Öz
Objective: We know that the risk of contracting COVID-19 infection increases due to the immunosuppression of cancer patients in the pandemic and the mortality rates due to infection are higher than the general population. In our study, it was aimed to observe the effects of the pandemic in patients who received radiotherapy for breast cancer, and to analyze the factors affecting their severe COVID-19 infection.
Materials and Method: In this study122 patients who were treated and followed up between 01/05/2019-31/12/21 were evaluated during their outpatient clinic controls with a 20-question form created by us after taking their consent.
Results: The median age was 50 (range 25-84), and 62 (50.8%) patients had COVID-19 disease. Fatigue was observed in all patients. 86% of the patients had been vaccinated. 63.1% of them were using masks for precaution. The rate of vitamin use was 21.3%. None of the patients with severe disease used vitamins (p:0.61). Vitamin use was less in early-stage patients than in advanced-stage patients (p:0.005). Age, performance, stage, having the disease before or after treatment, time of vaccination were not found statistically significant on severe disease.
Conclusion: It has been seen that vaccination, mask and distance are the most effective methods in the prevention of COVID-19 infection in the radiotherapy process of oncology patients. A larger number of patients is needed to evaluate the effect of vitamin use and the type of vitamin used on the severity of COVID-19 infection.
Anahtar Kelimeler
Kaynakça
- Singhal T. A review of coronavirus disease-2019 (COVID-19). Indian J Pediatr 2020; 87: 281-6.
- Dai M, Liu D, Liu M, et al. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 Outbreak. Cancer Discov 2020; 10: 6: 783-91.
- Zhang H, Han H, He T, et.al. Clinical characteristics and outcomes of COVID-19–ınfected cancer patients: a systematic review and meta-analysis, JNCI 2021; 113: 4: 371–80.
- Liang W, Guan W, Chen R, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol 2020; 21: 335- 7.
- WHO. Draft landscape and tracker of COVID-19 candidate vaccines. Accessed May 21, 2021. https://www.who.int/publications/m/item/draftlandscape-of-covid-19-candidate-vaccines.)
- Ribas A, Sengupta R, Locke T, et al. Priority COVID-19 vaccination for patients with cancer while vaccine supply ıs limited. Cancer Discov 2021; 11: 2:233-6.
- Network. NCC. Recommendations of the NCCN COVID-19 vaccination advisory committee. 2021 [updated Accessed March 24, 2021. Available from: https://www.nccn.org/docs/default-source/covid19/2021_covid19_vaccination_guidance_v3- 0.pdf?sfvrsn=b483da2b_60.)
- https://covid19bilgi.saglik.gov.tr/depo/enfeksiyonkontorlonlemleri/COVID19 Kanser Hastalari Tani Ve Tedavi Merkezlerinde Alinmasi Gereken Enfeksiyon Kontrol Onlemleri.pdf.)
- Achard V, Tsoutsou P, Zilli T. Radiotherapy in the time of the Coronavirus pandemic: when less is better. International Journal of Radiation Oncology Biology Physics 2020; 107: 3.
- Guckenberger M, Belka C, Bezjak A, et al. Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An EsTRO-AsTRO consensus statement. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology 2020.
- Centers for Disease Control and Prevention (2020). CDC Activities and Initiatives Supporting the COVID-19 Response and the President’s Plan for Opening America Up Again. Erişim adresi (28.05.2020): https://www.cdc. gov/coronavirus/2019-ncov/downloads/php/CDC-ActivitiesInitiatives-for-COVID-19-Response.pdf .
- Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020; 10242: 1973–87.
- Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, et al. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. J Steroid Biochem Mol Biol 2020; 203:105751
- Pereira M, Dantas Damascena A, Galvao Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Crit Rev Food Sci Nutr 2020; 1- 9.
- Shakoor H, Feehan J, Al Dhaheri AS, et al. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas 2021; 143:1- 9.
- Charoenngam N, Shirvani A, Holick MF. Vitamin D and Its Potential Benefit for the COVID-19 Pandemic. Endocr Pract 2021; 27: 5: 484–93
- Hemila H. Vitamin C and Infections. Nutrients 2017; 9: 4: 339
- Dos Santos LMJ. Can vitamin B12 be an adjuvant to COVID‐19 treatment?. GSC Biol Pharm Sci 2020; 11: 3: 1‐5.
- Herrmann W, Obeid R. Causes and early diagnosis of vitamin B12 deficiency. Dtsch Arztebl Int 2008;105: 40: 680-5.
- Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients 2018; 10: 10: 1531.
- Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020; 12: 1: 236.
- Giordano SH. A review of the diagnosis and management of male breast cancer. Oncologist 2005; 10: 7: 471-9. CrossRef
- Uğurluer G, İlhan M, Edirne T, Şahin HA, Turan N. Erkek Meme Kanserleri. Van Tıp Derg 2009; 16: 1: 1-5.
- Eroğlu A, Ersöz Ş. Erkek Meme Kanseri. Yeni Tıp Dergisi 2010; 27: 202-7.
- Yu J, Ouyang W, Chua ML, ve Xie C. (2020). SARSCoV-2 transmission in cancer patients of a tertiary hospital in Wuhan. JAMA Oncol 2020; 6: 7:1108-10.
- World Health Organization (2020). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Erişim adresi (23.04.2020): https://www.who.int/docs/ default-source/coronaviruse/who-china-joint-mission-oncovid-19-final-report.pdf
- Bese NS, Hendry J, Jeremic B. Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumorsites and practical methods for compensation. Int J Radiat Oncol Biol Phys 2007; 68: 654-61.
- Our World in Data. Coronavirus (COVID-19) Vaccinations https://ourworldindata.org/covidvaccinations (Accessed on August 14, 2021).
- Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020;10242:1973–87.
Öz
Amaç: Pandemide kanser hastalarının immünsupresif olmaları nedeniyle COVID-19 enfeksiyonuna yakalanma riskinin arttığını ve enfeksiyona bağlı mortalite oranlarının genel popülasyondan daha yüksek olduğunu biliyoruz. Çalışmamızda meme kanseri nedeniyle radyoterapi yapılan hastalarda pandemi etkilerini gözlemlemek, COVID-19 enfeksiyonunu ağır geçirmelerini etkileyen faktörleri analiz etmek amaçlanmıştır.
Gereç ve Yöntem: Çalışmada 01/05/2019-31/12/21 tarihleri arasında tedavi uyguladığımız ve takipteki 122 hasta, onamları alınarak tarafımızca oluşturulan 20 soruluk bir form ile poliklinik kontrolleri sırasında değerlendirildi.
Bulgular: Medyan yaş 50 (aralık 25-84) olup, 62 (%50,8) hasta COVID-19 hastalığını geçirmişti. Hastaların tamamında halsizlik yorgunluk görülmüştü. Hastaların %86’sı aşı yaptırmıştı. %63,1’i önlem için maske kullanmaktaydı. Vitamin kullanımı oranı %21,3’tü. Hastalığı ağır geçirenlerin hiçbiri vitamin kullanmamıştı (p:0,61). Erken evre hastalarda ileri evre hastalara göre vitamin kullanımı daha azdı (p:0,005). Yaş, performans, evre, hastalığı tedavi öncesi veya sonrasında geçirmiş olmak, aşının yapılış zamanı hastalığın ağır geçirilmesi üzerinde istatistiksel olarak anlamlı bulunmamıştır.
Sonuç: Onkoloji hastalarının radyoterapi sürecinde COVID-19 enfeksiyonundan korunmada aşı, maske ve mesafenin en etkili yöntemler olduğu görülmüştür. Vitamin kullanımı ve kullanılan vitamin türünün COVID-19 enfeksiyonunun şiddetine etkisini değerlendirebilmek için daha fazla hasta sayısına ihtiyaç vardır.
Anahtar Kelimeler
Kaynakça
- Singhal T. A review of coronavirus disease-2019 (COVID-19). Indian J Pediatr 2020; 87: 281-6.
- Dai M, Liu D, Liu M, et al. Patients with cancer appear more vulnerable to SARS-CoV-2: a multicenter study during the COVID-19 Outbreak. Cancer Discov 2020; 10: 6: 783-91.
- Zhang H, Han H, He T, et.al. Clinical characteristics and outcomes of COVID-19–ınfected cancer patients: a systematic review and meta-analysis, JNCI 2021; 113: 4: 371–80.
- Liang W, Guan W, Chen R, et al. Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China. Lancet Oncol 2020; 21: 335- 7.
- WHO. Draft landscape and tracker of COVID-19 candidate vaccines. Accessed May 21, 2021. https://www.who.int/publications/m/item/draftlandscape-of-covid-19-candidate-vaccines.)
- Ribas A, Sengupta R, Locke T, et al. Priority COVID-19 vaccination for patients with cancer while vaccine supply ıs limited. Cancer Discov 2021; 11: 2:233-6.
- Network. NCC. Recommendations of the NCCN COVID-19 vaccination advisory committee. 2021 [updated Accessed March 24, 2021. Available from: https://www.nccn.org/docs/default-source/covid19/2021_covid19_vaccination_guidance_v3- 0.pdf?sfvrsn=b483da2b_60.)
- https://covid19bilgi.saglik.gov.tr/depo/enfeksiyonkontorlonlemleri/COVID19 Kanser Hastalari Tani Ve Tedavi Merkezlerinde Alinmasi Gereken Enfeksiyon Kontrol Onlemleri.pdf.)
- Achard V, Tsoutsou P, Zilli T. Radiotherapy in the time of the Coronavirus pandemic: when less is better. International Journal of Radiation Oncology Biology Physics 2020; 107: 3.
- Guckenberger M, Belka C, Bezjak A, et al. Practice recommendations for lung cancer radiotherapy during the COVID-19 pandemic: An EsTRO-AsTRO consensus statement. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology 2020.
- Centers for Disease Control and Prevention (2020). CDC Activities and Initiatives Supporting the COVID-19 Response and the President’s Plan for Opening America Up Again. Erişim adresi (28.05.2020): https://www.cdc. gov/coronavirus/2019-ncov/downloads/php/CDC-ActivitiesInitiatives-for-COVID-19-Response.pdf .
- Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020; 10242: 1973–87.
- Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, et al. “Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study”. J Steroid Biochem Mol Biol 2020; 203:105751
- Pereira M, Dantas Damascena A, Galvao Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Crit Rev Food Sci Nutr 2020; 1- 9.
- Shakoor H, Feehan J, Al Dhaheri AS, et al. Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19? Maturitas 2021; 143:1- 9.
- Charoenngam N, Shirvani A, Holick MF. Vitamin D and Its Potential Benefit for the COVID-19 Pandemic. Endocr Pract 2021; 27: 5: 484–93
- Hemila H. Vitamin C and Infections. Nutrients 2017; 9: 4: 339
- Dos Santos LMJ. Can vitamin B12 be an adjuvant to COVID‐19 treatment?. GSC Biol Pharm Sci 2020; 11: 3: 1‐5.
- Herrmann W, Obeid R. Causes and early diagnosis of vitamin B12 deficiency. Dtsch Arztebl Int 2008;105: 40: 680-5.
- Maggini S, Pierre A, Calder PC. Immune Function and Micronutrient Requirements Change over the Life Course. Nutrients 2018; 10: 10: 1531.
- Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System-Working in Harmony to Reduce the Risk of Infection. Nutrients 2020; 12: 1: 236.
- Giordano SH. A review of the diagnosis and management of male breast cancer. Oncologist 2005; 10: 7: 471-9. CrossRef
- Uğurluer G, İlhan M, Edirne T, Şahin HA, Turan N. Erkek Meme Kanserleri. Van Tıp Derg 2009; 16: 1: 1-5.
- Eroğlu A, Ersöz Ş. Erkek Meme Kanseri. Yeni Tıp Dergisi 2010; 27: 202-7.
- Yu J, Ouyang W, Chua ML, ve Xie C. (2020). SARSCoV-2 transmission in cancer patients of a tertiary hospital in Wuhan. JAMA Oncol 2020; 6: 7:1108-10.
- World Health Organization (2020). Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19). Erişim adresi (23.04.2020): https://www.who.int/docs/ default-source/coronaviruse/who-china-joint-mission-oncovid-19-final-report.pdf
- Bese NS, Hendry J, Jeremic B. Effects of prolongation of overall treatment time due to unplanned interruptions during radiotherapy of different tumorsites and practical methods for compensation. Int J Radiat Oncol Biol Phys 2007; 68: 654-61.
- Our World in Data. Coronavirus (COVID-19) Vaccinations https://ourworldindata.org/covidvaccinations (Accessed on August 14, 2021).
- Chu DK, Akl EA, Duda S, Solo K, Yaacoub S, Schünemann HJ. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis. Lancet 2020;10242:1973–87.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Research Articles [en] Araştırma Makaleleri [tr] |
| Yazarlar | |
| Yayımlanma Tarihi | 26 Aralık 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 3 Sayı: 4 |
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