Araştırma Makalesi
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Yıl 2022, Cilt: 6 Sayı: 1, 6 - 9, 07.05.2022

Bihter Şahin

Öz

Kaynakça

  • Alzheimer’s Association Report. (2019). Alzheimer’s disease facts and figures. Alzheimers Dement. 15:321–387.
  • Atta-ur- Rahman and Choudhary, M.I. (2001). Bioactive natural products as a potential source of new pharmacophores. A theory of memory. Pure and Applied Chemistry, 73(3):555-560.
  • Bonta, V., Dezmirean, D. S., Marghitas, L. A., Urcan, A. C., Bobis, O. (2020). Sugar spectrum, hydroxymethylfurfural and diastase activity in honey: a validated approach as indicator of possible adulteration. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Animal Science and Biotechnologies, 77(2), 44-53. doi:10.15835/buasvmcn-asb:2020.0008.
  • do Nascimento, K.S., Sattler, J.A.G., Macedo, L.F.L., González, C.V.S., de Melo, I.L.P., da Silva Araújo, Granato, D., Sattler, A. (2018). Phenolic compounds, antioxidant capacity and physicochemical properties of Brazilian Apis mellifera honeys. LWT-Food Science and Technology, 91, pp. 85-94, 10.1016/j.lwt.2018.01.016.
  • Gul, A., and Pehlivan, T. (2018). Antioxidant activities of some monofloral honey types produced across Turkey. Saudi J. Biol. Sci, 25(6), 1056–1065. doi.org/10.1016/j.sjbs.2018.02.011.
  • Guzelmeric, E., Ciftci, I., Yuksel, P.I., Yesilada, E. (2020). Importance of chromatographic and spectrophotometric methods in determining authenticity, classification and bioactivity of honey. LWT--Food Science and Technology, 132, 109921. Publisher: (Elsevier Ltd., ) CODEN:LSTWB3 ISSN:0023-6438.
  • Howes, M.J.R, Houghton, P.J, Perry, N.S.L. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother Res, 17(1):1-18. doi: 10.1002/ptr.1280.
  • Maric, A., Jovanov, P., Sakac, M., Novakovic, A., Hadnadjev, M., Pezo, L., Mandic, A., Milicevic, N., Djurovic, A., Gadzuric, S. (2021). A comprehensive study of parameters correlated with honey health benefits. RSC Advances, Ahead of Print. DOI:10.1039/d0ra10887a.
  • Melzer, D. (1998). New drug treatment for alzheimer’s diseases: lessons for healthcare policy. BMJ Clinical Research, 316(7133):762-4. doi: 10.1136/bmj.316.7133.762.
  • Ozturk, M., Tel, G., Ozturk, F.A., Duru, M.E. (2014). The cooking effect on two edible mushrooms in Anatolia: Fatty acid composition, total bioactive compounds, antioxidant and anticholinesterase activities. Rec. Nat. Prod. 8, 189-194.
  • Sarhan, W. A., and Azzazy, H. M. E. (2015). High concentration honey chitosan electrospun nanofibers: Biocompatibility and antibacterial effects. Carbohydrate Polymers, 122, 135–143. https://doi.org/10.1016/j.carbpol.2014.12.051.
  • Uzun, Ü. (2011). Farklı orjinli balların antioksidan, antikolinesteraz ve tirozinaz enzim aktiviteleri ve aktif bileşenlerin araştırılması. Yüksek Lisans Tezi. Fen Bilimleri Enstitüsü, Muğla Sıtkı Koçman Üniversitesi.

Can sunflower honey have a protective effect against Alzheimer's disease?

Yıl 2022, Cilt: 6 Sayı: 1, 6 - 9, 07.05.2022

Bihter Şahin

Öz

Alzheimer disease is neurodegenerative disease which has no exact cure. In this study the anticholinesterase activity of sunflower honey samples produced in four regions of Adana city and various wholesalers through Turkey was screened. The anticholinesterase activity was performed according to the Elman's method against acetylcholinesterase and butyrylcholinesterase which are the chief enzymes against Alzheimer disease. All sunflower honey samples exhibited anticholinesterase activity. The honey samples produced under control dose dependently inhibited acetylcholinesterase and butyrylcholinesterase in the range of 28.33-34.86% and 27.57-39.75% at 10 mg/mL, respectively. The sunflower honey samples from various wholesalers, however, served 14.77-21.36 and 14.18-23.64% at the same concentration, respectively. The anticholinesterase activity of processed sunflower honey samples exhibited less or no activity when compared to those of produced under control ones. It was concluded that the filtering process and honey sample's shelf life might affect the lesser enzyme inhibitory activity. Moreover, the possibilities such as storage and processing of honey are among the factors that affect the composition of honey. Consuming or using honey freshly, therefore, advised to be benefited from the anticholinesterase property of honey.

Anahtar Kelimeler

Alzheimer Sunflower honey Anticholinesterase activity

Kaynakça

  • Alzheimer’s Association Report. (2019). Alzheimer’s disease facts and figures. Alzheimers Dement. 15:321–387.
  • Atta-ur- Rahman and Choudhary, M.I. (2001). Bioactive natural products as a potential source of new pharmacophores. A theory of memory. Pure and Applied Chemistry, 73(3):555-560.
  • Bonta, V., Dezmirean, D. S., Marghitas, L. A., Urcan, A. C., Bobis, O. (2020). Sugar spectrum, hydroxymethylfurfural and diastase activity in honey: a validated approach as indicator of possible adulteration. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, Animal Science and Biotechnologies, 77(2), 44-53. doi:10.15835/buasvmcn-asb:2020.0008.
  • do Nascimento, K.S., Sattler, J.A.G., Macedo, L.F.L., González, C.V.S., de Melo, I.L.P., da Silva Araújo, Granato, D., Sattler, A. (2018). Phenolic compounds, antioxidant capacity and physicochemical properties of Brazilian Apis mellifera honeys. LWT-Food Science and Technology, 91, pp. 85-94, 10.1016/j.lwt.2018.01.016.
  • Gul, A., and Pehlivan, T. (2018). Antioxidant activities of some monofloral honey types produced across Turkey. Saudi J. Biol. Sci, 25(6), 1056–1065. doi.org/10.1016/j.sjbs.2018.02.011.
  • Guzelmeric, E., Ciftci, I., Yuksel, P.I., Yesilada, E. (2020). Importance of chromatographic and spectrophotometric methods in determining authenticity, classification and bioactivity of honey. LWT--Food Science and Technology, 132, 109921. Publisher: (Elsevier Ltd., ) CODEN:LSTWB3 ISSN:0023-6438.
  • Howes, M.J.R, Houghton, P.J, Perry, N.S.L. (2003). Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother Res, 17(1):1-18. doi: 10.1002/ptr.1280.
  • Maric, A., Jovanov, P., Sakac, M., Novakovic, A., Hadnadjev, M., Pezo, L., Mandic, A., Milicevic, N., Djurovic, A., Gadzuric, S. (2021). A comprehensive study of parameters correlated with honey health benefits. RSC Advances, Ahead of Print. DOI:10.1039/d0ra10887a.
  • Melzer, D. (1998). New drug treatment for alzheimer’s diseases: lessons for healthcare policy. BMJ Clinical Research, 316(7133):762-4. doi: 10.1136/bmj.316.7133.762.
  • Ozturk, M., Tel, G., Ozturk, F.A., Duru, M.E. (2014). The cooking effect on two edible mushrooms in Anatolia: Fatty acid composition, total bioactive compounds, antioxidant and anticholinesterase activities. Rec. Nat. Prod. 8, 189-194.
  • Sarhan, W. A., and Azzazy, H. M. E. (2015). High concentration honey chitosan electrospun nanofibers: Biocompatibility and antibacterial effects. Carbohydrate Polymers, 122, 135–143. https://doi.org/10.1016/j.carbpol.2014.12.051.
  • Uzun, Ü. (2011). Farklı orjinli balların antioksidan, antikolinesteraz ve tirozinaz enzim aktiviteleri ve aktif bileşenlerin araştırılması. Yüksek Lisans Tezi. Fen Bilimleri Enstitüsü, Muğla Sıtkı Koçman Üniversitesi.
Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kimya Mühendisliği
Bölüm Research Article
Yazarlar

Bihter Şahin

Yayımlanma Tarihi 7 Mayıs 2022
Kabul Tarihi 11 Nisan 2021
Yayımlandığı Sayı Yıl 2022 Cilt: 6 Sayı: 1

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