Araştırma Makalesi
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Yıl 2022, Cilt: 12 Sayı: 3, 1550 - 1557, 01.09.2022

Sevgi Oğuz Akın Ozlem Yesil Celiktas Canan Sevimli Gür

https://doi.org/10.21597/jist.1099409

Öz

Destekleyen Kurum

Kocaeli Üniversitesi, Bilimsel Araştırma Fon Saymanlığı

Proje Numarası

KOU/BAP/2017/113

Teşekkür

Bu proje Kocaeli Üniversitesi Fon Saymanlığı tarafından desteklendiği için teşekkür ederiz.

Kaynakça

  • Begum, S. J., Pratibha, S., Rawat, J. M., Venugopal, D., Sahu, P., Gowda, A., Jaremko, M. 2022. Recent Advances in Green Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles. Pharmaceuticals, 15 (4), 455.
  • Cavaleiro C, Pinto E, Goncalves MJ and Salgueiro M, 2006. Antifungal activity of Juniperus essential oils against dermatophyte Aspergillus and Candida strains, Journal of Applied Microbiology, 100 (6), 1333-1338.
  • Damayanthi D, Mab A, Ahk A, Hamid A, Khh N, 2011. Effects of Smilax myosotiflora on testicular 11 a-hydroxysteroid dehydro-genase oxidative activity and plasma hormone levels in rats, Biomed. Res., 22, 188–193.
  • El-Sayed, A. S., Hassan, W. H., Sweilam, S. H., Alqarni, M. H. S., El Sayed, Z. I., Abdel-Aal, M. M., Abdelaziz, S. 2022. Production, Bioprocessing and Anti-Proliferative Activity of Camptothecin from Penicillium chrysogenum,“An Endozoic of Marine Sponge, Cliona sp.”, as a Metabolically Stable Camptothecin Producing Isolate. Molecules, 27 (9), 3033.
  • Ivanova A, Mikhova B, Batsalova T, Dzhambazov B, Kostova I, 2011. New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity, Fitoterapia, 82, 282–287.
  • Karaman I, Sahin F, Gulluce M, Ogutcu H, Sengul M, Adiguzel A., 2003. Antimicrobial activity of aqueous and methanol extracts of Juniperus oxycedrus L., Journal of Ethnopharmacology, 85, 231–235.
  • Koyuncu M, Coskun M, Tanker N, 2007. Farmasotik Botanik, 3. Baski, Ankara Universitesi, Eczacilik Fakultesi, Ankara.
  • Lesjaka MM, Beara IN, Orcic DZ, Petar KN, Simin N-D, Emilija S-D, Mimica-Dukic NM, 2014. Phytochemical composition and antioxidant, anti-inflammatory and antimicrobial activities of Juniperus macrocarpa Sibth. et Sm., Journal of Functional Foods, 7, 57– 268.
  • Lim JP, Song YC, Kim JW, Ku CH, Eun JS, Leem KH, Kim DK, 2002. Free radical scavengers from the heartwood of Juniperus chinensis, Arch. Pharm. Res., 25, 449–452.
  • Memis Y, 2011. Bazi Juniperus turlerinden ucucu yaglarin ekstraksiyonu ve bunlarin biyolojik aktivitelerinin incelenmesi, Nigde Omer Halisdemir Universitesi, Fen Bilimleri Enstitusu, Yuksek Lisans Tezi (Basılmıs).
  • Murali A, Ashok P, Madhavan V, 2011. In vitro antioxidant activity and HPTLC studies on the roots and rhizomes of Smilax zeylenica L. (Smilacaceae), International Journal of Pharmacy and Pharmaceutical Sciences, 3, 192-195.
  • Orhan N, Orhan IE, Ergun F, 2011. Insights into cholinesterase inhibitory and antioxidant activities of five Juniperus species, Food and Chemical Toxicology, 49, 2305–2312.
  • Sadeghi-aliabadi H, Emami A, Saidi M, Sadeghi B, Jafarian A, 2009. Evaluation of in vitro cytotoxic effects of Juniperus foetidissima and Juniperus sabina extracts against a panel of cancer cells,Iranian Journal of Pharmaceutical Research, 8 (4), 281-286.
  • Sevimli-Gur C, Cetin B, Akay S, Gulce-Iz S, Yesil-Celiktas O, 2013. Extracts from black carrot tissue culture as potent anticancer agents. Plant Foods for Human Nutrition, 68, 293- 298.
  • Sparg SG, Light ME, Van Staden J, 2004. Biological activities and distribution of plant saponins, Journal of Ethnopharm, 94, 219–243.
  • Subramanyan, S., Karunakaran, V., Deepika, S., Gracy, A. J., Sheeba, V., Joseph, K., Radhakrishnan, K. V. 2022. Libocedroquinone: A Promising Anticancer Lead against Lung Cancer from Calocedrus Decurrens. Planta Medica International Open, 9 (01), 54-59.
  • Taviano MF, Marino A, Trovato A, Bellinghieri V, Melchini A, Dugo P, Cacciola F, Donato P, Mondello L, Guvenc A, De Pasquale R, Miceli N., Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. ‘‘berries’’ from Turkey: Comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities, Food and Chemical Toxicology, 2013, 58, 22–29.
  • Tuzlaci, E, Erol MK, 1993. Turkish folk medicinal plants, Part II, Egirdir (Isparta) Fitoterapia, 70, 593–610. Wang, T., Ye, Y., Ji, J., Zhang, S., Yang, X., Xu, J., Sun, X. 2022. Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction. Food & Function, open access.
  • Weinstein M. P., 2018. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 11th Edition, ISBN Number: 1-56238-836-3.
  • Yesil-Celiktas O, Otto F, Gruener S, Parlar H 2009. Determination of extractability of pine bark using supercritical CO2 extraction and different solvents - optimization and prediction. Journal of Agricultural and Food Chemistry, 57, 341-347.
  • Yildiz-Ozturk E, Tag O, Yesil-Celiktas O, 2014. Subcritical water extraction of steviol glycosides from Stevia rebaudiana leaves and characterization of the raffinate phase. Journal of Supercritical Fluids, 95, 422-430.
  • Zubair M, Rizwan K, Rashid U, Saeed R, Saeed AA, Rasool N, Riaz M, 2017. GC/MS profiling, in vitro antioxidant, antimicrobial and haemolytic activities of Smilax macrophylla leaves, Arabian Journal of Chemistry, 10, 1460–1468.

Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts

Yıl 2022, Cilt: 12 Sayı: 3, 1550 - 1557, 01.09.2022

Sevgi Oğuz Akın Ozlem Yesil Celiktas Canan Sevimli Gür

https://doi.org/10.21597/jist.1099409

Öz

This research was carried out to determine the anti-tumorigenic, antioxidant and antimicrobial activities of extracts obtained from Juniperus oxycedrus L. oxycedrus (Cupressaceae) and Smilax aspera L. (Smilacaceae) fruits. The cytotoxic effects of ethanol extracts of Juniperus oxycedrus L. oxycedrus and Smilax aspera L. fruits were determined with six different tumorogenic cell lines including breast adenocarcinoma, small cell lung carcinoma, osteosarcoma, neuroblastoma and healthy kidney epithelial cells. Among the tested ethanol extracts of Juniperus oxycedrus L. oxycedrus and Smilax aspera L. fruits the ethanol extract obtained from Juniperus oxycedrus fruits was determined to have the highest anti-tumorigenic effect against small cell lung carcinoma with an IC50 value of 7.2 μg ml-1. At the end of cytotoxicity studies, ethanol extracts of Juniperus oxycedrus L. oxycedrus fruits proved to be good candidates for small cell lung carcinoma (A569). Antimicrobial effects were analyzed by the MIC test. MIC values of ethanol extracts of Juniperus oxycedrus L. oxycedrus and Smilax aspera L. fruits against Escherichia coli and Candida albicans were found to be 31.25 μg ml-1. Moreover, the radical scavenging capacity of Juniperus oxycedrus L. oxycedrus and Smilax aspera L. fruit extracts was elucidated. S. aspera L. (61%) and J. oxycedrus L. oxycedrus (47.3%) were found to have good free radical scavenging capacity.

Anahtar Kelimeler

Antitumorogenic antioxidant antimicrobial Juniperus oxycedrus Smilax aspera

Proje Numarası

KOU/BAP/2017/113

Kaynakça

  • Begum, S. J., Pratibha, S., Rawat, J. M., Venugopal, D., Sahu, P., Gowda, A., Jaremko, M. 2022. Recent Advances in Green Synthesis, Characterization, and Applications of Bioactive Metallic Nanoparticles. Pharmaceuticals, 15 (4), 455.
  • Cavaleiro C, Pinto E, Goncalves MJ and Salgueiro M, 2006. Antifungal activity of Juniperus essential oils against dermatophyte Aspergillus and Candida strains, Journal of Applied Microbiology, 100 (6), 1333-1338.
  • Damayanthi D, Mab A, Ahk A, Hamid A, Khh N, 2011. Effects of Smilax myosotiflora on testicular 11 a-hydroxysteroid dehydro-genase oxidative activity and plasma hormone levels in rats, Biomed. Res., 22, 188–193.
  • El-Sayed, A. S., Hassan, W. H., Sweilam, S. H., Alqarni, M. H. S., El Sayed, Z. I., Abdel-Aal, M. M., Abdelaziz, S. 2022. Production, Bioprocessing and Anti-Proliferative Activity of Camptothecin from Penicillium chrysogenum,“An Endozoic of Marine Sponge, Cliona sp.”, as a Metabolically Stable Camptothecin Producing Isolate. Molecules, 27 (9), 3033.
  • Ivanova A, Mikhova B, Batsalova T, Dzhambazov B, Kostova I, 2011. New furostanol saponins from Smilax aspera L. and their in vitro cytotoxicity, Fitoterapia, 82, 282–287.
  • Karaman I, Sahin F, Gulluce M, Ogutcu H, Sengul M, Adiguzel A., 2003. Antimicrobial activity of aqueous and methanol extracts of Juniperus oxycedrus L., Journal of Ethnopharmacology, 85, 231–235.
  • Koyuncu M, Coskun M, Tanker N, 2007. Farmasotik Botanik, 3. Baski, Ankara Universitesi, Eczacilik Fakultesi, Ankara.
  • Lesjaka MM, Beara IN, Orcic DZ, Petar KN, Simin N-D, Emilija S-D, Mimica-Dukic NM, 2014. Phytochemical composition and antioxidant, anti-inflammatory and antimicrobial activities of Juniperus macrocarpa Sibth. et Sm., Journal of Functional Foods, 7, 57– 268.
  • Lim JP, Song YC, Kim JW, Ku CH, Eun JS, Leem KH, Kim DK, 2002. Free radical scavengers from the heartwood of Juniperus chinensis, Arch. Pharm. Res., 25, 449–452.
  • Memis Y, 2011. Bazi Juniperus turlerinden ucucu yaglarin ekstraksiyonu ve bunlarin biyolojik aktivitelerinin incelenmesi, Nigde Omer Halisdemir Universitesi, Fen Bilimleri Enstitusu, Yuksek Lisans Tezi (Basılmıs).
  • Murali A, Ashok P, Madhavan V, 2011. In vitro antioxidant activity and HPTLC studies on the roots and rhizomes of Smilax zeylenica L. (Smilacaceae), International Journal of Pharmacy and Pharmaceutical Sciences, 3, 192-195.
  • Orhan N, Orhan IE, Ergun F, 2011. Insights into cholinesterase inhibitory and antioxidant activities of five Juniperus species, Food and Chemical Toxicology, 49, 2305–2312.
  • Sadeghi-aliabadi H, Emami A, Saidi M, Sadeghi B, Jafarian A, 2009. Evaluation of in vitro cytotoxic effects of Juniperus foetidissima and Juniperus sabina extracts against a panel of cancer cells,Iranian Journal of Pharmaceutical Research, 8 (4), 281-286.
  • Sevimli-Gur C, Cetin B, Akay S, Gulce-Iz S, Yesil-Celiktas O, 2013. Extracts from black carrot tissue culture as potent anticancer agents. Plant Foods for Human Nutrition, 68, 293- 298.
  • Sparg SG, Light ME, Van Staden J, 2004. Biological activities and distribution of plant saponins, Journal of Ethnopharm, 94, 219–243.
  • Subramanyan, S., Karunakaran, V., Deepika, S., Gracy, A. J., Sheeba, V., Joseph, K., Radhakrishnan, K. V. 2022. Libocedroquinone: A Promising Anticancer Lead against Lung Cancer from Calocedrus Decurrens. Planta Medica International Open, 9 (01), 54-59.
  • Taviano MF, Marino A, Trovato A, Bellinghieri V, Melchini A, Dugo P, Cacciola F, Donato P, Mondello L, Guvenc A, De Pasquale R, Miceli N., Juniperus oxycedrus L. subsp. oxycedrus and Juniperus oxycedrus L. subsp. macrocarpa (Sibth. & Sm.) Ball. ‘‘berries’’ from Turkey: Comparative evaluation of phenolic profile, antioxidant, cytotoxic and antimicrobial activities, Food and Chemical Toxicology, 2013, 58, 22–29.
  • Tuzlaci, E, Erol MK, 1993. Turkish folk medicinal plants, Part II, Egirdir (Isparta) Fitoterapia, 70, 593–610. Wang, T., Ye, Y., Ji, J., Zhang, S., Yang, X., Xu, J., Sun, X. 2022. Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction. Food & Function, open access.
  • Weinstein M. P., 2018. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically, 11th Edition, ISBN Number: 1-56238-836-3.
  • Yesil-Celiktas O, Otto F, Gruener S, Parlar H 2009. Determination of extractability of pine bark using supercritical CO2 extraction and different solvents - optimization and prediction. Journal of Agricultural and Food Chemistry, 57, 341-347.
  • Yildiz-Ozturk E, Tag O, Yesil-Celiktas O, 2014. Subcritical water extraction of steviol glycosides from Stevia rebaudiana leaves and characterization of the raffinate phase. Journal of Supercritical Fluids, 95, 422-430.
  • Zubair M, Rizwan K, Rashid U, Saeed R, Saeed AA, Rasool N, Riaz M, 2017. GC/MS profiling, in vitro antioxidant, antimicrobial and haemolytic activities of Smilax macrophylla leaves, Arabian Journal of Chemistry, 10, 1460–1468.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Mühendisliği
Bölüm Gıda Mühendisliği / Food Engineering
Yazarlar

Sevgi Oğuz Akın Bu kişi benim 0000-0001-6349-4536

Ozlem Yesil Celiktas Bu kişi benim 0000-0003-4509-2212

Canan Sevimli Gür 0000-0002-2210-5925

Proje Numarası KOU/BAP/2017/113
Erken Görünüm Tarihi 26 Ağustos 2022
Yayımlanma Tarihi 1 Eylül 2022
Gönderilme Tarihi 6 Nisan 2022
Kabul Tarihi 6 Haziran 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 12 Sayı: 3

Kaynak Göster

APA Oğuz Akın, S., Yesil Celiktas, O., & Sevimli Gür, C. (2022). Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts. Journal of the Institute of Science and Technology, 12(3), 1550-1557. https://doi.org/10.21597/jist.1099409
AMA Oğuz Akın S, Yesil Celiktas O, Sevimli Gür C. Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts. Iğdır Üniv. Fen Bil Enst. Der. Eylül 2022;12(3):1550-1557. doi:10.21597/jist.1099409
Chicago Oğuz Akın, Sevgi, Ozlem Yesil Celiktas, ve Canan Sevimli Gür. “Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts”. Journal of the Institute of Science and Technology 12, sy. 3 (Eylül 2022): 1550-57. https://doi.org/10.21597/jist.1099409.
EndNote Oğuz Akın S, Yesil Celiktas O, Sevimli Gür C (01 Eylül 2022) Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts. Journal of the Institute of Science and Technology 12 3 1550–1557.
IEEE S. Oğuz Akın, O. Yesil Celiktas, ve C. Sevimli Gür, “Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts”, Iğdır Üniv. Fen Bil Enst. Der., c. 12, sy. 3, ss. 1550–1557, 2022, doi: 10.21597/jist.1099409.
ISNAD Oğuz Akın, Sevgi vd. “Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts”. Journal of the Institute of Science and Technology 12/3 (Eylül 2022), 1550-1557. https://doi.org/10.21597/jist.1099409.
JAMA Oğuz Akın S, Yesil Celiktas O, Sevimli Gür C. Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts. Iğdır Üniv. Fen Bil Enst. Der. 2022;12:1550–1557.
MLA Oğuz Akın, Sevgi vd. “Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts”. Journal of the Institute of Science and Technology, c. 12, sy. 3, 2022, ss. 1550-7, doi:10.21597/jist.1099409.
Vancouver Oğuz Akın S, Yesil Celiktas O, Sevimli Gür C. Anticancer, Antioxidant and Antimicrobial Activities of Some Mediterranean Plants Extracts. Iğdır Üniv. Fen Bil Enst. Der. 2022;12(3):1550-7.
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