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Vitamin K ve Hemostaz

Yıl 2011, Cilt: 9 Sayı: 1, 113 - 118, 01.06.2011

Fatih Demirtaş Melike Sezgin Evim Birol Baytan Adalet Meral Güneş

Öz

Vitamin K, kanda bulunan normal pıhtılaşma faktörlerinin sentezi için gerekli bir faktördür. Yenidoğanlarda vitamin K eksikliğine yatkınlık vardır, çünkü çok az bir miktar K vitamini plasentadan geçer. Doğumdan sonraki ilk birkaç gün bağırsak florası henüz bakteri içermediği için vitamin K üretilemez. Bu vitamin K eksikliği kanama ile karakterize yenidoğanın hemorajik hastalığına yol açar. Doğumdan sonrakanama riskini azaltmak için tüm yenidoğanlara intramusküler vitamin K uygulanmasıönerilmektedir

Anahtar Kelimeler

Vitamin K çocuklar hemostaz

Kaynakça

  • 1. Muntean W. General vitamin K prevention in newborn infants. Z Geburtshilfe Perinatol 1986;190:107-13.
  • 2. Ferland G. The vitamin K-dependent proteins: an update. Nutr Rev 1998;56:223-30.
  • 6. Lehmann J. Vitamin K as a prophylactic in 13,000 babies. Lancet 1944;1:493-4.
  • 7. Sanford HN, Shmigelsky L, Chapin JM. Is administration of vitamin K to the newborn of clinical value? JAMA 1942;118:697-702.
  • 8. Grontoft O. Intracranial haemorrhage and blood-brain barrier problems in the new-born: a pathologico-anatomical and experimental investigation. Acta Pathol Microbiol Scand 1954;100:8-109.
  • 9. Allison AC. Danger of vitamin K to newborn. Lancet 1955;2:669.
  • 10. Mayer TC, Angus J. The effect of large doses of `Synkavit’ in the newborn. Arch Dis Child 1956;31:212-5.
  • 11. Golding J, Greenwood R, Birmingham K, Mott M. Childhood cancer, intramuscular vitamin K and pethidine given during labour. BMJ 1992;305:341-6.
  • 12. Klebanoff MA, Read JS, Mills JL, Shiono PH. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 1993;329:905-8.
  • 13. Costakos DT, Greer FR, Love LA, Dahlen LR, Suttie JW. Vitamin K prophylaxis for premature infants: 1 mg versus 0.5 mg. Am J Perinatol 2003;20:485-90.
  • 14. Booth SL, Suttie JW. Dietary Intake and Adequacy of Vitamin K1. J Nutr 1998;128:785-8.
  • 15. Monagle P, Andrew M. Nathan and Oski’s Hematology of Infancy and Childhood, In: Nathan DG, Orkin SH, Ginsburg D, Look AT (eds), Neonatal Hematology, Developmental hemostasis: relevance to newborns and infants. 6th edition: Saunders, Philadelphia; 2003. P.121-68.
  • 16. Vitamin K, Arsenic, Boron, Chromium, copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academic Press; 2002. p.162-89.
  • 17. American Academy of Pediatrics (AAP). 141 Northwest Point Boulevard, Elk Grove Village, IL 60007. (847) 434-4000.
  • 18. Suttie JW. Vitamin K. In: Diplock AD, ed. Fat-soluble vitamins: their biochemistry and applications. London, Heinemann 1985. p.225-311.
  • 19. Furie B, Furie BC. Molecular basis of vitamin K-dependent g-carboxylation. Blood 1990;75:1753-62.
  • 20. Ni R, Nishikawa Y, Carr BI. Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation. J Biol Chem 1998;273:9906-11.
  • 21. Matsueda K, Yamamoto H, Yoshida Y, Notohara K. Hepatoid carcinoma of the pancreas producing protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP). J Gastroenterol 2006;41:1011-9.
  • 22. von Kries R, Becker A, Göbel U. Vitamin K in the newborn: influence of nutritional factors on acarboxy-prothrombin detectability and factor II and VII clotting activity. European Journal of Pediatrics 1987;146:123-7.
  • 23. Vermeer C. g-Carboxyglutamate-containing proteins and the vitamin Kdependent carboxylase. Biochemical Journal 1990;266:625-36.
  • 24. Kasatkar P, Shetty S, Ghosh K. Delayed vitamin K deficiency as a cause of bleeding: still a concern in the 21st century. Am J Clin Nutr 2010;92:660-7.
  • 25. Vermeer C, Jie K-S, Knapen MHJ. Role of vitamin K in bone metabolism. Annual Review of Nutrition 1995;15:1-22.
  • 26. Binkley NC, Suttie JW. Vitamin K nutrition and osteoporosis. Journal of Nutrition 1995;125:1812-21.
  • 27. Philip Lanzkowsky. Hemostasis. Manual of Pediatric Hematology and Oncology. Third Edition. Academic Press, New York 2000; 287-331.
  • 28. Sutor Ah, Von Kries R, Cornelissen Eam, MorneLissen Eam, Mcninch Aw, Andrew M. Vitamin K deficiency bleeding (VKDB) in infancy. Throm Haemost 1999;81:456-61.
  • 29. Hey E. Effect of maternal anticonvulsant treatment on neonatal blood coagulation. Arch Dis Child Fetal Neonatal Ed 1999;81: F208-10.
  • 30. Erja Kaaja, Risto Kaaja, Riitta Matila, Vilho Hiilesmaa. Enzymeinducing antiepileptic drugs and the risk of bleeding in the neonate. Neurology 2002;58:549-53.
  • 31. Puckett RM, Offringa M. Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. Cochrane Database Syst Rev 2000;4:CD002776.
  • 32. McNinch AW, Barton J, Tripp JH. Vitamin K deficiency bleeding in the British Isles and the changing pattern of vitamin K prophylaxis. In: Sutor AH, Hathaway WE, eds. Vitamin K in infancy. Stuttgart: Schattauer Verlag; 1995. p.165-72.
  • 33. Choo KE, Tan KK, Chuah SP, Ariffin WA, Gururaj A. Haemorrhagic disease in newborn and older infants: a study of hospitalised children in Kelantan, Malasia. Ann Trop Paediatr 1994;14:231-7.
  • 34. Koc A, Sarrao¤lu S, Alt›ntafl, Minnet C. Vitamin B12 deficiency as one the major causes of post-neonatal vitamin K deficiency. XXXth World Congress of International Society of Hematology, 28 September-2 October 2005, ‹stanbul, Abstract Book, Abstract: 356, Poster: 263. p.160-1.
  • 35. Tovar A, Ameho CK, Blumberg JB, Peterson JW, Smith D, Booth SL. Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet. Nutr Metab (Lond) 2006;3:29.
  • 36. Schaefer C. Exposure to vitamin K antagonists during pregnancy. Clin Adv Hematol Oncol 2006;4:509-10.
  • 37. Liu J, Wang Q, Chen YH, Qin GL, Zhao JH, Zhu LC. [Level of vitamin K-dependent coagulation factors in premature infants and the influence of maternal antenatal administration of vitamin K1 on their activity] Zhonghua Er Ke Za Zhi 2005;43:908-10.
  • 38. American Academy of Pediatrics Committee on Fetus and Newborn. Controversies concerning vitamin K and the newborn. Pediatrics 2003;112:191-2.
  • 39. Sutor AH. Vitamin K deficiency bleeding in infants and children. A status report. In: Sutor AH, Hathaway WE, eds. Vitamin K in Infancy. Stuttgart: Schattauer; 1995. p.3-18.
  • 40. Bahar A, Karademir F, Göçmen ‹. Yenido¤an›n hemorajik hastal›¤› ve K vitamini uygulamas›. DEU T›p Fakültesi Dergisi 2002;2:67-72.
  • 41. Tsujioka T, Miura Y, Otsuki T, et al. The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 2006;91:613-9.
  • 42. Casas JS, Castellano EE, Couce MD, Ellena J, Sánchez A, Sordo J. A gold (I) complex with a vitamin K3 derivative: characterization and antitumoral activity. J Inorg Biochem 2006;100:1858-60.
  • 43. Parekh H,Chavan S, Advani S, Chitnis M. Single and combination treatment with vitamin K3 and adriamcin: in vitro effects on cell survival and DNA damage in human chronic myeloid leukemia cells. Sel Cancer Ther 1991;7:127-35.
  • 44. Xu CJ, Zhang Y, Wang J, Zhang TM. Menadione reduced doxorubicin resistance in Ehrlich ascites carcinoma cells in vitro. Zhongguo Yao Li Xue Bao 1998;19:273-6.
  • 45. Kassouf W, Highshaw R, Nelkin GM, Dinney CP, Kamat AM. Vitamins C and K3 sensitize human urothelial tumors to gemcitabine. J Urol 2006;176:1642-7.
  • 46. Hubbard D, Tobias JD. Intracerebral hemorrhage due to hemorrhagic disease of the newborn and failure to administer vitamin K at birth. South Med J 2006;99:1216-20.

Vitamin K and Hemostasis

Yıl 2011, Cilt: 9 Sayı: 1, 113 - 118, 01.06.2011

Fatih Demirtaş Melike Sezgin Evim Birol Baytan Adalet Meral Güneş

Öz

Vitamin K is necessary for the synthesis of the proteins that help control bleeding clotting factors and thus for the normal clotting of blood. Newborns are prone tovitamin K deficiency because only small amounts of vitamin K cross the placentaand because, during the first few days after birth, their intestine does not containbacteria to produce vitamin K. The deficiency can cause hemorrhagic disease ofthe newborn, characterized by a tendency to bleed. A vitamin K injection in themuscle is recommended for all newborns to reduce the risk of bleeding within thebrain after delivery

Anahtar Kelimeler

Vitamin K children hemostasis

Kaynakça

  • 1. Muntean W. General vitamin K prevention in newborn infants. Z Geburtshilfe Perinatol 1986;190:107-13.
  • 2. Ferland G. The vitamin K-dependent proteins: an update. Nutr Rev 1998;56:223-30.
  • 6. Lehmann J. Vitamin K as a prophylactic in 13,000 babies. Lancet 1944;1:493-4.
  • 7. Sanford HN, Shmigelsky L, Chapin JM. Is administration of vitamin K to the newborn of clinical value? JAMA 1942;118:697-702.
  • 8. Grontoft O. Intracranial haemorrhage and blood-brain barrier problems in the new-born: a pathologico-anatomical and experimental investigation. Acta Pathol Microbiol Scand 1954;100:8-109.
  • 9. Allison AC. Danger of vitamin K to newborn. Lancet 1955;2:669.
  • 10. Mayer TC, Angus J. The effect of large doses of `Synkavit’ in the newborn. Arch Dis Child 1956;31:212-5.
  • 11. Golding J, Greenwood R, Birmingham K, Mott M. Childhood cancer, intramuscular vitamin K and pethidine given during labour. BMJ 1992;305:341-6.
  • 12. Klebanoff MA, Read JS, Mills JL, Shiono PH. The risk of childhood cancer after neonatal exposure to vitamin K. N Engl J Med 1993;329:905-8.
  • 13. Costakos DT, Greer FR, Love LA, Dahlen LR, Suttie JW. Vitamin K prophylaxis for premature infants: 1 mg versus 0.5 mg. Am J Perinatol 2003;20:485-90.
  • 14. Booth SL, Suttie JW. Dietary Intake and Adequacy of Vitamin K1. J Nutr 1998;128:785-8.
  • 15. Monagle P, Andrew M. Nathan and Oski’s Hematology of Infancy and Childhood, In: Nathan DG, Orkin SH, Ginsburg D, Look AT (eds), Neonatal Hematology, Developmental hemostasis: relevance to newborns and infants. 6th edition: Saunders, Philadelphia; 2003. P.121-68.
  • 16. Vitamin K, Arsenic, Boron, Chromium, copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academic Press; 2002. p.162-89.
  • 17. American Academy of Pediatrics (AAP). 141 Northwest Point Boulevard, Elk Grove Village, IL 60007. (847) 434-4000.
  • 18. Suttie JW. Vitamin K. In: Diplock AD, ed. Fat-soluble vitamins: their biochemistry and applications. London, Heinemann 1985. p.225-311.
  • 19. Furie B, Furie BC. Molecular basis of vitamin K-dependent g-carboxylation. Blood 1990;75:1753-62.
  • 20. Ni R, Nishikawa Y, Carr BI. Cell growth inhibition by a novel vitamin K is associated with induction of protein tyrosine phosphorylation. J Biol Chem 1998;273:9906-11.
  • 21. Matsueda K, Yamamoto H, Yoshida Y, Notohara K. Hepatoid carcinoma of the pancreas producing protein induced by vitamin K absence or antagonist II (PIVKA-II) and alpha-fetoprotein (AFP). J Gastroenterol 2006;41:1011-9.
  • 22. von Kries R, Becker A, Göbel U. Vitamin K in the newborn: influence of nutritional factors on acarboxy-prothrombin detectability and factor II and VII clotting activity. European Journal of Pediatrics 1987;146:123-7.
  • 23. Vermeer C. g-Carboxyglutamate-containing proteins and the vitamin Kdependent carboxylase. Biochemical Journal 1990;266:625-36.
  • 24. Kasatkar P, Shetty S, Ghosh K. Delayed vitamin K deficiency as a cause of bleeding: still a concern in the 21st century. Am J Clin Nutr 2010;92:660-7.
  • 25. Vermeer C, Jie K-S, Knapen MHJ. Role of vitamin K in bone metabolism. Annual Review of Nutrition 1995;15:1-22.
  • 26. Binkley NC, Suttie JW. Vitamin K nutrition and osteoporosis. Journal of Nutrition 1995;125:1812-21.
  • 27. Philip Lanzkowsky. Hemostasis. Manual of Pediatric Hematology and Oncology. Third Edition. Academic Press, New York 2000; 287-331.
  • 28. Sutor Ah, Von Kries R, Cornelissen Eam, MorneLissen Eam, Mcninch Aw, Andrew M. Vitamin K deficiency bleeding (VKDB) in infancy. Throm Haemost 1999;81:456-61.
  • 29. Hey E. Effect of maternal anticonvulsant treatment on neonatal blood coagulation. Arch Dis Child Fetal Neonatal Ed 1999;81: F208-10.
  • 30. Erja Kaaja, Risto Kaaja, Riitta Matila, Vilho Hiilesmaa. Enzymeinducing antiepileptic drugs and the risk of bleeding in the neonate. Neurology 2002;58:549-53.
  • 31. Puckett RM, Offringa M. Prophylactic vitamin K for vitamin K deficiency bleeding in neonates. Cochrane Database Syst Rev 2000;4:CD002776.
  • 32. McNinch AW, Barton J, Tripp JH. Vitamin K deficiency bleeding in the British Isles and the changing pattern of vitamin K prophylaxis. In: Sutor AH, Hathaway WE, eds. Vitamin K in infancy. Stuttgart: Schattauer Verlag; 1995. p.165-72.
  • 33. Choo KE, Tan KK, Chuah SP, Ariffin WA, Gururaj A. Haemorrhagic disease in newborn and older infants: a study of hospitalised children in Kelantan, Malasia. Ann Trop Paediatr 1994;14:231-7.
  • 34. Koc A, Sarrao¤lu S, Alt›ntafl, Minnet C. Vitamin B12 deficiency as one the major causes of post-neonatal vitamin K deficiency. XXXth World Congress of International Society of Hematology, 28 September-2 October 2005, ‹stanbul, Abstract Book, Abstract: 356, Poster: 263. p.160-1.
  • 35. Tovar A, Ameho CK, Blumberg JB, Peterson JW, Smith D, Booth SL. Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet. Nutr Metab (Lond) 2006;3:29.
  • 36. Schaefer C. Exposure to vitamin K antagonists during pregnancy. Clin Adv Hematol Oncol 2006;4:509-10.
  • 37. Liu J, Wang Q, Chen YH, Qin GL, Zhao JH, Zhu LC. [Level of vitamin K-dependent coagulation factors in premature infants and the influence of maternal antenatal administration of vitamin K1 on their activity] Zhonghua Er Ke Za Zhi 2005;43:908-10.
  • 38. American Academy of Pediatrics Committee on Fetus and Newborn. Controversies concerning vitamin K and the newborn. Pediatrics 2003;112:191-2.
  • 39. Sutor AH. Vitamin K deficiency bleeding in infants and children. A status report. In: Sutor AH, Hathaway WE, eds. Vitamin K in Infancy. Stuttgart: Schattauer; 1995. p.3-18.
  • 40. Bahar A, Karademir F, Göçmen ‹. Yenido¤an›n hemorajik hastal›¤› ve K vitamini uygulamas›. DEU T›p Fakültesi Dergisi 2002;2:67-72.
  • 41. Tsujioka T, Miura Y, Otsuki T, et al. The mechanisms of vitamin K2-induced apoptosis of myeloma cells. Haematologica 2006;91:613-9.
  • 42. Casas JS, Castellano EE, Couce MD, Ellena J, Sánchez A, Sordo J. A gold (I) complex with a vitamin K3 derivative: characterization and antitumoral activity. J Inorg Biochem 2006;100:1858-60.
  • 43. Parekh H,Chavan S, Advani S, Chitnis M. Single and combination treatment with vitamin K3 and adriamcin: in vitro effects on cell survival and DNA damage in human chronic myeloid leukemia cells. Sel Cancer Ther 1991;7:127-35.
  • 44. Xu CJ, Zhang Y, Wang J, Zhang TM. Menadione reduced doxorubicin resistance in Ehrlich ascites carcinoma cells in vitro. Zhongguo Yao Li Xue Bao 1998;19:273-6.
  • 45. Kassouf W, Highshaw R, Nelkin GM, Dinney CP, Kamat AM. Vitamins C and K3 sensitize human urothelial tumors to gemcitabine. J Urol 2006;176:1642-7.
  • 46. Hubbard D, Tobias JD. Intracerebral hemorrhage due to hemorrhagic disease of the newborn and failure to administer vitamin K at birth. South Med J 2006;99:1216-20.
Toplam 43 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

Fatih Demirtaş Bu kişi benim

Melike Sezgin Evim Bu kişi benim

Birol Baytan

Adalet Meral Güneş Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 9 Sayı: 1

Kaynak Göster

APA Demirtaş, F., Evim, M. S., Baytan, B., Güneş, A. M. (2011). Vitamin K ve Hemostaz. Güncel Pediatri, 9(1), 113-118.
AMA Demirtaş F, Evim MS, Baytan B, Güneş AM. Vitamin K ve Hemostaz. Güncel Pediatri. Haziran 2011;9(1):113-118.
Chicago Demirtaş, Fatih, Melike Sezgin Evim, Birol Baytan, ve Adalet Meral Güneş. “Vitamin K Ve Hemostaz”. Güncel Pediatri 9, sy. 1 (Haziran 2011): 113-18.
EndNote Demirtaş F, Evim MS, Baytan B, Güneş AM (01 Haziran 2011) Vitamin K ve Hemostaz. Güncel Pediatri 9 1 113–118.
IEEE F. Demirtaş, M. S. Evim, B. Baytan, ve A. M. Güneş, “Vitamin K ve Hemostaz”, Güncel Pediatri, c. 9, sy. 1, ss. 113–118, 2011.
ISNAD Demirtaş, Fatih vd. “Vitamin K Ve Hemostaz”. Güncel Pediatri 9/1 (Haziran 2011), 113-118.
JAMA Demirtaş F, Evim MS, Baytan B, Güneş AM. Vitamin K ve Hemostaz. Güncel Pediatri. 2011;9:113–118.
MLA Demirtaş, Fatih vd. “Vitamin K Ve Hemostaz”. Güncel Pediatri, c. 9, sy. 1, 2011, ss. 113-8.
Vancouver Demirtaş F, Evim MS, Baytan B, Güneş AM. Vitamin K ve Hemostaz. Güncel Pediatri. 2011;9(1):113-8.