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Obezite Yönetiminde Adipoz Doku Kahverengileşmesi

Yıl 2023, Cilt: 7 Sayı: 1, 81 - 91, 28.04.2023
https://doi.org/10.25048/tudod.1250627

Öz

Tüm dünya sorunu olan obezitenin tedavisinde güncel olarak terapötik stratejiler geliştirilmektedir. Memelilerde, işlevleri ve morfolojileri
bakımından farklılık gösteren farklı iki tip adipoz doku mevcuttur. Bunlar, embriyogenez sırasında ortaya çıkan kahverengi adipoz
doku (KAD); ve doğum sonrası gelişen beyaz adipoz dokudur (BAD). KAD’nun hacmi, enerji harcaması ile pozitif ilişkili olduğu ve
obez kişilerde zayıf bireylere göre önemli ölçüde düşük olduğu bilinmektedir. KAD indüksiyonunu ve/veya aktivasyonunu hedefleyen
stratejiler, obezite tedavisinde potansiyel olarak faydalı olabileceği düşünülmektedir. Son yıllarda yapılan araştırmalar, KAD aktivasyonu
ve BAD kahverengileşmesi ile ilgili mekanizmalar üzerine olan ilgiyi önemli ölçüde artırmaktadır. Bu mekanizmaları amaçlayan kimyasal
bileşiklerin yanı sıra çeşitli farmakolojik olmayan bazı müdahale yaklaşımları bulunmaktadır. Bu derlemede, KAD aktivasyonu ve BAD
kahverengileşmesi sürecindeki potansiyel terapötik hedefler ve bunları amaçlayan mevcut stratejilere ilişkin kavramlar özetlenmiştir

Kaynakça

  • 1. Yıldırım M, Akyol A, Ersoy G. Şişmanlik (Obezite) Ve Fiziksel Aktivite, 2008.
  • 2. Catenacci VA, Hill JO, Wyatt HR. The obesity epidemic. Clin Chest Med. 2009;30(3):415-444, vii.
  • 3. Cannon B, Nedergaard J. Brown adipose tissue: Function and physiological significance. Physiol Rev. 2004;84(1):277-359.
  • 4. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:30.
  • 5. Contreras C, Nogueiras R, Diéguez C, Medina-Gómez G, López M. Hypothalamus and thermogenesis: Heating the BAT, browning the WAT. Mol Cell Endocrinol. 2016;438:107-115.
  • 6. Kuryłowicz A, Puzianowska-Kuźnicka M. Induction of Adipose Tissue Browning as a Strategy to Combat Obesity. Int J Mol Sci. 2020;21(17):6241.
  • 7. Concha F, Prado G, Quezada J, Ramirez A, Bravo N, Flores C, Herrera JJ, Lopez N, Uribe D, Duarte-Silva L, Lopez-Legarrea P, Garcia-Diaz DF. Nutritional and non-nutritional agents that stimulate white adipose tissue browning. Rev Endocr Metab Disord. 2019;20(2):161-171.
  • 8. Schulz TJ, Tseng YH. Brown adipose tissue: Development, metabolism and beyond. Biochem J. 2013;453(2):167-78.
  • 9. Saely CH, Geiger K, Drexel H. Brown versus white adipose tissue: A mini-review. Gerontology. 2012;58(1):15-23. 10. Medina-Gómez G. Mitochondria and endocrine function of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2012;26(6):791-804.
  • 11. Mermer M, Nilüfer A. Adipoz doku ve enerji metabolizması üzerine etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2017;8(3): 40-46.
  • 12. Cheng L, Wang J, Dai H, Duan Y, An Y, Shi L, Lv Y, Li H, Wang C, Ma Q, Li Y, Li P, Du H, Zhao B. Brown and beige adipose tissue: A novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte. 2021;10(1):48-65.
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  • 16. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007;293(2):E444-452.
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  • 19. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360(15):1509- 1517.
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  • 21. Kiefer FW. Browning and thermogenic programing of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2016;30(4):479- 485.
  • 22. Altuntuzcu Ş. 18-FDG PET/CT ile belirlenen kahverengi yağ dokusu glukoz uptake’i ile açlık kan glukozunun ilişkisi. Turk Diab Obes. 2019;3(3): 145-148.
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  • 26. Crichton PG, Lee Y, Kunji ER. The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism. Biochimie. 2017;134:35-50.
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Adipose Tissue Browning in Obesity Management

Yıl 2023, Cilt: 7 Sayı: 1, 81 - 91, 28.04.2023
https://doi.org/10.25048/tudod.1250627

Öz

Recently, therapeutic strategies have been developed for the treatment of obesity, which is a worldwide problem. There are two different
types of adipose tissue in mammals that differ in their function and morphology. These are brown adipose tissue (BAT), which develops
during embryogenesis and white adipose tissue (WAT), which develops after postnatal. It is known that the volume of BAT is positively
associated with energy discharge and is significantly lower in obese individuals than in slim individuals. Strategies targeting the BAT
induction and/or activation are considered potentially useful in the treatment of obesity. Recent research initiatives have significantly
attracted the interest in the mechanisms associated with the BAT activation and WAT browning. In addition to the chemical compounds
focusing on these mechanisms, there are various non-pharmacological intervention approaches. In this review, potential therapeutic
targets in BAT activation and WAT browning process as well as the concepts related to the strategies targeting them are summarized

Kaynakça

  • 1. Yıldırım M, Akyol A, Ersoy G. Şişmanlik (Obezite) Ve Fiziksel Aktivite, 2008.
  • 2. Catenacci VA, Hill JO, Wyatt HR. The obesity epidemic. Clin Chest Med. 2009;30(3):415-444, vii.
  • 3. Cannon B, Nedergaard J. Brown adipose tissue: Function and physiological significance. Physiol Rev. 2004;84(1):277-359.
  • 4. Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB. Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol (Lausanne). 2016;7:30.
  • 5. Contreras C, Nogueiras R, Diéguez C, Medina-Gómez G, López M. Hypothalamus and thermogenesis: Heating the BAT, browning the WAT. Mol Cell Endocrinol. 2016;438:107-115.
  • 6. Kuryłowicz A, Puzianowska-Kuźnicka M. Induction of Adipose Tissue Browning as a Strategy to Combat Obesity. Int J Mol Sci. 2020;21(17):6241.
  • 7. Concha F, Prado G, Quezada J, Ramirez A, Bravo N, Flores C, Herrera JJ, Lopez N, Uribe D, Duarte-Silva L, Lopez-Legarrea P, Garcia-Diaz DF. Nutritional and non-nutritional agents that stimulate white adipose tissue browning. Rev Endocr Metab Disord. 2019;20(2):161-171.
  • 8. Schulz TJ, Tseng YH. Brown adipose tissue: Development, metabolism and beyond. Biochem J. 2013;453(2):167-78.
  • 9. Saely CH, Geiger K, Drexel H. Brown versus white adipose tissue: A mini-review. Gerontology. 2012;58(1):15-23. 10. Medina-Gómez G. Mitochondria and endocrine function of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2012;26(6):791-804.
  • 11. Mermer M, Nilüfer A. Adipoz doku ve enerji metabolizması üzerine etkileri. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2017;8(3): 40-46.
  • 12. Cheng L, Wang J, Dai H, Duan Y, An Y, Shi L, Lv Y, Li H, Wang C, Ma Q, Li Y, Li P, Du H, Zhao B. Brown and beige adipose tissue: A novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte. 2021;10(1):48-65.
  • 13. Timmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N, Hamilton DL, Gimeno RE, Wahlestedt C, Baar K, Nedergaard J, Cannon B. Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proc Natl Acad Sci U S A. 2007;104(11):4401-4406.
  • 14. Jiménez G, López-Ruiz E, Griñán-Lisón C, Antich C, Marchal JA. Brown adipose tissue and obesity. Obesity: A Practical Guide, 2016:13-28.
  • 15. Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014;10(1):24-36.
  • 16. Nedergaard J, Bengtsson T, Cannon B. Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol Endocrinol Metab. 2007;293(2):E444-452.
  • 17. Palou A, Picó C, Bonet ML, Oliver P. The uncoupling protein, thermogenin. Int J Biochem Cell Biol. 1998;30(1):7-11.
  • 18. Sun K, Kusminski CM, Scherer PE. Adipose tissue remodeling and obesity. J Clin Invest. 2011;121(6):2094-2101.
  • 19. Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360(15):1509- 1517.
  • 20. Wijers SL, Saris WH, van Marken Lichtenbelt WD. Coldinduced adaptive thermogenesis in lean and obese. Obesity (Silver Spring). 2010;18(6):1092-1099.
  • 21. Kiefer FW. Browning and thermogenic programing of adipose tissue. Best Pract Res Clin Endocrinol Metab. 2016;30(4):479- 485.
  • 22. Altuntuzcu Ş. 18-FDG PET/CT ile belirlenen kahverengi yağ dokusu glukoz uptake’i ile açlık kan glukozunun ilişkisi. Turk Diab Obes. 2019;3(3): 145-148.
  • 23. Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med. 2015;21(7):760-768.
  • 24. Farmer SR. Transcriptional control of adipocyte formation. Cell Metab. 2006;4(4):263-273.
  • 25. Montanari T, Pošćić N, Colitti M. Factors involved in whiteto- brown adipose tissue conversion and in thermogenesis: A review. Obes Rev. 2017;18(5):495-513.
  • 26. Crichton PG, Lee Y, Kunji ER. The molecular features of uncoupling protein 1 support a conventional mitochondrial carrier-like mechanism. Biochimie. 2017;134:35-50.
  • 27. Rosell M, Kaforou M, Frontini A, Okolo A, Chan YW, Nikolopoulou E, Millership S, Fenech ME, MacIntyre D, Turner JO, Moore JD, Blackburn E, Gullick WJ, Cinti S, Montana G, Parker MG, Christian M. Brown and white adipose tissues: Intrinsic differences in gene expression and response to cold exposure in mice. Am J Physiol Endocrinol Metab. 2014;306(8):E945-964.
  • 28. Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998;92(6):829-839.
  • 29. Kern PA, Finlin BS, Zhu B, Rasouli N, McGehee RE Jr, Westgate PM, Dupont-Versteegden EE. The effects of temperature and seasons on subcutaneous white adipose tissue in humans: Evidence for thermogenic gene induction. J Clin Endocrinol Metab. 2014;99(12):E2772-2779.
  • 30. Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, Miyagawa M, Tsujisaki M, Saito M. Agerelated decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity (Silver Spring). 2011;19(9):1755-1760.
  • 31. Shimizu Y, Nikami H, Saito M. Sympathetic activation of glucose utilization in brown adipose tissue in rats. J Biochem. 1991;110(5):688-692.
  • 32. Murano I, Barbatelli G, Giordano A, Cinti S. Noradrenergic parenchymal nerve fiber branching after cold acclimatisation correlates with brown adipocyte density in mouse adipose organ. J Anat. 2009;214(1):171-178.
  • 33. Aldiss P, Betts J, Sale C, Pope M, Budge H, Symonds ME. Exercise-induced ‘browning’ of adipose tissues. Metabolism. 2018;81:63-70.
  • 34. Crujeiras AB, Pardo M, Casanueva FF. Irisin: ‘fat’ or artefact. Clin Endocrinol (Oxf). 2015;82(4):467-474.
  • 35. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-468.
  • 36. Aslıhan İ, Ünübol Aypak S. İrisin ve metabolik etkileri. Turkiye Klinikleri J Endocrin. 2016;11(1):15-21.
  • 37. Aslan NN, Yardımcı H. Obezite üzerine etkili yeni bir hormon: İrisin. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2017;6(3):176-183.
  • 38. Yoneshiro T, Matsushita M, Saito M. Translational aspects of brown fat activation by food-derived stimulants, in Brown Adipose Tissue, Springer, 2018:359-379.
  • 39. Baskaran P, Krishnan V, Ren J, Thyagarajan B. Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms. Br J Pharmacol. 2016;173(15):2369-2389.
  • 40. Ohyama K, Nogusa Y, Shinoda K, Suzuki K, Bannai M, Kajimura S. A synergistic antiobesity effect by a combination of capsinoids and cold temperature through promoting beige adipocyte biogenesis. Diabetes. 2016;65(5):1410-1423.
  • 41. Andrade JM, Frade AC, Guimarães JB, Freitas KM, Lopes MT, Guimarães AL, de Paula AM, Coimbra CC, Santos SH. Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet. Eur J Nutr. 2014;53(7):1503-1510.
  • 42. Alberdi G, Rodríguez VM, Miranda J, Macarulla MT, Churruca I, Portillo MP. Thermogenesis is involved in the body-fat lowering effects of resveratrol in rats. Food Chem. 2013;141(2):1530-1535.
  • 43. Wang S, Liang X, Yang Q, Fu X, Rogers CJ, Zhu M, Rodgers BD, Jiang Q, Dodson MV, Du M. Resveratrol induces brownlike adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1. Int J Obes (Lond). 2015;39(6):967-976.
  • 44. Lone J, Choi JH, Kim SW, Yun JW. Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes. J Nutr Biochem. 2016;27:193-202.
  • 45. Nomura S, Ichinose T, Jinde M, Kawashima Y, Tachiyashiki K, Imaizumi K. Tea catechins enhance the mRNA expression of uncoupling protein 1 in rat brown adipose tissue. J Nutr Biochem. 2008;19(12):840-847.
  • 46. Nirengi S, Amagasa S, Homma T, Yoneshiro T, Matsumiya S, Kurosawa Y, Sakane N, Ebi K, Saito M, Hamaoka T. Daily ingestion of catechin-rich beverage increases brown adipose tissue density and decreases extramyocellular lipids in healthy young women. Springerplus. 2016;5(1):1363.
  • 47. Zhao M, Chen X. Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes. Biochem Biophys Res Commun. 2014;450(4):1446- 1451.
  • 48. Laiglesia LM, Lorente-Cebrián S, Prieto-Hontoria PL, Fernández-Galilea M, Ribeiro SM, Sáinz N, Martínez JA, Moreno-Aliaga MJ. Eicosapentaenoic acid promotes mitochondrial biogenesis and beige-like features in subcutaneous adipocytes from overweight subjects. J Nutr Biochem. 2016;37:76-82.
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  • 61. Westerterp-Plantenga M, Diepvens K, Joosen AM, Bérubé- Parent S, Tremblay A. Metabolic effects of spices, teas, and caffeine. Physiol Behav. 2006;89(1):85-91.
  • 62. Rains TM, Agarwal S, Maki KC. Antiobesity effects of green tea catechins: A mechanistic review. J Nutr Biochem. 2011;22(1):1- 7.
  • 63. Basu A, Lucas EA. Mechanisms and effects of green tea on cardiovascular health. Nutr Rev. 2007;65(8 Pt 1):361-375.
  • 64. Anderson BM, Ma DW. Are all n-3 polyunsaturated fatty acids created equal? Lipids Health Dis. 2009;8:33.
  • 65. Lorente-Cebrián S, Costa AG, Navas-Carretero S, Zabala M, Martínez JA, Moreno-Aliaga MJ. Role of omega-3 fatty acids in obesity, metabolic syndrome, and cardiovascular diseases: A review of the evidence. J Physiol Biochem. 2013;69(3):633-651.
  • 66. Kim J, Okla M, Erickson A, Carr T, Natarajan SK, Chung S. Eicosapentaenoic acid potentiates brown thermogenesis through FFAR4-dependent up-regulation of miR-30b and miR-378. J Biol Chem. 2016;291(39):20551-20562.
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Toplam 66 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Hümeyra Başkent 0000-0002-9580-6706

Nazlı Nur Aslan Çin 0000-0002-4458-8817

Taner Bayraktaroğlu 0000-0003-3159-6663

Figen Barut 0000-0003-2084-1678

Yayımlanma Tarihi 28 Nisan 2023
Kabul Tarihi 26 Nisan 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 7 Sayı: 1

Kaynak Göster

APA Başkent, H., Aslan Çin, N. N., Bayraktaroğlu, T., Barut, F. (2023). Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet Ve Obezite Dergisi, 7(1), 81-91. https://doi.org/10.25048/tudod.1250627
AMA Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F. Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Turk J Diab Obes. Nisan 2023;7(1):81-91. doi:10.25048/tudod.1250627
Chicago Başkent, Hümeyra, Nazlı Nur Aslan Çin, Taner Bayraktaroğlu, ve Figen Barut. “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”. Türkiye Diyabet Ve Obezite Dergisi 7, sy. 1 (Nisan 2023): 81-91. https://doi.org/10.25048/tudod.1250627.
EndNote Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F (01 Nisan 2023) Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Türkiye Diyabet ve Obezite Dergisi 7 1 81–91.
IEEE H. Başkent, N. N. Aslan Çin, T. Bayraktaroğlu, ve F. Barut, “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”, Turk J Diab Obes, c. 7, sy. 1, ss. 81–91, 2023, doi: 10.25048/tudod.1250627.
ISNAD Başkent, Hümeyra vd. “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”. Türkiye Diyabet ve Obezite Dergisi 7/1 (Nisan 2023), 81-91. https://doi.org/10.25048/tudod.1250627.
JAMA Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F. Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Turk J Diab Obes. 2023;7:81–91.
MLA Başkent, Hümeyra vd. “Obezite Yönetiminde Adipoz Doku Kahverengileşmesi”. Türkiye Diyabet Ve Obezite Dergisi, c. 7, sy. 1, 2023, ss. 81-91, doi:10.25048/tudod.1250627.
Vancouver Başkent H, Aslan Çin NN, Bayraktaroğlu T, Barut F. Obezite Yönetiminde Adipoz Doku Kahverengileşmesi. Turk J Diab Obes. 2023;7(1):81-9.

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