Araştırma Makalesi
Yıl 2023,
Cilt: 2 Sayı: 1, 8 - 17, 28.03.2023
Öz
Cadmium (Cd) is a toxicant metal derived from horticultural and industrial sources. In recent work, we reported that olive leaf extract (Olea europaea L.) (OLE) restores liver functions from cadmium induced liver injury. Rats were pretreated with OLE and consecutively injected with CdCl2 (6.5 mg/kg) for 5 days. To evaluate liver function, alanine aminotransferase (ALT), aspartate aminotrans-ferase (AST) and γ-glutamyl transferase (GGT) were detected in the serum, total antioxidant (TAS) and total oxidative stress (TOS) statuses were established in the liver and expression of caspase 3 were determined for the antioxidative and anti‐apoptotic effects of OLE. Tissue sections were also evaluated histopathologically. The results demonstrated that Cd exposure could induce release of reactive oxygen species generation, increase levels of TOS and decrease levels of TAS, upregulate mRNA levels of Caspase-3, and induce cell apoptosis. The extracts also prevented the Cd induced increase in AST and GGT levels. Furthermore, the changes of these indicators in OLE treated group was remarkable. The results indicated that exposure to Cd could induce oxidative stress and apoptosis.
Anahtar Kelimeler
Kaynakça
- References 1. Lucia, M. André, JM. Gontier, K. Diot, N. Veiga, J. Davail, S., Trace element concentrations (mercury, cadmium, copper, zinc, lead, aluminium, nickel, arsenic, and selenium) in some aquatic birds of the Southwest Atlantic Coast of France. Arch. Environ. Contam. Toxicol., 58, 844-853, 2010.
- 2. Satarug, S. Nishijo, M. Ujjin, P. Vanavanitkun, Y. Moore, MR., Cadmium-induced nephropathy in the development of high blood pressure. Toxicol Lett. 157(1):57–68, 2005.
- 3. Sinkakarimi, MH. Pourkhabbaz, AR. Hassanpour, M. Levengood, JM. Study on metal concentrations in tissues of Mallard and Pochard from two major wintering sites in Southeastern Caspian Sea, Iran. Bull. Environ. Contam. Toxicol., 95, 292-297, 2015.
- 4. Pérez-Bonilla, M., et al., Isolation and identification of radical scavengers in olive tree (Olea europaea) wood. Journal of Chromatography A, 1112(1–2), 311–318, 2006.
- 5. Yang, SH. He, JB. Yu, LH. Li, L. Long, M. Liu, MD. Li, P., Protective role of curcumin in cadmium-induced testicular injury in mice by attenuating oxidative stress via Nrf2/ARE pathway. Environ Sci Pollut Res Int. 2019. doi: 10.1007/s11356-019-06587-9.
- 6. Deniz, GY., and Geyikoglu F., Extract of the Punica granatum Flowers Attenuates Progression of Hepatoxicity against Cadmium Chloride-Induced Liver Injury in Rats. international journal of medical research & health sciences. 8(6), 143-150, 2019.
- 7. Long, M. Yang, SH. Han, JX. Li, P. Zhang, Y. Dong, S., The protective effect of grape-seed proanthocyanidin extract on oxidative damage induced by zearalenone in Kunming mice liver. Int J Mol Sci 17, 808, 2016.
- 8. Ke, Y. Yu, K. Zeng, W. Lian, G., Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats. Acta Cir Bras. 12,34(7), 2019.
- 9. Vezza, T. Rodríguez-Nogales, A. Algieri, F. Garrido-Mesa, J. Romero, M. Sánchez, M. Toral, M. Martín-García, B. Gómez-Caravaca, AM. Arráez-Román, D. Segura-Carretero, A. Micol, V. García, F. Utrilla, MP. Duarte, J. Rodríguez-Cabezas, ME. Gálvez, J., The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties. Pharmacol Res. 11:104487. doi: 10.1016/j.phrs.2019.104487. 2019.
- 10. Ayoub, L. Hassan, F. Hamid, S. Abdelhamid, Z. Souad, A., Phytochemical screening, antioxidant activity and inhibitory potential of Ficus carica and Olea europaea leaves. Bioinformation. 15;15(3),226-232, 2019.
- 11. Lockyer, S. Rowland, I. Spencer, JPE. Yaqoob, P. Stonehouse, W., Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomized controlled trial. European Journal of Nutrition. 56(4), 1421–1432, 2016.
- 12. McIlwain, DR. Thorsten, B. Tak, WM., Caspase Functions in Cell Death and Disease. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 1;5(4), 2013.
- 13. Eugenia, GM. Harmeet, M. Justin, L. Gregory, J., Apoptosis and Necrosis in the Liver. Compr Physiol.3(2) , 2013.
- 14. Al-Attar, AM. And Abu Zeid, IM., Effect of tea (Camellia sinensis) and olive (Olea europaea L.) leaves extracts on male mice exposed to diazinon. BioMed Res. Int. 1–6.2013.
- 15. Atef, M. Al-Attar, F. Alsalmi, A., Effect of Olea europaea leaves extract on streptozotocin induced diabetes in male albino rats. Saudi J Biol Sci. 26(1), 118–128, 2019.
- 16. Erel, O., A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 38(12), 1103-11, 2005.
- 17. Erel, O., A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 37(2), 112-9, 2004.
- 18. Satarug, S. Garrett, S. Sens, MA. Sens, DA., Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect. 118(2), 182–190, 2010.
- 19. Toppo, R. Roy, BK. Gora, RH. Baxla, SL. Kumar, P., Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats. Vet. World. 8(4), 537–540, 2015.
- 20. Bahri, S. Kaddour, H. Karoui, D. Bouraoui, S. Amri, M. Mokni, M., Protective role of vitamin E against cadmium induced oxidative stress into the rat liver. Tunis Med. 97(1), 100-105, 2019.
- 21. Ağır, MS. And Eraslan, G., The effect of diosmin against liver damage caused by cadmium in rats. J Food Biochem. 43(9), 2019.
Yıl 2023,
Cilt: 2 Sayı: 1, 8 - 17, 28.03.2023
Öz
Kaynakça
- References 1. Lucia, M. André, JM. Gontier, K. Diot, N. Veiga, J. Davail, S., Trace element concentrations (mercury, cadmium, copper, zinc, lead, aluminium, nickel, arsenic, and selenium) in some aquatic birds of the Southwest Atlantic Coast of France. Arch. Environ. Contam. Toxicol., 58, 844-853, 2010.
- 2. Satarug, S. Nishijo, M. Ujjin, P. Vanavanitkun, Y. Moore, MR., Cadmium-induced nephropathy in the development of high blood pressure. Toxicol Lett. 157(1):57–68, 2005.
- 3. Sinkakarimi, MH. Pourkhabbaz, AR. Hassanpour, M. Levengood, JM. Study on metal concentrations in tissues of Mallard and Pochard from two major wintering sites in Southeastern Caspian Sea, Iran. Bull. Environ. Contam. Toxicol., 95, 292-297, 2015.
- 4. Pérez-Bonilla, M., et al., Isolation and identification of radical scavengers in olive tree (Olea europaea) wood. Journal of Chromatography A, 1112(1–2), 311–318, 2006.
- 5. Yang, SH. He, JB. Yu, LH. Li, L. Long, M. Liu, MD. Li, P., Protective role of curcumin in cadmium-induced testicular injury in mice by attenuating oxidative stress via Nrf2/ARE pathway. Environ Sci Pollut Res Int. 2019. doi: 10.1007/s11356-019-06587-9.
- 6. Deniz, GY., and Geyikoglu F., Extract of the Punica granatum Flowers Attenuates Progression of Hepatoxicity against Cadmium Chloride-Induced Liver Injury in Rats. international journal of medical research & health sciences. 8(6), 143-150, 2019.
- 7. Long, M. Yang, SH. Han, JX. Li, P. Zhang, Y. Dong, S., The protective effect of grape-seed proanthocyanidin extract on oxidative damage induced by zearalenone in Kunming mice liver. Int J Mol Sci 17, 808, 2016.
- 8. Ke, Y. Yu, K. Zeng, W. Lian, G., Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats. Acta Cir Bras. 12,34(7), 2019.
- 9. Vezza, T. Rodríguez-Nogales, A. Algieri, F. Garrido-Mesa, J. Romero, M. Sánchez, M. Toral, M. Martín-García, B. Gómez-Caravaca, AM. Arráez-Román, D. Segura-Carretero, A. Micol, V. García, F. Utrilla, MP. Duarte, J. Rodríguez-Cabezas, ME. Gálvez, J., The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties. Pharmacol Res. 11:104487. doi: 10.1016/j.phrs.2019.104487. 2019.
- 10. Ayoub, L. Hassan, F. Hamid, S. Abdelhamid, Z. Souad, A., Phytochemical screening, antioxidant activity and inhibitory potential of Ficus carica and Olea europaea leaves. Bioinformation. 15;15(3),226-232, 2019.
- 11. Lockyer, S. Rowland, I. Spencer, JPE. Yaqoob, P. Stonehouse, W., Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomized controlled trial. European Journal of Nutrition. 56(4), 1421–1432, 2016.
- 12. McIlwain, DR. Thorsten, B. Tak, WM., Caspase Functions in Cell Death and Disease. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 1;5(4), 2013.
- 13. Eugenia, GM. Harmeet, M. Justin, L. Gregory, J., Apoptosis and Necrosis in the Liver. Compr Physiol.3(2) , 2013.
- 14. Al-Attar, AM. And Abu Zeid, IM., Effect of tea (Camellia sinensis) and olive (Olea europaea L.) leaves extracts on male mice exposed to diazinon. BioMed Res. Int. 1–6.2013.
- 15. Atef, M. Al-Attar, F. Alsalmi, A., Effect of Olea europaea leaves extract on streptozotocin induced diabetes in male albino rats. Saudi J Biol Sci. 26(1), 118–128, 2019.
- 16. Erel, O., A new automated colorimetric method for measuring total oxidant status. Clin Biochem. 38(12), 1103-11, 2005.
- 17. Erel, O., A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 37(2), 112-9, 2004.
- 18. Satarug, S. Garrett, S. Sens, MA. Sens, DA., Cadmium, environmental exposure, and health outcomes. Environ. Health Perspect. 118(2), 182–190, 2010.
- 19. Toppo, R. Roy, BK. Gora, RH. Baxla, SL. Kumar, P., Hepatoprotective activity of Moringa oleifera against cadmium toxicity in rats. Vet. World. 8(4), 537–540, 2015.
- 20. Bahri, S. Kaddour, H. Karoui, D. Bouraoui, S. Amri, M. Mokni, M., Protective role of vitamin E against cadmium induced oxidative stress into the rat liver. Tunis Med. 97(1), 100-105, 2019.
- 21. Ağır, MS. And Eraslan, G., The effect of diosmin against liver damage caused by cadmium in rats. J Food Biochem. 43(9), 2019.
Toplam 21 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Birinci Basamak Sağlık Hizmetleri |
| Bölüm | Research Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 28 Mart 2023 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 2 Sayı: 1 |
