BibTex RIS Kaynak Göster
Yıl 2016, Cilt: 7 Sayı: 3, 24 - 30, 03.01.2017

Öz

The effect of the overweight on the circulating cytokines and adipokines

Yıl 2016, Cilt: 7 Sayı: 3, 24 - 30, 03.01.2017

Öz

Objective: Interleukin (IL)-1β, IL-4, IL-6, and tumor necrosis factor (TNF-α) are forefront cytokines in the periodontitis pathogenesis. Therefore, this study aimed to test the hypothesis that overweight rats with periodontitis have higher pro-inflammatory cytokines and/or adipokines, and lower anti-inflammatory cytokines and/or adipokines in serum than normal weight rats.
Material-Method: Thirty-two 4-month old male Wistar rats were divided into 4 groups: normal weight, periodontally healthy rats (NH, n = 8), normal weight rats with periodontitis (NP, n = 8), overweight, periodontally healthy rats (OH, n = 8); and overweight rats with periodontitis (OP, n = 8). Periodontitis was induced by ligature for 14 days. The serum cytokine’ and adipokine’ levels were investigated using ELISA.
Results: IL-4 levels were higher in the NH and NP groups than their counterparts in the overweight rats (P <0.01). The IL-6 level was significantly higher in the OP group than in the NP group (P < 0.01). The adiponectin level was significantly higher in the NH group than in the OH and OP groups (P < 0.01). Leptin and resistin levels didn’t differ significantly among the groups (P > 0.01).
Conclusions: The overweight status affected the cytokine’ and adipokine’ level independent from the periodontal status in this experimental model. Overweight rats with and without periodontitis have lower serum levels of anti-inflammatory cytokine and adipokines (IL-4 and adiponectin) and higher serum levels of pro-inflammatory cytokine (IL-6) than their counterparts in normal weight rat groups.

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırma Makaleleri
Yazarlar

Zuhal Yetkin Ay

Fethiye Çağlar Özşahin

Duygu Kumbul Doğuç

Birsen Harun Dağdeviren Bu kişi benim

Ersin Uskun

Fatma Yeşim Kırzıoğlu Bu kişi benim

Yayımlanma Tarihi 3 Ocak 2017
Gönderilme Tarihi 26 Mayıs 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 7 Sayı: 3

Kaynak Göster

Vancouver Yetkin Ay Z, Çağlar Özşahin F, Kumbul Doğuç D, Harun Dağdeviren B, Uskun E, Kırzıoğlu FY. The effect of the overweight on the circulating cytokines and adipokines. Süleyman Demirel Üniversitesi Sağlık Bilimleri Dergisi. 2017;7(3):24-30.

SDÜ Sağlık Bilimleri Dergisi, makalenin gönderilmesi ve yayınlanması dahil olmak üzere hiçbir aşamada herhangi bir ücret talep etmemektedir. Dergimiz, bilimsel araştırmaları okuyucuya ücretsiz sunmanın bilginin küresel paylaşımını artıracağı ilkesini benimseyerek, içeriğine anında açık erişim sağlamaktadır.