Research Article
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Antioxidant and 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitory activities of some plant samples

Year 2023, Volume: 9 Issue: 4, 293 - 303, 08.10.2023
https://doi.org/10.3153/FH23026

Abstract

The antioxidant activity capacities of some plants, and their inhibitory effects on the HMG-CoA reductase enzyme, the rate-determining enzyme of cholesterol synthesis, were investigated in our study. Antioxidant activity capacity and inhibitory effect of the HMG-CoA reductase enzyme were detected in all plant extracts used in our research. The results obtained determined that both antioxidant activity and % inhibition values of HMG-CoA reductase enzyme increased as the plant extracts concentration increased. The strongest ABTS and DPPH radical scavenging activities were exhibited by pomegranate fruit extract (IC50= 1.07 ±0.04 mg/mL and IC50= 0.39 ±0.01 mg/mL, respectively). At the same time, lemon had the strongest DMPD radical scavenging activity (IC50= 9×10-4 ±6×10-5 mg/mL). The best HMG-CoA reductase inhibitory activity was observed in persimmon fruit extract (IC50= 0.71 ±0.18 µg/mL). The inhibitory power of this extract was much higher than that of the enzyme’s standard inhibitor, Atorvastatin (IC50 = 1.76 ±0.12 µg/mL). The extracts' potent antioxidant and inhibitory properties can be attributed to the rich phytochemical composition of plant extracts. Thus, it may be a potential source of new bioactive compounds effective against oxidative stress, hypercholesterolemia and cardiovascular complications.

Supporting Institution

The Scientific Research Project Coordination Unit of Istanbul University-Cerrahpaşa

References

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Year 2023, Volume: 9 Issue: 4, 293 - 303, 08.10.2023
https://doi.org/10.3153/FH23026

Abstract

References

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  • Agudelo, C., Barros, L., Santos-Buelga, C., Martinez-Navarrete, N., Ferreira, I.C.F.R. (2017). Phytochemical content and antioxidant activity of grapefruit (Star Ruby): A comparison between fresh freeze-dried fruits and different powder formulations. LWT - Food Science and Technology, 80, 106-112. https://doi.org/10.1016/j.lwt.2017.02.006
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Details

Primary Language English
Subjects Structural Biology, Chemical Engineering (Other)
Journal Section Research Articles
Authors

Elmas Irmak ÇİL ARSLAN 0000-0001-7888-5118

Özlem SAÇAN 0000-0001-6503-4613

Project Number Project No. 28070
Early Pub Date July 27, 2023
Publication Date October 8, 2023
Submission Date February 8, 2023
Published in Issue Year 2023Volume: 9 Issue: 4

Cite

APA ÇİL ARSLAN, E. I., & SAÇAN, Ö. (2023). Antioxidant and 3-hydroxy-3-methylglutaryl Coenzyme A reductase inhibitory activities of some plant samples. Food and Health, 9(4), 293-303. https://doi.org/10.3153/FH23026

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