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Bazı Benzotiyazol Türevlerinin Antifungal Aktivitesinin Değerlendirilmesi

Yıl 2019, Cilt: 12 Sayı: 4, 407 - 412, 31.12.2019

Derya Osmaniye Begüm Nurpelin Sağlık Ulviye Acar Çevik Mustafa Eser

https://doi.org/10.30607/kvj.595819

Öz

Hayvanlarda
oluşan candida kaynaklı hastalıklara çözüm üretmek amacıyla daha önceden
sentezi yapılmış bileşikler benzer metot kullanarak tekrar sentezlenmiş ve
antifungal etkinlikleri değerlendirilmiştir. Mevcut çalışmada, 10 tane
benzotiyazol türevi bileşik (4a-4j), antifungal aktivitelerini
değerlendirmek üzere yeniden sentezlenmiştir. Sentezlenen bileşiklerin yapı
tanımlamaları IR, 1HNMR, 13C-NMR ve HRMS (Kızılötesi
Spektroskopi, 1H Nükleer Manyetik Rezonans Spektroskopisi, 13C
Nükleer Manyetik Rezonans Spektroskopisi, Yüksek Çözünürlüklü Kütle
Spektrometresi) spektroskopik yöntemleri kullanılarak gerçekleştirilmiştir.
Yeniden sentezlenmiş bileşiklerin Candida türlerine karşı MIC50
(Minimum İnhibitör Konsantrasyon) değerleri in vitro deneyler yapılarak
değerlendirilmiştir. Yapılan aktivite çalışmaları sonucunda 4c ve 4d bileşikleri önemli aktivite göstermiştir. 4d bileşiğinin Candida krusei’ye
karşı 1.95 µg / mL MIC50 değeri ile güçlü bir türev olduğu
bulunmuştur. 

Anahtar Kelimeler

Benzotiyazol Antifungal Aktivite Candida krusei

Kaynakça

  • Álvarez-Pérez S, García ME, Cutuli MT, Fermín ML, Daza MÁ, Peláez T, Blanco JL. Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog. Med Mycol Case Rep. 2016; 11: 9-12.
  • Arda M, Minbay A, Leloğlu N, Aydın N, Kahraman M, Akay Ö, Ilgaz A, İzgür M, Diker KS. Özel Mikrobiyoloji, Medisan Yayın, Ankara. 1999; pp. 309-341.
  • Edelmann A, Krüger M, Schmid J. Genetic relationship between human and animal isolates of Candida albicans. J Clin Microbiol. 2005; 43(12): 6164-6166.
  • Fidel PL, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999; 12(1): 80-96.
  • Jin Y, Lin D. Fungal urinary tract infections in the dog and cat: a retrospective study (2001–2004). J Am Anim Hosp Assoc. 2005; 41(6): 373-381.
  • Karaburun AC, Acar Çevik U, Osmaniye D, Sağlık BN, Kaya Çavuşoğlu B, Levent S, Özkay Y, Koparal AS, Behçet M, Kaplancıklı ZA. Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents. Molecules. 2018; 23(12): 3129.
  • Karaburun AC, Kaya Çavuşoğlu B, Acar Çevik U, Osmaniye D, Sağlık BN, Levent S, Özkay Y, Atlı Ö, Koparal AS, Kaplancıklı ZA. Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds. Molecules. 2019; 24(1): 191.
  • McEwan NA. Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract. 2001; 42: 291–297.
  • Osmaniye D, Levent S, Karaduman AB, Ilgın S, Ozkay Y, Kaplancıklı ZA. Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents. Molecules. 2018; 23: 1054.
  • Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ. Invasive candidiasis. Nat Rev Dis Primers. 2018; 4: 18026.
  • Perlin DS. Echinocandin resistance in Candida. Clin Infect Dis. 2015; 61: 612-617.
  • Pressler BM, Vaden SL, Lane IF, Cowgill LD, Dye JA. Candida spp. urinary tract infections Assoc. 2003; 39: 263–270.
  • Reilly LK, Palmer JE. Systemic candidiasis in four foals. J Am Vet Med Assoc. 1994; 205(3): 464-466.
  • Rothenburg LS, Snider TA, Wilson A, Confer AW, Ramachandran A, Mani R, Nafe L. Disseminated phaeohyphomycosis in a dog. Med Mycol Case Rep. 2017; 15: 28-32.
  • Sanguinetti M, Posteraro B, Lass‐Flörl C. Antifungal drug resistance among Candida species: mechanisms and clinical impact. Mycoses. 2015; 58: 2-13.
  • Wilson D. Candida albicans. Trends in Microbiology. 2019; 27(2): https://doi.org/10.1016/j.tim.2018.10.010

Evaluation of Antifungal Activity of Some Benzothiazole Derivatives

Yıl 2019, Cilt: 12 Sayı: 4, 407 - 412, 31.12.2019

Derya Osmaniye Begüm Nurpelin Sağlık Ulviye Acar Çevik Mustafa Eser

https://doi.org/10.30607/kvj.595819

Öz

The antifungal activity of the previously synthesized
compounds was evaluated in order to provide solutions to the candida-induced
diseases in animals. In the present study, 10 benzothiazole derivatives (4a-4j)
were re-synthesized to evaluate their antifungal activity. IR, 1HNMR, 13C-NMR
and HRMS (Infrared Spectroscopy, 1H Nuclear Magnetic Resonance
Spectroscopy, 13C Nuclear Magnetic Resonance Spectroscopy, High
Resolution Mass Spectrometry) spectroscopic methods, determined the structure
of the synthesized compounds. MIC50(Minimum Inhibitory
Concentration) values of the re-synthesized compounds against Candida species were evaluated by in vitro experiments. As a result of
activity studies, it was found that compounds 4c and 4d showed significant
activity. Compound 4d was found to be the most potent derivative against Candida krusei with a MIC50
value of 1.95 µg / mL.

Anahtar Kelimeler

Benzothiazole Antifungal Activity Candida krusei

Kaynakça

  • Álvarez-Pérez S, García ME, Cutuli MT, Fermín ML, Daza MÁ, Peláez T, Blanco JL. Acquired multi-azole resistance in Candida tropicalis during persistent urinary tract infection in a dog. Med Mycol Case Rep. 2016; 11: 9-12.
  • Arda M, Minbay A, Leloğlu N, Aydın N, Kahraman M, Akay Ö, Ilgaz A, İzgür M, Diker KS. Özel Mikrobiyoloji, Medisan Yayın, Ankara. 1999; pp. 309-341.
  • Edelmann A, Krüger M, Schmid J. Genetic relationship between human and animal isolates of Candida albicans. J Clin Microbiol. 2005; 43(12): 6164-6166.
  • Fidel PL, Vazquez JA, Sobel JD. Candida glabrata: review of epidemiology, pathogenesis, and clinical disease with comparison to C. albicans. Clin Microbiol Rev. 1999; 12(1): 80-96.
  • Jin Y, Lin D. Fungal urinary tract infections in the dog and cat: a retrospective study (2001–2004). J Am Anim Hosp Assoc. 2005; 41(6): 373-381.
  • Karaburun AC, Acar Çevik U, Osmaniye D, Sağlık BN, Kaya Çavuşoğlu B, Levent S, Özkay Y, Koparal AS, Behçet M, Kaplancıklı ZA. Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents. Molecules. 2018; 23(12): 3129.
  • Karaburun AC, Kaya Çavuşoğlu B, Acar Çevik U, Osmaniye D, Sağlık BN, Levent S, Özkay Y, Atlı Ö, Koparal AS, Kaplancıklı ZA. Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds. Molecules. 2019; 24(1): 191.
  • McEwan NA. Malassezia and Candida infections in bull terriers with lethal acrodermatitis. J Small Anim Pract. 2001; 42: 291–297.
  • Osmaniye D, Levent S, Karaduman AB, Ilgın S, Ozkay Y, Kaplancıklı ZA. Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents. Molecules. 2018; 23: 1054.
  • Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ. Invasive candidiasis. Nat Rev Dis Primers. 2018; 4: 18026.
  • Perlin DS. Echinocandin resistance in Candida. Clin Infect Dis. 2015; 61: 612-617.
  • Pressler BM, Vaden SL, Lane IF, Cowgill LD, Dye JA. Candida spp. urinary tract infections Assoc. 2003; 39: 263–270.
  • Reilly LK, Palmer JE. Systemic candidiasis in four foals. J Am Vet Med Assoc. 1994; 205(3): 464-466.
  • Rothenburg LS, Snider TA, Wilson A, Confer AW, Ramachandran A, Mani R, Nafe L. Disseminated phaeohyphomycosis in a dog. Med Mycol Case Rep. 2017; 15: 28-32.
  • Sanguinetti M, Posteraro B, Lass‐Flörl C. Antifungal drug resistance among Candida species: mechanisms and clinical impact. Mycoses. 2015; 58: 2-13.
  • Wilson D. Candida albicans. Trends in Microbiology. 2019; 27(2): https://doi.org/10.1016/j.tim.2018.10.010
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm ARAŞTIRMA MAKALESİ
Yazarlar

Derya Osmaniye 0000-0002-0499-436X

Begüm Nurpelin Sağlık 0000-0002-0151-6266

Ulviye Acar Çevik 0000-0003-1879-1034

Mustafa Eser 0000-0003-1542-2989

Yayımlanma Tarihi 31 Aralık 2019
Kabul Tarihi 17 Eylül 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 12 Sayı: 4

Kaynak Göster

APA Osmaniye, D., Sağlık, B. N., Acar Çevik, U., Eser, M. (2019). Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal, 12(4), 407-412. https://doi.org/10.30607/kvj.595819
AMA Osmaniye D, Sağlık BN, Acar Çevik U, Eser M. Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. kvj. Aralık 2019;12(4):407-412. doi:10.30607/kvj.595819
Chicago Osmaniye, Derya, Begüm Nurpelin Sağlık, Ulviye Acar Çevik, ve Mustafa Eser. “Evaluation of Antifungal Activity of Some Benzothiazole Derivatives”. Kocatepe Veterinary Journal 12, sy. 4 (Aralık 2019): 407-12. https://doi.org/10.30607/kvj.595819.
EndNote Osmaniye D, Sağlık BN, Acar Çevik U, Eser M (01 Aralık 2019) Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. Kocatepe Veterinary Journal 12 4 407–412.
IEEE D. Osmaniye, B. N. Sağlık, U. Acar Çevik, ve M. Eser, “Evaluation of Antifungal Activity of Some Benzothiazole Derivatives”, kvj, c. 12, sy. 4, ss. 407–412, 2019, doi: 10.30607/kvj.595819.
ISNAD Osmaniye, Derya vd. “Evaluation of Antifungal Activity of Some Benzothiazole Derivatives”. Kocatepe Veterinary Journal 12/4 (Aralık 2019), 407-412. https://doi.org/10.30607/kvj.595819.
JAMA Osmaniye D, Sağlık BN, Acar Çevik U, Eser M. Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. kvj. 2019;12:407–412.
MLA Osmaniye, Derya vd. “Evaluation of Antifungal Activity of Some Benzothiazole Derivatives”. Kocatepe Veterinary Journal, c. 12, sy. 4, 2019, ss. 407-12, doi:10.30607/kvj.595819.
Vancouver Osmaniye D, Sağlık BN, Acar Çevik U, Eser M. Evaluation of Antifungal Activity of Some Benzothiazole Derivatives. kvj. 2019;12(4):407-12.
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