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DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN

Yıl 2024, Cilt: 48 Sayı: 2, 406 - 411

Yasemin Yücel Yücel Ebru Özdemir Nath

https://doi.org/10.33483/jfpau.1372535

Öz

Objective: Lamiaceae family has a wide variety of well-known and lesser-known plants with strong medicinal qualities. The genus Micromeria Benth. is a member of this family consisting of herbaceous plants with a variety of significant biological, phytochemical, and ethnobotanical uses. In this study, the biological activities of methanol and ethanol extracts of Micromeria myrtifolia were evaluated.
Material and Method: To demonstrate the antioxidant activity DPPH radical scavenging activity and total phenolic content assays were done. The effects of the extracts on acetylcholinesterase (AChE) and monoamine oxidase-A were then assessed.
Result and Discussion: Methanol extract showed the highest DPPH scavenging activity, at the dose of 10 mg/ml with a value of 96.55%. For the highest concentration that can be applicable, AChE inhibitions for the methanol and ethanol extracts were 25% and 27%, respectively. On the other hand, the inhibitory effects of the ethanol and methanol extracts of the plant on MAO-A were determined; for the ethanol extract IC50 value was found as 32.5876 ± 0.89 g/ml, and for the methanol extract it was found as 34.6544 ± 0.76 g/ml. It can be told that M. myrtifolia can act as a potential antioxidant. With further research and investigation, it is thought that Micromeria myrtifolia could be used as a natural source for the treatment of various neurological diseases.

Anahtar Kelimeler

Acetylcholinesterase antioxidant activity Micromeria myrtifolia monoamine oxidase-A neurodegenerative diseases

Etik Beyan

The authors declare that the ethics committee approval is not required for this study.

Destekleyen Kurum

This research project was supported by Altınbaş University Scientific Research Fund. Project Number: PB2020-ECZ-3

Proje Numarası

Project Number: PB2020-ECZ-3.

Kaynakça

  • 1. Ďuračková, Z. (2010). Some current insights into oxidative stress. Physiological Research, 59(4), 459-469. [CrossRef]
  • 2. Reuter, S., Gupta, S.C., Chaturvedi, M.M., Aggarwal, B.B. (2010). Oxidative stress, inflammation, and cancer: How are they linked? Free Radical Biology and Medicine, 49(11), 1603-1616. [CrossRef]
  • 3. Kim, D., Baik, S.H., Kang, S., Cho, S.W., Bae, J., Cha, M.Y., Sailor, M.J., Mook-Jung, I., Ahn, K.H. (2016). Close correlation of monoamine oxidase activity with progress of Alzheimer’s disease in mice, observed by in vivo two-photon imaging. ACS Centeral Science 2(12), 967-975. [CrossRef]
  • 4. Kaduszkiewicz, H., van den Bussche, H. (2009). Acetylcholinesterase inhibitors and Alzheimer’s disease, Encyclopedia of Neuroscience, 9-13. [CrossRef]
  • 5. Petrovska, B.B. (2012). Historical review of medicinal plants’ usage. Pharmacognosy Reviews, 6(11), 1-5. [CrossRef]
  • 6. Vladimir-Knežević, S., Blažeković, B., Štefan, M.B., Alegro, A., Kőszegi, T., Petrik, J. (2011). Antioxidant activities and polyphenolic contents of three selected Micromeria species from Croatia. Molecules, 16(2), 1454-1470. [CrossRef]
  • 7. Dirmenci, T. (2012). Micromeria. Bizimbitkiler. Published October 28, 2013. http://www.bizimbitkiler.org .tr. Accessed date: June 5, 2023.
  • 8. Bentham, (2023). World Flora Online. Retrieved October 28, 2023. From http://www.worldfloraonline.org. Accessed date: June 5, 2023.
  • 9. Bentham, (1982). Micromeria. In: Davis PH, ed. Flora of Turkey and the East Aegean Islands. Vol 7, 353-367.
  • 10. Korkmaz, M., Karakurt, E. (2015). An ethnobotanical ınvestigation to determine plants used as folk medicine in Kelkit Gümüşhane/Turkey district. Biyolojik Çeşitlilik ve Koruma, 8(3), 290-303.
  • 11. Bulut, G., Tuzlaci, E. (2008). Folk Medicinal Plants of Bayramiç (Çanakale-Turkey). Journal of Pharmacy of Istanbul University, 40, 87-99.
  • 12. Everest, A., Ozturk, E. (2005). Focusing on the ethnobotanical uses of plants in Mersin and Adana provinces (Turkey). Journal of Ethnobiology and Ethnomedicine, 1, 1-6. [CrossRef]
  • 13. Sargin, S.A. (2015). Ethnobotanical survey of medicinal plants in Bozyazı district of Mersin, Turkey. Journal of Ethnopharmacology, 173, 105-126. [CrossRef]
  • 14. Nath, E.Ö., Kültür, Ş. (2022). An ethnobotanical study of medicinal plants In Savaştepe (Balıkesir-Turkey). Clinical and Experimental Health Sciences, 12(4), 954-980. [CrossRef]
  • 15. Marin, P.D., Grayer, R.J., Veitch, N.C., Kite, G.C., Harborne, J.B. (2001). Acacetin glycosides as taxonomic markers in Calamintha and Micromeria. Phytochemistry, 58(6), 943-947. [CrossRef]
  • 16. Tomas-Barberan, F.A., Gil, M.I., Marin, P.D., Tomas-Lorente, F. (1991). Flavonoids from some Yugoslavian Micromeria species: Chemotaxonomical aspects. Biochemical Systematics and Ecology, 19(8), 697-698. [CrossRef]
  • 17. Küpeli Akkol, E., Gürağaç Dereli, F.T., Ilhan, M. (2019). Assessment of antidepressant effect of the aerial parts of Micromeria myrtifolia Boiss. & Hohen on mice. Molecules, 24(10), 1869. [CrossRef]
  • 18. Özek, T., Kirimer, N., Baser, K.H.C. (1992). Composition of the essential oil of Micromeria myrtifolia Boiss. et Hohen. Journal of Essential Oil Research, 4(1), 79-80. [CrossRef]
  • 19. Formisano, C., Oliviero, F., Rigano, D., Saab, A.M., Senatore, F. (2014). Chemical composition of essential oils and in vitro antioxidant properties of extracts and essential oils of Calamintha origanifolia and Micromeria myrtifolia, two Lamiaceae from the Lebanon flora. Industrial Crops and Products, 62, 405-411. [CrossRef]
  • 20. El-Seedi, H.R., Khattab, A., Gaara, A.H., Mohamed, T.K., Hassan, N.A., El-kattan, A.E. (2008). Essential oil analysis of Micromeria nubigena HBK and its antimicrobial activity. Journal of Essential Oil Research, 20(5), 452-456. [CrossRef]
  • 21. Duru, M.E., Öztürk, M., Uğur, A., Ceylan, Ö. (2004). The constituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey. Journal of Ethnopharmacology, 94(1), 43-48. [CrossRef]
  • 22. Abu-Gharbieh, E., Ahmed, N.G. (2016). Bioactive content, hepatoprotective and antioxidant activities of whole plant extract of Micromeria fruticosa (L) Druce ssp serpyllifolia F Lamiaceae against carbon tetrachloride-induced hepatotoxicity in mice. Tropical Journal of Pharmaceutical Research, 15(10), 2099-2106. [CrossRef]
  • 23. Koc, K., Ozdemir, O., Kizilkaya, F.O., Sengul, M., Turkez, H. (2017). Cytotoxic activity of the aqueous extract of Micromeria fruticosa (L.) Druce subsp. serpyllifolia on human U-87 MG cell lines. Archives of Biological Sciences, 69(3), 449-453. [CrossRef]
  • 24. Formisano, C., Oliviero, F., Rigano, D., Saab, A.M., Senatore, F. (2014). Chemical composition of essential oils and in vitro antioxidant properties of extracts and essential oils of Calamintha origanifolia and Micromeria myrtifolia, two Lamiaceae from the Lebanon flora. Industrial Crops and Products, 62, 405-411. [CrossRef]
  • 25. Brand-Williams, W., Cuvelier, M.E., Berset, C.L.W.T. (1995). Use of a free radical method to evaluate antioxidant activity. LWT-Food Science and Technology, 28(1), 25-30. [CrossRef]
  • 26. Slinkard, K., Singleton, V.L. (1977). Total phenol analysis: Automation and comparison with manual methods. American Journal of Enology and Viticulture, 28(1), 49-55. [CrossRef]
  • 27. Ellman, G.L., Courtney, K.D., Andres Jr, V., Featherstone, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88-95. [CrossRef]
  • 28. Krajl, M. (1965). A rapid microfluorimetric determination of monoamine oxidase. Biochemical Pharmacology, 14(11), 1684-1685. [CrossRef]
  • 29. Urban, P., Andersen, J.K., Hsu, H.P., Pompon, D. (1991). Comparative membrane locations and activities of human monoamine oxidases expressed in yeast. FEBS Letters, 286(1-2), 142-146. [CrossRef]
  • 30. Sarikurkcu, C., Hanine, H., Sarikurkcu, R.B., Sarikurkcu, R.T., Amarowicz, R. (2020). Micromeria myrtifolia: The influence of the extracting solvents on phenolic composition and biological activity. Industrial Crops and Products, 145, 111923. [CrossRef]
  • 31. El Hamaoui, B.A.S.S.E.M., Bakkour, Y., El-Omar, F. (2015). Chemical composition, antimicrobial and antioxidant activities of the ethanolic extract of Micromeria fruticosa growing in Lebanon. International Journal of Chemical Sciences, 13(1), 325-335.
  • 32. Küpeli Akkol, E., Gürağaç Dereli, F.T., Ilhan, M. (2019). Assessment of antidepressant effect of the aerial parts of Micromeria myrtifolia Boiss. & Hohen on mice. Molecules, 24(10), 1869. [CrossRef]
  • 33. Selleck Chemicals web site (2023). MAO-A Selective Inhibitors from https://www.selleckchem.com/sub units/MAO-A_MAO_selpan.html. Accessed date: 29.10.2023.

MICROMERIA MYRTIFOLIA BOISS. & HOHEN’İN BİYOLOJİK AKTİVİTELERİNİN BELİRLENMESİ

Yıl 2024, Cilt: 48 Sayı: 2, 406 - 411

Yasemin Yücel Yücel Ebru Özdemir Nath

https://doi.org/10.33483/jfpau.1372535

Öz

Amaç: Lamiaceae familyası, güçlü tıbbi niteliklere sahip bilinen veya az bilinen değişik bitkileri içeren bir bitki ailesidir. Micromeria Benth cinsi bu familyaya ait, çok çeşitli biyolojik, fitokimyasal ve etnobotanik kullanımı olan, çoğunlukla otsu bitkilerden oluşan cinslerden biridir. Bu çalışmada, Micromeria myrtifolia'nın metanol ve etanol ekstreleri, bitkinin biyolojik aktiviteleri gösterilmek üzere seçilmiştir
Gereç ve Yöntem: Antioksidan aktiviteyi göstermek için DPPH radikal süpürücü aktivitesi ve total fenolik içerik deneyleri yapılmıştır. Daha sonra ekstrelerin asetilkolinesteraz (AChE) ve monoamin oksidaz-A (MAO-A) üzerindeki etkileri değerlendirilmiştir.
Sonuç ve Tartışma: Çalışma sonunda metanol ekstraktı, 10 mg/ml dozunda % 96.55 değeriyle en yüksek DPPH radikal süpürücü aktivitesi göstermiştir. Uygulanabilecek en yüksek konsantrasyonlarda metanol ve etanol ekstreleri için AChE inhibisyonları sırasıyla %25 ve %27 olarak saptanmıştır. Ayrıca bitkinin MAO-A üzerine etkisi de tespit edilmiştir. Buna göre etanol ekstresi için IC50 değeri 32.5876 ± 0.89 g/ml ve metanol ekstresi için ise 34.6544 ± 0.76 g/ml olarak bulunmuştur. Elde edilen sonuçlara göre M. myrtifolia'nın potansiyel bir antioksidan etkisi gösterebileceği söylenebilir. Daha ileri çalımalar ile Micromeria myrtifolia'nın çeşitli nörolojik hastalıkların tedavisi için doğal bir kaynak olarak kullanılabileceği düşünülmektedir.

Anahtar Kelimeler

Antioksidan aktivite asetilkolinesteraz Micromeria myrtifolia monoamin oksidaz-A nörodejeneratif hastalıklar

Proje Numarası

Project Number: PB2020-ECZ-3.

Kaynakça

  • 1. Ďuračková, Z. (2010). Some current insights into oxidative stress. Physiological Research, 59(4), 459-469. [CrossRef]
  • 2. Reuter, S., Gupta, S.C., Chaturvedi, M.M., Aggarwal, B.B. (2010). Oxidative stress, inflammation, and cancer: How are they linked? Free Radical Biology and Medicine, 49(11), 1603-1616. [CrossRef]
  • 3. Kim, D., Baik, S.H., Kang, S., Cho, S.W., Bae, J., Cha, M.Y., Sailor, M.J., Mook-Jung, I., Ahn, K.H. (2016). Close correlation of monoamine oxidase activity with progress of Alzheimer’s disease in mice, observed by in vivo two-photon imaging. ACS Centeral Science 2(12), 967-975. [CrossRef]
  • 4. Kaduszkiewicz, H., van den Bussche, H. (2009). Acetylcholinesterase inhibitors and Alzheimer’s disease, Encyclopedia of Neuroscience, 9-13. [CrossRef]
  • 5. Petrovska, B.B. (2012). Historical review of medicinal plants’ usage. Pharmacognosy Reviews, 6(11), 1-5. [CrossRef]
  • 6. Vladimir-Knežević, S., Blažeković, B., Štefan, M.B., Alegro, A., Kőszegi, T., Petrik, J. (2011). Antioxidant activities and polyphenolic contents of three selected Micromeria species from Croatia. Molecules, 16(2), 1454-1470. [CrossRef]
  • 7. Dirmenci, T. (2012). Micromeria. Bizimbitkiler. Published October 28, 2013. http://www.bizimbitkiler.org .tr. Accessed date: June 5, 2023.
  • 8. Bentham, (2023). World Flora Online. Retrieved October 28, 2023. From http://www.worldfloraonline.org. Accessed date: June 5, 2023.
  • 9. Bentham, (1982). Micromeria. In: Davis PH, ed. Flora of Turkey and the East Aegean Islands. Vol 7, 353-367.
  • 10. Korkmaz, M., Karakurt, E. (2015). An ethnobotanical ınvestigation to determine plants used as folk medicine in Kelkit Gümüşhane/Turkey district. Biyolojik Çeşitlilik ve Koruma, 8(3), 290-303.
  • 11. Bulut, G., Tuzlaci, E. (2008). Folk Medicinal Plants of Bayramiç (Çanakale-Turkey). Journal of Pharmacy of Istanbul University, 40, 87-99.
  • 12. Everest, A., Ozturk, E. (2005). Focusing on the ethnobotanical uses of plants in Mersin and Adana provinces (Turkey). Journal of Ethnobiology and Ethnomedicine, 1, 1-6. [CrossRef]
  • 13. Sargin, S.A. (2015). Ethnobotanical survey of medicinal plants in Bozyazı district of Mersin, Turkey. Journal of Ethnopharmacology, 173, 105-126. [CrossRef]
  • 14. Nath, E.Ö., Kültür, Ş. (2022). An ethnobotanical study of medicinal plants In Savaştepe (Balıkesir-Turkey). Clinical and Experimental Health Sciences, 12(4), 954-980. [CrossRef]
  • 15. Marin, P.D., Grayer, R.J., Veitch, N.C., Kite, G.C., Harborne, J.B. (2001). Acacetin glycosides as taxonomic markers in Calamintha and Micromeria. Phytochemistry, 58(6), 943-947. [CrossRef]
  • 16. Tomas-Barberan, F.A., Gil, M.I., Marin, P.D., Tomas-Lorente, F. (1991). Flavonoids from some Yugoslavian Micromeria species: Chemotaxonomical aspects. Biochemical Systematics and Ecology, 19(8), 697-698. [CrossRef]
  • 17. Küpeli Akkol, E., Gürağaç Dereli, F.T., Ilhan, M. (2019). Assessment of antidepressant effect of the aerial parts of Micromeria myrtifolia Boiss. & Hohen on mice. Molecules, 24(10), 1869. [CrossRef]
  • 18. Özek, T., Kirimer, N., Baser, K.H.C. (1992). Composition of the essential oil of Micromeria myrtifolia Boiss. et Hohen. Journal of Essential Oil Research, 4(1), 79-80. [CrossRef]
  • 19. Formisano, C., Oliviero, F., Rigano, D., Saab, A.M., Senatore, F. (2014). Chemical composition of essential oils and in vitro antioxidant properties of extracts and essential oils of Calamintha origanifolia and Micromeria myrtifolia, two Lamiaceae from the Lebanon flora. Industrial Crops and Products, 62, 405-411. [CrossRef]
  • 20. El-Seedi, H.R., Khattab, A., Gaara, A.H., Mohamed, T.K., Hassan, N.A., El-kattan, A.E. (2008). Essential oil analysis of Micromeria nubigena HBK and its antimicrobial activity. Journal of Essential Oil Research, 20(5), 452-456. [CrossRef]
  • 21. Duru, M.E., Öztürk, M., Uğur, A., Ceylan, Ö. (2004). The constituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey. Journal of Ethnopharmacology, 94(1), 43-48. [CrossRef]
  • 22. Abu-Gharbieh, E., Ahmed, N.G. (2016). Bioactive content, hepatoprotective and antioxidant activities of whole plant extract of Micromeria fruticosa (L) Druce ssp serpyllifolia F Lamiaceae against carbon tetrachloride-induced hepatotoxicity in mice. Tropical Journal of Pharmaceutical Research, 15(10), 2099-2106. [CrossRef]
  • 23. Koc, K., Ozdemir, O., Kizilkaya, F.O., Sengul, M., Turkez, H. (2017). Cytotoxic activity of the aqueous extract of Micromeria fruticosa (L.) Druce subsp. serpyllifolia on human U-87 MG cell lines. Archives of Biological Sciences, 69(3), 449-453. [CrossRef]
  • 24. Formisano, C., Oliviero, F., Rigano, D., Saab, A.M., Senatore, F. (2014). Chemical composition of essential oils and in vitro antioxidant properties of extracts and essential oils of Calamintha origanifolia and Micromeria myrtifolia, two Lamiaceae from the Lebanon flora. Industrial Crops and Products, 62, 405-411. [CrossRef]
  • 25. Brand-Williams, W., Cuvelier, M.E., Berset, C.L.W.T. (1995). Use of a free radical method to evaluate antioxidant activity. LWT-Food Science and Technology, 28(1), 25-30. [CrossRef]
  • 26. Slinkard, K., Singleton, V.L. (1977). Total phenol analysis: Automation and comparison with manual methods. American Journal of Enology and Viticulture, 28(1), 49-55. [CrossRef]
  • 27. Ellman, G.L., Courtney, K.D., Andres Jr, V., Featherstone, R.M. (1961). A new and rapid colorimetric determination of acetylcholinesterase activity. Biochemical Pharmacology, 7(2), 88-95. [CrossRef]
  • 28. Krajl, M. (1965). A rapid microfluorimetric determination of monoamine oxidase. Biochemical Pharmacology, 14(11), 1684-1685. [CrossRef]
  • 29. Urban, P., Andersen, J.K., Hsu, H.P., Pompon, D. (1991). Comparative membrane locations and activities of human monoamine oxidases expressed in yeast. FEBS Letters, 286(1-2), 142-146. [CrossRef]
  • 30. Sarikurkcu, C., Hanine, H., Sarikurkcu, R.B., Sarikurkcu, R.T., Amarowicz, R. (2020). Micromeria myrtifolia: The influence of the extracting solvents on phenolic composition and biological activity. Industrial Crops and Products, 145, 111923. [CrossRef]
  • 31. El Hamaoui, B.A.S.S.E.M., Bakkour, Y., El-Omar, F. (2015). Chemical composition, antimicrobial and antioxidant activities of the ethanolic extract of Micromeria fruticosa growing in Lebanon. International Journal of Chemical Sciences, 13(1), 325-335.
  • 32. Küpeli Akkol, E., Gürağaç Dereli, F.T., Ilhan, M. (2019). Assessment of antidepressant effect of the aerial parts of Micromeria myrtifolia Boiss. & Hohen on mice. Molecules, 24(10), 1869. [CrossRef]
  • 33. Selleck Chemicals web site (2023). MAO-A Selective Inhibitors from https://www.selleckchem.com/sub units/MAO-A_MAO_selpan.html. Accessed date: 29.10.2023.
Toplam 33 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılık Biyokimyası
Bölüm Araştırma Makalesi
Yazarlar

Yasemin Yücel Yücel 0000-0002-6595-6850

Ebru Özdemir Nath 0000-0002-0250-9084

Proje Numarası Project Number: PB2020-ECZ-3.
Erken Görünüm Tarihi 5 Şubat 2024
Yayımlanma Tarihi
Gönderilme Tarihi 6 Ekim 2023
Kabul Tarihi 17 Ocak 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 48 Sayı: 2

Kaynak Göster

APA Yücel, Y. Y., & Özdemir Nath, E. (2024). DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN. Journal of Faculty of Pharmacy of Ankara University, 48(2), 406-411. https://doi.org/10.33483/jfpau.1372535
AMA Yücel YY, Özdemir Nath E. DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN. Ankara Ecz. Fak. Derg. Şubat 2024;48(2):406-411. doi:10.33483/jfpau.1372535
Chicago Yücel, Yasemin Yücel, ve Ebru Özdemir Nath. “DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN”. Journal of Faculty of Pharmacy of Ankara University 48, sy. 2 (Şubat 2024): 406-11. https://doi.org/10.33483/jfpau.1372535.
EndNote Yücel YY, Özdemir Nath E (01 Şubat 2024) DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN. Journal of Faculty of Pharmacy of Ankara University 48 2 406–411.
IEEE Y. Y. Yücel ve E. Özdemir Nath, “DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN”, Ankara Ecz. Fak. Derg., c. 48, sy. 2, ss. 406–411, 2024, doi: 10.33483/jfpau.1372535.
ISNAD Yücel, Yasemin Yücel - Özdemir Nath, Ebru. “DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN”. Journal of Faculty of Pharmacy of Ankara University 48/2 (Şubat 2024), 406-411. https://doi.org/10.33483/jfpau.1372535.
JAMA Yücel YY, Özdemir Nath E. DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN. Ankara Ecz. Fak. Derg. 2024;48:406–411.
MLA Yücel, Yasemin Yücel ve Ebru Özdemir Nath. “DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN”. Journal of Faculty of Pharmacy of Ankara University, c. 48, sy. 2, 2024, ss. 406-11, doi:10.33483/jfpau.1372535.
Vancouver Yücel YY, Özdemir Nath E. DETERMINATION OF BIOLOGICAL ACTIVITIES OF MICROMERIA MYRTIFOLIA BOISS. & HOHEN. Ankara Ecz. Fak. Derg. 2024;48(2):406-11.
 Kapak Resmi İndir

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.