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Yıl 2022, Cilt: 2 Sayı: 4, 125 - 129, 14.10.2022

Öz

Kaynakça

  • Purnell JQ. Definitions, Classification, and Epidemiology of Obesity. 2018 Apr 12. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, Dungan K, Hershman JM, Hofland J, Kalra S, Kaltsas G, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Morley JE, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.
  • Chobot A, Górowska-Kowolik K, Sokołowska M, Jarosz-Chobot P. Obesity and diabetes-Not only a simple link between two epidemics. Diabetes Metab Res Rev 2018;34(7):e3042.
  • International Diabetes Federation: IDF Diabetes Atlas, t. e. B., Belgium: International Diabetes Federation, 2013.
  • Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N, Karsidag K, Genc S, Telci A, Canbaz B, Turker F, Yilmaz T, Cakir B, Tuomilehto J; TURDEP-II Study Group. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28(2):169-80.
  • https://dosyamerkez.saglik.gov.tr/Eklenti/27344.
  • Blaslov K, Naranđa FS, Kruljac I, Renar IP. Treatment approach to type 2 diabetes: Past, present and future. World J Diabetes 2018;9(12):209-219.
  • Krhač M, Lovrenčić MV. Update on biomarkers of glycemic control. World J Diabetes 2019;10(1):1-15.
  • Herder C, Baumert J, Zierer A, Roden M, Meisinger C, Karakas M, Chambless L, Rathmann W, Peters A, Koenig W, Thorand B. Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study. PLoS One 2011;6(6):e19852.
  • Jiang Y, Owei I, Wan J, Ebenibo S, Dagogo-Jack S. Adiponectin levels predict prediabetes risk: the Pathobiology of Prediabetes in A Biracial Cohort (POP-ABC) study. BMJ Open Diabetes Res Care 2016 ;4(1):e000194.
  • Lai H, Lin N, Xing Z, Weng H, Zhang H. Association between the level of circulating adiponectin and prediabetes: A meta-analysis. J Diabetes Investig 2015;6(4):416-29.
  • Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2009;302(2):179-88.
  • Lindberg S, Mogelvang R, Pedersen SH, Bjerre M, Frystyk J, Flyvbjerg A, Galatius S, Jensen JS. Relation of serum adiponectin levels to number of traditional atherosclerotic risk factors and all-cause mortality and major adverse cardiovascular events (from the Copenhagen City Heart Study). Am J Cardiol. 2013 Apr 15;111(8):1139-45.
  • Polyzos SA, Anastasilakis AD, Efstathiadou ZA, Makras P, Perakakis N, Kountouras J, Mantzoros CS. Irisin in metabolic diseases. Endocrine 2018;59(2):260-274.
  • Ishtiaq SM, Rashid H, Hussain Z, Arshad MI, Khan JA. Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease. Rev Endocr Metab Disord 2019; 20(3):253-261.
  • Trefts E, Shaw RJ. AMPK: restoring metabolic homeostasis over space and time. Mol Cell 2021;81(18):3677-3690.
  • Esmaili S, Hemmati M, Karamian M. Physiological role of adiponectin in different tissues: a review. Arch Physiol Biochem 2020;126(1):67-73.

Type II DM candidate biomarkers in the Framework of Obesity, Exercise, and Diet

Yıl 2022, Cilt: 2 Sayı: 4, 125 - 129, 14.10.2022

Öz

Biomarkers used in the early diagnosis and treatment of prediabetes and diabetes, which are based on obesity and metabolic syndrome, are inadequate due to the complexity of the etiology of diabetes, and studies for developing new biomarkers for diabetes and/or determining an early diagnosis biomarker are ongoing in the scientific world.
Since obesity can be prevented to a certain extent by long-term diet and exercise, it can be considered that long-term and periodic investigation of a group of cytokines related to exercise and body fat mass may be meaningful. For example, the cytokines irisin (a myokine released from muscle by exercise) and adiponectin (adipokine, an indicator of decreased body fat mass have similar effects in terms of antiobesity and antidiabetic effects. Therefore, high levels of adiponectin and irisin can be considered in diabetic patients, and delayed micro and macrovascular complications of diabetes due to obesity and metabolic syndrome can be considered. On the other hand, adiponectin levels are low in diabetes and obesity, and these patients generally have low irisin levels due to being sedentary. It is a common belief that for overweight individuals, other than morbid obese people, and prediabetic and diabetic individuals, candidate biomarker (s) from cytokines to monitor the effectiveness of diet and exercise can generally be detected.
It is known that adipokines are involved in the pathogenesis of obesity and Type 2 diabetes mellitus together with pro-inflammatory cytokines and can be used as prognostic markers and may be involved in the therapeutic approaches to obesity-related Type 2 DM. During the long-term latent course of diabetes at the prediabetic stage, it is important to identify an early diagnostic biomarker.

Kaynakça

  • Purnell JQ. Definitions, Classification, and Epidemiology of Obesity. 2018 Apr 12. In: Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dhatariya K, Dungan K, Hershman JM, Hofland J, Kalra S, Kaltsas G, Koch C, Kopp P, Korbonits M, Kovacs CS, Kuohung W, Laferrère B, Levy M, McGee EA, McLachlan R, Morley JE, New M, Purnell J, Sahay R, Singer F, Sperling MA, Stratakis CA, Trence DL, Wilson DP, editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000–.
  • Chobot A, Górowska-Kowolik K, Sokołowska M, Jarosz-Chobot P. Obesity and diabetes-Not only a simple link between two epidemics. Diabetes Metab Res Rev 2018;34(7):e3042.
  • International Diabetes Federation: IDF Diabetes Atlas, t. e. B., Belgium: International Diabetes Federation, 2013.
  • Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N, Karsidag K, Genc S, Telci A, Canbaz B, Turker F, Yilmaz T, Cakir B, Tuomilehto J; TURDEP-II Study Group. Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28(2):169-80.
  • https://dosyamerkez.saglik.gov.tr/Eklenti/27344.
  • Blaslov K, Naranđa FS, Kruljac I, Renar IP. Treatment approach to type 2 diabetes: Past, present and future. World J Diabetes 2018;9(12):209-219.
  • Krhač M, Lovrenčić MV. Update on biomarkers of glycemic control. World J Diabetes 2019;10(1):1-15.
  • Herder C, Baumert J, Zierer A, Roden M, Meisinger C, Karakas M, Chambless L, Rathmann W, Peters A, Koenig W, Thorand B. Immunological and cardiometabolic risk factors in the prediction of type 2 diabetes and coronary events: MONICA/KORA Augsburg case-cohort study. PLoS One 2011;6(6):e19852.
  • Jiang Y, Owei I, Wan J, Ebenibo S, Dagogo-Jack S. Adiponectin levels predict prediabetes risk: the Pathobiology of Prediabetes in A Biracial Cohort (POP-ABC) study. BMJ Open Diabetes Res Care 2016 ;4(1):e000194.
  • Lai H, Lin N, Xing Z, Weng H, Zhang H. Association between the level of circulating adiponectin and prediabetes: A meta-analysis. J Diabetes Investig 2015;6(4):416-29.
  • Li S, Shin HJ, Ding EL, van Dam RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2009;302(2):179-88.
  • Lindberg S, Mogelvang R, Pedersen SH, Bjerre M, Frystyk J, Flyvbjerg A, Galatius S, Jensen JS. Relation of serum adiponectin levels to number of traditional atherosclerotic risk factors and all-cause mortality and major adverse cardiovascular events (from the Copenhagen City Heart Study). Am J Cardiol. 2013 Apr 15;111(8):1139-45.
  • Polyzos SA, Anastasilakis AD, Efstathiadou ZA, Makras P, Perakakis N, Kountouras J, Mantzoros CS. Irisin in metabolic diseases. Endocrine 2018;59(2):260-274.
  • Ishtiaq SM, Rashid H, Hussain Z, Arshad MI, Khan JA. Adiponectin and PPAR: a setup for intricate crosstalk between obesity and non-alcoholic fatty liver disease. Rev Endocr Metab Disord 2019; 20(3):253-261.
  • Trefts E, Shaw RJ. AMPK: restoring metabolic homeostasis over space and time. Mol Cell 2021;81(18):3677-3690.
  • Esmaili S, Hemmati M, Karamian M. Physiological role of adiponectin in different tissues: a review. Arch Physiol Biochem 2020;126(1):67-73.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık ve İlaç Bilimleri
Bölüm Reviews
Yazarlar

Nurcan Kılıç Baygutalp 0000-0002-3584-5252

Yayımlanma Tarihi 14 Ekim 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 2 Sayı: 4

Kaynak Göster

EndNote Kılıç Baygutalp N (01 Ekim 2022) Type II DM candidate biomarkers in the Framework of Obesity, Exercise, and Diet. International Journal of PharmATA 2 4 125–129.