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Evaluation of Factors Affecting Health-Related Quality of Life in Patients with Diabetic Retinopathy

Yıl 2022, Cilt: 6 Sayı: 3, 230 - 240, 29.12.2022

Ahmet Sakallıoğlu İrfan Akaray Sultan Kaya Özlem Kaya Gizem Köse Rüveyde Garip Hande Guclu

https://doi.org/10.25048/tudod.1127641

Öz

Aim: To investigate the factors affecting health-related quality of life (HRQOL) in diabetic retinopathy (DRP) patients.
Material and Methods: The study included 800 eyes of 400 type 2 diabetes patients who were followed up for DRP. After the ophthalmologic examination, the patients completed the Short Form-36 (SF-36) questionnaire. According to SF-36, summary measures of physical function, physical role, body pain, general health, vitality, social functionality, emotional role, and mental health, physical and mental components were calculated. Demographic characteristics of the patients were noted from the patient files. To compare two independent groups, the independent sample T-test was used when normal distribution was assumed, and the Mann-Whitney U test was used when the normality of the data was rejected. In the comparison of more than two independent groups, Bonferroni or Tamhane’s T2 corrected ANOVA test was used and the relationship between numerical variables was evaluated with the Pearson correlation test. The significance level was accepted as p<0.05.
Results: HRQOL was low in females (p<0.001) and patients with diabetes more than 15 years (p=0.002 for body pain; p<0.001 for others). Physical and mental component summary measurement values were lower in older patients (p=0.046, p=0.034, respectively). In patients who underwent pan-retinal photocoagulation (PRFC) and were diagnosed with ischemia; except body pain (for PRFC p=0.178;for ischemia p=0.252), HRQoL values were found to be significantly lower (p<0.05). From proliferative diabetic retinopathy (PDR) patients to DRP(-) patients, except for body pain, HRQ was significantly increased (p<0.05). All subgroup values were low in patients with visual acuity less than 20/40, except mental health (p=0.335) and body pain (p=0.069).
Conclusion: Considering that in patients who are female, have a history of DM for 15 years or more, are partially older; patients with more PRFC, patients with retinal ischemia, and have a lower vision, the HRQOL may be low; so this may prompt us to be more careful in the treatment management of these patients

Anahtar Kelimeler

Diabetic retinopathy Diabetes Mellitus Quality of Life.

Kaynakça

  • 1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–1053.
  • 2. Stojanović M, Cvetanović G, Anđelković Apostolović M, Stojanović D, Rančić N. Impact of socio-demographic characteristics and long-term complications on quality of life in patients with diabetes mellitus. Cent Eur J Public Health. 2018;26(2):104–110.
  • 3. Cheung N, Wong T. Diabetic retinopathy and systemic complications. In: Duh EJ (ed) Diabetic retinopathy. Totowa, Humana Press, 2008.
  • 4. Wong TY, Klein R. The epidemiology of eye diseases in diabetes. Epidemiol diabetes Mellit. 2008;475–497.
  • 5. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–136.
  • 6. Currie CJ, Peyrot M, Morgan CL, Poole CD, Jenkins-Jones S, Rubin RR, Burton CM, Evans M. The impact of treatment noncompliance on mortality in people with type 2 diabetes. Diabetes Care. 2012;35(6):1279–1284.
  • 7. Saito I, Inami F, Ikebe T, Moriwaki C, Tsubakimoto A, Yonemasu K, Ozawa H. Impact of diabetes on health-related quality of life in a population study in Japan. Diabetes Res Clin Pract. 2006;73(1):51–57.
  • 8. Scollan-Koliopoulos M, Bleich D, Rapp KJ, Wong P, Hofmann CJ, Raghuwanshi M. Health-related quality of life, disease severity, and anticipated trajectory of diabetes. Diabetes Educ. 2013;39(1):83–91.
  • 9. Oguntibeju OO, Odunaiya NA, Oladipo B, Truter EJ. Health behaviour and quality of life of patients with type 2 diabetes attending selected hospitals in south western Nigeria. West Indian Med J. 2012;61(6):619-626.
  • 10. Zanuso S, Balducci S, Jimenez A. Physical activity, a key factor to quality of life in type 2 diabetic patients. Diabetes Metab Res Rev. 2009;25(S1):S24–28.
  • 11. Wong CKH, Lo YYC, Wong WHT, Fung CSC. The associations of body mass index with physical and mental aspects of health-related quality of life in Chinese patients with type 2 diabetes mellitus: results from a cross-sectional survey. Health Qual Life Outcomes. 2013;11(1):1–9.
  • 12. Bourdel-Marchasson I, Druet C, Helmer C, Eschwege E, Lecomte P, Le-Goff M, Sinclair AJ, Fagot-Campagna A. Correlates of health-related quality of life in French people with type 2 diabetes. Diabetes Res Clin Pract. 2013;101(2):226–235.
  • 13. Ali MK, Feeney P, Hire D, Simmons DL, O’Connor PJ, Ganz‐Lord F, Goff Jr D, Zhang P, Anderson RT, Narayan KMV, Sullivan MD. Glycaemia and correlates of patient‐reported outcomes in ACCORD trial participants. Diabet Med. 2012;29(7):e67–74.
  • 14. Aguilar D, Solomon SD, Køber L, Rouleau J-L, Skali H, McMurray JJ V, Francis GS, Henis M, O Connor CM, Diaz R, Belenkov YN, Varshavsky S, Leimberger JD, Velazquez EJ, Califf RM, Pfeffer MA. Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. Circulation. 2004;110(12):1572–1578.
  • 15. Zimbudzi E, Lo C, Ranasinha S, Gallagher M, Fulcher G, Kerr PG, Russel G, Teede H, Usherwood T, Walker R, Zoungas S. Predictors of health-related quality of life in patients with co-morbid diabetes and chronic kidney disease. PLoS One. 2016;11(12):e0168491.
  • 16. Pedras S, Carvalho R, Pereira M da G. Sociodemographic and clinical characteristics of patients with diabetic foot ulcer. Rev Assoc Med Bras. 2016;62(2):171–178.
  • 17. Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract. 2000;47(2):123–128.
  • 18. Trikkalinou A, Papazafiropoulou AK, Melidonis A. Type 2 diabetes and quality of life. World J Diabetes. 2017;8(4):120-129.
  • 19. Ware JE. SF-36 health survey: manual and interpretation guide. Heal Inst. 1993.
  • 20. Ware JE, Kosinski M, Keller SK. SF-36 Physical and Mental Health Summary Scales: A User’s Manual. Boston, MA: The Health Institute, 1994.
  • 21. Demiral Y, Ergor G, Unal B, Semin S, Akvardar Y, Kıvırcık B, Alptekin K. Normative data and discriminative properties of short form 36 (SF-36) in Turkish urban population. BMC Public Health. 2006;6:247.
  • 22. Hopman WM, Towheed T, Anastassiades T, Tenenhouse A, Poliquin S, Berger C, Joseph L, Brown JP, Murray TM, Adachi JD, Hanley DA, Papadimitropoulos E. Canadian normative data for the SF-36 health survey. CMAJ. 2000;163(3):265–271.
  • 23. Jenkinson C, Stewart-Brown S, Petersen S, Paice C. Assessment of the SF-36 version 2 in the United Kingdom. J Epidemiol Community Health. 1999;53(1):46–50.
  • 24. Fenwick EK, Xie J, Pesudovs K, Ratcliffe J, Chiang PPC, Finger RP, Lamoureux EL. Assessing disutility associated with diabetic retinopathy, diabetic macular oedema and associated visual impairment using the Vision and Quality of Life Index. Clin Exp Optom. 2012;95(3):362–370.
  • 25. Pereira DM, Shah A, D’Souza M, Simon P, George T, D’Souza N, Suresh S, Shrinath Baliga M. Quality of life in people with diabetic retinopathy: Indian study. J Clin Diagn Res. 2017;11(4):NC01-NC026.
  • 26. Davidov E, Breitscheidel L, Clouth J, Reips M, Happich M. Diabetic retinopathy and health-related quality of life. Graefe’s Arch Clin Exp Ophthalmol. 2009;247(2):267–272.
  • 27. Fenwick EK, Xie J, Ratcliffe J, Pesudovs K, Finger RP, Wong TY, Lamoureux EL. The impact of diabetic retinopathy and diabetic macular edema on health-related quality of life in type 1 and type 2 diabetes. Invest Ophthalmol Vis Sci. 2012;53(2):677–684.

Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi

Yıl 2022, Cilt: 6 Sayı: 3, 230 - 240, 29.12.2022

Ahmet Sakallıoğlu İrfan Akaray Sultan Kaya Özlem Kaya Gizem Köse Rüveyde Garip Hande Guclu

https://doi.org/10.25048/tudod.1127641

Öz

Amaç: Diyabetik retinopati (DRP) hastalarında sağlıkla ilişkili yaşam kalitesini (SİYK) etkileyen faktörlerin araştırılması.
Gereç ve Yöntemler: Çalışmaya tip 2 diyabet nedeniyle DRP açısından takipli 400 hastanın 800 gözü katılmıştır. Hastalar oftalmolojik muayene sonrasında Kısa Form-36 (SF-36) anketini doldurmuştur. SF-36’ya göre fiziksel işlev, fiziksel rol, bedensel ağrı, genel sağlık, canlılık, sosyal işlevsellik, duygusal rol ve ruh sağlığı, fiziksel ve zihinsel bileşen özet ölçümleri hesaplandı. Hastaların demografik özellikleri hasta dosyalarından not edilmiştir. İki bağımsız grubu karşılaştırmak için normal dağılım varsayıldığında bağımsız örneklemlerde T-testi, verilerin normalliği reddedildiğinde Mann-Whitney U testi kullanıldı. İkiden fazla olan bağımsız grupların karşılaştırılmasında Bonferroni veya Tamhane’s T2 düzeltmeli ANOVA testi, sayısal değişkenler arasındaki ilişki Pearson korelasyon testi ile değerlendirildi. Anlamlılık düzeyi p<0,05 olarak kabul edildi.
Bulgular: Kadınların (p<0,001), diyabet süresi 15 yıldan fazla olanların (bedensel ağrı için p=0,002; diğerleri için p<0,001) SİYK düşük saptandı. Fiziksel ve zihinsel bileşen özet ölçüm değerleri 65 yaşından büyük hastalarda düşüktü (sırasıyla p=0,046, p=0,034). Panretinal fotokogülasyon (PRFK) yapılan ve iskemi saptanan hastalarda SİYK değerleri bedensel ağrı hariç (PRFK için p=0,178; iskemi için p=0,252) anlamlı düşük saptandı (p<0,05). Proliferatif diyabetik retinopati (PDR) hastalarından DRP(-) hastalara doğru SİYK bedensel ağrı hariç anlamlı şekilde yükseldi (p<0,05). Görme keskinliği 20/40’tan az olan hastalarda ruh sağlığı (p=0,335) ve bedensel ağrı (p=0,069) hariç tüm alt grup değerleri düşüktü.
Sonuç: Kadın cinsiyetin, 15 yıl ve üzerinde diyabet öyküsünün, kısmen ileri yaşın, daha fazla PRFK yapılmış olan hastaların, retinal iskemisi olan hastaların ve daha düşük görme düzeyine sahip hastaların SİYK’sının düşük olabileceği göz önünde bulundurulması, bu hastaların tedavi yönetiminde daha dikkatli olmamızı sağlayabilir

Anahtar Kelimeler

Diyabetik retinopati Diyabet Yaşam kalitesi

Kaynakça

  • 1. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–1053.
  • 2. Stojanović M, Cvetanović G, Anđelković Apostolović M, Stojanović D, Rančić N. Impact of socio-demographic characteristics and long-term complications on quality of life in patients with diabetes mellitus. Cent Eur J Public Health. 2018;26(2):104–110.
  • 3. Cheung N, Wong T. Diabetic retinopathy and systemic complications. In: Duh EJ (ed) Diabetic retinopathy. Totowa, Humana Press, 2008.
  • 4. Wong TY, Klein R. The epidemiology of eye diseases in diabetes. Epidemiol diabetes Mellit. 2008;475–497.
  • 5. Cheung N, Mitchell P, Wong TY. Diabetic retinopathy. Lancet. 2010;376(9735):124–136.
  • 6. Currie CJ, Peyrot M, Morgan CL, Poole CD, Jenkins-Jones S, Rubin RR, Burton CM, Evans M. The impact of treatment noncompliance on mortality in people with type 2 diabetes. Diabetes Care. 2012;35(6):1279–1284.
  • 7. Saito I, Inami F, Ikebe T, Moriwaki C, Tsubakimoto A, Yonemasu K, Ozawa H. Impact of diabetes on health-related quality of life in a population study in Japan. Diabetes Res Clin Pract. 2006;73(1):51–57.
  • 8. Scollan-Koliopoulos M, Bleich D, Rapp KJ, Wong P, Hofmann CJ, Raghuwanshi M. Health-related quality of life, disease severity, and anticipated trajectory of diabetes. Diabetes Educ. 2013;39(1):83–91.
  • 9. Oguntibeju OO, Odunaiya NA, Oladipo B, Truter EJ. Health behaviour and quality of life of patients with type 2 diabetes attending selected hospitals in south western Nigeria. West Indian Med J. 2012;61(6):619-626.
  • 10. Zanuso S, Balducci S, Jimenez A. Physical activity, a key factor to quality of life in type 2 diabetic patients. Diabetes Metab Res Rev. 2009;25(S1):S24–28.
  • 11. Wong CKH, Lo YYC, Wong WHT, Fung CSC. The associations of body mass index with physical and mental aspects of health-related quality of life in Chinese patients with type 2 diabetes mellitus: results from a cross-sectional survey. Health Qual Life Outcomes. 2013;11(1):1–9.
  • 12. Bourdel-Marchasson I, Druet C, Helmer C, Eschwege E, Lecomte P, Le-Goff M, Sinclair AJ, Fagot-Campagna A. Correlates of health-related quality of life in French people with type 2 diabetes. Diabetes Res Clin Pract. 2013;101(2):226–235.
  • 13. Ali MK, Feeney P, Hire D, Simmons DL, O’Connor PJ, Ganz‐Lord F, Goff Jr D, Zhang P, Anderson RT, Narayan KMV, Sullivan MD. Glycaemia and correlates of patient‐reported outcomes in ACCORD trial participants. Diabet Med. 2012;29(7):e67–74.
  • 14. Aguilar D, Solomon SD, Køber L, Rouleau J-L, Skali H, McMurray JJ V, Francis GS, Henis M, O Connor CM, Diaz R, Belenkov YN, Varshavsky S, Leimberger JD, Velazquez EJ, Califf RM, Pfeffer MA. Newly diagnosed and previously known diabetes mellitus and 1-year outcomes of acute myocardial infarction: the VALsartan In Acute myocardial iNfarcTion (VALIANT) trial. Circulation. 2004;110(12):1572–1578.
  • 15. Zimbudzi E, Lo C, Ranasinha S, Gallagher M, Fulcher G, Kerr PG, Russel G, Teede H, Usherwood T, Walker R, Zoungas S. Predictors of health-related quality of life in patients with co-morbid diabetes and chronic kidney disease. PLoS One. 2016;11(12):e0168491.
  • 16. Pedras S, Carvalho R, Pereira M da G. Sociodemographic and clinical characteristics of patients with diabetic foot ulcer. Rev Assoc Med Bras. 2016;62(2):171–178.
  • 17. Galer BS, Gianas A, Jensen MP. Painful diabetic polyneuropathy: epidemiology, pain description, and quality of life. Diabetes Res Clin Pract. 2000;47(2):123–128.
  • 18. Trikkalinou A, Papazafiropoulou AK, Melidonis A. Type 2 diabetes and quality of life. World J Diabetes. 2017;8(4):120-129.
  • 19. Ware JE. SF-36 health survey: manual and interpretation guide. Heal Inst. 1993.
  • 20. Ware JE, Kosinski M, Keller SK. SF-36 Physical and Mental Health Summary Scales: A User’s Manual. Boston, MA: The Health Institute, 1994.
  • 21. Demiral Y, Ergor G, Unal B, Semin S, Akvardar Y, Kıvırcık B, Alptekin K. Normative data and discriminative properties of short form 36 (SF-36) in Turkish urban population. BMC Public Health. 2006;6:247.
  • 22. Hopman WM, Towheed T, Anastassiades T, Tenenhouse A, Poliquin S, Berger C, Joseph L, Brown JP, Murray TM, Adachi JD, Hanley DA, Papadimitropoulos E. Canadian normative data for the SF-36 health survey. CMAJ. 2000;163(3):265–271.
  • 23. Jenkinson C, Stewart-Brown S, Petersen S, Paice C. Assessment of the SF-36 version 2 in the United Kingdom. J Epidemiol Community Health. 1999;53(1):46–50.
  • 24. Fenwick EK, Xie J, Pesudovs K, Ratcliffe J, Chiang PPC, Finger RP, Lamoureux EL. Assessing disutility associated with diabetic retinopathy, diabetic macular oedema and associated visual impairment using the Vision and Quality of Life Index. Clin Exp Optom. 2012;95(3):362–370.
  • 25. Pereira DM, Shah A, D’Souza M, Simon P, George T, D’Souza N, Suresh S, Shrinath Baliga M. Quality of life in people with diabetic retinopathy: Indian study. J Clin Diagn Res. 2017;11(4):NC01-NC026.
  • 26. Davidov E, Breitscheidel L, Clouth J, Reips M, Happich M. Diabetic retinopathy and health-related quality of life. Graefe’s Arch Clin Exp Ophthalmol. 2009;247(2):267–272.
  • 27. Fenwick EK, Xie J, Ratcliffe J, Pesudovs K, Finger RP, Wong TY, Lamoureux EL. The impact of diabetic retinopathy and diabetic macular edema on health-related quality of life in type 1 and type 2 diabetes. Invest Ophthalmol Vis Sci. 2012;53(2):677–684.
Toplam 27 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makalesi
Yazarlar

Ahmet Sakallıoğlu 0000-0003-1206-9753

İrfan Akaray 0000-0002-3872-9214

Sultan Kaya 0000-0002-8665-4755

Özlem Kaya 0000-0002-7137-2085

Gizem Köse 0000-0001-6211-1548

Rüveyde Garip 0000-0003-2235-9017

Hande Guclu 0000-0002-3021-0493

Yayımlanma Tarihi 29 Aralık 2022
Kabul Tarihi 17 Kasım 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 6 Sayı: 3

Kaynak Göster

APA Sakallıoğlu, A., Akaray, İ., Kaya, S., Kaya, Ö., vd. (2022). Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi. Türkiye Diyabet Ve Obezite Dergisi, 6(3), 230-240. https://doi.org/10.25048/tudod.1127641
AMA Sakallıoğlu A, Akaray İ, Kaya S, Kaya Ö, Köse G, Garip R, Guclu H. Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi. Turk J Diab Obes. Aralık 2022;6(3):230-240. doi:10.25048/tudod.1127641
Chicago Sakallıoğlu, Ahmet, İrfan Akaray, Sultan Kaya, Özlem Kaya, Gizem Köse, Rüveyde Garip, ve Hande Guclu. “Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi”. Türkiye Diyabet Ve Obezite Dergisi 6, sy. 3 (Aralık 2022): 230-40. https://doi.org/10.25048/tudod.1127641.
EndNote Sakallıoğlu A, Akaray İ, Kaya S, Kaya Ö, Köse G, Garip R, Guclu H (01 Aralık 2022) Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi. Türkiye Diyabet ve Obezite Dergisi 6 3 230–240.
IEEE A. Sakallıoğlu, “Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi”, Turk J Diab Obes, c. 6, sy. 3, ss. 230–240, 2022, doi: 10.25048/tudod.1127641.
ISNAD Sakallıoğlu, Ahmet vd. “Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi”. Türkiye Diyabet ve Obezite Dergisi 6/3 (Aralık 2022), 230-240. https://doi.org/10.25048/tudod.1127641.
JAMA Sakallıoğlu A, Akaray İ, Kaya S, Kaya Ö, Köse G, Garip R, Guclu H. Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi. Turk J Diab Obes. 2022;6:230–240.
MLA Sakallıoğlu, Ahmet vd. “Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi”. Türkiye Diyabet Ve Obezite Dergisi, c. 6, sy. 3, 2022, ss. 230-4, doi:10.25048/tudod.1127641.
Vancouver Sakallıoğlu A, Akaray İ, Kaya S, Kaya Ö, Köse G, Garip R, Guclu H. Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi. Turk J Diab Obes. 2022;6(3):230-4.
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