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Türkiye'de Bir Üniversite Hastanesi Dermatoloji Kliniğine Başvuran Vitiligo Hastalarının Klinik Bulguları

Yıl 2020, Cilt: 7 Sayı: 2, 81 - 85, 31.08.2020

Aynure Oztekin

Öz

Vitiligo, dünya nüfusunun yaklaşık %1'ini etkileyen yaygın bir hastalıktır. Bu çalışmanın amacı vitiligo hastalarının epidemiyolojik verilerini, komorbid hastalıkları ve çeşitli kan parametrelerini değerlendirmektir. Bu çalışma retrospektif olarak yapıldı. Hasta kayıtları hastanenin elektronik veri tabanından tarandı. Verilerin dağılımına göre tanımlayıcı istatistikler ortalama ± standart sapma veya ortanca ve çeyrekler arası değerler olarak verildi. Kategorik değişkenler sayı ve yüzde olarak özetlendi. İstatistiksel analizler Jamovi programı ile yapıldı ve istatistiksel analizlerde anlamlılık düzeyi (p değeri) olarak p <0.05 kabul edildi. Çalışmaya 30'u (%44.1) erkek, 38'i (%55.9) kadın olan 68 kişi katıldı. Komorbid hastalıklar 22 (%32,4) hastada tespit edildi. 15 (%22.1) hastada tiroid hastalığı, 12 (%17.6) hastada tiroid otoantikorları pozitif bulundu. Hastalık alevlenmeleri (p=0.025) ve stres öyküsü kadınlarda daha sıktı (p=0.011). Strese bağlı alevlenme öyküsü kadınlarda ve 18 yaşından büyük hastalarda daha sık görüldü. Bu nedenle, özellikle vitiligolu kadınlarda psikolojik faktörlerin değerlendirilmesi ve gerektiğinde psikiyatriste danışılması önemlidir.

Anahtar Kelimeler

Stres Tiroid otoantikorları Vitiligo

Kaynakça

  • Tarle RG, Nascimento LM, Mira MT, Castro CC. Vitiligo--part 1. An Bras Dermatol. 2014;89(3):461-70.
  • Behl PN, Bhatia RK. 400 cases of vitiligo. A clinico-therapeutic analysis. Indian J Dermatol. 1972;17(2):51-6.
  • Ezzedine K, Lim HW, Suzuki T, et al. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012;25(3):E1-13.
  • Pradhan V, Patwardhan M, Thakkar V, et al. Vitiligo patients from India (Mumbai) show differences in clinical, demographic and autoantibody profiles compared to patients in western countries. J Eur Acad Dermatol Venereol. 2013;27(3):279-86.
  • Gonul M, Cakmak SK, Oguz D, Gul U, Kilic S. Profile of vitiligo patients attending a training and research hospital in Central Anatolia: a retrospective study. J Dermatol. 2012;39(2):156-9.
  • Hadler RM, Taliaferro SJ. Vitiligo In: Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller A, Leffell D, editors. Fitzpatrick’s Dermatology in General Medicine 7th ed. New York: McGraw-Hill; 2008. p. 616-22.
  • Ongenae K, Van Geel N, Naeyaert JM. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res. 2003;16(2):90-100.
  • Mohammed GF, Gomaa AH, Al-Dhubaibi MS. Highlights in pathogenesis of vitiligo. World J Clin Cases. 2015;3(3):221-30.
  • Gill L, Zarbo A, Isedeh P, Jacobsen G, Lim HW, Hamzavi I. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016;74(2):295-302.
  • Akay BN, Bozkir M, Anadolu Y, Gullu S. Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey. J Eur Acad Dermatol Venereol. 2010;24(10):1144-50.
  • Ezzedine K, Gauthier Y, Leaute-Labreze C, et al. Segmental vitiligo associated with generalized vitiligo (mixed vitiligo): a retrospective case series of 19 patients. J Am Acad Dermatol. 2011;65(5):965-71.
  • Taieb A, Picardo M. Clinical practice. Vitiligo. N Engl J Med. 2009;360(2):160-9.
  • Boisseau-Garsaud AM, Garsaud P, Cales-Quist D, Helenon R, Queneherve C, Claire RC. Epidemiology of vitiligo in the French West Indies (Isle of Martinique). Int J Dermatol. 2000;39(1):18-20.
  • Onunu AN, Kubeyinje EP. Vitiligo in the Nigerian African: a study of 351 patients in Benin City, Nigeria. Int J Dermatol. 2003;42(10):800-2.
  • Topal IO, Duman H, Gungor S, Kocaturk E, Kuteyla Can P. Evaluation of the Clinical and Sociodemographic Features of Turkish Patients with Vitiligo. Acta Dermatovenerol Croat. 2016;24(2):124-9.
  • Zhang Z, Xu SX, Zhang FY, et al. The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients. Arch Dermatol Res. 2009;301(2):167-73.
  • Yoshida A, Takagi A, Ikejima A, Takenaka H, Fukai T, Ikeda S. A retrospective study of 231 Japanese vitiligo patients with special reference to phototherapy. Acta Dermatovenerol Croat. 2014;22(1):13-8.
  • Akrem J, Baroudi A, Aichi T, Houch F, Hamdaoui MH. Profile of vitiligo in the south of Tunisia. Int J Dermatol. 2008;47(7):670-4.
  • Onarslan G, Ersoy L. Immunoperoxidase method for investigation of presence Ig G and C3 in vitiligo patients. Turkderm. 1991;25:97-102.
  • Singh M, Singh G, Kanwar AJ, Belhaj MS. Clinical pattern of vitiligo in Libya. Int J Dermatol. 1985;24(4):233-5.
  • Viana MC, Andrade LH. Lifetime Prevalence, age and gender distribution and age-of-onset of psychiatric disorders in the Sao Paulo Metropolitan Area, Brazil: results from the Sao Paulo Megacity Mental Health Survey. Braz J Psychiatry.2012;34(3):249-60.

Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey

Yıl 2020, Cilt: 7 Sayı: 2, 81 - 85, 31.08.2020

Aynure Oztekin

Öz

Vitiligo is a common disorder which affects about 1% of the world population. The aim of this study was to evaluate the epidemiological data, comorbid diseases, and several blood parameters of the vitiligo patients. This study was performed as a retrospective chart review. Patient records were screened from the electronic database of the hospital. Descriptive statistics were given as mean ± standard deviation or median and interquartile ranges according to the distribution of the data. Categorical variables were summarized as number and percentage. Statistical analyses were performed with Jamovi program and p<0.05 was accepted as significance level (p value) in statistical analyses. This study included 68 individuals, 30 (44.1%) of whom were males, and 38 (55.9%) of whom were females. Comorbid diseases were detected in 22 (32.4%) patients. Thyroid diseases were present in 15 (22.1%) patients, and thyroid autoantibodies were positive in 12 (17.6%) patients. Exacerbations of disease were more frequent in females (p=0.025), and history of stress was also more frequent in females (p=0.011). History of stress related exacerbations were more frequent in females and patients older than 18 years of age. Therefore, it is important to evaluate psychological factors especially in women with vitiligo and to consult to a psychiatrist when necessary.

Anahtar Kelimeler

Stress Thyroid autoantibodies Vitiligo

Kaynakça

  • Tarle RG, Nascimento LM, Mira MT, Castro CC. Vitiligo--part 1. An Bras Dermatol. 2014;89(3):461-70.
  • Behl PN, Bhatia RK. 400 cases of vitiligo. A clinico-therapeutic analysis. Indian J Dermatol. 1972;17(2):51-6.
  • Ezzedine K, Lim HW, Suzuki T, et al. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment Cell Melanoma Res. 2012;25(3):E1-13.
  • Pradhan V, Patwardhan M, Thakkar V, et al. Vitiligo patients from India (Mumbai) show differences in clinical, demographic and autoantibody profiles compared to patients in western countries. J Eur Acad Dermatol Venereol. 2013;27(3):279-86.
  • Gonul M, Cakmak SK, Oguz D, Gul U, Kilic S. Profile of vitiligo patients attending a training and research hospital in Central Anatolia: a retrospective study. J Dermatol. 2012;39(2):156-9.
  • Hadler RM, Taliaferro SJ. Vitiligo In: Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller A, Leffell D, editors. Fitzpatrick’s Dermatology in General Medicine 7th ed. New York: McGraw-Hill; 2008. p. 616-22.
  • Ongenae K, Van Geel N, Naeyaert JM. Evidence for an autoimmune pathogenesis of vitiligo. Pigment Cell Res. 2003;16(2):90-100.
  • Mohammed GF, Gomaa AH, Al-Dhubaibi MS. Highlights in pathogenesis of vitiligo. World J Clin Cases. 2015;3(3):221-30.
  • Gill L, Zarbo A, Isedeh P, Jacobsen G, Lim HW, Hamzavi I. Comorbid autoimmune diseases in patients with vitiligo: A cross-sectional study. J Am Acad Dermatol. 2016;74(2):295-302.
  • Akay BN, Bozkir M, Anadolu Y, Gullu S. Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey. J Eur Acad Dermatol Venereol. 2010;24(10):1144-50.
  • Ezzedine K, Gauthier Y, Leaute-Labreze C, et al. Segmental vitiligo associated with generalized vitiligo (mixed vitiligo): a retrospective case series of 19 patients. J Am Acad Dermatol. 2011;65(5):965-71.
  • Taieb A, Picardo M. Clinical practice. Vitiligo. N Engl J Med. 2009;360(2):160-9.
  • Boisseau-Garsaud AM, Garsaud P, Cales-Quist D, Helenon R, Queneherve C, Claire RC. Epidemiology of vitiligo in the French West Indies (Isle of Martinique). Int J Dermatol. 2000;39(1):18-20.
  • Onunu AN, Kubeyinje EP. Vitiligo in the Nigerian African: a study of 351 patients in Benin City, Nigeria. Int J Dermatol. 2003;42(10):800-2.
  • Topal IO, Duman H, Gungor S, Kocaturk E, Kuteyla Can P. Evaluation of the Clinical and Sociodemographic Features of Turkish Patients with Vitiligo. Acta Dermatovenerol Croat. 2016;24(2):124-9.
  • Zhang Z, Xu SX, Zhang FY, et al. The analysis of genetics and associated autoimmune diseases in Chinese vitiligo patients. Arch Dermatol Res. 2009;301(2):167-73.
  • Yoshida A, Takagi A, Ikejima A, Takenaka H, Fukai T, Ikeda S. A retrospective study of 231 Japanese vitiligo patients with special reference to phototherapy. Acta Dermatovenerol Croat. 2014;22(1):13-8.
  • Akrem J, Baroudi A, Aichi T, Houch F, Hamdaoui MH. Profile of vitiligo in the south of Tunisia. Int J Dermatol. 2008;47(7):670-4.
  • Onarslan G, Ersoy L. Immunoperoxidase method for investigation of presence Ig G and C3 in vitiligo patients. Turkderm. 1991;25:97-102.
  • Singh M, Singh G, Kanwar AJ, Belhaj MS. Clinical pattern of vitiligo in Libya. Int J Dermatol. 1985;24(4):233-5.
  • Viana MC, Andrade LH. Lifetime Prevalence, age and gender distribution and age-of-onset of psychiatric disorders in the Sao Paulo Metropolitan Area, Brazil: results from the Sao Paulo Megacity Mental Health Survey. Braz J Psychiatry.2012;34(3):249-60.
Toplam 21 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular İç Hastalıkları
Bölüm Araştırma Makalesi
Yazarlar

Aynure Oztekin 0000-0002-3669-6631

Yayımlanma Tarihi 31 Ağustos 2020
Gönderilme Tarihi 3 Kasım 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 7 Sayı: 2

Kaynak Göster

APA Oztekin, A. (2020). Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 7(2), 81-85.
AMA Oztekin A. Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey. MMJ. Ağustos 2020;7(2):81-85.
Chicago Oztekin, Aynure. “Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7, sy. 2 (Ağustos 2020): 81-85.
EndNote Oztekin A (01 Ağustos 2020) Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7 2 81–85.
IEEE A. Oztekin, “Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey”, MMJ, c. 7, sy. 2, ss. 81–85, 2020.
ISNAD Oztekin, Aynure. “Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 7/2 (Ağustos 2020), 81-85.
JAMA Oztekin A. Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey. MMJ. 2020;7:81–85.
MLA Oztekin, Aynure. “Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, c. 7, sy. 2, 2020, ss. 81-85.
Vancouver Oztekin A. Clinical Findings of Vitiligo Patients Attending a University Hospital Dermatology Clinic in Turkey. MMJ. 2020;7(2):81-5.
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