Araştırma Makalesi
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Evaluation of Prognostic Factors In Nasopharyngeal Cancers

Yıl 2017, Cilt: 1 Sayı: 2, 72 - 76, 15.07.2017
https://doi.org/10.30565/medalanya.314531

Öz

Aim: We aimed to examine
prognostic factors that affect the survival of patients with nasopharyngeal
cancer (NPC) who were diagnosed and treated in our clinic.


Methods: Patients with
nasopharyngeal cancer, who were diagnosed and treated in our clinic between 2009-2013,
were examined retrospectively.


Results: In our study, 33
patients were male (%73.3), 12 patients were female (%26.6), and
  male/female ratio was 2.75. Mean age was
50,8; the youngest patient was 14 and the oldest one was 84 years old.
  The most common presenting cause was cervical
lymph node metastasis (%66,7). %66,6 of our patients had advanced stage tumor
(Stage 3-4). Longer survival was detected in low T-stage patients, whereas no
relation was determined between N-stage and survival. No statistical relation
was determined between histopathological types and 2-year survival. Longer
survival was observed in young age group and male patients; however, this was
not statistically significant.

























Conclusion: Younger age are good
prognostic factors, however, the advanced T and N stages at diagnosis are poor
prognostic factors. Therefore, early diagnosis is important in terms of
treatment and survival.

Kaynakça

  • 1. Heng DM, Wee J, Fong KW, Lian LG, Sethi VK, Chua ET et al. Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma. Cancer. 1999;86(10):1912-20.
  • 2. Terence P. Farias, Fernando L. Dias, Roberto A. Lima, Jacob Kligerman, Geraldo M. de Sá, Mauro M. Barbosa et al. Prognostic Factors and Outcome for Nasopharyngeal Carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129(7):794-9.
  • 3. Sutton, J.B., Green, J.P., Meyer, J.L., Louie, D., Heltzel, M., Karp, A.H. Nasopharyngeal carcinoma: a study examining Asian patients treated in the United States. Am. J. Clin. Oncol. 1995;18:337–42.
  • 4. Sanguineti G, Geara FB, Garden AS. Carcinoma of nasopharynx treated by radiotherapy alone; determinants of local control and regional control. Int J Radiat Oncol Biol Phys (US). 1997; 37(5): 985-96.
  • 5. Xiao Guangli, Cao Yabing, Qiu Xibin, Wang Weihua, Wang Yufeng. Influence of gender and age on the survival of patients with nasopharyngeal carcinoma. BMC Cancer. 2013; 13:226.
  • 6. Nasr HB, Dimassi S, M'hadhbi R, Debbabi H, Kortas M, Tabka Z et al. Functional G894T (rs1799983) polymorphism and intron-4 VNTR variant of nitric oxide synthase (NOS3) gene are susceptibility biomarkers of obesity among Tunisians. Obes Res Clin Pract. 2016;10(4):465-75.
  • 7. Liu X, Luo W, Liu M, Sun Y, Xia Y. Treatment results and prognostic analysis of 1093 primary nasopharyngeal carcinoma: The experience of a single institution of Guangzhou in the beginning of the 21st century. Chin-Ger J Clin Oncol. 2008;7(4):187-195.
  • 8. Sham JS, Choy D: Prognostic factors of NPC: A review of 759 patients. Br J Radiol.1990; 63: 51-8.
  • 9. Ma J, Mai HQ, Hong MH, Cui NJ, Lu TX, Lu LX etal. İs The 1997 AJCC staging system for nasopharyngeal carcinoma prognostically useful for Chinese patient populations? Int J Radiat Oncol Biol Phys. 2001;50(5):1181-9.
  • 10. Kaasa S, Kragh-Jensen E, Bjordal K. Prognostic factors in patients with NPC. Acta Oncol 1993; 32: 531-6.
  • 11. Itami J, Anzai Y, Nemoto K. Prognostic factors for local control in NPC: Analysis by multivariate proportional hazards models. Radiother Oncol. 1991; 21: 233-9.
  • 12. Lu Han, ShaoJun Lin, JianJi Pan, ChuanBen Chen, Yu Zhang, XiuChun Zhang et al. Prognostic factors of 305 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. Chinese Journal of Cancer. 2010; 29(2):153-158.
  • 13. Lee AWM, Law SCK, Foo W. Retrospective analysis of NPC treated during 1976-1985: Survival after local recurrence. Int J Radiat Oncol Biol Phys. 1993;26: 773-82.
  • 14. Zietek E, Jarema A, Wasilewska M. Results of nasopharynx cancer treatment: some prognostic factors. The Polish Otolaryngology . 1999; 53(1): 5-11.
  • 15. Tang SGJ, Lin FJ, Chen MS. Prognostic factors of NPC: A multivariate analysis. Int J Radiat Oncol Biol Phys. 1990; 19: 1143-9.
  • 16. Sanguineti G, Geara FB, Garden AS, Tucker SL, Ang KK, Morrison WH et al. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional control. Int J Radiat Oncol Biol Phys. 1997;37:985–96.
  • 17. Perez CA, Devineni VR, Marcial-Vega V, Marks JE, Simpson JR, Kucik N. Carcinoma of the nasopharynx: factors affecting prognosis. Int J Radiat Oncol Biol Phys. 1992;23:271–80.

Nazofaringeal Kanserlerde Prognostik Faktörlerin Değerlendirilmesi

Yıl 2017, Cilt: 1 Sayı: 2, 72 - 76, 15.07.2017
https://doi.org/10.30565/medalanya.314531

Öz

 Amaç: Kliniğimizde teşhis
ve tedavi edilen nazofaringeal kanserli (NPC) hastaların hayatta kalmasını
etkileyen prognostik faktörleri incelemektir.



















Yöntemler: Kliniğimizde
2009-2013 yılları arasında teşhis ve tedavi edilen nazofaringeal kanserli
hastalar geriye dönük olarak incelendi.




Bulgular: Çalışmamızda 33
hasta erkek (% 73.3), 12 hasta kadın (% 26.6), erkek / kadın oranı 2.75 idi.
Ortalama yaş 50,8; En genç hasta 14 ve en yaşlısı 84 yaşında idi. En sık
görülen neden servikal lenf nodu metastazı (% 66,7) idi. Hastalarımızın%
66,6'sında ileri evre tümör vardı (Evre 3-4). Düşük T evresi hastalarında daha
uzun sağkalım süresi saptanırken, N-evresi ile sağkalım arasında ilişki
saptanmadı. Histopatolojik tiplerle 2 yıllık sağkalım arasında istatistiksel
olarak bir ilişki saptanmadı. Genç yaş grubu ve erkek hastalarda daha uzun
sağkalım süresi gözlemlendi fakat bu istatistiksel olarak anlamlı değildi.




Sonuç: Genç yaş iyi
prognostik faktörlerdir, ancak tanıdaki ilerlemiş T ve N evreleri kötü
prognostik faktörlerdir. Bu nedenle erken teşhis, tedavi ve sağkalım açısından
önemlidir.

Kaynakça

  • 1. Heng DM, Wee J, Fong KW, Lian LG, Sethi VK, Chua ET et al. Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma. Cancer. 1999;86(10):1912-20.
  • 2. Terence P. Farias, Fernando L. Dias, Roberto A. Lima, Jacob Kligerman, Geraldo M. de Sá, Mauro M. Barbosa et al. Prognostic Factors and Outcome for Nasopharyngeal Carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129(7):794-9.
  • 3. Sutton, J.B., Green, J.P., Meyer, J.L., Louie, D., Heltzel, M., Karp, A.H. Nasopharyngeal carcinoma: a study examining Asian patients treated in the United States. Am. J. Clin. Oncol. 1995;18:337–42.
  • 4. Sanguineti G, Geara FB, Garden AS. Carcinoma of nasopharynx treated by radiotherapy alone; determinants of local control and regional control. Int J Radiat Oncol Biol Phys (US). 1997; 37(5): 985-96.
  • 5. Xiao Guangli, Cao Yabing, Qiu Xibin, Wang Weihua, Wang Yufeng. Influence of gender and age on the survival of patients with nasopharyngeal carcinoma. BMC Cancer. 2013; 13:226.
  • 6. Nasr HB, Dimassi S, M'hadhbi R, Debbabi H, Kortas M, Tabka Z et al. Functional G894T (rs1799983) polymorphism and intron-4 VNTR variant of nitric oxide synthase (NOS3) gene are susceptibility biomarkers of obesity among Tunisians. Obes Res Clin Pract. 2016;10(4):465-75.
  • 7. Liu X, Luo W, Liu M, Sun Y, Xia Y. Treatment results and prognostic analysis of 1093 primary nasopharyngeal carcinoma: The experience of a single institution of Guangzhou in the beginning of the 21st century. Chin-Ger J Clin Oncol. 2008;7(4):187-195.
  • 8. Sham JS, Choy D: Prognostic factors of NPC: A review of 759 patients. Br J Radiol.1990; 63: 51-8.
  • 9. Ma J, Mai HQ, Hong MH, Cui NJ, Lu TX, Lu LX etal. İs The 1997 AJCC staging system for nasopharyngeal carcinoma prognostically useful for Chinese patient populations? Int J Radiat Oncol Biol Phys. 2001;50(5):1181-9.
  • 10. Kaasa S, Kragh-Jensen E, Bjordal K. Prognostic factors in patients with NPC. Acta Oncol 1993; 32: 531-6.
  • 11. Itami J, Anzai Y, Nemoto K. Prognostic factors for local control in NPC: Analysis by multivariate proportional hazards models. Radiother Oncol. 1991; 21: 233-9.
  • 12. Lu Han, ShaoJun Lin, JianJi Pan, ChuanBen Chen, Yu Zhang, XiuChun Zhang et al. Prognostic factors of 305 nasopharyngeal carcinoma patients treated with intensity-modulated radiotherapy. Chinese Journal of Cancer. 2010; 29(2):153-158.
  • 13. Lee AWM, Law SCK, Foo W. Retrospective analysis of NPC treated during 1976-1985: Survival after local recurrence. Int J Radiat Oncol Biol Phys. 1993;26: 773-82.
  • 14. Zietek E, Jarema A, Wasilewska M. Results of nasopharynx cancer treatment: some prognostic factors. The Polish Otolaryngology . 1999; 53(1): 5-11.
  • 15. Tang SGJ, Lin FJ, Chen MS. Prognostic factors of NPC: A multivariate analysis. Int J Radiat Oncol Biol Phys. 1990; 19: 1143-9.
  • 16. Sanguineti G, Geara FB, Garden AS, Tucker SL, Ang KK, Morrison WH et al. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional control. Int J Radiat Oncol Biol Phys. 1997;37:985–96.
  • 17. Perez CA, Devineni VR, Marcial-Vega V, Marks JE, Simpson JR, Kucik N. Carcinoma of the nasopharynx: factors affecting prognosis. Int J Radiat Oncol Biol Phys. 1992;23:271–80.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Rüstem Hasanov Bu kişi benim

Hüseyin Günizi

Kenan Güney Bu kişi benim

Yayımlanma Tarihi 15 Temmuz 2017
Gönderilme Tarihi 17 Mayıs 2017
Kabul Tarihi 20 Haziran 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 1 Sayı: 2

Kaynak Göster

Vancouver Hasanov R, Günizi H, Güney K. Evaluation of Prognostic Factors In Nasopharyngeal Cancers. Acta Med. Alanya. 2017;1(2):72-6.

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