Öz
Amaç: Bu çalışmada adenoidektomi hastalarında platelet-lenfosit oranının (PLO) prediktif bir faktör olup olmadığının ve adenoid hipertrofisi olan hastalarda platelet-lenfosit oranının sistemik inflamasyonu gösterip göstermediğinin ortaya konulması amaçlandı. Gereç ve Yöntemler: Çalışma grubuna Süleyman Demirel Üniversitesi Tıp Fakültesi Kulak Burun Boğaz Anabilim Dalı’nda (KBB) 2017-2018 yılları arasında adenoid hipertrofisi tanısı alan 3-11 yaşları arasında toplam 100 erkek hasta dahil edilmiştir. Kontrol grubu, Üroloji ve Çocuk Cerrahisi kliniklerinde sünnet edilen 100 sağlıklı erkekten oluşmaktaydı. Hastaların tıbbi kayıtları retrospektif olarak incelendi. Preoperatif laboratuvar parametreleri hasta dosyaları gözden geçirilerek değerlendirildi. Platelet-lenfosit oranı mutlak platelet sayısının mutlak lenfosit sayısına bölünmesi ile elde edildi. Bulgular: Platelet-lenfosit oranı kontrol ve çalışma grupları için sırasıyla 91,68 ve 84,15 idi ve istatistiksel olarak iki grup arasında anlamlı bir fark yoktu. (Mann-Whitney U testi, p=0,062). Mann-Whitney U testi, WBC, platelet ve lenfosit sayılarında çalışma ve kontrol grupları arasında anlamlı bir fark olmadığını gösterdi. (p>0,05). Kontrol grubunda platelet-lenfosit oranı, çalışma grubuna göre daha yüksekti. Sonuç: Platelet ve lenfosit standart sapmalarının çok yüksek olduğunu gözlemledik, bu nedenle adenoidektomide platelet-lenfosit oranının güvenilir bir değer olmadığı kanaatine varıldı.
Anahtar Kelimeler
Adenoid hipertrofisi Platelet-Lenfosit Oranı (PLO) Sistemik İnflamasyon
Kaynakça
- 1. Korkmaz M, Korkmaz H, Küçüker F, Ayyıldız SN, Çankaya S. Evaluation of the Association of Sleep Apnea-Related Systemic Inflammation with CRP, ESR, and Neutrophil-to-Lymphocyte Ratio. Medical Science Monitor. 2015;21:477-481.
- 2. Kiliçkaya M, Tuz M, Yariktaş M, Yasan H, Aynalı G, Bagci Ö. The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. International Journal of Otolaryngology. 2015;2015:1-4.
- 3. Atan D, Ozcan KM, Koseoglu S, Ikinciogullari A, Cetin MA, Ensari S, et al. New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. The Turkish Journal of Ear Nose and Throat. 2015;25(2):97-101.
- 4. Kilickaya MM, Aynali G, Tuz M, Bagci O. Is There A Systemıc Inflammatory Effect of Cholesteatoma?. International Archives of Otorhinolaryngology. 2016;21(01):42-45.
- 5. Şentürk M, Azgın İ, Övet G, Alataş N, Ağırgöl B, Yılmaz E. The role of the mean platelet volume and neutrophil-to-lymphocyte ratio in peritonsillar abscesses. Brazilian Journal of Otorhinolaryngology. 2016;82(6):662-667.
- 6. Ulu S, Ulu M, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-Lymphocyte Ratio as a New, Quick, and Reliable Indicator for Predicting Diagnosis and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. Otology & Neurotology. 2013;34(8):1400-1404.
- 7. Derin S, Erdogan S, Sahan M, Topal H, Sozen H. Neutrophil–Lymphocyte Ratio in Patients with Adenoidectomy. Journal of Clinical and Diagnostic Research. 2016;10(3):3-5
- 8. Tamhane U, Aneja S, Montgomery D, Rogers E, Eagle K, Gurm H. Association Between Admission Neutrophil to Lymphocyte Ratio and Outcomes in Patients With Acute Coronary Syndrome. The American Journal of Cardiology. 2008;102(6):653-657.
- 9. Núñez J, Núñez E, Bodí V, Sanchis J, Miñana G, Mainar L et al. Usefulness of the Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality in ST Segment Elevation Myocardial Infarction. The American Journal of Cardiology. 2008;101(6):747-752.
- 10. Acharya S, Rai P, Hallikeri K, Anehosur V, Kale J. Preoperative platelet lymphocyte ratio is superior to neutrophil lymphocyte ratio to be used as predictive marker for lymph node metastasis in oral squamous cell carcinoma. Journal of Investigative and Clinical Dentistry. 2016;8(3):e12219.
- 11. Ozturk K, Akyildiz N, Uslu M, Gode S, Uluoz U. The effect of preoperative neutrophil, platelet and lymphocyte counts on local recurrence and survival in early-stage tongue cancer. European Archives of Oto-Rhino-Laryngology. 2016;273(12):4425-4429.
- 12. Karadeniz G, Aktoğu S, Erer O, Kır S, Doruk S, Demir M et al. Predictive value of platelet-to-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. Biomarkers in Medicine. 2016;10(7):701-710.
- 13. Karatas MB, Ipek G, Onuk T, Gungor B, Durmus G, Canga Y, et al. Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism. Acta Cardiologica Sinica. 2016;32(3):313-20.
- 14. Liu W, Lin S, Wang L, Fang C, Lin Y, Braddock M et al. Platelet-to- Lymphocyte Ratio: A Novel Prognostic Factor for Prediction of 90-day Outcomes in Critically Ill Patients With Diabetic Ketoacidosis. Medicine. 2016;95(4):1-7.
- 15. You J, Zhu G, Xie L, Liu W, Shi L, Wang O et al. Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer. Oncotarget. 2016;7(18):1-12.
Öz
Objective: This study aimed to investigate Platelet-to-lymphocyte (PLR) ratios in adenoidectomy patients to determine whether this ratio can be a possible predictive factor in adenoidectomy. We also aimed to investigate whether PLR can help indicate ongoing systemic inflammation on patients with adenoid hypertrophy. Materials and Methods: A total of 100 boys aged 3-11 years, who had undergone adenoidectomy for adenoid hypertrophy between 2012 and 2018 at Suleyman Demirel University School of Medicine, Department of Ear Nose and Throat (ENT), were assigned to the study group. The control group consisted of 100 healthy boys who had been circumcised in the Urology or Pediatric Surgery Departments. Patients medical records were retrospectively reviewed. The results of preoperative complete blood counts were evaluated by reviewing the patient files. The PLR value is obtained by dividing absolute platelet count by absolute lymphocyte count. Results: PLR were 91,47 and 84,15 for control and study groups respectively with no statistically significant difference (Mann-Whitney U test, p = 0.062). The Mann-Whitney U test showed no significant difference between study and control groups among WBC, platelet and lymphocyte counts (p>0.05). PLR was higher in the control group as compared to the study group. Conclusion: We observed platelet and lymphocyte standard deviations are too high, therefore we beleive that PLR is not a reliable value in adenoidectomy.
Anahtar Kelimeler
Adenoidectomy Adenoid Hypertrophy Platelet-to-Lymphocyte Ratio (PLR)
Kaynakça
- 1. Korkmaz M, Korkmaz H, Küçüker F, Ayyıldız SN, Çankaya S. Evaluation of the Association of Sleep Apnea-Related Systemic Inflammation with CRP, ESR, and Neutrophil-to-Lymphocyte Ratio. Medical Science Monitor. 2015;21:477-481.
- 2. Kiliçkaya M, Tuz M, Yariktaş M, Yasan H, Aynalı G, Bagci Ö. The Importance of the Neutrophil-Lymphocyte Ratio in Patients with Idiopathic Peripheral Facial Palsy. International Journal of Otolaryngology. 2015;2015:1-4.
- 3. Atan D, Ozcan KM, Koseoglu S, Ikinciogullari A, Cetin MA, Ensari S, et al. New predictive parameters of nasal polyposis: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. The Turkish Journal of Ear Nose and Throat. 2015;25(2):97-101.
- 4. Kilickaya MM, Aynali G, Tuz M, Bagci O. Is There A Systemıc Inflammatory Effect of Cholesteatoma?. International Archives of Otorhinolaryngology. 2016;21(01):42-45.
- 5. Şentürk M, Azgın İ, Övet G, Alataş N, Ağırgöl B, Yılmaz E. The role of the mean platelet volume and neutrophil-to-lymphocyte ratio in peritonsillar abscesses. Brazilian Journal of Otorhinolaryngology. 2016;82(6):662-667.
- 6. Ulu S, Ulu M, Bucak A, Ahsen A, Yucedag F, Aycicek A. Neutrophil-to-Lymphocyte Ratio as a New, Quick, and Reliable Indicator for Predicting Diagnosis and Prognosis of Idiopathic Sudden Sensorineural Hearing Loss. Otology & Neurotology. 2013;34(8):1400-1404.
- 7. Derin S, Erdogan S, Sahan M, Topal H, Sozen H. Neutrophil–Lymphocyte Ratio in Patients with Adenoidectomy. Journal of Clinical and Diagnostic Research. 2016;10(3):3-5
- 8. Tamhane U, Aneja S, Montgomery D, Rogers E, Eagle K, Gurm H. Association Between Admission Neutrophil to Lymphocyte Ratio and Outcomes in Patients With Acute Coronary Syndrome. The American Journal of Cardiology. 2008;102(6):653-657.
- 9. Núñez J, Núñez E, Bodí V, Sanchis J, Miñana G, Mainar L et al. Usefulness of the Neutrophil to Lymphocyte Ratio in Predicting Long-Term Mortality in ST Segment Elevation Myocardial Infarction. The American Journal of Cardiology. 2008;101(6):747-752.
- 10. Acharya S, Rai P, Hallikeri K, Anehosur V, Kale J. Preoperative platelet lymphocyte ratio is superior to neutrophil lymphocyte ratio to be used as predictive marker for lymph node metastasis in oral squamous cell carcinoma. Journal of Investigative and Clinical Dentistry. 2016;8(3):e12219.
- 11. Ozturk K, Akyildiz N, Uslu M, Gode S, Uluoz U. The effect of preoperative neutrophil, platelet and lymphocyte counts on local recurrence and survival in early-stage tongue cancer. European Archives of Oto-Rhino-Laryngology. 2016;273(12):4425-4429.
- 12. Karadeniz G, Aktoğu S, Erer O, Kır S, Doruk S, Demir M et al. Predictive value of platelet-to-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. Biomarkers in Medicine. 2016;10(7):701-710.
- 13. Karatas MB, Ipek G, Onuk T, Gungor B, Durmus G, Canga Y, et al. Assessment of Prognostic Value of Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio in Patients with Pulmonary Embolism. Acta Cardiologica Sinica. 2016;32(3):313-20.
- 14. Liu W, Lin S, Wang L, Fang C, Lin Y, Braddock M et al. Platelet-to- Lymphocyte Ratio: A Novel Prognostic Factor for Prediction of 90-day Outcomes in Critically Ill Patients With Diabetic Ketoacidosis. Medicine. 2016;95(4):1-7.
- 15. You J, Zhu G, Xie L, Liu W, Shi L, Wang O et al. Preoperative platelet to lymphocyte ratio is a valuable prognostic biomarker in patients with colorectal cancer. Oncotarget. 2016;7(18):1-12.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Klinik Tıp Bilimleri |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2020 |
| Gönderilme Tarihi | 20 Mart 2019 |
| Kabul Tarihi | 17 Nisan 2019 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 27 Sayı: 2 |
Süleyman Demirel Üniversitesi Tıp Fakültesi Dergisi/Medical Journal of Süleyman Demirel University is licensed under Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International.