Araştırma Makalesi
BibTex RIS Kaynak Göster

EFFECT OF COMBINED EXERCISES ON IRISIN, INSULIN, LIPID PROFILE AND BODY COMPOSITION

Yıl 2024, Cilt: 25 Sayı: 1 - OCAK 2024 SAYISI, 16 - 23, 17.01.2024
https://doi.org/10.18229/kocatepetip.1138553

Öz

OBJECTIVE: Despite the indisputable beneficial effects of regular exercise on health, more data are needed on the underlying molecular pathways that regulate these effects. In this study, it was aimed to investigate the effects of regular combined exercises on serum irisin and insulin levels and lipid profile in sedentary healthy young women.
MATERIAL AND METHODS: The sample group of the study consisted of 35 healthy sedentary young women. The mean age of the participants was 21.4±1.94 years, their mean height was 164.3±5.89 cm, and their body weight was 62.2±8.1 kg. The participants were given combined exercises (aerobic + resistance) for 10 weeks, 3 days a week, 75 minutes a day. The variables to be measured in the study (height, body weight, waist and hip circumference, body fat percentage, lipid profile markers, irisin and insulin hormones) were measured before starting the exercise (week 0) and after the exercise application (10 weeks). Data analysis was evaluated with a dependent sample t-test and pearson correlation test.
RESULTS: As a result of the evaluation of the data, it was found that 10 weeks of regular combined exercises decreased insulin levels (p=0.003) and increased irisin levels (p=0.012) in sedentary young women. A statistically significant difference was also found in triglyceride values, which is one of the lipid profile markers (p=0.008).
CONCLUSIONS: It was determined that the combined exercises performed regularly for 10 weeks have significant effects on irisin and insulin of healthy sedentary young women. It is thought that the application of aerobic and resistance exercises together is an important type of exercise to protect the public health by preventing and treating diseases caused by inactivity.

Proje Numarası

18.KARİYER.267

Kaynakça

  • 1. World Health Organization (WHO) (2020). Obesity and overweight https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweig (Erişim tarihi 23.02.2021). 2. Amanat S, Sinaei E, Panji M, et al. A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR. Frontiers in Physiology. 2020;11:562895. 3. Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism-Clinical and experimental. 2012;61(12):1725-38. 4. Li H, Wang F, Yang M, Sun J, Zhao Y, Tang D. The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity. International Journal of Endocrinology. 2021;221:6572342. 5. Boström P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463-8. 6. Millender DJ, Mang ZA, Beam JR, Realzola RA, Kravitz L. The Effect of Rest Interval Length on Upper and Lower Body Exercises in Resistance-Trained Females. International Journal of Exercise Science. 2021;14(7):1178–91. 7. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiological Reviews. 2000;80(3):1055-81. 8. Zhang Y, Xie C, Wang H, et al. Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. Am J Physiol Endocrinol Metab. 2016;311:E530–41. 9. Gao S, Li F, Li H, Huang Y, Liu Y, Chen Y. Effects and molecular mechanism of GST-irisin on lipolysis and autocrine function in 3T3-L1 adipocytes. PloS One. 2016;11(1):e0147480. 10. Perakakis N, Triantafyllou GA, Fernández-Real JM, et al. Physiology and role of irisin in glucose homeostasis. Nature Reviews Endocrinology. 2017;13(6):324-37. 11. Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine. 2018; 59(2):260-74. 12. Koz M. The Effects of Exercise on the Endocrine System and Hormonal Regulations. Turkiye Klinikleri J Physiother Rehabil-Special Topics. 2016;2(1):48-56. 13. Kim HJ, So B, Choi M, Kang D, Song W. Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. Experimental Gerontology. 2015;70:11-7. 14. Pekkala S, Wiklund PK, Hulmi JJ, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?. The Journal of Physiology. 2013;591(21):5393-400. 15. Czarkowska-Paczek B, Zendzian-Piotrowska M, Gala K, Sobol M, Paczek L. One session of exercise or endurance training does not influence serum levels of irisin in rats. J Physiol Pharmacol. 2014;65(3):449-54. 16. Hecksteden A, Wegmann M, Steffen A, et al. Irisin and exercise training in humans–results from a randomized controlled training trial. BMC Medicine. 2013;11(1):1-8. 17. Norheim F, Langleite TM, Hjorth M, et al. The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS Journal. 2014;281(3):739-49. 18. Karvonen MJ. The effects of training on heart rate: A longitudinal study. Ann Med Exp Biol Fenn. 1957;35:307-15. 19. Baechle TR, Earle RW (Edited by). Essentials of strength training and conditioning. 3rd ed. Champaign, IL: Human Kinetics. 2008;395-425. 20. Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. The Journal of Clinical Endocrinology & Metabolism. 2015;100(3):E453-7. 21. Daskalopoulou SS, Cooke AB, Gomez YH, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol. 2014;171(3):343-52. 22. Choi HY, Kim S, Park JW, et al. Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans. The Journal of Clinical Endocrinology & Metabolism. 2014;99(8):2778-85. 23. Moreno-Navarrete JM, Ortega F, Serrano M, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism. 2013;98(4):E769-77. 24. Qiu S, Cai X, Sun Z, Schumann U, Zuegel M, Steinacker JM. Chronic exercise training and circulating irisin in adults: A meta-analysis. Sports Medicine. 2015;45(11):1577-88. 25. Borghouts LB, Keizer HA. Exercise and Insulin Sensitivity: A Review. International Journal of Sports medicine. 2000;21(1):1–12. 26. Nassis GP, Papantakou K, Skenderi K, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism: Clinical and Experimental. 2005;54(11):1472–9. 27. Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annual Review of Medicine. 1998;49(1):235-61. 28. Lee HS. Lee J. Effects of Combined Exercise and Low Carbohydrate Ketogenic Diet Interventions on Waist Circumference and Triglycerides in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public health. 2021;18(2):828. 29. Valsdottir TD, Øvrebø B, Falck TM, et al. Low-Carbohydrate High-Fat Diet and Exercise: Effect of a 10-Week Intervention on Body Composition and CVD Risk Factors in Overweight and Obese Women A Randomized Controlled Trial. Nutrients. 2021;13(1):110. 30. Dianatinasab A, Koroni R, Bahramian M, et al. The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial. Journal of Exercise Science & Fitness. 2020;18(3):168-76. 31. Karagöz Ş, Ünveren A, Köken T. The effect of cardio tennis exercises on lipid metabolism of sedentary women. Progress in Nutrition. 2020;22(2):588-95. 32. Askari H, Rajani SF, Poorebrahim M, Haghi-Aminjan H, Raeis-Abdollahi E, Abdollahi M. A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: an introductory review. Pharmacological Research. 2018;129:44-55.

KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ

Yıl 2024, Cilt: 25 Sayı: 1 - OCAK 2024 SAYISI, 16 - 23, 17.01.2024
https://doi.org/10.18229/kocatepetip.1138553

Öz

AMAÇ: Düzenli egzersizin sağlık üzerindeki tartışılmaz yararlı etkilerine rağmen, bu etkileri düzenleyen altta yatan moleküler yolaklar hakkında daha çok veriye ihtiyaç vardır.Bu çalışmada, sedanter sağlıklı genç kadınlarda düzenli kombine egzersizlerin serum irisin ve insülin düzeyleri ile lipid profili üzerine etkilerinin incelenmesi amaçlandı.
GEREÇ VE YÖNTEM: Araştırmanın örneklem grubunu 35 sağlıklı genç sedanter kadın oluşturdu. Katılımcıların yaş ortalamaları 21.4±1.94 yıl, boy ortalamaları 164.3±5.89 cm ve vücut ağılıkları 62.2±8.1 kg idi. Katılımcılara 10 hafta, haftada 3 gün ve günde 75’er dakika kombine egzersizler (aerobik + direnç) yaptırıldı. Araştırmada öçülmek istenen değişkenler (boy,vücut ağırlığı, bel ve kalça çevresi,vücut yağ yüzdesi, lipit profili belirteçleri, irisin ve insülin hormonları) egzersize başlamadan önce(0.hafta) ve egzersiz uyglamasından (10.hafta) sonra ölçüldü. Verilerin analizi, bağımlı örneklem t-testi ve pearson kolerasyon testi ile değerlendirildi.
BULGULAR: Verilerin değerlendirilmesi sonucunda, sedanter genç kadınlarda 10 haftalık düzenli kombine egzersizlerin insülin düzeyini azaltırken (p=0.003), irisin düzeyilerini artırdığı (p=0.012) bulunmuştur. Lipid profili belirteçlerinden biri olan trigliserit değerlerinde de istatistiksel olarak anlamlı bir fark olduğu bulunmuştur (p=0.008).
SONUÇ: 10 hafta boyunca düzenli olarak yapılan kombine egzersizlerin sağlıklı sedanter genç kadınların irisin ve insülin üzerinde önemli etkileri olduğu belirlendi. Aerobik ve direnç egzersizlerinin birlikte uygulanmasının halk sağlığını korumada ve hareketsizliğin neden olduğu hastalıkları önlemede ve tedavi etmede önemli bir egzersiz türü olduğu düşünülmektedir.

Destekleyen Kurum

Afyon Kocatepe Üniversitesi Bilimsel Araştırmalar Proje Birimi

Proje Numarası

18.KARİYER.267

Teşekkür

Afyon Kocatepe Üniversitesi Bilimsel Araştırmalar Proje Birimi Başkanlığına desteklerinden dolayı teşekkür ederiz.

Kaynakça

  • 1. World Health Organization (WHO) (2020). Obesity and overweight https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweig (Erişim tarihi 23.02.2021). 2. Amanat S, Sinaei E, Panji M, et al. A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR. Frontiers in Physiology. 2020;11:562895. 3. Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism-Clinical and experimental. 2012;61(12):1725-38. 4. Li H, Wang F, Yang M, Sun J, Zhao Y, Tang D. The Effect of Irisin as a Metabolic Regulator and Its Therapeutic Potential for Obesity. International Journal of Endocrinology. 2021;221:6572342. 5. Boström P, Wu J, Jedrychowski MP, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481:463-8. 6. Millender DJ, Mang ZA, Beam JR, Realzola RA, Kravitz L. The Effect of Rest Interval Length on Upper and Lower Body Exercises in Resistance-Trained Females. International Journal of Exercise Science. 2021;14(7):1178–91. 7. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiological Reviews. 2000;80(3):1055-81. 8. Zhang Y, Xie C, Wang H, et al. Irisin exerts dual effects on browning and adipogenesis of human white adipocytes. Am J Physiol Endocrinol Metab. 2016;311:E530–41. 9. Gao S, Li F, Li H, Huang Y, Liu Y, Chen Y. Effects and molecular mechanism of GST-irisin on lipolysis and autocrine function in 3T3-L1 adipocytes. PloS One. 2016;11(1):e0147480. 10. Perakakis N, Triantafyllou GA, Fernández-Real JM, et al. Physiology and role of irisin in glucose homeostasis. Nature Reviews Endocrinology. 2017;13(6):324-37. 11. Polyzos SA, Anastasilakis AD, Efstathiadou ZA, et al. Irisin in metabolic diseases. Endocrine. 2018; 59(2):260-74. 12. Koz M. The Effects of Exercise on the Endocrine System and Hormonal Regulations. Turkiye Klinikleri J Physiother Rehabil-Special Topics. 2016;2(1):48-56. 13. Kim HJ, So B, Choi M, Kang D, Song W. Resistance exercise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. Experimental Gerontology. 2015;70:11-7. 14. Pekkala S, Wiklund PK, Hulmi JJ, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health?. The Journal of Physiology. 2013;591(21):5393-400. 15. Czarkowska-Paczek B, Zendzian-Piotrowska M, Gala K, Sobol M, Paczek L. One session of exercise or endurance training does not influence serum levels of irisin in rats. J Physiol Pharmacol. 2014;65(3):449-54. 16. Hecksteden A, Wegmann M, Steffen A, et al. Irisin and exercise training in humans–results from a randomized controlled training trial. BMC Medicine. 2013;11(1):1-8. 17. Norheim F, Langleite TM, Hjorth M, et al. The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS Journal. 2014;281(3):739-49. 18. Karvonen MJ. The effects of training on heart rate: A longitudinal study. Ann Med Exp Biol Fenn. 1957;35:307-15. 19. Baechle TR, Earle RW (Edited by). Essentials of strength training and conditioning. 3rd ed. Champaign, IL: Human Kinetics. 2008;395-425. 20. Huh JY, Siopi A, Mougios V, Park KH, Mantzoros CS. Irisin in response to exercise in humans with and without metabolic syndrome. The Journal of Clinical Endocrinology & Metabolism. 2015;100(3):E453-7. 21. Daskalopoulou SS, Cooke AB, Gomez YH, et al. Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol. 2014;171(3):343-52. 22. Choi HY, Kim S, Park JW, et al. Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans. The Journal of Clinical Endocrinology & Metabolism. 2014;99(8):2778-85. 23. Moreno-Navarrete JM, Ortega F, Serrano M, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism. 2013;98(4):E769-77. 24. Qiu S, Cai X, Sun Z, Schumann U, Zuegel M, Steinacker JM. Chronic exercise training and circulating irisin in adults: A meta-analysis. Sports Medicine. 2015;45(11):1577-88. 25. Borghouts LB, Keizer HA. Exercise and Insulin Sensitivity: A Review. International Journal of Sports medicine. 2000;21(1):1–12. 26. Nassis GP, Papantakou K, Skenderi K, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism: Clinical and Experimental. 2005;54(11):1472–9. 27. Goodyear LJ, Kahn BB. Exercise, glucose transport, and insulin sensitivity. Annual Review of Medicine. 1998;49(1):235-61. 28. Lee HS. Lee J. Effects of Combined Exercise and Low Carbohydrate Ketogenic Diet Interventions on Waist Circumference and Triglycerides in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis. International Journal of Environmental Research and Public health. 2021;18(2):828. 29. Valsdottir TD, Øvrebø B, Falck TM, et al. Low-Carbohydrate High-Fat Diet and Exercise: Effect of a 10-Week Intervention on Body Composition and CVD Risk Factors in Overweight and Obese Women A Randomized Controlled Trial. Nutrients. 2021;13(1):110. 30. Dianatinasab A, Koroni R, Bahramian M, et al. The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome: A randomized controlled trial. Journal of Exercise Science & Fitness. 2020;18(3):168-76. 31. Karagöz Ş, Ünveren A, Köken T. The effect of cardio tennis exercises on lipid metabolism of sedentary women. Progress in Nutrition. 2020;22(2):588-95. 32. Askari H, Rajani SF, Poorebrahim M, Haghi-Aminjan H, Raeis-Abdollahi E, Abdollahi M. A glance at the therapeutic potential of irisin against diseases involving inflammation, oxidative stress, and apoptosis: an introductory review. Pharmacological Research. 2018;129:44-55.
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Makaleler-Araştırma Yazıları
Yazarlar

Şeniz Karagöz 0000-0003-2899-1689

İrfan Yıldırım 0000-0002-9632-8697

Yasin Ersöz 0000-0001-5116-3246

Halit Buğra Koca 0000-0002-5353-3228

Tülay Köken 0000-0001-5510-9415

Proje Numarası 18.KARİYER.267
Yayımlanma Tarihi 17 Ocak 2024
Kabul Tarihi 26 Şubat 2023
Yayımlandığı Sayı Yıl 2024 Cilt: 25 Sayı: 1 - OCAK 2024 SAYISI

Kaynak Göster

APA Karagöz, Ş., Yıldırım, İ., Ersöz, Y., Koca, H. B., vd. (2024). KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ. Kocatepe Tıp Dergisi, 25(1), 16-23. https://doi.org/10.18229/kocatepetip.1138553
AMA Karagöz Ş, Yıldırım İ, Ersöz Y, Koca HB, Köken T. KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ. KTD. Ocak 2024;25(1):16-23. doi:10.18229/kocatepetip.1138553
Chicago Karagöz, Şeniz, İrfan Yıldırım, Yasin Ersöz, Halit Buğra Koca, ve Tülay Köken. “KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ”. Kocatepe Tıp Dergisi 25, sy. 1 (Ocak 2024): 16-23. https://doi.org/10.18229/kocatepetip.1138553.
EndNote Karagöz Ş, Yıldırım İ, Ersöz Y, Koca HB, Köken T (01 Ocak 2024) KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ. Kocatepe Tıp Dergisi 25 1 16–23.
IEEE Ş. Karagöz, İ. Yıldırım, Y. Ersöz, H. B. Koca, ve T. Köken, “KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ”, KTD, c. 25, sy. 1, ss. 16–23, 2024, doi: 10.18229/kocatepetip.1138553.
ISNAD Karagöz, Şeniz vd. “KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ”. Kocatepe Tıp Dergisi 25/1 (Ocak 2024), 16-23. https://doi.org/10.18229/kocatepetip.1138553.
JAMA Karagöz Ş, Yıldırım İ, Ersöz Y, Koca HB, Köken T. KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ. KTD. 2024;25:16–23.
MLA Karagöz, Şeniz vd. “KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ”. Kocatepe Tıp Dergisi, c. 25, sy. 1, 2024, ss. 16-23, doi:10.18229/kocatepetip.1138553.
Vancouver Karagöz Ş, Yıldırım İ, Ersöz Y, Koca HB, Köken T. KOMBİNE EGZERSİZLERİN İRİSİN, İNSÜLİN, LİPİD PROFİLİ VE VÜCUT BİLEŞİMİ ÜZERİNE ETKİSİ. KTD. 2024;25(1):16-23.

88x31.png
Bu Dergi Creative Commons Atıf-GayriTicari-AynıLisanslaPaylaş 4.0 Uluslararası Lisansı ile lisanslanmıştır.