Year 2017, Volume 3 , Issue 1, Pages 1 - 11 2017-01-01

HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE

Duong Thi Phuong LİEN [1] , Cao Thi Kim HOANG [2] , Nguyen Thi HANH [3] , Duong Xuan CHU [4] , Phan Thi Bich TRAM [5] , Ha Thanh TOAN [6]


The hepatoprotective activities of silk tofu made from germinated and non germinated soybeans at different doses of feeding against CCl4 induced hepatic cell toxicity in mice was investigated in this study. The heptatoprotective activity was analyzed by assessing the ratio of liver weight to body weight (L/B), the levels of serum alanine aminotransferase (ALT), total cholesterols (TC), the hepatic malondehydyde (MDA), protein carbonyl (PC) and vitamin C levels as well as the histopathological analysis of liver tissue. All types of silk tofu significantly reduced the L/B value; ALT activity, total cholesterol, hepatic MDA and PC levels, beside, liver vitamin C content increased compared to CCl4 intoxicated mice. Silk tofu made from germinated soybeans expressed higher hepatoprotective activity as compared to silk tofu made from non germinated soybeans. Mice fed with silk tofu made from germinated soybeans at the dose of 0.4 g/g body weight/day displayed all biochemical parameters as well as the liver tissue histopathological analysis that were similar to that of normal mice and silymarin treated mice. It was suggested that tofu specially made from germinated soybeans expressed great hepatoprotective effect.

Liver injury, Carbon tetrachloride, Silk to-fu, Germination, Antioxidants
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Subjects Science
Journal Section Articles
Authors

Author: Duong Thi Phuong LİEN
Institution: Cantho University, College of Agriculture and Applied Biology
Country: Vietnam


Author: Cao Thi Kim HOANG
Institution: Cantho University of Medicine and Pharmacy, Pharmacy Faculty, Department of Pharmacology
Country: Vietnam


Author: Nguyen Thi HANH
Institution: Cantho University of Medicine and Pharmacy, Pharmacy Faculty, Department of Pharmacology
Country: Vietnam


Author: Duong Xuan CHU
Institution: Cantho University of Medicine and Pharmacy, Pharmacy Faculty, Department of Pharmacology
Country: Vietnam


Author: Phan Thi Bich TRAM
Institution: Cantho University, College of Agriculture and Applied Biology
Country: Vietnam


Author: Ha Thanh TOAN
Institution: Cantho University, Biotechnology Research and Development Institute
Country: Vietnam


Dates

Application Date : August 12, 2016
Acceptance Date : September 26, 2016
Publication Date : January 1, 2017

Bibtex @research article { jfhs289860, journal = {Food and Health}, issn = {}, eissn = {2602-2834}, address = {Vidin Caddesi No:28 D:4 Kocamustafapaşa 34107 Fatih İstanbul}, publisher = {Özkan ÖZDEN}, year = {2017}, volume = {3}, pages = {1 - 11}, doi = {10.3153/JFHS17001}, title = {HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE}, key = {cite}, author = {Lien, Duong Thi Phuong and Hoang, Cao Thi Kim and Hanh, Nguyen Thi and Chu, Duong Xuan and Tram, Phan Thi Bich and Toan, Ha Thanh} }
APA Lien, D , Hoang, C , Hanh, N , Chu, D , Tram, P , Toan, H . (2017). HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE . Food and Health , 3 (1) , 1-11 . DOI: 10.3153/JFHS17001
MLA Lien, D , Hoang, C , Hanh, N , Chu, D , Tram, P , Toan, H . "HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE" . Food and Health 3 (2017 ): 1-11 <https://jfhs.scientificwebjournals.com/en/pub/issue/27554/289860>
Chicago Lien, D , Hoang, C , Hanh, N , Chu, D , Tram, P , Toan, H . "HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE". Food and Health 3 (2017 ): 1-11
RIS TY - JOUR T1 - HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE AU - Duong Thi Phuong Lien , Cao Thi Kim Hoang , Nguyen Thi Hanh , Duong Xuan Chu , Phan Thi Bich Tram , Ha Thanh Toan Y1 - 2017 PY - 2017 N1 - doi: 10.3153/JFHS17001 DO - 10.3153/JFHS17001 T2 - Food and Health JF - Journal JO - JOR SP - 1 EP - 11 VL - 3 IS - 1 SN - -2602-2834 M3 - doi: 10.3153/JFHS17001 UR - https://doi.org/10.3153/JFHS17001 Y2 - 2016 ER -
EndNote %0 Food and Health HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE %A Duong Thi Phuong Lien , Cao Thi Kim Hoang , Nguyen Thi Hanh , Duong Xuan Chu , Phan Thi Bich Tram , Ha Thanh Toan %T HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE %D 2017 %J Food and Health %P -2602-2834 %V 3 %N 1 %R doi: 10.3153/JFHS17001 %U 10.3153/JFHS17001
ISNAD Lien, Duong Thi Phuong , Hoang, Cao Thi Kim , Hanh, Nguyen Thi , Chu, Duong Xuan , Tram, Phan Thi Bich , Toan, Ha Thanh . "HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE". Food and Health 3 / 1 (January 2017): 1-11 . https://doi.org/10.3153/JFHS17001
AMA Lien D , Hoang C , Hanh N , Chu D , Tram P , Toan H . HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE. Food Health. 2017; 3(1): 1-11.
Vancouver Lien D , Hoang C , Hanh N , Chu D , Tram P , Toan H . HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE. Food and Health. 2017; 3(1): 1-11.
IEEE D. Lien , C. Hoang , N. Hanh , D. Chu , P. Tram and H. Toan , "HEPATOPROTECTIVE EFFECT OF TOFU PROCESSED FROM GERMINATED SOYBEAN ON CARBON TETRACHLORIDE INDUCED CHRONIC LIVER INJURY IN MICE", Food and Health, vol. 3, no. 1, pp. 1-11, Jan. 2017, doi:10.3153/JFHS17001

Authors of the Article
Duong Thi Phuong LİEN [1]
Cao Thi Kim HOANG [2]
Nguyen Thi HANH [3]
Duong Xuan CHU [4]
Phan Thi Bich TRAM [5]
Ha Thanh TOAN [6]