The ulcer is a vital disease that unfavorably affects human health globally. Helicobacter pylori, a reason forhave an antibacterial effect against ulcers and some stomach disorders, live on using the urease enzyme and induces the condition to occur. Metal coordination complexes (MCC) are used in numerous industrial areas and the health field. Cyanide bridged metal complexes are also applied in several places. In the current study, antibacterial characteristic of (C1), [Ni(bishydeten)2Ag(CN)2][Ag(CN)2].H2O), and (C2), ([Ni(hydeten)2Ag(CN)2][Ag(CN)2], MCC were analyzed by disk diffusion and broth dilution broth and urease enzyme inhibition assays were performed. As a result of both antibacterial tests, C1 and C2 were observed to provide favorable effects. The synthesized compounds have effective inhibitory potential with IC50 value between 26.65±1.21 and 12.37±0.87 µM for urease.
Metal coordination complexes Helicobacter pylori antibacterial enzyme activity urease
TÜBİTAK
1919B011902147
We would like to thank TÜBİTAK for supporting this project.
1919B011902147
Birincil Dil | İngilizce |
---|---|
Konular | Yapısal Biyoloji |
Bölüm | Araştırma Makalesi |
Yazarlar | |
Proje Numarası | 1919B011902147 |
Yayımlanma Tarihi | 31 Ağustos 2022 |
Gönderilme Tarihi | 5 Şubat 2022 |
Kabul Tarihi | 16 Haziran 2022 |
Yayımlandığı Sayı | Yıl 2022 Cilt: 26 Sayı: 4 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.