Derleme
BibTex RIS Kaynak Göster

Salivary Gland Cancers in Children and Adolescents

Yıl 2020, Ağız Kanserleri Özel Sayısı, 265 - 270, 28.09.2020
https://doi.org/10.20515/otd.771452

Öz

Aim: This report aimed to present up-to-date information about early symptoms, intraoral findings and treatment options for salivary gland tumours in children.
Materials-Methods: The key words "salivary gland", "malignancy" and "children" were searched by using the search engines PUBMED AND GOOGLE SCHOLAR. The titles and summaries of the literatures were evaluated, the suitable ones were included and analysed.
Results: In children, the most common benign salivary gland tumour is pleomorphic adenoma and the most common malignant tumour is mucoepidermoid carcinoma. In benign tumours, the symptom could be only swelling, while in malignant ones’ pain and paralysis can be involved. While the parotid gland tumours can cause the facial nerve paralysis, the submandibular and sublingual gland tumours can affect alveolar, lingual and hypoglossal nerves. Treatment of salivary gland neoplasms is the surgical treatment in children same as in adult patients. In addition to surgical removal, postoperative radiotherapy and chemotherapy may be required. Asymmetrical face growth, dental problems, trismus and osteoradionecrosis can be observed after radiation therapy, so radiation therapy option should be carefully evaluated especially in children and adolescents. The prognosis of salivary gland cancers in children and adolescents is quite good. The 5-year and 10-year survival rate differ from 80% to 100%. The recurrence rate is very low.
Conclusions: Although the incidence of salivary gland tumours in children is considerably lower than in adults, it is important that malignant salivary gland tumours are more common in children.

Kaynakça

  • Erdoğan N, Karaça G. Tükürük bezleri.Trd Sem. 2018; 6(3): 462-482.
  • Ord RA, Carlson ER. Pediatric salivary gland malignancies. Oral Maxillofac Surg Clin. 2016;28(1):83-9.
  • Sultan I, Rodriguez-Galindo C, Al-Sharabati S. Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases. Head Neck. 2011;33(10):1476-81.
  • Kupferman ME, de la Garza GO, Santillan AA. Outcomes of pediatric patients with malignancies of the major salivary glands. Ann Surg Oncol. 2010;17(12):3301-7.
  • Guzzo M, Ferrari A, Marcon I. Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer. 2006;47(6):806-10.
  • Venkateswaran L, Gan Yj, Sixbey JW. Epstein–Barr virus infection in salivary gland tumors in children and young adults. Cancer. 2000;89(2):463-6.
  • Yoshida EJ, Garcia J, Eisele DW. Salivary gland malignancies in children. Int J Pediatr Otorhinolaryngol. 2014;78(2):174-8.
  • Védrine PO, Coffinet L, Team S. Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 second malignant neoplasms. Head Neck. 2006;28(9):827-33.
  • Dulguerov P, Quinodoz D, Cosendai G. Prevention of Frey syndrome during parotidectomy. Arch Otolaryngol Head Neck Surg. 1999;125(8):833-9.
  • Wang X, Luo Y, Li M. Management of salivary gland carcinomas - a review. Oncotarget. 2017;8(3):3946-56.
  • Radomski S, Dermody S, Harley EH, Jr. Clinical characteristics and outcomes of major salivary gland malignancies in children. Laryngoscope. 2018;128(5):1126-32.
  • To VSH, Chan JYW, Tsang RK. Review of salivary gland neoplasms. ISRN Otolaryngol. 2012 Feb 16. doi: 10.5402/2012/872982.
  • Liu Y, Li J, Tan YR. Accuracy of diagnosis of salivary gland tumors with the use of ultrasonography, computed tomography, and magnetic resonance imaging: a meta-analysis. Oral surg, Oral Med, Oral Pathol Oral Radiol. 2015;119(2):238-45.e2.
  • Rebours C, Couloigner V, Galmiche L. Pediatric salivary gland carcinomas: Diagnostic and therapeutic management. Laryngoscope. 2017;127(1):140-7.
  • Ribeiro Kde C, Kowalski LP, Saba LM. Epithelial salivary glands neoplasms in children and adolescents: a forty-four-year experience. Med and Pediatr Oncol. 2002;39(6):594-600.
  • Baker SR, Malone B. Salivary gland malignancies in children. Cancer. 1985;55(8):1730-6.
  • Deveci H, Çankal DAU. Ağız kanserleri ve diş hekimlerinin rolü. Ortadoğu Tıp Derg. 2019;11(1):78-84.
  • Wani V, Kulkarni A, Pustake B. Prevalence, complications and dental management of the oral cancer in the pediatric patients. J Cancer Res Ther. 2018;14(6):1407-11
  • Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leuk res. 2003;27(1):45-50.
  • Avsar A, Elli M, Darka O. Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral surg, oral med, oral pathol, oral radiol, and endod. 2007;104(6):781-9.
  • Kılınç G, Bulut G, Olgun N, et al. Kanser tedavisi gören çocuklarda tedavinin diş gelişimine olan geç yan Eekileri (Dört olgu sunumu). Atatürk Üniv Diş Hek Fak Derg.2013;23(7):48-54.

Çocuk ve Gençlerde Tükürük Bezi Kanserleri

Yıl 2020, Ağız Kanserleri Özel Sayısı, 265 - 270, 28.09.2020
https://doi.org/10.20515/otd.771452

Öz

Bu derlemeyle, çocuklarda tükürük bezi tümörlerine ait erken belirtiler, ağız içi bulgular ve tedavi seçenekleri ile ilgili güncel bilgilerin verilmesi amaçlanmıştır. Pubmed ve Google Scholar arama motorlarında “tükürük bezi”, “malignite” ve “çocuk” kelimeleri aratıldı. Literatürlerin başlık ve özetleri değerlendirildi, uygun olanlar seçilerek analiz edildi. Çocuklarda en sık görülen benign tükürük bezi tümörü pleomorfik adenom iken, en sık görülen malign tümör ise mukoepidermoid karsinomdur. Benign tümörlerde belirti sadece şişlik olabilirken, malign olanlarda şişlikle birlikte ağrı ve sinir paralizi de görülebilmektedir. Parotis bezi tümörlerinde fasiyal sinirde, submandibular ve sublingual bezlerin tümörlerinde alveolar, lingual ve hipoglossal sinirlerde paraliz olabilmektedir. Tükürük bezi neoplazmalarının tedavisi yetişkinlerde olduğu gibi çocuklarda da cerrahi tedavidir. Bunlara ek olarak postoperatif radyoterapi ve kemoterapi de gerekli olabilir. Hastalarda radyoterapi sonrası yüzde asimetrik büyüme, dental problemler, trismus ve osteoradyonekroz görülebilmektedir, bu nedenle özellikle çocuk ve genç hastalarda radyoterapi seçeneği dikkatlice değerlendirilmelidir. Çocuk ve gençlerde tükürük bezi kanserlerinin prognozu oldukça iyidir. 5 yıllık ve 10 yıllık hayatta kalma oranı farklı çalışmalarda %80 ile %100 olarak gösterilmiştir. Nüks olasılığı ise oldukça düşüktür. Tükürük bezi tümörlerinin çocuk hastalarda görülme sıklığı yetişkinlere oranla oldukça düşük olmasına rağmen, malignite oranının çocuk ve gençlerde yetişkinlere kıyasla daha yüksek görülmesi nedeniyle önemlidir.

Kaynakça

  • Erdoğan N, Karaça G. Tükürük bezleri.Trd Sem. 2018; 6(3): 462-482.
  • Ord RA, Carlson ER. Pediatric salivary gland malignancies. Oral Maxillofac Surg Clin. 2016;28(1):83-9.
  • Sultan I, Rodriguez-Galindo C, Al-Sharabati S. Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases. Head Neck. 2011;33(10):1476-81.
  • Kupferman ME, de la Garza GO, Santillan AA. Outcomes of pediatric patients with malignancies of the major salivary glands. Ann Surg Oncol. 2010;17(12):3301-7.
  • Guzzo M, Ferrari A, Marcon I. Salivary gland neoplasms in children: the experience of the Istituto Nazionale Tumori of Milan. Pediatr Blood Cancer. 2006;47(6):806-10.
  • Venkateswaran L, Gan Yj, Sixbey JW. Epstein–Barr virus infection in salivary gland tumors in children and young adults. Cancer. 2000;89(2):463-6.
  • Yoshida EJ, Garcia J, Eisele DW. Salivary gland malignancies in children. Int J Pediatr Otorhinolaryngol. 2014;78(2):174-8.
  • Védrine PO, Coffinet L, Team S. Mucoepidermoid carcinoma of salivary glands in the pediatric age group: 18 clinical cases, including 11 second malignant neoplasms. Head Neck. 2006;28(9):827-33.
  • Dulguerov P, Quinodoz D, Cosendai G. Prevention of Frey syndrome during parotidectomy. Arch Otolaryngol Head Neck Surg. 1999;125(8):833-9.
  • Wang X, Luo Y, Li M. Management of salivary gland carcinomas - a review. Oncotarget. 2017;8(3):3946-56.
  • Radomski S, Dermody S, Harley EH, Jr. Clinical characteristics and outcomes of major salivary gland malignancies in children. Laryngoscope. 2018;128(5):1126-32.
  • To VSH, Chan JYW, Tsang RK. Review of salivary gland neoplasms. ISRN Otolaryngol. 2012 Feb 16. doi: 10.5402/2012/872982.
  • Liu Y, Li J, Tan YR. Accuracy of diagnosis of salivary gland tumors with the use of ultrasonography, computed tomography, and magnetic resonance imaging: a meta-analysis. Oral surg, Oral Med, Oral Pathol Oral Radiol. 2015;119(2):238-45.e2.
  • Rebours C, Couloigner V, Galmiche L. Pediatric salivary gland carcinomas: Diagnostic and therapeutic management. Laryngoscope. 2017;127(1):140-7.
  • Ribeiro Kde C, Kowalski LP, Saba LM. Epithelial salivary glands neoplasms in children and adolescents: a forty-four-year experience. Med and Pediatr Oncol. 2002;39(6):594-600.
  • Baker SR, Malone B. Salivary gland malignancies in children. Cancer. 1985;55(8):1730-6.
  • Deveci H, Çankal DAU. Ağız kanserleri ve diş hekimlerinin rolü. Ortadoğu Tıp Derg. 2019;11(1):78-84.
  • Wani V, Kulkarni A, Pustake B. Prevalence, complications and dental management of the oral cancer in the pediatric patients. J Cancer Res Ther. 2018;14(6):1407-11
  • Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leuk res. 2003;27(1):45-50.
  • Avsar A, Elli M, Darka O. Long-term effects of chemotherapy on caries formation, dental development, and salivary factors in childhood cancer survivors. Oral surg, oral med, oral pathol, oral radiol, and endod. 2007;104(6):781-9.
  • Kılınç G, Bulut G, Olgun N, et al. Kanser tedavisi gören çocuklarda tedavinin diş gelişimine olan geç yan Eekileri (Dört olgu sunumu). Atatürk Üniv Diş Hek Fak Derg.2013;23(7):48-54.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm DERLEMELER / REVIEWS
Yazarlar

Dilara Gülçin Demirkol 0000-0002-0141-2838

Seçil Çalışkan 0000-0002-8099-584X

Yayımlanma Tarihi 28 Eylül 2020
Yayımlandığı Sayı Yıl 2020 Ağız Kanserleri Özel Sayısı

Kaynak Göster

Vancouver Demirkol DG, Çalışkan S. Çocuk ve Gençlerde Tükürük Bezi Kanserleri. Osmangazi Tıp Dergisi. 2020;42(5):265-70.


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