Derleme
BibTex RIS Kaynak Göster

COVİD 19 HASTALARINDA TAT VE KOKU BOZUKLUKLARI

Yıl 2021, Cilt: 28 Sayı: COVİD-19 ÖZEL SAYI, 153 - 156, 01.05.2021

Hasan Yasan Mehmet Emre Sivrice

https://doi.org/10.17343/sdutfd.915067

Öz

Covid 19 enfeksiyonun klinik bulguları tanınmaya başladıkça tat ve koku bozukluklarının da oldukça sık rastlanan semptomlardan oldukları tespit edilmiştir. Mekanizmaları halen kesin olarak ortaya konulmamıştır. Koku bozukluğu içi ilk tedavi rehberi yayınlanmış olup geliştirilmesi gerekmektedir. Tat bozukluğu için ise henüz tedavi algoritması yetersizdir.

Anahtar Kelimeler

Covid 19 Koku Bozuklukları Tat Bozuklukları

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

Yok

Kaynakça

  • 1. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020;277(8):2251-61.
  • 2. Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngol Head Neck Surg 2020;163(1):114-20.
  • 3. Mehraeen E, Behnezhad F, Salehi MA, Noori T, Harandi H, Seyed Alinaghi S. Olfactory and gustatory dysfunctions due to coronavirus disease (COVID-19): a review of current evidence. Eur Arch Otorhinolaryngol 2020;17:1–6.
  • 4. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study. Clin Infect Dis 2020;71(15):889-90.
  • 5. Singer-Cornelius T, Cornelius J, Oberle M, Metternich FU, Brockmeier SJ. Objective gustatory and olfactory dysfunction in COVID-19 patients: a prospective cross-sectional study. Eur Arch Otorhinolaryngol 2021;20:1–8.
  • 6. Mullol J, Alobid I, Mariño-Sánchez F, Izquierdo-Domínguez A, Marin C, Klimek L, et al. The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries. Curr Allergy Asthma Rep 2020;20(10):61.
  • 7. Han Q, Peng J, Xu H, Chen Q. Taste cell is abundant in the expression of ACE2 receptor of 2019-nCoV. Preprints 2020;2020040424.
  • 8. Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med 2020;26(5):681-7.
  • 9. Meunier N, Briand L, Jacquin-Piques A, Brondel L, Pénicaud L. COVID 19-Induced Smell and Taste Impairments: Putative Impact on Physiology. Front Physiol 2021;11:625110.
  • 10. Mastrangelo A, Bonato M, Cinque P. Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes. Neurosci Lett 2021;748:135694.
  • 11. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, et al. Position paper on olfactory dysfunction. Rhinol Suppl 2017;54:1–30.
  • 12. Butowt R, Bilinska K. SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection. ACS Chem Neurosci 2020;11(9):1200–3.
  • 13. Letko M, Marz A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol 2020;5:562–9.
  • 14. Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH III, et al. SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract. Cell 2020;182:429–46.
  • 15. Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R. Expression of the SARS-CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium: identification of cell types and trends with age. ACS Chem Neurosci 2020;11(11):155–62.
  • 16. Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 2008;82:7264–75.
  • 17. Ye Q, Zhou J, Yang G, Li RT, He Q, Zhang Y, et al. SARS-CoV-2 infection causes transient olfactory dysfunction in mice. BioRxiv 2020:1-28.
  • 18. Zheng J, Wong LR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, et al. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature 2021;589(7843):603-7.
  • 19. Wang H, Zhou M, Brand J, Huang L. Inflammation activates the interferon signaling pathways in taste bud cells. J Neurosci 2007;27:10703–13.
  • 20. Wang H, Zhou M, Brand J, Huang L. Inflammation and taste disorders: mechanisms in taste buds. Ann NY Acad Sci 2009;1170:596–603.
  • 21. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell 2020;181:1016–35.
  • 22. Meunier N, Briand L, Jacquin-Piques A, Brondel L, Pénicaud L. COVID 19-Induced Smell and Taste Impairments: Putative Impact on Physiology. Front Physiol 2021;11:625110.

TASTE AND SMELL DISORDERS IN COVID 19 PATIENTS

Yıl 2021, Cilt: 28 Sayı: COVİD-19 ÖZEL SAYI, 153 - 156, 01.05.2021

Hasan Yasan Mehmet Emre Sivrice

https://doi.org/10.17343/sdutfd.915067

Öz

With the recognition of the clinical signs of Covid 19 infection, it was determined that taste and smell disorders were among the most common symptoms of this infection. The underlying mechanisms of these symptoms are still not well established. The first guideline to smell disorders has been published, but still needs improvement. For taste disorders, the treatment algorithm is still insufficient.

Anahtar Kelimeler

Covid 19 Olfaction Disorders Taste Disorders

Proje Numarası

Yok

Kaynakça

  • 1. Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol 2020;277(8):2251-61.
  • 2. Speth MM, Singer-Cornelius T, Oberle M, Gengler I, Brockmeier SJ, Sedaghat AR. Olfactory Dysfunction and Sinonasal Symptomatology in COVID-19: Prevalence, Severity, Timing, and Associated Characteristics. Otolaryngol Head Neck Surg 2020;163(1):114-20.
  • 3. Mehraeen E, Behnezhad F, Salehi MA, Noori T, Harandi H, Seyed Alinaghi S. Olfactory and gustatory dysfunctions due to coronavirus disease (COVID-19): a review of current evidence. Eur Arch Otorhinolaryngol 2020;17:1–6.
  • 4. Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study. Clin Infect Dis 2020;71(15):889-90.
  • 5. Singer-Cornelius T, Cornelius J, Oberle M, Metternich FU, Brockmeier SJ. Objective gustatory and olfactory dysfunction in COVID-19 patients: a prospective cross-sectional study. Eur Arch Otorhinolaryngol 2021;20:1–8.
  • 6. Mullol J, Alobid I, Mariño-Sánchez F, Izquierdo-Domínguez A, Marin C, Klimek L, et al. The Loss of Smell and Taste in the COVID-19 Outbreak: a Tale of Many Countries. Curr Allergy Asthma Rep 2020;20(10):61.
  • 7. Han Q, Peng J, Xu H, Chen Q. Taste cell is abundant in the expression of ACE2 receptor of 2019-nCoV. Preprints 2020;2020040424.
  • 8. Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med 2020;26(5):681-7.
  • 9. Meunier N, Briand L, Jacquin-Piques A, Brondel L, Pénicaud L. COVID 19-Induced Smell and Taste Impairments: Putative Impact on Physiology. Front Physiol 2021;11:625110.
  • 10. Mastrangelo A, Bonato M, Cinque P. Smell and taste disorders in COVID-19: From pathogenesis to clinical features and outcomes. Neurosci Lett 2021;748:135694.
  • 11. Hummel T, Whitcroft KL, Andrews P, Altundag A, Cinghi C, Costanzo RM, et al. Position paper on olfactory dysfunction. Rhinol Suppl 2017;54:1–30.
  • 12. Butowt R, Bilinska K. SARS-CoV-2: olfaction, brain infection, and the urgent need for clinical samples allowing earlier virus detection. ACS Chem Neurosci 2020;11(9):1200–3.
  • 13. Letko M, Marz A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol 2020;5:562–9.
  • 14. Hou YJ, Okuda K, Edwards CE, Martinez DR, Asakura T, Dinnon KH III, et al. SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract. Cell 2020;182:429–46.
  • 15. Bilinska K, Jakubowska P, Von Bartheld CS, Butowt R. Expression of the SARS-CoV-2 entry proteins, ACE2 and TMPRSS2, in cells of the olfactory epithelium: identification of cell types and trends with age. ACS Chem Neurosci 2020;11(11):155–62.
  • 16. Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S. Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 2008;82:7264–75.
  • 17. Ye Q, Zhou J, Yang G, Li RT, He Q, Zhang Y, et al. SARS-CoV-2 infection causes transient olfactory dysfunction in mice. BioRxiv 2020:1-28.
  • 18. Zheng J, Wong LR, Li K, Verma AK, Ortiz ME, Wohlford-Lenane C, et al. COVID-19 treatments and pathogenesis including anosmia in K18-hACE2 mice. Nature 2021;589(7843):603-7.
  • 19. Wang H, Zhou M, Brand J, Huang L. Inflammation activates the interferon signaling pathways in taste bud cells. J Neurosci 2007;27:10703–13.
  • 20. Wang H, Zhou M, Brand J, Huang L. Inflammation and taste disorders: mechanisms in taste buds. Ann NY Acad Sci 2009;1170:596–603.
  • 21. Ziegler CGK, Allon SJ, Nyquist SK, Mbano IM, Miao VN, Tzouanas CN, et al. SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues. Cell 2020;181:1016–35.
  • 22. Meunier N, Briand L, Jacquin-Piques A, Brondel L, Pénicaud L. COVID 19-Induced Smell and Taste Impairments: Putative Impact on Physiology. Front Physiol 2021;11:625110.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Derlemeler
Yazarlar

Hasan Yasan 0000-0002-5470-6784

Mehmet Emre Sivrice 0000-0002-2396-6794

Proje Numarası Yok
Yayımlanma Tarihi 1 Mayıs 2021
Gönderilme Tarihi 13 Nisan 2021
Kabul Tarihi 14 Nisan 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 28 Sayı: COVİD-19 ÖZEL SAYI

Kaynak Göster

Vancouver Yasan H, Sivrice ME. COVİD 19 HASTALARINDA TAT VE KOKU BOZUKLUKLARI. SDÜ Tıp Fak Derg. 2021;28(COVİD-19 ÖZEL SAYI):153-6.
 Kapak Resmi İndir

                                                                                         14791


Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.