BibTex RIS Kaynak Göster

Alerjen Spesifik İmmünoterapi

Yıl 2015, Cilt: 13 Sayı: 1, 46 - 55, 01.06.2015
https://doi.org/10.4274/jcp.02419

Öz

Alerjen spesifik immünoterapi SİT , alerjik hastalıklarda kür sağlayabilen tek tedavi yöntemidir. Duyarlı olunan alerjenin belirli aralıklarla ve giderek artan dozlarda verilmesiyle bu alerjene karşı immüntolerans gelişmesi esasına dayanır. Alerjik hastalıkların tedavisinde, alerjenden korunma ve farmakoterapiden sonra gelir. İmmünoterapide klinik tablodan sorumlu, deri prik testi ya da spesifik immünglobulin E pozitifliği ile duyarlılığın gösterildiği alerjenler kullanılmalı ve tedavi alerji uzmanlarının yönetiminde yapılmalıdır. Çalışmalarda; immünoterapi ile astım bulgularında anlamlı iyileşme sağlandığı, hastalarda ilaç kullanımının azaldığı, rinitli hastalarda astım gelişimin önlendiği ve yeni duyarlanmaları azaltılabildiği gösterilmiştir. Önceki yıllarda sık görülen yan etkiler, standardize alerjen solüsyonlarının kullanıma girmesi ile azalmıştır. Ağır astımda kullanımı kontrendikedir, beta bloker ve anjiotensin konverting enzim AKE inhibitörü kullanımı olanlarda immünoterapiden kaçınılması önerilmekle birlikte mecbur kalınılan durumlarda fayda/zarar oranı dikkate alınarak başlanabileceği bildirilmektedir. En sık kullanılan subkütan ve sublingual yollar yanında, epikütan ve intralenfatik kullanım gibi yeni yöntemler geliştirilmektedir

Kaynakça

  • 1. Kılıçturgay K. İmmünolojinin gelişimi. In; İmmünoloji. K Kılıçturgay (ed). Güneş ve Nobel Tıp Kitabevleri, Bursa, pp2, 1997.
  • 2. Noon L. Prophylactic inoculation against hay fever. Lancet 1911;1:1572-3.
  • 3. Freeman J. Further observations on the treatment of hay fever by hypodermic inoculations of pollen vaccine. Lancet 1911;2:814- 7.
  • 4. Pajno GB, Caminiti L, Vita D, Barberio G, Salzano G, Lombardo F, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo￾controlled study. J Allergy Clin Immunol 2007;120:164-70.
  • 5. Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, et al. Allergen immunotherapy: A practice parameter third update. J Allergy Clın Immunol 2011;127:1-55.
  • 6. Cantani A, Arcese G, Lucenti P, Gagliesi D, Bartolucci M. A three-year prospective study of specific immunotherapy to inhalant allergens: evidence of safety and efficacy in 300 children with allergic asthma. J Investig Allergol Clin Immunol 1997;7:90-7.
  • 7. Metzger WJ, Turner E, Patterson R. The safety of immunotherapy during pregnancy. J Allergy Clin Immunol 1978;61:268-72.
  • 8. Rueff F, Przybilla B, Bilo MB, Müller U, Scheipl F, Aberer W, et al. Predictors of side effects during the build-up phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase. J Allergy Clin Immunol 2010;126:105-11.
  • 9. Haeberli G, Bronnimann M, Hunziker T, Muller U. Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy. Clin Exp Allergy 2003;33:1216-20.
  • 10. Robert E, Lenoir NC. Allergen immunotherapy: What can and cannot be mixed? J Allergy Clin Immunol 2008;122:659-60.
  • 11. Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev 2003;4:CD001186.
  • 12. Scadding GK, Brostoff J. Low dose sublingual therapy in patients with allergic rhinitis due to dust mite. Clin Allergy 1986;16:483- 91.
  • 13. Enrique E, Malek T, Pineda F, Palacios R, Bartra J, Tella R, et al. Sublingual immunotherapy for hazelnut food allergy: a follow￾up study. Ann Allergy Asthma Immunol 2008;100:283-4.
  • 14. de Boissieu D, Dupont C. Sublingual immunotherapy for cow’s milk protein allergy: a preliminary report. Allergy 2006;61:1238-9.
  • 15. Kerzl R, Simonowa A, Ring J, Ollert M, Mempel M. Life￾threatening anaphylaxis to kiwi fruit: protective sublingual allergen immunotherapy effect persists even after discontinuation. J Allergy Clin Immunol 2007;119:507-8.
  • 16. Bahçeciler NN, Özdemir C, Barlan I. Sublingual İmmünoterapi. Turkiye Klinikleri J Int Med Sci 2007;3:30-5.
  • 17. Werfel T. Epicutaneous allergen administration: a novel approach for allergen-specific immunotherapy? J Allergy Clin Immunol 2009;124:1003-4.
  • 18. Mondoulet L, Dioszeghy V, Vanoirbeek JA, Nemery B, Dupont C, Benhamou PH. Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int Arch Allergy Immunol 2010;154:299–309.
  • 19. Senti G, Graf N, Haug S, Rüedi N, von Moos S, Sonderegger T, et al. Epicutaneous allergen administration as a novelmethod of allergen-specific immunotherapy. J Allergy Clin Immunol 2009;124:997-1002.
  • 20. Mondoulet L, Dioszeghy V, Vanoirbeek JA, Nemery B, Dupont C, Benhamou PH. Epicutaneous Immunotherapy Using a New Epicutaneous Delivery System in Mice Sensitized to Peanuts. Int Arch Allergy Immunol 2011;154:299–309.
  • 21. Senti G, Prinz Vavricka BM, Erdmann I, Diaz MI, Markus R, McCormack SJ, et al. Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial. Proc Natl Acad Sci U S A 2008;105:17908-12.
  • 22. Martínez-Gómez JM, Johansen P, Erdmann I, Senti G, Crameri R, Kündig TM. Intralymphatic injections as a new administration route for allergen-specific immunotherapy. Int Arch Allergy Immunol 2009;150:59-65.
  • 23. Coop CA, Tankersley MS. Patient perceptions regarding local reactions from allergen immunotherapy injections. Ann Allergy Asthma Immunol 2008;101:96-100.
  • 24. Roy SR, Sigmon JR, Olivier J, Moffitt JE, Brown DA, Marshall GD. Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy. Ann Allergy Asthma Immunol 2007;99:82-6.
  • 25. Windom H, Lockey R. An update on the safety of specific immunotherapy. Curr Opin Allergy Clin Immunol 2008;8:571-6.
  • 26. Portnoy J, Bagstad K, Kanarek H, Pacheco F, Hall B, Barnes C. Premedication reduces the incidence of systemic reactions during inhalant rush immunotherapy with mixtures of allergenic extracts. Ann Allergy 1994;73:409-18.
  • 27. Stewart GE, Lockey RF. Systemic reactions from allergen immunotherapy. J Allergy Clin Immunol 1992;90:567-78.
  • 28. Amin HS, Liss GM, Bernstein DI. Evaluation of near-fatal reactions to allergen immunotherapy injections. J Allergy Clin Immunol 2006;117:169-75.
  • 29. Reid MJ, Lockey RF, Turkeltaub PC, Platts-Mills TA. Survey of fatalities from skin testing and immunotherapy 1985-1989. J Allergy Clin Immunol 1993;92:6-15.
  • 30. Lockey RF, Benedict LM, Turkeltaub PC, Bukantz SC. Fatalities from immunotherapy (IT) and skin testing (ST). J Allergy Clin Immunol 1987;79:660-77.
  • 31. Bernstein DI, Wanner M, Borish L, Liss GM. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990- 2001. J Allergy Clin Immunol 2004;113:1129-36.
  • 32. Rank MA, Oslie CL, Krogman JL, Park MA, Li JT. Allergen immunotherapy safety: characterizing systemic reactions and identifying risk factors. Allergy Asthma Proc 2008;29:400-5.
  • 33. Ohashi Y, Nakai Y, Murata K. Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis. Ann Allergy Asthma Immunol 2006;96:600-5.
  • 34. Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007;204:1837-47.
  • 35. Bilsborough J, Leung DY, Maurer M, Howell M, Boguniewicz M, Yao L, et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol 2006;117:418-25.
  • 36. Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol 2010;10:103-10.
  • 37. Akkoc T, de Koning PJ, Rückert B, Barlan I, Akdis M, Akdis CA. Increased activation-induced cell death of high IFNgamma- producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases. J Allergy Clin Immunol 2008;121:652-8.
  • 38. Meyer N, Zimmermann M, Bürgler S, Bassin C, Woehrl S, Moritz K, et al. IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol 2010;125:858-65.
  • 39. Solarewicz-Madejek K, Basinski TM, Crameri R, Akdis M, Akkaya A, Blaser K, et al. T cells and eosinophils in bronchial smooth muscle cell death in asthma. Clin Exp Allergy 2009;39:845-55.
  • 40. Zimmermann M, Koreck A, Meyer N, Basinski T, Meiler F, Simone B, et al. TNF-like weak inducer of apoptosis (TWEAK) and TNF-alpha cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol 2011;127:200-7.
  • 41. Akdis C, Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011;127:18-27.
  • 42. Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005;116:961- 9.
  • 43. Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 2000;106:75-81.
  • 44. Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27:20-1.
  • 45. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004;199:1567-75.
  • 46. Meiler F, Zumkehr J, Klunker S, Rückert B, Akdis CA, Akdis M. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008;205:2887-98.
  • 47. Anderson AE, Mackerness KJ, Aizen M, Carr VA, Nguyen D, Du Pre F, et al. Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25+ population. Clin Exp Allergy 2009;39:1693-9.
  • 48. Han D, Wang C, Lou W, Gu Y, Wang Y, Zhang L. Allergen￾specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis. Clin Immunol 2010;136:292-301.
  • 49. Schandene L, Alonso-Vega C, Willems F, Gérard C, Delvaux A, Velu T, et al. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. J Immunol 1994;152:4368-74.
  • 50. Rak S, Hakanson L, Venge P. Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activity during pollen season. J Allergy Clin Immunol 1990;86:706-13.
  • 51. Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10- producing B cells. J Exp Med 2003;197:489-501.
  • 52. Ito S, Ansari P, Sakatsume M, Dickensheets H, Vazquez N, Donnelly RP, et al. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 1999;93:1456-63.
  • 53. Fujimoto M. Regulatory B cells in skin and connective tissue diseases. J Dermatol Sci 2010;60:1-7.
  • 54. Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117:530-41.
  • 55. Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007;37:3021-9.
  • 56. Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, et al. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 2010;11:1093-101.
  • 57. Saçkesen C. Allerjen immünoterapisinde yenilikler. Turkiye klinikleri j ınt med sci. 2007;3:45-8.
  • 58. Karamloo F, Schmid-Grendelmeier P, Kussebi F, Akdis M, Salagianni M, von Beust BR, et al. Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. Eur J Immunol 2005;35:3268-76.
  • 59. Focke M, Mahler V, Ball T, Sperr WR, Majlesi Y, Valent P, et al. Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination. FASEB J 2001;15:2042-4.
  • 60. Westritschnig K, Focke M, Verdino P, Goessler W, Keller W, Twardosz A, et al. Generation of an allergy vaccine by disruption of the three-dimensional structure of the cross-reactive calcium￾binding allergen. J Immunol 2004;172:5684-92.
  • 61. Crameri R, Rhyner C. Novel vaccines and adjuvants for allergen￾specific immunotherapy. Curr Opin Immunol 2006;18:761-8.
  • 62. Drachenberg KJ, Wheeler AW, Stuebner P, Horak F. A well￾tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy 2001;56:498-505.
  • 63. Roth-Walter F, Schöll I, Untersmayr E, Ellinger A, Boltz￾Nitulescu G, Scheiner O, et al. Mucosal targeting of allergenloaded microspheres by Aleuria aurantia lectin. Vaccine 2005;23:2703-10.
  • 64. Kündig TM, Senti G, Schnetzler G, Wolf C, Prinz Vavricka BM, Fulurija A, et al. Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults. J Allergy Clin Immunol 2006;117:1470-6.
  • 65. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nature Rev 2006;6:761- 71.
  • 66. Li XM, Srivastava K, Grishin A, Huang CK, Schofield B, Burks W, et al. Persistent protective effect of heat-killed Escherichia coli producing ‘engineered,’ recombinant peanut proteins in a murine model of peanut allergy. J Allergy Clin Immunol 2003;112:159- 67.
  • 67. Chua KY, Kuo IC, Huang CH. DNA vaccines for the prevention and treatment of allergy. Current opinion in allergy and clinical immunology 2009;9:50-4

Allergen Specific Immunotherapy

Yıl 2015, Cilt: 13 Sayı: 1, 46 - 55, 01.06.2015
https://doi.org/10.4274/jcp.02419

Öz

Allergen specific immunotherapy SIT is the only treatment that can provide a cure for allergic disorders. This treatment is based on development of immune tolerance by exposure to allergen in repetitive and increasing doses. It is tertiary to avoidance of allergen and pharmacotherapy. Allergens used for immunotherapy, must be confirmed by skin prick test or specific IgE and must be applied in supervision of allergy specialists. Studies show that immunotherapy, improve asthma symptoms, decreases drug consumption, prevent development of asthma in rhinitis patients and reduce new sensitizations. Common side effects diminished with the usage of standardized allergen solutions. It is contraindicated in severe asthma. Though it is recommended to avoid immunotherapy in patients using beta blockers and ACE inhibitors, immunotherapy can be considered in mandatory situations regarding possible benefits and harms. Most common ways of administration are subcutaneous and sublingual; new methods such as epicutaneous and intralymphatic injections are currently being studied

Kaynakça

  • 1. Kılıçturgay K. İmmünolojinin gelişimi. In; İmmünoloji. K Kılıçturgay (ed). Güneş ve Nobel Tıp Kitabevleri, Bursa, pp2, 1997.
  • 2. Noon L. Prophylactic inoculation against hay fever. Lancet 1911;1:1572-3.
  • 3. Freeman J. Further observations on the treatment of hay fever by hypodermic inoculations of pollen vaccine. Lancet 1911;2:814- 7.
  • 4. Pajno GB, Caminiti L, Vita D, Barberio G, Salzano G, Lombardo F, et al. Sublingual immunotherapy in mite-sensitized children with atopic dermatitis: a randomized, double-blind, placebo￾controlled study. J Allergy Clin Immunol 2007;120:164-70.
  • 5. Cox L, Nelson H, Lockey R, Calabria C, Chacko T, Finegold I, et al. Allergen immunotherapy: A practice parameter third update. J Allergy Clın Immunol 2011;127:1-55.
  • 6. Cantani A, Arcese G, Lucenti P, Gagliesi D, Bartolucci M. A three-year prospective study of specific immunotherapy to inhalant allergens: evidence of safety and efficacy in 300 children with allergic asthma. J Investig Allergol Clin Immunol 1997;7:90-7.
  • 7. Metzger WJ, Turner E, Patterson R. The safety of immunotherapy during pregnancy. J Allergy Clin Immunol 1978;61:268-72.
  • 8. Rueff F, Przybilla B, Bilo MB, Müller U, Scheipl F, Aberer W, et al. Predictors of side effects during the build-up phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase. J Allergy Clin Immunol 2010;126:105-11.
  • 9. Haeberli G, Bronnimann M, Hunziker T, Muller U. Elevated basal serum tryptase and hymenoptera venom allergy: relation to severity of sting reactions and to safety and efficacy of venom immunotherapy. Clin Exp Allergy 2003;33:1216-20.
  • 10. Robert E, Lenoir NC. Allergen immunotherapy: What can and cannot be mixed? J Allergy Clin Immunol 2008;122:659-60.
  • 11. Abramson MJ, Puy RM, Weiner JM. Allergen immunotherapy for asthma. Cochrane Database Syst Rev 2003;4:CD001186.
  • 12. Scadding GK, Brostoff J. Low dose sublingual therapy in patients with allergic rhinitis due to dust mite. Clin Allergy 1986;16:483- 91.
  • 13. Enrique E, Malek T, Pineda F, Palacios R, Bartra J, Tella R, et al. Sublingual immunotherapy for hazelnut food allergy: a follow￾up study. Ann Allergy Asthma Immunol 2008;100:283-4.
  • 14. de Boissieu D, Dupont C. Sublingual immunotherapy for cow’s milk protein allergy: a preliminary report. Allergy 2006;61:1238-9.
  • 15. Kerzl R, Simonowa A, Ring J, Ollert M, Mempel M. Life￾threatening anaphylaxis to kiwi fruit: protective sublingual allergen immunotherapy effect persists even after discontinuation. J Allergy Clin Immunol 2007;119:507-8.
  • 16. Bahçeciler NN, Özdemir C, Barlan I. Sublingual İmmünoterapi. Turkiye Klinikleri J Int Med Sci 2007;3:30-5.
  • 17. Werfel T. Epicutaneous allergen administration: a novel approach for allergen-specific immunotherapy? J Allergy Clin Immunol 2009;124:1003-4.
  • 18. Mondoulet L, Dioszeghy V, Vanoirbeek JA, Nemery B, Dupont C, Benhamou PH. Epicutaneous immunotherapy using a new epicutaneous delivery system in mice sensitized to peanuts. Int Arch Allergy Immunol 2010;154:299–309.
  • 19. Senti G, Graf N, Haug S, Rüedi N, von Moos S, Sonderegger T, et al. Epicutaneous allergen administration as a novelmethod of allergen-specific immunotherapy. J Allergy Clin Immunol 2009;124:997-1002.
  • 20. Mondoulet L, Dioszeghy V, Vanoirbeek JA, Nemery B, Dupont C, Benhamou PH. Epicutaneous Immunotherapy Using a New Epicutaneous Delivery System in Mice Sensitized to Peanuts. Int Arch Allergy Immunol 2011;154:299–309.
  • 21. Senti G, Prinz Vavricka BM, Erdmann I, Diaz MI, Markus R, McCormack SJ, et al. Intralymphatic allergen administration renders specific immunotherapy faster and safer: a randomized controlled trial. Proc Natl Acad Sci U S A 2008;105:17908-12.
  • 22. Martínez-Gómez JM, Johansen P, Erdmann I, Senti G, Crameri R, Kündig TM. Intralymphatic injections as a new administration route for allergen-specific immunotherapy. Int Arch Allergy Immunol 2009;150:59-65.
  • 23. Coop CA, Tankersley MS. Patient perceptions regarding local reactions from allergen immunotherapy injections. Ann Allergy Asthma Immunol 2008;101:96-100.
  • 24. Roy SR, Sigmon JR, Olivier J, Moffitt JE, Brown DA, Marshall GD. Increased frequency of large local reactions among systemic reactors during subcutaneous allergen immunotherapy. Ann Allergy Asthma Immunol 2007;99:82-6.
  • 25. Windom H, Lockey R. An update on the safety of specific immunotherapy. Curr Opin Allergy Clin Immunol 2008;8:571-6.
  • 26. Portnoy J, Bagstad K, Kanarek H, Pacheco F, Hall B, Barnes C. Premedication reduces the incidence of systemic reactions during inhalant rush immunotherapy with mixtures of allergenic extracts. Ann Allergy 1994;73:409-18.
  • 27. Stewart GE, Lockey RF. Systemic reactions from allergen immunotherapy. J Allergy Clin Immunol 1992;90:567-78.
  • 28. Amin HS, Liss GM, Bernstein DI. Evaluation of near-fatal reactions to allergen immunotherapy injections. J Allergy Clin Immunol 2006;117:169-75.
  • 29. Reid MJ, Lockey RF, Turkeltaub PC, Platts-Mills TA. Survey of fatalities from skin testing and immunotherapy 1985-1989. J Allergy Clin Immunol 1993;92:6-15.
  • 30. Lockey RF, Benedict LM, Turkeltaub PC, Bukantz SC. Fatalities from immunotherapy (IT) and skin testing (ST). J Allergy Clin Immunol 1987;79:660-77.
  • 31. Bernstein DI, Wanner M, Borish L, Liss GM. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990- 2001. J Allergy Clin Immunol 2004;113:1129-36.
  • 32. Rank MA, Oslie CL, Krogman JL, Park MA, Li JT. Allergen immunotherapy safety: characterizing systemic reactions and identifying risk factors. Allergy Asthma Proc 2008;29:400-5.
  • 33. Ohashi Y, Nakai Y, Murata K. Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis. Ann Allergy Asthma Immunol 2006;96:600-5.
  • 34. Wang YH, Angkasekwinai P, Lu N, Voo KS, Arima K, Hanabuchi S, et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 2007;204:1837-47.
  • 35. Bilsborough J, Leung DY, Maurer M, Howell M, Boguniewicz M, Yao L, et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol 2006;117:418-25.
  • 36. Liew FY, Pitman NI, McInnes IB. Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat Rev Immunol 2010;10:103-10.
  • 37. Akkoc T, de Koning PJ, Rückert B, Barlan I, Akdis M, Akdis CA. Increased activation-induced cell death of high IFNgamma- producing T(H)1 cells as a mechanism of T(H)2 predominance in atopic diseases. J Allergy Clin Immunol 2008;121:652-8.
  • 38. Meyer N, Zimmermann M, Bürgler S, Bassin C, Woehrl S, Moritz K, et al. IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol 2010;125:858-65.
  • 39. Solarewicz-Madejek K, Basinski TM, Crameri R, Akdis M, Akkaya A, Blaser K, et al. T cells and eosinophils in bronchial smooth muscle cell death in asthma. Clin Exp Allergy 2009;39:845-55.
  • 40. Zimmermann M, Koreck A, Meyer N, Basinski T, Meiler F, Simone B, et al. TNF-like weak inducer of apoptosis (TWEAK) and TNF-alpha cooperate in the induction of keratinocyte apoptosis. J Allergy Clin Immunol 2011;127:200-7.
  • 41. Akdis C, Akdis M. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol 2011;127:18-27.
  • 42. Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. J Allergy Clin Immunol 2005;116:961- 9.
  • 43. Chatila TA, Blaeser F, Ho N, Lederman HM, Voulgaropoulos C, Helms C, et al. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome. J Clin Invest 2000;106:75-81.
  • 44. Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, Whitesell L, et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet. 2001;27:20-1.
  • 45. Akdis M, Verhagen J, Taylor A, Karamloo F, Karagiannidis C, Crameri R, et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004;199:1567-75.
  • 46. Meiler F, Zumkehr J, Klunker S, Rückert B, Akdis CA, Akdis M. In vivo switch to IL-10-secreting T regulatory cells in high dose allergen exposure. J Exp Med 2008;205:2887-98.
  • 47. Anderson AE, Mackerness KJ, Aizen M, Carr VA, Nguyen D, Du Pre F, et al. Seasonal changes in suppressive capacity of CD4+ CD25+ T cells from patients with hayfever are allergen-specific and may result in part from expansion of effector T cells among the CD25+ population. Clin Exp Allergy 2009;39:1693-9.
  • 48. Han D, Wang C, Lou W, Gu Y, Wang Y, Zhang L. Allergen￾specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis. Clin Immunol 2010;136:292-301.
  • 49. Schandene L, Alonso-Vega C, Willems F, Gérard C, Delvaux A, Velu T, et al. B7/CD28-dependent IL-5 production by human resting T cells is inhibited by IL-10. J Immunol 1994;152:4368-74.
  • 50. Rak S, Hakanson L, Venge P. Immunotherapy abrogates the generation of eosinophil and neutrophil chemotactic activity during pollen season. J Allergy Clin Immunol 1990;86:706-13.
  • 51. Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10- producing B cells. J Exp Med 2003;197:489-501.
  • 52. Ito S, Ansari P, Sakatsume M, Dickensheets H, Vazquez N, Donnelly RP, et al. Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1. Blood 1999;93:1456-63.
  • 53. Fujimoto M. Regulatory B cells in skin and connective tissue diseases. J Dermatol Sci 2010;60:1-7.
  • 54. Iwata Y, Matsushita T, Horikawa M, Dilillo DJ, Yanaba K, Venturi GM, et al. Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. Blood 2011;117:530-41.
  • 55. Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells. Eur J Immunol 2007;37:3021-9.
  • 56. Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, et al. IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol 2010;11:1093-101.
  • 57. Saçkesen C. Allerjen immünoterapisinde yenilikler. Turkiye klinikleri j ınt med sci. 2007;3:45-8.
  • 58. Karamloo F, Schmid-Grendelmeier P, Kussebi F, Akdis M, Salagianni M, von Beust BR, et al. Prevention of allergy by a recombinant multi-allergen vaccine with reduced IgE binding and preserved T cell epitopes. Eur J Immunol 2005;35:3268-76.
  • 59. Focke M, Mahler V, Ball T, Sperr WR, Majlesi Y, Valent P, et al. Nonanaphylactic synthetic peptides derived from B cell epitopes of the major grass pollen allergen, Phl p 1, for allergy vaccination. FASEB J 2001;15:2042-4.
  • 60. Westritschnig K, Focke M, Verdino P, Goessler W, Keller W, Twardosz A, et al. Generation of an allergy vaccine by disruption of the three-dimensional structure of the cross-reactive calcium￾binding allergen. J Immunol 2004;172:5684-92.
  • 61. Crameri R, Rhyner C. Novel vaccines and adjuvants for allergen￾specific immunotherapy. Curr Opin Immunol 2006;18:761-8.
  • 62. Drachenberg KJ, Wheeler AW, Stuebner P, Horak F. A well￾tolerated grass pollen-specific allergy vaccine containing a novel adjuvant, monophosphoryl lipid A, reduces allergic symptoms after only four preseasonal injections. Allergy 2001;56:498-505.
  • 63. Roth-Walter F, Schöll I, Untersmayr E, Ellinger A, Boltz￾Nitulescu G, Scheiner O, et al. Mucosal targeting of allergenloaded microspheres by Aleuria aurantia lectin. Vaccine 2005;23:2703-10.
  • 64. Kündig TM, Senti G, Schnetzler G, Wolf C, Prinz Vavricka BM, Fulurija A, et al. Der p 1 peptide on virus-like particles is safe and highly immunogenic in healthy adults. J Allergy Clin Immunol 2006;117:1470-6.
  • 65. Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nature Rev 2006;6:761- 71.
  • 66. Li XM, Srivastava K, Grishin A, Huang CK, Schofield B, Burks W, et al. Persistent protective effect of heat-killed Escherichia coli producing ‘engineered,’ recombinant peanut proteins in a murine model of peanut allergy. J Allergy Clin Immunol 2003;112:159- 67.
  • 67. Chua KY, Kuo IC, Huang CH. DNA vaccines for the prevention and treatment of allergy. Current opinion in allergy and clinical immunology 2009;9:50-4
Toplam 67 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Collection
Yazarlar

Şükrü Çekiç

Nihat Sapan Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 13 Sayı: 1

Kaynak Göster

APA Çekiç, Ş., & Sapan, N. (2015). Alerjen Spesifik İmmünoterapi. Güncel Pediatri, 13(1), 46-55. https://doi.org/10.4274/jcp.02419
AMA Çekiç Ş, Sapan N. Alerjen Spesifik İmmünoterapi. Güncel Pediatri. Haziran 2015;13(1):46-55. doi:10.4274/jcp.02419
Chicago Çekiç, Şükrü, ve Nihat Sapan. “Alerjen Spesifik İmmünoterapi”. Güncel Pediatri 13, sy. 1 (Haziran 2015): 46-55. https://doi.org/10.4274/jcp.02419.
EndNote Çekiç Ş, Sapan N (01 Haziran 2015) Alerjen Spesifik İmmünoterapi. Güncel Pediatri 13 1 46–55.
IEEE Ş. Çekiç ve N. Sapan, “Alerjen Spesifik İmmünoterapi”, Güncel Pediatri, c. 13, sy. 1, ss. 46–55, 2015, doi: 10.4274/jcp.02419.
ISNAD Çekiç, Şükrü - Sapan, Nihat. “Alerjen Spesifik İmmünoterapi”. Güncel Pediatri 13/1 (Haziran 2015), 46-55. https://doi.org/10.4274/jcp.02419.
JAMA Çekiç Ş, Sapan N. Alerjen Spesifik İmmünoterapi. Güncel Pediatri. 2015;13:46–55.
MLA Çekiç, Şükrü ve Nihat Sapan. “Alerjen Spesifik İmmünoterapi”. Güncel Pediatri, c. 13, sy. 1, 2015, ss. 46-55, doi:10.4274/jcp.02419.
Vancouver Çekiç Ş, Sapan N. Alerjen Spesifik İmmünoterapi. Güncel Pediatri. 2015;13(1):46-55.