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The Role of Vitamins in Alzheimer's Disease

Yıl 2022, Cilt: 7 Sayı: 1, 1 - 18, 29.04.2022
https://doi.org/10.47115/jshs.977442

Öz

Alzheimer's disease is a progressive neurodegenerative disease that occurs due to loss of neurons and synapses in various parts of the central nervous system, characterized by decreased cognitive functions, self-care deficits, and various neuropsychiatric and behavioral disorders. Many factors such as oxidative stress, abnormal tau protein, amyloid deposition, metabolism, inflammation, age, genetic factors, head trauma, vascular damage, infections, environmental factors and nutrition play a role in the etiology of Alzheimer's disease, which is a multifactorial disease. Prophylactic and therapeutic approaches are being developed against Alzheimer's disease, which has a significant impact on human life and has not yet been fully cured. Emphasizing the importance of healthy nutrition in Alzheimer's disease, patients and their relatives are tried to be informed. In this review, information about the role and importance of vitamins associated with Alzheimer's disease, which has become an important health problem for the whole world, is presented.

Kaynakça

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ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ

Yıl 2022, Cilt: 7 Sayı: 1, 1 - 18, 29.04.2022
https://doi.org/10.47115/jshs.977442

Öz

Alzheimer hastalığı, merkezi sinir sisteminin çeşitli bölgelerinde nöron ve sinaps kayıpları nedeniyle ortaya çıkan, bilişsel işlevlerde azalma, öz bakım eksiklikleri, çeşitli nöropsikiyatrik ve davranışsal bozukluklar ile karakterize progresif bir nörodejeneratif hastalıktır. Çok faktörlü bir hastalık olan Alzheimer hastalığının etiyolojisinde oksidatif stres, anormal tau protein metabolizması, amiloid birikimi, enflamasyon, yaş, genetik faktörler, kafa travmaları, vasküler hasar, enfeksiyonlar, çevresel faktörler ve beslenme gibi birçok faktör rol oynamaktadır. İnsan hayatını önemli ölçüde etkileyen, henüz tam olarak tedavi edilemeyen Alzheimer hastalığına karşı profilaktik ve tedavi edici yaklaşımlar geliştirilmektedir. Alzheimer hastalığında sağlıklı beslenmenin önemi vurgulanarak hastalar ve yakınları bilgilendirilmeye çalışılmaktadır. Bu derlemede, tüm dünya için önemli bir sağlık sorunu haline gelen Alzheimer hastalığı ile ilişkili vitaminlerin hastalıktaki rolü ve önemi hakkında bilgiler sunulmuştur.

Kaynakça

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  • Harrison, F. E., May, J. M. (2009). Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic Biol Med, 46(6), 719-730.
  • Holick, M. F. (2015). Vitamin D and brain health: the need for vitamin D supplementation and sensible sun exposure. J Intern Med, 277(1), 90-93.
  • Ito, S., Ohtsuki, S., Nezu, Y., Koitabashi, Y., Murata, S., Terasaki, T. (2011). 1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier. Fluids Barriers CNS, 8(8), 20.
  • Jiménez-Jiménez, F. J., Molina, J. A., de Bustos, F., Ortí-Pareja, M., Benito-León, J., Tallón-Barranco, A., Gasalla, T., Porta, J., Arenas J. (1999). Serum levels of beta-carotene, alpha-carotene and vitamin A in patients with Alzheimer's disease. Eur J Neurol, (4), 495-497.
  • Knopman, D. S., DeKosky, S. T., Cummings, J. L., Chui, H., Corey-Bloom, J., Relkin, N., Small, G. W., Miller, B., Stevens, J. C. (2001). Practice parameter: diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56(9), 1143-1153.
  • Koryakina, A., Aeberhard, J., Kiefer, S., Hamburger, M., Küenzi, P. (2009). Regulation of secretases by all-trans-retinoic acid. FEBS J, 276(9), 2645-255.
  • Kruman, I. I., Culmsee, C., Chan, S. L., Kruman, Y., Guo, Z., Penix, L., Mattson, M. P. (2000). Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity. J Neurosci, 20(18), 6920-6926.
  • Kryscio, R. J., Abner, E. L., Caban-Holt, A., Lovell, M., Goodman, P., Darke, A. K., Yee, M., Crowley, J., Schmitt, F. A. (2017). Association of antioxidant supplement use and dementia in the prevention of Alzheimer’s disease by vitamin E and selenium trial (PREADViSE). JAMA Neurol, 74, 567-573.
  • La Fata, G., Weber, P., Mohajeri, M. H. (2014). Effects of vitamin E on cognitive performance during ageing and in Alzheimer's disease. Nutrients, 6(12), 5453-5472. Lam, D. K., Daniel, P. M. (1986). The influx of ascorbic acid into the rat's brain. Q J Exp Physiol, 71(3), 483-489.
  • Lamson, D. W., Plaza, S. M. (2003). The anticancer effects of vitamin K. Altern Med Rev, 8(3), 303-318.
  • Lane, M. A., Bailey, S. J. (2005). Role of retinoid signalling in the adult brain. Prog Neurobiol, 75(4), 275-293.
  • Llewellyn, D. J., Langa, K. M., Lang, I. A. (2009). Serum 25-hydroxyvitamin D concentration and cognitive impairment. J Geriatr Psychiatry Neurol, 3, 188-195.
  • Ma, F., Wu, T., Zhao, J., Ji, L., Song, A., Zhang, M., Huang, G. (2017). Plasma homocysteine and serum folate and vitamin B12 levels in mild cognitive impairment and Alzheimer's disease: A Case-Control Study. Nutrients, 9(7), pii: E725.
  • Mariani, E., Polidori, M. C., Cherubini, A., Mecocci, P. (2005). Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci, 827(1), 65-75.
  • Masaki, K. H., Losonczy, K. G., Izmirlian, G., Foley, D. J., Ross, G. W., Petrovitch, H., Havlik, R., White, L. R. (2000). Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology, 54(6), 1265-1272.
  • Masoumi, A., Goldenson, B., Ghirmai, S., Avagyan, H., Zaghi, J., Abel, K., Zheng, X., Espinosa-Jeffrey, A., Mahanian, M., Liu, P. T., Hewison, M., Mizwickie, M., Cashman, J., Fiala, M. (2009). 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers Dis, 17(3), 703-717.
  • Masoumi, A., Goldenson, B., Ghirmai, S., Avagyan, H., Zaghi, J., Abel, K., Zheng, X., Espinosa-Jeffrey, A., Mahanian, M., Liu, P. T., Hewison, M., Mizwickie, M., Cashman, J., Fiala, M. (2009). 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. Journal of Alzheimer's disease, 17(3), 703-717.
  • McCann, A., Jeffery, I. B., Ouliass, B, Ferland, G., Fu, X., Booth, S. L., Tran, T. T. T., O'Toole, P. W., O'Connor, E. M. (2019). Exploratory analysis of covariation of microbiota-derived vitamin K and cognition in older adults. Am J Clin Nutr, 110(6), 1404-1415.
  • Medrano, M., Carrillo-Cruz, E., Montero, I., Perez-Simon, J. A. (2018). Vitamin D: Effect on haematopoiesis and immune system and clinical applications. Int J Mol Sci, 19(9), 2663.
  • Min, J. Y., Min, K. B. (2014). Serum lycopene, lutein and zeaxanthin, and the risk of Alzheimer's disease mortality in older adults. Dement Geriatr Cogn Disord, 37(3-4), 246-256.
  • Mizwicki, M. T., Menegaz, D., Zhang, J., Barrientos-Durán, A., Tse, S., Cashman, J. R., Griffin, P. R., Fiala, M. (2012). Genomic and nongenomic signaling induced by 1α,25(OH)2-vitamin D3 promotes the recovery of amyloid-β phagocytosis by Alzheimer's disease macrophages. J Alzheimers Dis, 29(1), 51-62.
  • Monacelli, F., Acquarone, E., Giannotti C., Borghi, R., Nencioni A. (2017). Vitamin C, aging and Alzheimer's disease. Nutrients, 9(7), pii: E670.
  • Morello, M., Landel, V., Lacassagne, E., Baranger, K., Annweiler, C., Féron, F., Millet, P. (2018). Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer's Disease. Mol Neurobiol, 55(8), 6463-6479.
  • Morris, M. S. (2003). Homocysteine and Alzheimer's disease. Lancet Neurol, (7), 425-428. Nakajima, M., Furukawa, S., Hayashi, K., Yamada, A., Kawashima, T., Hayashi, Y. (1993). Age-dependent survival-promoting activity of vitamin K on cultured CNS neurons. Brain Res Dev Brain Res, 73(1), 17-23.
  • Nolan, J. M., Loskutova, E., Howard, A., Mulcahy, R., Moran, R., Stack, J., Bolger, M., Coen, R. F., Dennison, J., Akuffo, K. O., Owens, N., Power, R., Thurnham, D., Beatty, S. (2015). The impact of supplemental macular carotenoids in Alzheimer's disease: a randomized clinical trial. J Alzheimers Dis, 44(4), 1157-1169.
  • Nystad, A. E., Wergeland, S., Aksnes, L., Myhr, K. M., Bø, L., Torkildsen, O. (2014). Effect of high-dose 1.25 dihydroxyvitamin D3 on remyelination in the cuprizone model. APMIS, 122(12), 1178-1186.
  • Olajide, O. J., Yawson, E. O., Gbadamosi, I. T., Arogundade, T. T., Lambe, E., Obasi, K., Lawal, I. T., Ibrahim, A., Ogunrinola, K. Y. (2017). Ascorbic acid ameliorates behavioural deficits and neuropathological alterations in rat model of Alzheimer's disease. Environ Toxicol Pharmacol, 50, 200-211.
  • Ortega, R. M., Requejo, A. M., López-Sobaler, A. M., Andrés, P., Navia, B., Perea, J. M., Robles, F. (2002). Cognitive function in elderly people is influenced by vitamin E status. J Nutr, 132(7), 2065-2068.
  • Perrig, W. J., Perrig, P., Stähelin, H. B. (1997). The relation between antioxidants and memory performance in the old and very old. J Am Geriatr Soc, (6), 718-724.
  • Plaza, S. M., Lamson, D. W. (2005). Vitamin K2 in bone metabolism and osteoporosis. Altern Med Rev, 10(1), 24-35.
  • Popescu, D. C., Huang, H., Singhal, N. K., Shriver, L., McDonough, J., Clements, R. J., Freeman, E. J. (2018). Vitamin K enhances the production of brain sulfatides during remyelination. PLoS One, 13(8), e0203057.
  • Presse, N., Belleville, S., Gaudreau, P., Greenwood, C. E., Kergoat, M. J., Morais, J. A., Payette, H., Shatenstein, B., Ferland, G. (2013). Vitamin K status and cognitive function in healthy older adults. Neurobiol Aging, 34(12), 2777-2783.
  • Presse, N., Shatenstein, B., Kergoat, M. J., Ferland, G. (2008). Low vitamin K intakes in community-dwelling elders at an early stage of Alzheimer's disease. J Am Diet Assoc, 108(12), 2095-2099.
  • Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., Porcellini, E., Licastro, F. (2005). Homocysteine and folate as risk factors for dementia and Alzheimer disease. Am J Clin Nutr, 82(3), 636-643.
  • Reinhardt, S., Grimm, M. O., Stahlmann, C., Hartmann, T., Shudo, K., Tomita, T., Endres, K. (2016). Rescue of hypovitaminosis A induces non-amyloidogenic amyloid precursor protein (APP) processing. Curr Alzheimer Res, 13(11), 1277-1289.
  • Rinaldi, P., Polidori, M. C., Metastasio, A., Mariani, E., Mattioli, P., Cherubini, A., Catani, M., Cecchetti, R., Senin, U., Mecocci, P. (2003). Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer's disease. Neurobiol Aging, 24(7), 915-919.
  • Robinson, N., Grabowski, P., Rehman, I. (2018). Alzheimer's disease pathogenesis: Is there a role for folate? Mech Ageing Dev, 174, 86-94.
  • Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., Schneider, L. S., Thal, L. J. (1997). A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med, 336(17), 1216-1222.
  • Sato, Y., Honda, Y., Hayashida, N., Iwamoto, J., Kanoko, T., Satoh, K. (2005). Vitamin K deficiency and osteopenia in elderly women with Alzheimer's disease. Arch Phys Med Rehabil, 86(3), 576-581.
  • Schwalfenberg, G. K. (2017). Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health. J Nutr Metab, 2017, 6254836.
  • Seshadri, S., Beiser, A., Selhub, J., Jacques, P. F., Rosenberg, I. H., D'Agostino, R. B., Wilson, P. W., Wolf, P. A. (2002). Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med, 346(7), 476-483.
  • Shearer, M. J., Fu, X., Booth, S. L. (2012). Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv Nutr, 3(2), 182-195.
  • Shearer, M. J., Newman, P. (2008). Metabolism and cell biology of vitamin K. Thromb Haemost, 100(4), 530-547.
  • Shiraki, M., Tsugawa, N., Okano, T. (2015). Recent advances in vitamin K-dependent Gla-containing proteins and vitamin K nutrition. Osteoporos Sarcopenia, 1(1), 22-38.
  • Sil, S., Ghosh, T., Gupta, P., Ghosh, R., Kabir, S. N., Roy A. (2016). Dual role of vitamin C on the neuroinflammation mediated neurodegeneration and memory impairments in colchicine induced rat model of Alzheimer disease. J Mol Neurosci, 60(4), 421-435.
  • Smith, A. D., Smith, S. M., de Jager, C. A., Whitbread, P., Johnston, C., Agacinski, G., Oulhaj, A., Bradley, K. M., Jacoby, R., Refsum, H. (2010). Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trial. PLoS One, 5(9), e12244.
  • Sodhi, R. K., Singh, N. (2014). Retinoids as potential targets for Alzheimer's disease. Pharmacol Biochem Behav, 120, 117-23.
  • Soutif-Veillon, A., Ferland, G., Rolland, Y., Presse, N., Boucher, K., Féart, C., Annweiler, C. (2016). Increased dietary vitamin K intake is associated with less severe subjective memory complaint among older adults. Maturitas, 93, 131-136.
  • Swaminathan, A., Jicha, G. A. (2014). Nutrition and prevention of Alzheimer's dementia. Front Aging Neurosci, 6, 282.
  • Tamadon-Nejad, S., Ouliass, B., Rochford, J., Ferland, G. (2018). Vitamin K Deficiency Induced by Warfarin Is Associated With Cognitive and Behavioral Perturbations, and Alterations in Brain Sphingolipids in Rats. Front Aging Neurosci, 16(10), 213.
  • Tarawneh, R., Holtzman, D. M. (2012). The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment. Cold Spring Harb Perspect Med, (5), a006148. Troesch, B., Weber, P., Mohajeri, M. H. (2016). Potential links between impaired one-carbon metabolism due to polymorphisms, inadequate B-vitamin status, and the development of Alzheimer's disease. Nutrients, 8(12), 803.
  • Tsang, CK, Kamei, Y. (2002). Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells. Neurosci Lett, 323(1), 9-12.
  • Wang, S. W., Yang, S. G., Liu, W. Zhang, Y. X., Xu, P. X., Wang, T., Ling, T. J., Liu, R. T. (2016). Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease. Behav Brain Res, 296, 109-117.
  • Yu, J., Gattoni-Celli, M., Zhu, H., Bhat, N. R., Sambamurti, K., Gattoni-Celli, S., Kindy, M. S. (2011). Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AβPP transgenic mice. J Alzheimers Dis, 25(2), 295-307.
  • Zeng, J., Chen, L., Wang, Z., Chen, Q., Fan, Z., Jiang, H., Wu, Y., Ren, L., Chen, J., Li, T., Song, W. (2017). Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis. Acta Neuropathol, 133(6), 967-982.
  • Zhang, D. M., Ye, J. X., Mu, J. S., Cui, X. P. (2017). Efficacy of Vitamin B Supplementation on Cognition in Elderly Patients With Cognitive-Related Diseases. J Geriatr Psychiatry Neurol, (1), 50-59.
Toplam 93 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Derleme
Yazarlar

Seçil Müderrisoğlu 0000-0001-8802-5752

Gül Yarım 0000-0003-4050-429X

Erken Görünüm Tarihi 28 Nisan 2022
Yayımlanma Tarihi 29 Nisan 2022
Gönderilme Tarihi 1 Ağustos 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 7 Sayı: 1

Kaynak Göster

APA Müderrisoğlu, S., & Yarım, G. (2022). ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ. Samsun Sağlık Bilimleri Dergisi, 7(1), 1-18. https://doi.org/10.47115/jshs.977442
AMA Müderrisoğlu S, Yarım G. ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ. JSHS. Nisan 2022;7(1):1-18. doi:10.47115/jshs.977442
Chicago Müderrisoğlu, Seçil, ve Gül Yarım. “ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ”. Samsun Sağlık Bilimleri Dergisi 7, sy. 1 (Nisan 2022): 1-18. https://doi.org/10.47115/jshs.977442.
EndNote Müderrisoğlu S, Yarım G (01 Nisan 2022) ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ. Samsun Sağlık Bilimleri Dergisi 7 1 1–18.
IEEE S. Müderrisoğlu ve G. Yarım, “ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ”, JSHS, c. 7, sy. 1, ss. 1–18, 2022, doi: 10.47115/jshs.977442.
ISNAD Müderrisoğlu, Seçil - Yarım, Gül. “ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ”. Samsun Sağlık Bilimleri Dergisi 7/1 (Nisan 2022), 1-18. https://doi.org/10.47115/jshs.977442.
JAMA Müderrisoğlu S, Yarım G. ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ. JSHS. 2022;7:1–18.
MLA Müderrisoğlu, Seçil ve Gül Yarım. “ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ”. Samsun Sağlık Bilimleri Dergisi, c. 7, sy. 1, 2022, ss. 1-18, doi:10.47115/jshs.977442.
Vancouver Müderrisoğlu S, Yarım G. ALZHEİMER HASTALIĞINDA VİTAMİNLERİN ROLÜ. JSHS. 2022;7(1):1-18.

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