BibTex RIS Kaynak Göster

Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi

Yıl 2007, Cilt: 5 Sayı: 1, 25 - 27, 01.06.2007

Öz

Preterm doğuma ve neonatal komplikasyonlara neden olan faktörler içerisinde en sık saptanan nedenlerin başında intrauterin enfeksiyonve/veya enflamasyon gelmektedir. Mikroorganizma veya ürünlerinin fetusa ulaşması sitokin salınışına ve sistemik fetal enflamatuar cevaba FIRS neden olmaktadır. FIRS; fetal veya neonatal beyin hasarına neden olarak ileride serebral palsi CP gelişimine yol açmaktadır. intrauterin dönemde sitokinlerin neden olacağı beyaz cevher hasarı ve preterm doğum ile CP arasındaki ilişki günümüzde iyi bilinmektedir. Klinikte karşımıza periventriküler lökomalazi PVL olarak çıkan beyaz cevher hasarı, nörogelişimsel prognoz ve CP’nin ağırlığı açısından oldukça önemlidir. Güncel Pediatri 2007; 5: 25-7

Kaynakça

  • 1. Rezaie P, Dean A. Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 2002; 22:106-32.
  • 2. Dammann O, Leviton A. Inflammatory brain damage in preterm newborns dry numbers, wet lab, and causal inferences. Early Hum Dev 2004; 79:1-15.
  • 3. Gomez R, Romero R, Ghezzi F, Yoon H, Mazor M, Berry S. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998; 179:194-202.
  • 4. Kim GJ, Yoon BH, Romero R, Moon JB, Kim M, Park SS, Chi JG. Umbilical arteritis and phelibitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol 2001; 185:496-500.
  • 5. Ugwumadu A. Infection and fetal neurologic injury. Curr Opin Obstet Gynecol 2006; 18:106-11.
  • 6. de Vries LS, van Bel F. Doppler ultrasound and periventricular leukomalacia. Pediatrics 2006; 117:112-3.
  • 7. Fukuda S, Kato T, Kakita H, Yamada Y, Hussein MH, Kato I, Suzuki S, Togari H. Hemodynamics of the cerebral arteries of infants with periventricular leukomalacia. Pediatrics 2006; 117:1-8.
  • 8. Volpe JJ. Neurobiology of periventricular leukomalacia in the preterm infants. Pediatr Res 2001; 50:553-62.
  • 9. Yoon BH, Park CW, Chaiworapongsa. Intrauterine infection and the development of cerebral palsy. BJOG 2003; 110:124-7.
  • 10. Bashiri A, Burstein E, Mazor M. Cerebral palsy and fetal inflammatory response syndrome: a review. J Perinat Med 2006; 34:5-12.
  • 11. Dammann O, Leviton A. Maternal intrauterine infection, cytokines, and brain damage in the preterm infants. Pediatr Res 1997; 42:1-8.
  • 12. Dammann O, Durum S, Leviton A. Do white cells matter in white matter damage? Trends in Neurosciences 2001; 24:320-4
  • 13. Dammann O, Durum S, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr 2000; 12:99-104.
  • 14. Duggan PJ, Maalouf EF, Watts TL, Sullivan MH, Counsell SJ, Allsop J, Al-Nakib L,Rutherford MA, Battin M, Roberts I, Edwards AD. Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions. Lancet 2001; 17;358:1699-700.
  • 15. Mittendorf R, Montag AG, MacMillan W, Janeczek S, Pryde PG, Besinger RE, Gianopoulos JG, Roizen N. Components of the systemic fetal inflammatory response syndrome as predictors of impaired neurologic outcomes in children. Am J Obstet Gynecol 2003; 188:1438-46.
  • 16. Yoon BH, Romero R, Park JS, Kim CJ, Kim SH, Choi JH, Han TR. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 2000 Mar; 182:675-81.
  • 17. Dammann O, Kuban KC, Leviton A. Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm. Ment Retard Dev Disabil Res Rev 2002; 8:46-50.
  • 18. Wu YW, Colford JM. Chorioamnionitis as a risk factor for cerebral palsy. JAMA 2000; 284:1417-24.

Fetal Inflammatory Response Syndrome and Brain Damage

Yıl 2007, Cilt: 5 Sayı: 1, 25 - 27, 01.06.2007

Öz

Intrauterine infection/inflammation has been identified as the most common cause of preterm delivery and neonatal complications. When microorganisms or their products gain access to the fetus they stimulate the production of cytokines and a systemic response termed FIRS Fetal Inflammatory Response Syndrome . Subsequently, FIRS was implicated as a cause of fetal or neonatal brain injury that leads to cerebral palsy CP . A relationship between CP and intra-amniotic inflammation was demonstrated, intrauterine infection may lead to activation of the cytokine network which in turn can cause white matter brain damage and preterm delivery, as well and as the future development of CP. This white matter insult is identified clinically as periventricular leucomalacia PVL which is associated with the subsequent development of impaired neurological outcomes of variable severity including CP.

Kaynakça

  • 1. Rezaie P, Dean A. Periventricular leukomalacia, inflammation and white matter lesions within the developing nervous system. Neuropathology 2002; 22:106-32.
  • 2. Dammann O, Leviton A. Inflammatory brain damage in preterm newborns dry numbers, wet lab, and causal inferences. Early Hum Dev 2004; 79:1-15.
  • 3. Gomez R, Romero R, Ghezzi F, Yoon H, Mazor M, Berry S. The fetal inflammatory response syndrome. Am J Obstet Gynecol 1998; 179:194-202.
  • 4. Kim GJ, Yoon BH, Romero R, Moon JB, Kim M, Park SS, Chi JG. Umbilical arteritis and phelibitis mark different stages of the fetal inflammatory response. Am J Obstet Gynecol 2001; 185:496-500.
  • 5. Ugwumadu A. Infection and fetal neurologic injury. Curr Opin Obstet Gynecol 2006; 18:106-11.
  • 6. de Vries LS, van Bel F. Doppler ultrasound and periventricular leukomalacia. Pediatrics 2006; 117:112-3.
  • 7. Fukuda S, Kato T, Kakita H, Yamada Y, Hussein MH, Kato I, Suzuki S, Togari H. Hemodynamics of the cerebral arteries of infants with periventricular leukomalacia. Pediatrics 2006; 117:1-8.
  • 8. Volpe JJ. Neurobiology of periventricular leukomalacia in the preterm infants. Pediatr Res 2001; 50:553-62.
  • 9. Yoon BH, Park CW, Chaiworapongsa. Intrauterine infection and the development of cerebral palsy. BJOG 2003; 110:124-7.
  • 10. Bashiri A, Burstein E, Mazor M. Cerebral palsy and fetal inflammatory response syndrome: a review. J Perinat Med 2006; 34:5-12.
  • 11. Dammann O, Leviton A. Maternal intrauterine infection, cytokines, and brain damage in the preterm infants. Pediatr Res 1997; 42:1-8.
  • 12. Dammann O, Durum S, Leviton A. Do white cells matter in white matter damage? Trends in Neurosciences 2001; 24:320-4
  • 13. Dammann O, Durum S, Leviton A. Role of the fetus in perinatal infection and neonatal brain damage. Curr Opin Pediatr 2000; 12:99-104.
  • 14. Duggan PJ, Maalouf EF, Watts TL, Sullivan MH, Counsell SJ, Allsop J, Al-Nakib L,Rutherford MA, Battin M, Roberts I, Edwards AD. Intrauterine T-cell activation and increased proinflammatory cytokine concentrations in preterm infants with cerebral lesions. Lancet 2001; 17;358:1699-700.
  • 15. Mittendorf R, Montag AG, MacMillan W, Janeczek S, Pryde PG, Besinger RE, Gianopoulos JG, Roizen N. Components of the systemic fetal inflammatory response syndrome as predictors of impaired neurologic outcomes in children. Am J Obstet Gynecol 2003; 188:1438-46.
  • 16. Yoon BH, Romero R, Park JS, Kim CJ, Kim SH, Choi JH, Han TR. Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years. Am J Obstet Gynecol 2000 Mar; 182:675-81.
  • 17. Dammann O, Kuban KC, Leviton A. Perinatal infection, fetal inflammatory response, white matter damage, and cognitive limitations in children born preterm. Ment Retard Dev Disabil Res Rev 2002; 8:46-50.
  • 18. Wu YW, Colford JM. Chorioamnionitis as a risk factor for cerebral palsy. JAMA 2000; 284:1417-24.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

Abdullah Kumral

Didem Cemile Yeşilırmak Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2007
Yayımlandığı Sayı Yıl 2007 Cilt: 5 Sayı: 1

Kaynak Göster

APA Kumral, A., & Yeşilırmak, D. C. (2007). Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi. Güncel Pediatri, 5(1), 25-27.
AMA Kumral A, Yeşilırmak DC. Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi. Güncel Pediatri. Haziran 2007;5(1):25-27.
Chicago Kumral, Abdullah, ve Didem Cemile Yeşilırmak. “Fetal Enflamatuar Yanıt Sendromu Ve Beyin Zedelenmesi”. Güncel Pediatri 5, sy. 1 (Haziran 2007): 25-27.
EndNote Kumral A, Yeşilırmak DC (01 Haziran 2007) Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi. Güncel Pediatri 5 1 25–27.
IEEE A. Kumral ve D. C. Yeşilırmak, “Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi”, Güncel Pediatri, c. 5, sy. 1, ss. 25–27, 2007.
ISNAD Kumral, Abdullah - Yeşilırmak, Didem Cemile. “Fetal Enflamatuar Yanıt Sendromu Ve Beyin Zedelenmesi”. Güncel Pediatri 5/1 (Haziran 2007), 25-27.
JAMA Kumral A, Yeşilırmak DC. Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi. Güncel Pediatri. 2007;5:25–27.
MLA Kumral, Abdullah ve Didem Cemile Yeşilırmak. “Fetal Enflamatuar Yanıt Sendromu Ve Beyin Zedelenmesi”. Güncel Pediatri, c. 5, sy. 1, 2007, ss. 25-27.
Vancouver Kumral A, Yeşilırmak DC. Fetal Enflamatuar Yanıt Sendromu ve Beyin Zedelenmesi. Güncel Pediatri. 2007;5(1):25-7.