Öz
Parathyroid
carcinoma is one of the rarest endocrinologic tumors. It covers on average %1 of all hyperparathyroid cases. It can be seen as a part of genetic
syndromes or generally as sporadic
cases. Man/Woman ratio is 0,8/1 . 90% of parathyroid carcinoma is usually
hormonally active and presents with hypercalcemia clinic, and in many cases
also a palpable or detectable big
neck mass is present. Our case is an exciting and rare
case due to first presentation is hypercalcemia and hyperparathyroidia with
lung methastazes without detectable parathyroid
mass in neck.
Anahtar Kelimeler
Kaynakça
- 1. Wei CH, Harari A, et al. Parathyroid carcinoma:update and guidelines for management.Current Treat Options Oncol. 2012 Mar;13[1]:11-23.
- 2. Vila Duckworth L. et al. İntrathyroidal parathyroid carcinoma:report an unusual case andr eview of literature. Case Rep. Pathol. 2013;2013:198643-48.
- 3. Verges MP, Herges HI, Kleiner DE, et al.The role of prognostic markers [MIB-1,RB and bcl-2] in the diagnosis of parathyroid tumors.Modern Pathology.1997;10[1]:12-17.
- 4. Vasef MA, Brynes RK, et al. Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias:a parafin immunohistochemical study .modern Pathol. 1999;12[4]:412-16.
- 5. Erickson LA, Jin L, Wollen P,T hompson GB. Paratihroid hyperplasia adenomas and carcınomas: a differential expression of P27[kip 1] protein.American Journal of Surgical Pathol.1999;23[3]:288-295.
- 6. Tan M, Morrison C, Wang P, et al. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroidcarcinoma. ClinicalCancerResearch. 2004;10[19]:6629–6637.
- 7. Owen RP ,Silver CE, Pellitteri PK et al. Parathyroid Carcinoma:areview. Head and Neck 2011;33:429.
- 8. Shaha AR, Ferlito A, et al. Distant methastasis from throid and parathyroid cancer.OrlJ.Otorhinolarangeal.Relatspec 2001 Jul-Aug;63[4]:243-9.
- 9. Obara T, Okamoto T,et al. Functioning parathroid carcinoma, clinicopathologic features and rational treatment.Semin .surg Oncol 1997 Mar-April;13[2]:134-41.
- 10. Yamamoto T, Matsumura A. Comment on ‘Clinicalreview 122:Parathyroid Carcınoma’. J Clin Endocrinol Metab 2001:86;5091.
- 11. Hundley JC, Albertson FA, et al.Resection of pulmonary methastasis from parathroid carcinoma .Am Surg 2003 Sp;69[9]:779-83.
- 12. Van Hooven ER ,Kievit J, et al. Successfull resection for hepatic and pulmonary methastazis in a patient with parathyoid carcınoma.Jpn J Clin. Oncol.1996 ap;26[2]:99-102.
- 13. Obara J,Okamoto T, et al. Surgical and medical management of patients with pulmonary methastasis from parathroid carcınoma.Surgery 1993 Dec;114[6]:1040-8.
- 14. Tochio M, Takali H, et al. A case report of 20 lung radiofrequencyablation sessions for 50 lung methastasis from parathroidcarcinoma causing hyperparathroidism.Cardiovasc. İntervent Radiol.2010 Jun;33[3]:657-9.
- 15. Kuhlencordt F, Lozano-Tonkin C, Kracht J, Bartelheimer H. Pulmonary nodüles as early sign of primary parathyroid carcinoma. Deutsch Med Wochenschr 1974 oct 4;99[40]:1957-60.
Öz
Paratiroid karsinomu en nadir görülen endokrin tümörlerden biridir.
Hiperparatiroidi vakalarının ortalama %1 ini oluşturur. Sporadik olarak görülebildiği gibi, genetik
bir sendromun komponenti olarak da
görülebilir. E/K oranı 0,8/1 dir. Paratiroid
karsinomlarının %90’ı hormonal olarak aktiftir ve hiperkalsemi kliniği ile prezente olurlar. Ayrıca birçok
vakada boyunda palpabl büyük bir kitle
de bulunur. Bizim vakamız preoperatif görüntülemelerde primer tümör ile ilgili
hiçbir iz bulunamamış; akciğer metastazları ile prezente olmuş nadir ve heyecan verici bir vakadır
Anahtar Kelimeler
Kaynakça
- 1. Wei CH, Harari A, et al. Parathyroid carcinoma:update and guidelines for management.Current Treat Options Oncol. 2012 Mar;13[1]:11-23.
- 2. Vila Duckworth L. et al. İntrathyroidal parathyroid carcinoma:report an unusual case andr eview of literature. Case Rep. Pathol. 2013;2013:198643-48.
- 3. Verges MP, Herges HI, Kleiner DE, et al.The role of prognostic markers [MIB-1,RB and bcl-2] in the diagnosis of parathyroid tumors.Modern Pathology.1997;10[1]:12-17.
- 4. Vasef MA, Brynes RK, et al. Expression of cyclin D1 in parathyroid carcinomas,adenomas and hyperplasias:a parafin immunohistochemical study .modern Pathol. 1999;12[4]:412-16.
- 5. Erickson LA, Jin L, Wollen P,T hompson GB. Paratihroid hyperplasia adenomas and carcınomas: a differential expression of P27[kip 1] protein.American Journal of Surgical Pathol.1999;23[3]:288-295.
- 6. Tan M, Morrison C, Wang P, et al. Loss of parafibromin immunoreactivity is a distinguishing feature of parathyroidcarcinoma. ClinicalCancerResearch. 2004;10[19]:6629–6637.
- 7. Owen RP ,Silver CE, Pellitteri PK et al. Parathyroid Carcinoma:areview. Head and Neck 2011;33:429.
- 8. Shaha AR, Ferlito A, et al. Distant methastasis from throid and parathyroid cancer.OrlJ.Otorhinolarangeal.Relatspec 2001 Jul-Aug;63[4]:243-9.
- 9. Obara T, Okamoto T,et al. Functioning parathroid carcinoma, clinicopathologic features and rational treatment.Semin .surg Oncol 1997 Mar-April;13[2]:134-41.
- 10. Yamamoto T, Matsumura A. Comment on ‘Clinicalreview 122:Parathyroid Carcınoma’. J Clin Endocrinol Metab 2001:86;5091.
- 11. Hundley JC, Albertson FA, et al.Resection of pulmonary methastasis from parathroid carcinoma .Am Surg 2003 Sp;69[9]:779-83.
- 12. Van Hooven ER ,Kievit J, et al. Successfull resection for hepatic and pulmonary methastazis in a patient with parathyoid carcınoma.Jpn J Clin. Oncol.1996 ap;26[2]:99-102.
- 13. Obara J,Okamoto T, et al. Surgical and medical management of patients with pulmonary methastasis from parathroid carcınoma.Surgery 1993 Dec;114[6]:1040-8.
- 14. Tochio M, Takali H, et al. A case report of 20 lung radiofrequencyablation sessions for 50 lung methastasis from parathroidcarcinoma causing hyperparathroidism.Cardiovasc. İntervent Radiol.2010 Jun;33[3]:657-9.
- 15. Kuhlencordt F, Lozano-Tonkin C, Kracht J, Bartelheimer H. Pulmonary nodüles as early sign of primary parathyroid carcinoma. Deutsch Med Wochenschr 1974 oct 4;99[40]:1957-60.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 13 Kasım 2018 |
| Gönderilme Tarihi | 9 Mart 2018 |
| Kabul Tarihi | 12 Nisan 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 2 Sayı: 3 |
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