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DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A

Yıl 2017, Cilt 3, Sayı 4, 150 - 160, 22.09.2017
https://doi.org/10.3153/JFHS17018

Öz

Bisphenol-A (BPA) which is a plastic monomer acting as endocrine disruptor, can cause developmental effects and change the metabolism even at low concentrations. This study was carried out to make (i) a general assessment by performing residue analysis on the polycarbonate baby bottles, (ii) determining the factors affecting the migration of BPA to the food and (iii) determining the effect of repetitive procedures on PC baby bottles in daily use. Amount of residual BPA ranged from 0.60 ±0.05 ppm to 6.23 ±0.24 ppm and BPA migration could not be detected in any of contact conditions. Estimated daily intakes of BPA via infant formula in PC baby bottle were calculated as  1.8 µg kg-1 bw day-1 for a 3 month-old infant  and 1.22 µg kg-1 bw day-1 for a 6 month-old  infant which was lower than but very close to the latest value of t-TDI (4 µg kg-1 bw day-1) determined by EFSA. Sterilization procedures changed the amount of residual BPA significantly. Although it is concluded that the use of brand-new PC baby bottles does not pose a risk to health, sterilization procedures can lead to the higher amounts of migrated BPA which can be toxically important. 

Kaynakça

  • Biedermann-Brem, S. & Grob, K. (2009). Release of Bisphenol A from polycarbonate baby bottles: water hardness as the most relevant factor. European Food Research Technology, 228, 679-684.
  • Biedermann-Brem, S., Grob, K. & Fjeldahl, P. (2008). Release of bisphenol A from polycarbonate baby bottles: mechanism of formation and investigation of worst case scenarios. European Food Research Technology, 227, 1053-1060.
  • Biles, J.E., McNeal, T.P., Begley, T.H. & Hollifield, H.C. (1997). Determination of bisphenol-a in reusable polycarbonate food-contact plastics and migration to food-simulating liquids. Journal of Agricultural and Food Chemistry, 45, 3541-3544.
  • Brede, C., Fjeldal, P., Skjevrak, I. & Herikstad, H. (2003). Increased migration levels of Bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing conditions. Food Additives and Contaminants, 20(7), 684-689.
  • CSL (Central Science Laboratory). (2004). A study of the migration of bisphenol A from polycarbonate feeding bottles into food simulants. Central Science Laboratory Test Report L6BB-1008 for the Boots Group.
  • Commission Directive. 2002/72/EC. (2002). Relating to plastic materials and articles intended to come into contact with foodstuffs. Official Journal of the European Communities, L 220/ 27.
  • Commission Directive. 2011/8/EU. (2011). Amending Directive 2002/72/EC as regards the restriction of use of Bisphenol A in plastic infant feeding bottles. Official Journal of the European Communities, L 26/ 11.
  • Commission Regulation. No 10/2011. (2011). Plastic materials and articles intended to come into contact with food. Official Journal of the European Communities, L 12/1.
  • Council Directive. 85/572/EEC. (1985) .The list of simulants to be used for testing migration of constituents of plastic materials and articles intended to come into contact with foodstuffs. Official Journal of the European Communities, L 372 /14
  • Davis, M., Fould, J., Freeman, A., Khatter, K., Polyzou, C., Robinson, J., Schade, M., Smith, R. & Vom Saal, F. (2007). Baby’s Toxic Bottle: Bisphenol a leaching from popular baby bottles. Columbia: University of Missouri.
  • Ehlert, K.A., Beumer, C.W.E. and Groot, M.C.E. (2008). Migration of bisphenol A into water from polycarbonate baby bottles during microwave heating. Food Additives and Contaminants A, 25(7), 904-910.
  • EFSA (European Food Safety Authority). (2002). Opinion of the scientific committee on food on Bisphenol A.
  • EFSA (European Food Safety Authority). (2006). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-bis(4-hydroxyphenyl)propane (Bisphenol A). EFSA Journal, 428, 1-75.
  • EFSA (European Food Safety Authority). (2008). Toxicokinetics of bisphenol a: scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food (AFC). EFSA Journal, 759, 1-10.
  • EFSA (European Food Safety Authority). (2014). Draft scientific opinion on the risks to public health related to the presence 2 of bisphenol A (BPA) in foodstuffs: EFSA panel on food contact materials, enzymes, flavourings and processing aids.
  • EFSA (European Food Safety Authority). (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. EFSA panel on food contact materials, enzymes, flavourings and processing aids.
  • Geueke, B., Wagner, C.C. & Muncke, J. (2014). Food contact substances and chemicals of concern: a comparison of inventories. Food Additives and Contaminants A, 33, 1438-1450.
  • Hanai, Y. (1997). Bisphenol-A eluted from nursing bottles. Unpublishing data. Enviromental Science Research Center. Yokohama National University.
  • IBM Corp. Released 2010. IBM SPSS Statistics for Windows, Version 19.0. Armonk, NY: IBM Corp.
  • IAT (Institute for Agricult. and Trade Policy), (2007), Toxic Chemical Leaches from Popular Baby Bottles
  • Kawamura,Y., Koyama,Y., Takeda, Y. & Yamada T. (1998). Migration of bisphenol-A from polycarbonate products. Journal of the Food Hygienic Society of Japan, 39, 206-212.
  • Maia, J., Cruz, J.M., Sendon, R., Bustos J., Sanchez J.J. & Paseiro P. (2009). Effect of detergents in the release of bisphenol a from polycarbonate baby bottles. Food Research International, 42, 1410-1414.
  • Maragou, N.C., Marki, A., Lampi, E.N., Thomaidis, N.S. & Koupparis M.A. (2008). Migration of bisphenol A from poycarbonate baby bottles under real use conditions. Food Additives and Contaminants, 25(3), 373-383.
  • Mountfort, K.A., Kelly, J., Jickells, S.M. & Castle, L. (1997). Investigations in to the potential degradation of polycarbonate baby bottles during sterilization with consequent release of Bisphenol A. Food Additives and Contaminants, 14 (6-7), 737-740.
  • NTP (National Toxicology Program). (2008). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. Center for the Evaluation of Risks to Human Reproduction. NIH Publication No: 08-5994. Robertson, G.L. (2006). Food packaging: principles and practice. Boca Raton: Taylor and Francis. p. 9-42.
  • Sajiki, J., Yonekubo, J. (2004). Leaching of Bisphenol A (BPA) from polycarbonate plastic to water containing amino acids and its degradation by radical oxygen species. Chemosphere, 55, 861-867.
  • Sugiura-Ogasawara, M., Ozaki, Y., Sonta, S.I., Makino, T. & Suzumori, K. (2005). Exposure to bisphenol A is associated with recurrent miscarriage. Human Reproduction, 20, 2325-2329.
  • Takeuchi, T. & Tsutsumi, O. (2002). Serum bisphenol A concentrations showed gender differences, possibly linked to androgen levels. Biochemical and Biophysical Research Communications, 291, 76-78.
  • Üçüncü, M. (2007). Plastikler ve Plastik Esaslı Ambalaj Materyalleri. In Üçüncü, M. (Ed). Gıda Ambalajlama Teknolojisi. p. 328-329. İzmir: Meta Basım Matbaacılık Hizmetleri.
  • Vandenberg, N., Hauser, R., Marcus, M., Olea, N. & Wade, W. (2007). Human exposure to bisphenol A (BPA). Reproductive Toxicology, 24, 139-177.
  • Wong, K.O., Leo, L.W. & Seah, H.L. (2005). Dietary exposure assessment of infants to bisphenol A from the use of polycarbonate baby milk bottles. Food Additives and Contaminants A, 22(3), 280-288.
  • Yamada, H., Furuta, I., Kato, E.H., Kataoka, S., Usuki, Y. & Kobashi, G. (2002). Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reproductive Toxicology, 16, 735-739.

Yıl 2017, Cilt 3, Sayı 4, 150 - 160, 22.09.2017
https://doi.org/10.3153/JFHS17018

Öz

Kaynakça

  • Biedermann-Brem, S. & Grob, K. (2009). Release of Bisphenol A from polycarbonate baby bottles: water hardness as the most relevant factor. European Food Research Technology, 228, 679-684.
  • Biedermann-Brem, S., Grob, K. & Fjeldahl, P. (2008). Release of bisphenol A from polycarbonate baby bottles: mechanism of formation and investigation of worst case scenarios. European Food Research Technology, 227, 1053-1060.
  • Biles, J.E., McNeal, T.P., Begley, T.H. & Hollifield, H.C. (1997). Determination of bisphenol-a in reusable polycarbonate food-contact plastics and migration to food-simulating liquids. Journal of Agricultural and Food Chemistry, 45, 3541-3544.
  • Brede, C., Fjeldal, P., Skjevrak, I. & Herikstad, H. (2003). Increased migration levels of Bisphenol A from polycarbonate baby bottles after dishwashing, boiling and brushing conditions. Food Additives and Contaminants, 20(7), 684-689.
  • CSL (Central Science Laboratory). (2004). A study of the migration of bisphenol A from polycarbonate feeding bottles into food simulants. Central Science Laboratory Test Report L6BB-1008 for the Boots Group.
  • Commission Directive. 2002/72/EC. (2002). Relating to plastic materials and articles intended to come into contact with foodstuffs. Official Journal of the European Communities, L 220/ 27.
  • Commission Directive. 2011/8/EU. (2011). Amending Directive 2002/72/EC as regards the restriction of use of Bisphenol A in plastic infant feeding bottles. Official Journal of the European Communities, L 26/ 11.
  • Commission Regulation. No 10/2011. (2011). Plastic materials and articles intended to come into contact with food. Official Journal of the European Communities, L 12/1.
  • Council Directive. 85/572/EEC. (1985) .The list of simulants to be used for testing migration of constituents of plastic materials and articles intended to come into contact with foodstuffs. Official Journal of the European Communities, L 372 /14
  • Davis, M., Fould, J., Freeman, A., Khatter, K., Polyzou, C., Robinson, J., Schade, M., Smith, R. & Vom Saal, F. (2007). Baby’s Toxic Bottle: Bisphenol a leaching from popular baby bottles. Columbia: University of Missouri.
  • Ehlert, K.A., Beumer, C.W.E. and Groot, M.C.E. (2008). Migration of bisphenol A into water from polycarbonate baby bottles during microwave heating. Food Additives and Contaminants A, 25(7), 904-910.
  • EFSA (European Food Safety Authority). (2002). Opinion of the scientific committee on food on Bisphenol A.
  • EFSA (European Food Safety Authority). (2006). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to 2,2-bis(4-hydroxyphenyl)propane (Bisphenol A). EFSA Journal, 428, 1-75.
  • EFSA (European Food Safety Authority). (2008). Toxicokinetics of bisphenol a: scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food (AFC). EFSA Journal, 759, 1-10.
  • EFSA (European Food Safety Authority). (2014). Draft scientific opinion on the risks to public health related to the presence 2 of bisphenol A (BPA) in foodstuffs: EFSA panel on food contact materials, enzymes, flavourings and processing aids.
  • EFSA (European Food Safety Authority). (2015). Scientific Opinion on the risks to public health related to the presence of bisphenol A (BPA) in foodstuffs: Executive summary. EFSA panel on food contact materials, enzymes, flavourings and processing aids.
  • Geueke, B., Wagner, C.C. & Muncke, J. (2014). Food contact substances and chemicals of concern: a comparison of inventories. Food Additives and Contaminants A, 33, 1438-1450.
  • Hanai, Y. (1997). Bisphenol-A eluted from nursing bottles. Unpublishing data. Enviromental Science Research Center. Yokohama National University.
  • IBM Corp. Released 2010. IBM SPSS Statistics for Windows, Version 19.0. Armonk, NY: IBM Corp.
  • IAT (Institute for Agricult. and Trade Policy), (2007), Toxic Chemical Leaches from Popular Baby Bottles
  • Kawamura,Y., Koyama,Y., Takeda, Y. & Yamada T. (1998). Migration of bisphenol-A from polycarbonate products. Journal of the Food Hygienic Society of Japan, 39, 206-212.
  • Maia, J., Cruz, J.M., Sendon, R., Bustos J., Sanchez J.J. & Paseiro P. (2009). Effect of detergents in the release of bisphenol a from polycarbonate baby bottles. Food Research International, 42, 1410-1414.
  • Maragou, N.C., Marki, A., Lampi, E.N., Thomaidis, N.S. & Koupparis M.A. (2008). Migration of bisphenol A from poycarbonate baby bottles under real use conditions. Food Additives and Contaminants, 25(3), 373-383.
  • Mountfort, K.A., Kelly, J., Jickells, S.M. & Castle, L. (1997). Investigations in to the potential degradation of polycarbonate baby bottles during sterilization with consequent release of Bisphenol A. Food Additives and Contaminants, 14 (6-7), 737-740.
  • NTP (National Toxicology Program). (2008). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A. Center for the Evaluation of Risks to Human Reproduction. NIH Publication No: 08-5994. Robertson, G.L. (2006). Food packaging: principles and practice. Boca Raton: Taylor and Francis. p. 9-42.
  • Sajiki, J., Yonekubo, J. (2004). Leaching of Bisphenol A (BPA) from polycarbonate plastic to water containing amino acids and its degradation by radical oxygen species. Chemosphere, 55, 861-867.
  • Sugiura-Ogasawara, M., Ozaki, Y., Sonta, S.I., Makino, T. & Suzumori, K. (2005). Exposure to bisphenol A is associated with recurrent miscarriage. Human Reproduction, 20, 2325-2329.
  • Takeuchi, T. & Tsutsumi, O. (2002). Serum bisphenol A concentrations showed gender differences, possibly linked to androgen levels. Biochemical and Biophysical Research Communications, 291, 76-78.
  • Üçüncü, M. (2007). Plastikler ve Plastik Esaslı Ambalaj Materyalleri. In Üçüncü, M. (Ed). Gıda Ambalajlama Teknolojisi. p. 328-329. İzmir: Meta Basım Matbaacılık Hizmetleri.
  • Vandenberg, N., Hauser, R., Marcus, M., Olea, N. & Wade, W. (2007). Human exposure to bisphenol A (BPA). Reproductive Toxicology, 24, 139-177.
  • Wong, K.O., Leo, L.W. & Seah, H.L. (2005). Dietary exposure assessment of infants to bisphenol A from the use of polycarbonate baby milk bottles. Food Additives and Contaminants A, 22(3), 280-288.
  • Yamada, H., Furuta, I., Kato, E.H., Kataoka, S., Usuki, Y. & Kobashi, G. (2002). Maternal serum and amniotic fluid bisphenol A concentrations in the early second trimester. Reproductive Toxicology, 16, 735-739.

Ayrıntılar

Konular Gıda Bilimi ve Teknolojisi
Bölüm Articles
Yazarlar

Özlem KIZILIRMAK ESMER
Department of Food Engineering, Ege University, Bornova, Izmir
0000-0003-4652-0514
Türkiye


Özlem ÇAĞINDI
Department of Food Engineering, Manisa Celal Bayar University, Muradiye, Manisa
0000-0002-6436-9208
Türkiye


Büşra ŞAHİN
Department of Food Engineering, Ege University, Bornova, Izmir
0000-0002-5017-5760
Türkiye

Yayımlanma Tarihi 22 Eylül 2017
Başvuru Tarihi 15 Şubat 2017
Kabul Tarihi 21 Haziran 2017
Yayınlandığı Sayı Yıl 2017, Cilt 3, Sayı 4

Kaynak Göster

Bibtex @araştırma makalesi { jfhs339555, journal = {Food and Health}, issn = {}, eissn = {2602-2834}, address = {Vidin Caddesi No:28 D:4 Kocamustafapaşa 34107 Fatih İstanbul}, publisher = {Özkan ÖZDEN}, year = {2017}, volume = {3}, pages = {150 - 160}, doi = {10.3153/JFHS17018}, title = {DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A}, key = {cite}, author = {Kızılırmak Esmer, Özlem and Çağındı, Özlem and Şahin, Büşra} }
APA Kızılırmak Esmer, Ö. , Çağındı, Ö. & Şahin, B. (2017). DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A . Food and Health , 3 (4) , 150-160 . DOI: 10.3153/JFHS17018
MLA Kızılırmak Esmer, Ö. , Çağındı, Ö. , Şahin, B. "DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A" . Food and Health 3 (2017 ): 150-160 <http://jfhs.scientificwebjournals.com/tr/pub/issue/29942/339555>
Chicago Kızılırmak Esmer, Ö. , Çağındı, Ö. , Şahin, B. "DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A". Food and Health 3 (2017 ): 150-160
RIS TY - JOUR T1 - DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A AU - Özlem Kızılırmak Esmer , Özlem Çağındı , Büşra Şahin Y1 - 2017 PY - 2017 N1 - doi: 10.3153/JFHS17018 DO - 10.3153/JFHS17018 T2 - Food and Health JF - Journal JO - JOR SP - 150 EP - 160 VL - 3 IS - 4 SN - -2602-2834 M3 - doi: 10.3153/JFHS17018 UR - https://doi.org/10.3153/JFHS17018 Y2 - 2017 ER -
EndNote %0 Food and Health DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A %A Özlem Kızılırmak Esmer , Özlem Çağındı , Büşra Şahin %T DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A %D 2017 %J Food and Health %P -2602-2834 %V 3 %N 4 %R doi: 10.3153/JFHS17018 %U 10.3153/JFHS17018
ISNAD Kızılırmak Esmer, Özlem , Çağındı, Özlem , Şahin, Büşra . "DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A". Food and Health 3 / 4 (Eylül 2017): 150-160 . https://doi.org/10.3153/JFHS17018
AMA Kızılırmak Esmer Ö. , Çağındı Ö. , Şahin B. DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A. Food Health. 2017; 3(4): 150-160.
Vancouver Kızılırmak Esmer Ö. , Çağındı Ö. , Şahin B. DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A. Food and Health. 2017; 3(4): 150-160.
IEEE Ö. Kızılırmak Esmer , Ö. Çağındı ve B. Şahin , "DOES THE REALISTIC CONTACT AND DAILY USE CONDITIONS LIMIT THE USE OF POLYCARBONATE BABY BOTTLES FOR MIGRATION AND RESIDUE LEVEL OF BISPHENOL-A", Food and Health, c. 3, sayı. 4, ss. 150-160, Eyl. 2017, doi:10.3153/JFHS17018

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