., Han, J. (2012). Antioxidant and antimicrobial activities of various leafy herbal teas. Food Control, 31, 403-409.
- Orhan, İ., Aslan, S., Kartal, M., Şener, B., Başer, K.H.C. (2008). Inhibitory effect of Turkish Rosmarinus officinalis L. on acetylcholinesterase and butyrylcholinesterase enzymes. Food Chemistry, 108, 663-668.
- Park, Y.K., Koo, M.H., Ikegaki, M., Contado, J.L. (1997). Comparison of the flavonoid aglycone contents of Apis mellifera propolis from various regions of Brazil. Brazilian Archives of Biology and Technology, 40, 97-106.
- Piazzi, L., Cavalli, A., Colizzi, F., Belluti, F., Bartolini, M., Mancini, F., Recanatini, M., Andrisano, V., Rampa, A. (2008). Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds. Bioorganic & Medicinal Chemistry Letters, 18, 423-426.
- Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M., Rice-Evans, C. (1999). Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radical Biology & Medicine, 26, 1231-1237.
- Reische, D.W., Lillard, D.A., Eitenmiller, R.R. (2002). Antioxidants. In C.C. Akoh & D.B. Min (Eds.), Food Lipids: Chemistry, Nutrition, and Biotechnology (p. 489-516). New York, NY: Marcel Dekker Inc. ISBN 0-8247-0749-4
- Samuelsson, G., Bohlin L. (1999). Drugs of natural origin: a text book of pharmacognosy. Stockholm: Swedish P’ceutical Press, ISBN 9789186274818
- Slinkard, K., Singleton, V.L. (1977). Total phenol analysis automation and comparison with manual methods. American Journal of Enology and Viticulture, 28, 49-55.
- Wong, S.P., Leong, L.P., Koh, J.H.W. (2006). Antioxidant activities of aqueous extracts of selected plants. Food Chemistry, 99, 775-783.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Biyoloji |
| Bölüm | Research Articles |
| Yazarlar |
|
| Yayımlanma Tarihi | 1 Ocak 2019 |
| Başvuru Tarihi | 19 Ocak 2018 |
| Kabul Tarihi | 24 Mayıs 2018 |
| Yayınlandığı Sayı | Yıl 2019, Cilt 5, Sayı 1 |
Kaynak Göster
| Bibtex | @araştırma makalesi { jfhs381277, journal = {Food and Health}, issn = {}, eissn = {2602-2834}, address = {Vidin Caddesi No:28 D:4 Kocamustafapaşa 34107 Fatih İstanbul}, publisher = {Özkan ÖZDEN}, year = {2019}, volume = {5}, pages = {39 - 47}, doi = {10.3153/FH19005}, title = {EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS}, key = {cite}, author = {Ulaç, Ezgican and Köseoğlu Yılmaz, Pelin and Kolak, Ufuk} } |
| APA | Ulaç, E. , Köseoğlu Yılmaz, P. & Kolak, U. (2019). EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS . Food and Health , 5 (1) , 39-47 . DOI: 10.3153/FH19005 |
| MLA | Ulaç, E. , Köseoğlu Yılmaz, P. , Kolak, U. "EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS" . Food and Health 5 (2019 ): 39-47 <https://jfhs.scientificwebjournals.com/tr/pub/issue/38141/381277> |
| Chicago | Ulaç, E. , Köseoğlu Yılmaz, P. , Kolak, U. "EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS". Food and Health 5 (2019 ): 39-47 |
| RIS | TY - JOUR T1 - EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS AU - Ezgican Ulaç , Pelin Köseoğlu Yılmaz , Ufuk Kolak Y1 - 2019 PY - 2019 N1 - doi: 10.3153/FH19005 DO - 10.3153/FH19005 T2 - Food and Health JF - Journal JO - JOR SP - 39 EP - 47 VL - 5 IS - 1 SN - -2602-2834 M3 - doi: 10.3153/FH19005 UR - https://doi.org/10.3153/FH19005 Y2 - 2018 ER - |
| EndNote | %0 Food and Health EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS %A Ezgican Ulaç , Pelin Köseoğlu Yılmaz , Ufuk Kolak %T EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS %D 2019 %J Food and Health %P -2602-2834 %V 5 %N 1 %R doi: 10.3153/FH19005 %U 10.3153/FH19005 |
| ISNAD | Ulaç, Ezgican , Köseoğlu Yılmaz, Pelin , Kolak, Ufuk . "EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS". Food and Health 5 / 1 (Ocak 2019): 39-47 . https://doi.org/10.3153/FH19005 |
| AMA | Ulaç E. , Köseoğlu Yılmaz P. , Kolak U. EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS. Food Health. 2019; 5(1): 39-47. |
| Vancouver | Ulaç E. , Köseoğlu Yılmaz P. , Kolak U. EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS. Food and Health. 2019; 5(1): 39-47. |
| IEEE | E. Ulaç , P. Köseoğlu Yılmaz ve U. Kolak , "EVALUATION OF ANTIOXIDANT AND CHOLINESTERASE INHIBITORY ACTIVITIES OF SOME MEDICINAL PLANTS", Food and Health, c. 5, sayı. 1, ss. 39-47, Oca. 2019, doi:10.3153/FH19005 |
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