Akne vulgarisli kadın hastalarda tendon ve bağ kalınlıkları ölçümünün ve alt ekstremitelerde entezit varlığının değerlendirilmesi: randomize kontrollü bir çalışma
Öz
Amaç: Akne Vulgaris (AV), genç popülasyonu etkileyen ve en sık ergenlerde görülen multifaktöriyel bir hastalıktır. Literatürde AV’li hastalarda entezit varlığını ve alt ekstremite tendon ve bağ kalınlıklarını araştıran çalışma yoktur. AV’li hastalarda entezit varlığını araştırmak ve alt ekstremite tendon ve bağ kalınlıklarını değerlendirmek.
Gereç ve Yöntem: Çalışmaya AV tanılı 30 hasta ve 18 sağlıklı katılımcı dahil edildi. Akne şiddeti Global Acne Grading System (GAGS) ile belirlendi. Glasgow Ultrasonografik Entezit Skorlama Sistemine (GUESS) göre tek bir radyolog ultrasonografik değerlendirme yaptı. Ölçümler bilateral alt ekstremite kuadriseps tendonları, patellar tendonlar, aşil tendonları ve plantar fasyalardan yapıldı.
Bulgular: Gruplar arasında yaş, vücut kitle indeksi, alkol kullanımı ve sigara kullanımı benzerdi. GUESS skoru her iki grupta benzerdi. AV’li hastalarda dominant ve nondominant bacaklarda proksimal patellar ligaman, distal patellar ligaman, aşil tendonu ve plantar fasya kalınlıkları anlamlı olarak artmıştı (p<0.05).
Sonuç: Bu çalışma AV’nin bacak tendon ve bağ kalınlıklarında artışa yol açabileceğini düşündürmektedir.
Anahtar Kelimeler
Kaynakça
- Aksaç SE, Bilgili SG, Yavuz İH, Yavuz GÖ. Akne vulgariste etyopatogenez. Van Tıp Dergisi 2018; 25: 260-7.
- Agak GW, Kao S, Quyang K, et al. Phenotype and antimicrobial activity of Th17 cells induced by Propionibacterium acnes strains associated with healthy and acne skin. J Investigative Dermatol 2018; 138: 316-24.
- Watad A, Cuthbert RJ, Amital H, McGonagle D. Enthesitis: much more than focal insertion point inflammation. Current Rheumatology Reports 2018; 20: 41.
- Huhn CK, Schauer F, Schempp CM, Venhoff N, Finzel S. Skin inflammation associated with arthritis, synovitis and enthesitis. Part 1: psoriatic arthritis, SAPHO syndrome, Still’s disease, Behçet’s disease. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 2019; 17: 43-64.
- Ebstein E, Coustet B, Masson Behar V, et al. Enthesopathy in rheumatoid arthritis and spondyloarthritis: An ultrasound study. Joint Bone Spine 2018; 85: 577-81.
- Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 1997; 36: 416–8.
- Hacivelioglu S, Güngör ANC, Gencer M, et al. Acne severity and the Global Acne Grading System in polycystic ovary syndrome. Int J Gynaecol Obstet 2013; 123: 33-6.
- Balint PV, Kane D, Wilson H, McInnes IB, Sturrock R, al. Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis 2002; 61: 905–10.
- McGonagle D, Gibbon W, Emery P. Classification of inflammatory arthritis by enthesitis. The Lancet 1998; 352: 1137–40.
- Sherlock JP, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells. Nat Med 2012; 18: 1069–76.
- Lories RJU, Derese I, de Bari C, et al. Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis. Arthritis Rheum 2007; 56: 489–97.
- Armaka M, Apostolaki M, Jacques P, Kontoyiannis DL, Elewaut D, Kollias G. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 2008; 205: 331–7.
- Baeten D, Sieper J, Braun J, et al. Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis. N Engl J Med 2015; 373: 2534–48.
- Dubash S, Bridgewood C, McGonagle D, Marzo-Ortega H. The advent of IL-17A blockade in ankylosing spondylitis: secukinumab, ixekizumab and beyond. Expert Rev Clin Immunol 2019; 15: 123–34.
- Kelhälä HL, Palatsi R, Fhyrquist N, et al. IL-17/Th17 pathway is activated in acne lesions. PLoS One 2014; 9: e105238.
- Ebrahim AA, Mustafa AI, El-Abd AM. Serum interleukin-17 as a novel biomarker in patients with acne vulgaris. J Cosmet Dermatol. 2019; 18: 1975-9.
- Hatemi G, Fresko I, Tascilar K, Yazici H. Increased enthesopathy among Behçet’s syndrome patients with acne and arthritis: an ultrasonography study. Arthritis Rheum 2008; 58: 1539-45.
- Coskun BN, Yagiz B, Pehlivan Y, Dalkilic E. Isotretinoin-induced sacroiliitis in patients with hidradenitis suppurativa: a case-based review. Rheumatol Int 2019; 39: 2159-65.
- Alkan S, Kayiran N, Zengin O, et al. Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study. J Rheumatol 2015; 42: 2106-9.
Evaluation of the measurement of tendon and ligament thicknesses and the presence of enthesitis in lower extremities in female patients with acne vulgaris: a randomized controlled trial
Öz
Aim: Acne Vulgaris (AV) is a multifactorial disease which affects young population and is most common in adolescents. There are no studies in the literature invastigating the presence of enthesitis and lower extremity tendons and ligaments thicknesses in patients with AV. To investigate the presence of enthesitis and to evaluate the tendon and ligament thicknesses in lower extremities in patients with AV.
Material and Method: Thirty patients with a diagnosis of AV and 18 healthy participants, were included. Acne severity was determined with the Global Acne Grading System (GAGS). A single radiologist performed ultrasonographic evaluation with respect to Glasgow Ultrasonographic Enthesitis Scoring System (GUESS). Measurement were done on quadriceps tendons, patellar tendons, Achilles tendons and plantar fascias of the bilaterally lower extremity.
Results: Age, body mass index, alcohol usage and smoking were similar between groups. GUESS score was similar in both group. Proximal patellar ligaments, distal patellar ligaments, Achilles tendons and plantar fascias thicknesses were significantly increased in dominant and non-dominant legs in patients with AV (p<0.05).
Conclusion: This study suggest that AV may lead to increase leg tendons and ligaments’ thicknesses.
Anahtar Kelimeler
Kaynakça
- Aksaç SE, Bilgili SG, Yavuz İH, Yavuz GÖ. Akne vulgariste etyopatogenez. Van Tıp Dergisi 2018; 25: 260-7.
- Agak GW, Kao S, Quyang K, et al. Phenotype and antimicrobial activity of Th17 cells induced by Propionibacterium acnes strains associated with healthy and acne skin. J Investigative Dermatol 2018; 138: 316-24.
- Watad A, Cuthbert RJ, Amital H, McGonagle D. Enthesitis: much more than focal insertion point inflammation. Current Rheumatology Reports 2018; 20: 41.
- Huhn CK, Schauer F, Schempp CM, Venhoff N, Finzel S. Skin inflammation associated with arthritis, synovitis and enthesitis. Part 1: psoriatic arthritis, SAPHO syndrome, Still’s disease, Behçet’s disease. JDDG: Journal der Deutschen Dermatologischen Gesellschaft 2019; 17: 43-64.
- Ebstein E, Coustet B, Masson Behar V, et al. Enthesopathy in rheumatoid arthritis and spondyloarthritis: An ultrasound study. Joint Bone Spine 2018; 85: 577-81.
- Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol 1997; 36: 416–8.
- Hacivelioglu S, Güngör ANC, Gencer M, et al. Acne severity and the Global Acne Grading System in polycystic ovary syndrome. Int J Gynaecol Obstet 2013; 123: 33-6.
- Balint PV, Kane D, Wilson H, McInnes IB, Sturrock R, al. Ultrasonography of entheseal insertions in the lower limb in spondyloarthropathy. Ann Rheum Dis 2002; 61: 905–10.
- McGonagle D, Gibbon W, Emery P. Classification of inflammatory arthritis by enthesitis. The Lancet 1998; 352: 1137–40.
- Sherlock JP, Joyce-Shaikh B, Turner SP, et al. IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8− entheseal resident T cells. Nat Med 2012; 18: 1069–76.
- Lories RJU, Derese I, de Bari C, et al. Evidence for uncoupling of inflammation and joint remodeling in a mouse model of spondylarthritis. Arthritis Rheum 2007; 56: 489–97.
- Armaka M, Apostolaki M, Jacques P, Kontoyiannis DL, Elewaut D, Kollias G. Mesenchymal cell targeting by TNF as a common pathogenic principle in chronic inflammatory joint and intestinal diseases. J Exp Med 2008; 205: 331–7.
- Baeten D, Sieper J, Braun J, et al. Secukinumab, an interleukin-17A inhibitor, in ankylosing spondylitis. N Engl J Med 2015; 373: 2534–48.
- Dubash S, Bridgewood C, McGonagle D, Marzo-Ortega H. The advent of IL-17A blockade in ankylosing spondylitis: secukinumab, ixekizumab and beyond. Expert Rev Clin Immunol 2019; 15: 123–34.
- Kelhälä HL, Palatsi R, Fhyrquist N, et al. IL-17/Th17 pathway is activated in acne lesions. PLoS One 2014; 9: e105238.
- Ebrahim AA, Mustafa AI, El-Abd AM. Serum interleukin-17 as a novel biomarker in patients with acne vulgaris. J Cosmet Dermatol. 2019; 18: 1975-9.
- Hatemi G, Fresko I, Tascilar K, Yazici H. Increased enthesopathy among Behçet’s syndrome patients with acne and arthritis: an ultrasonography study. Arthritis Rheum 2008; 58: 1539-45.
- Coskun BN, Yagiz B, Pehlivan Y, Dalkilic E. Isotretinoin-induced sacroiliitis in patients with hidradenitis suppurativa: a case-based review. Rheumatol Int 2019; 39: 2159-65.
- Alkan S, Kayiran N, Zengin O, et al. Isotretinoin-induced Spondyloarthropathy-related Symptoms: A Prospective Study. J Rheumatol 2015; 42: 2106-9.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Research Articles [en] Araştırma Makaleleri [tr] |
| Yazarlar | |
| Yayımlanma Tarihi | 26 Aralık 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 3 Sayı: 4 |
Kaynak Göster
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