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PROBİYOTİK- İNSAN BAĞIŞIKLIK SİSTEMİ ETKİLEŞİMLERİ

Yıl 2019, , 265 - 280, 01.10.2019

Dicle Dilara Akpınar , Burcu Kaplan Türköz

https://doi.org/10.3153/FH19027

Öz

Probiyotikler
yeterli miktarda tüketildiklerinde sağlık üzerine yararlı etkiler gösteren
canlı mikroorganizmalardır. Bu mikroorganizmalar, patojenlerle mücadele, epitel
hücre kararlılığını sağlama ve bağışıklık sistemini düzenleyebilmeleri ile
sağlık üzerine olumlu etkiler göstermektedirler. Bağışıklık düzenleyici,
anti-inflamatuar, anti-mikrobiyal, anti-oksidan etkilerini, açığa çıkardıkları
metabolitleriyle, ürettikleri moleküllerle ve hücre yapı bileşenleriyle
sağlamaktadırlar. Peptidoglikan, teikoik asit, lipoteikoik asit, hücre yüzey
polisakkaritleri, salgılanan proteinler ve yüzey proteinleri gibi probiyotik
etken molekülleri doğal bağışıklıkta görevli reseptörler tarafından tanınarak
bağışıklık sistemini harekete geçirmektedir. Yapılan çalışmalarla bu etken
moleküllerinden bazılarının etki mekanizmaları aydınlatılmıştır.Bu derlemede
probiyotiklerin, probiyotik-konak etkileşimleri için kullandıkları bilinen
etken molekülleri hakkında ve etkileri üzerine bilgi verilmesi amaçlanmıştır.

Anahtar Kelimeler

Probiyotikler Sağlık etkileri Probiyotik-konak etkileşimleri Bağışıklık düzenleme Etken moleküller

Teşekkür

Bu derlemedeki bilgi birikiminin oluşmasına katkı sağlayan TÜBİTAK-KBAG (Proje No: 116Z299) ve Ege Üniversitesi Bilimsel Araştırma Projesi (Proje No: 16-Müh-083) desteklerine teşekkür ederiz.

Kaynakça

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PROBIOTIC-HUMAN IMMUNE SYSTEM INTERACTIONS

Yıl 2019, , 265 - 280, 01.10.2019

Dicle Dilara Akpınar , Burcu Kaplan Türköz

https://doi.org/10.3153/FH19027

Öz

Probiotics are
live microorganisms which when administered in adequate amounts confer a health
benefit on the host. These microorganisms are known to provide beneficial
health effects by competing with pathogens, providing epithelial cell stability
and showing regulatory effects on the immune system. They provide
immunomodulatory, anti-inflammatory, anti-microbial, antioxidant effects with
their released metabolites, produced molecules and cell structure components.
Effector molecules of probiotics such as peptidoglycan, teichoic acid,
lipoteichoic acid, cell surface polysaccharides, secreted proteins and surface
proteins are recognized by innate immunity receptors and activate the immune
system. The mechanisms of some effector molecules of probiotics have been
elucidated. The aim of this review is to give information on the effects of
probiotics and their active molecules known to be used for probiotic-host
interactions.

Anahtar Kelimeler

Probiotics Health Effects Probiotic-host interactions Immunomodulation Effector molecules

Kaynakça

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  • Nagpal, R., Yadav, H., Kumar, M., Jain, S., Yamashiro, Y., Marotta, F. (2014). Probiotics, Prebiotics and Synbiotics: An Introduction. İçinde S. Ötleş (Eds.). Probiotics and Prebiotics in Food, Nutrition and Health (s. 1-24). Boca Raton: Taylor & Francis Group. ISNB 13: 978-1-4665-8624-6 https://doi.org/10.1201/b15561-2
  • Neuhaus, F. C., Baddiley, J. (2003). A Continuum of Anionic Charge: Structures and Functions of D-Alanyl-Teichoic Acids in Gram-Positive Bacteria. Microbiology and Molecular Biology Reviews, 67(4), 686-723. https://doi.org/10.1128/MMBR.67.4.686-723.2003
  • Ogura, Y., Bonen, D.K., Inohara, N., Nicolae, D.L., Chen, F.F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerrk, R.H., Achkar, J.-P., Brant, S.R., Bayless, T.M., Kirschner, B.S., Hanauer, S,B., Nuñez, G.N., Cho, J.H. (2001). A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 411, 603-606. https://doi.org/10.1038/35079114
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  • Ouwehand, A.C., Salminen, S., Isolauri, E. (2002). Probiotics : an overview of beneficial effects. Antonie van Leeuwenhoek, 82, 279-289. https://doi.org/10.1023/A:1020620607611
  • Pandey, K.R., Naik, S.R., Vakil, B.V. (2015). Probiotics, prebiotics and synbiotics- a review. Association of Food Scientists and Technologists, 52(12), 7577-7587. https://doi.org/10.1007/s13197-015-1921-1
  • Parvez, S., Malik, K.A., Ah Kang, S., Kim, H.Y. (2006). Probiotics and their fermented food products are beneficial for health. Journal of Applied Microbiology, 100(6), 1171-1185. https://doi.org/10.1111/j.1365-2672.2006.02963.x
  • Rafter, J. (2002). Lactic acid bacteria and cancer: mechanistic perspective. British Journal of Nutrition, 88(1), 89-94. https://doi.org/10.1079/BJN2002633
  • Reunanen, J., von Ossowski, I., Hendrickx, A.P.A., Palva, A., de Vosa, W.M. (2012). Characterization of the SpaCBA pilus fibers in the probiotic Lactobacillus rhamnosus GG. Applied and Environmental Microbiology, 78(7), 2337-2344. https://doi.org/10.1128/AEM.07047-11
  • Rodgers, S. (2008). Novel applications of live bacteria in food services: probiotics and protective cultures. Trends in Food Science and Technology, 19(4), 188-197. https://doi.org/10.1016/j.tifs.2007.11.007
  • Ruas-Madiedo, P., Medrano, M., Salazar, N., De Los Reyes-Gavilán, C.G., Pérez, P.F., Abraham, A.G. (2010). Exopolysaccharides produced by Lactobacillus and Bifidobacterium strains abrogate in vitro the cytotoxic effect of bacterial toxins on eukaryotic cells. Journal of Applied Microbiology, 109(6), 2079-2086. https://doi.org/10.1111/j.1365-2672.2010.04839.x
  • Ruiz, L., Hevia, A., Bernardo, D., Margolles, A., Sánchez, B. (2014). Extracellular molecular effectors mediating probiotic attributes. FEMS Microbiology Letters, 359(1), 1-11. https://doi.org/10.1111/1574-6968.12576
  • Rupa, P., Mine, Y. (2012). Recent advances in the role of probiotics in human In flammation and gut health. Journal of Agricultural and Food Chemistry, 60(34), 8249-8256. https://doi.org/10.1021/jf301903t
  • Saber, R., Zadeh, M., Pakanati, K.C., Bere, P., Klaenhammer, T., Mansour, M. (2011). Lipoteichoic acid-deficient Lactobacillus acidophilus regulates downstream signals. Immunotherapy, 3(3), 337-347. https://doi.org/10.2217/imt.10.119
  • Sağdıç, O., Küçüköner, E., Özçelik, S. (2004). Probiyotik ve Prebiyotiklerin Fonksiyonel Özellikleri. Atatürk Üniversitesi Ziraat Fakültesi Dergisi, 35(3-4), 221-228.
  • Sarkar, A., Mandal, S. (2016). Bifidobacteria-Insight into clinical outcomes and mechanisms of its probiotic action. Microbiological Research, 192, 159-171. https://doi.org/10.1016/j.micres.2016.07.001
  • Sarkar, S. (2013). Probiotics as functional foods: gut colonization and safety concerns. Nutrition and Food Science, 43(5), 496-504. https://doi.org/10.1108/NFS-10-2011-0120
  • Schell, M.A., Karmirantzou, M., Snel, B., Vilanova, D., Berger, B., Pessi, G., Zwahlen, M.-C., Desiere, F., Bork, P., Delley, M., Pridmore, R.D., Arigoni, F. (2002). The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract. Proceedings of the National Academy of Sciences, 99(22), 14422-14427. https://doi.org/10.1073/pnas.212527599
  • Schlee, M., Harder, J., Köten, B., Stange, E.F., Wehkamp, J., Fellermann, K. (2008). Probiotic lactobacilli and VSL#3 induce enterocyte β-defensin 2. Clinical and Experimental Immunology, 151(3), 528-535. https://doi.org/10.1111/j.1365-2249.2007.03587.x
  • Schlee, M., Wehkamp, J., Altenhoefer, A., Oelschlaeger, T.A., Stange, E.F., Fellermann, K. (2007). Induction of human β-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin. Infection and Immunity, 75(5), 2399-2407. https://doi.org/10.1128/IAI.01563-06
  • Seth, A., Yan, F., Polk, D.B., Rao, R.K. (2008). Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(4), 1060-1069. https://doi.org/10.1152/ajpgi.00202.2007
  • Sheil, B., Shanahan, F., O'Mahony, L. (2007). Probiotic effects on inflammatory bowel disease. The Journal of Nutrition, 137(3), 819-824. https://doi.org/10.1093/jn/137.3.819S
  • Shida, K., Kiyoshima-Shibata, J., Kaji, R., Nagaoka, M., Nanno, M. (2009). Peptidoglycan from lactobacilli inhibits interleukin-12 production by macrophages induced by Lactobacillus casei through Toll-like receptor 2-dependent and independent mechanisms. Immunology, 128(1pt2), 858-869. https://doi.org/10.1111/j.1365-2567.2009.03095.x
  • Singh, K., Kallali, B., Kumar, A., Thaker, V. (2011). Probiotics: A review. Asian Pacific Journal of Tropical Biomedicine, 1(2), 287-290. https://doi.org/10.1016/S2221-1691(11)60174-3
  • Sudha, R.M., Bhonagiri, S. (2012). Efficacy of Bacillus Coagulans Strain Unique Is-2 in the Treatment of Patients With Acute Diarrhea. International Journal of Probiotics and Prebiotics, 7(1), 33-37.
  • Tabasco, R., Fernández, P., Palencia, D., Fontecha, J., Peláez, C., Requena, T. (2014). Competition mechanisms of lactic acid bacteria and bi fi dobacteria : Fermentative metabolism and colonization. LWT - Food Science and Technology, 55(2), 680-684. https://doi.org/10.1016/j.lwt.2013.10.004
  • Tanaka, Y., Kanazawa, M., Fukudo, S., Drossman, D.A. (2011). Biopsychosocial model of irritable bowel syndrome. Journal of Neurogastroenterology and Motility, 17(2), 131-139. https://doi.org/10.5056/jnm.2011.17.2.131
  • Tsilingiri, K., Rescigno, M. (2013). Postbiotics : what else ?. Beneficial Microbes, 4(1), 101-107. https://doi.org/10.3920/BM2012.0046
  • Turroni, F., Serafini, F., Foroni, E., Duranti, S., O'Connell Motherway, M., Taverniti, V., Mangifesta, M., Milani, C., Viappiani, A., Roversi, T., Sánchez, B., Santoni, A., Gioiosa, L., Ferrarini, A., Delledonne, M., Margolles, A., Piazza, L., Palanza, P., Bolchi, A., Guglielmetti, S., van Sinderen, D., Ventura, M. (2013). Role of sortase-dependent pili of Bifidobacterium bifidum PRL2010 in modulating bacterium-host interactions. Proceedings of the National Academy of Sciences of the United States of America, 110(27), 11151-11156. https://doi.org/10.1073/pnas.1303897110
  • Tytgat, H.L.P., Douillard, F.P., Reunanen, J., Rasinkangas, P., Hendrickx, A.P.A., Laine, P.K., Paulin, L., Satokari, R., Vos, W.M. de. (2016). Lactobacillus rhamnosus GG Outcompetes Enterococcus faecium via Mucus-Binding Pili: Evidence for a Novel and Heterospecific Probiotic Mechanism. Applied and Environmental Microbiology, 82(19), 5756-5762. https://doi.org/10.1128/AEM.01243-16
  • Van Hemert, S., Meijerink, M., Molenaar, D., Bron, P. A., De Vos, P., Kleerebezem, M., Wells, J., M. Marco, M. L. (2010). Identification of Lactobacillus plantarum genes modulating the cytokine response of human peripheral blood mononuclear cells. BMC Microbiology, 10(293), 1-13. https://doi.org/10.1186/1471-2180-10-293
  • Vargas García, C.E., Petrova, M., Claes, I.J.J., De Boeck, I., Verhoeven, T.L.A., Dilissen, E., Von Ossowski, I., Palva, A., Bullens, D.M., Vanderleyden, J., Lebeer, S. (2015). Piliation of Lactobacillus rhamnosus GG promotes adhesion, phagocytosis, and cytokine modulation in macrophages. Applied and Environmental Microbiology, 81(6), 2050-2062. https://doi.org/10.1128/AEM.03949-14
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  • Villena, J., Alvarez, S., Kitazawa, H. (2013). Introduction. İçinde Kitazawa, H., Villena, J. ve Alvarez, S. (Eds.), Probiotics: Immunobiotica And Immunogenics (s. 1-11). Boca Raton: Taylor & Francis Group. ISNB 978-1-4822-0685-2 https://doi.org/10.1201/b15532-2
  • Von Schillde, M.A., Hörmannsperger, G., Weiher, M., Alpert, C.A., Hahne, H., Bäuerl, C., Van Huynegem, K., Steidler, L., Hrncir, T., Pérez-Martínez, G., Kuster, B., Haller, D. (2012). Lactocepin secreted by Lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines. Cell Host and Microbe, 11(4), 387-396. https://doi.org/10.1016/j.chom.2012.02.006
  • Wu, M.H., Tzu-Ming P., Yu-Jen, W., Chang, S.J., Chang, M.S., Hu, C.Y. (2010). Exopolysaccharide activities from probiotic bifidobacterium: Immunomodulatory effects (on J774A.1 macrophages) and antimicrobial properties. International Journal of Food Microbiology, 144(1), 104-110. https://doi.org/10.1016/j.ijfoodmicro.2010.09.003
  • Yan, F., Liu, L., Dempsey, P.J., Tsai, Y.H., Raines, E.W., Wilson, C.L., Cao, H., Cao, Z., Liu, L., Polk, D.B. (2013). A lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor. Journal of Biological Chemistry, 288(42), 30742-30751. https://doi.org/10.1074/jbc.M113.492397
  • Yan, F., Cao, H., Cover, T.L., Whitehead, R., Washington, M.K., Polk, D.B. (2007). Soluble proteins produced by probiotic bacteria regulate intestinal epithelial cell sur vival and growth. Gastroenterology, 132(2), 562-575. https://doi.org/10.1053/j.gastro.2006.11.022
  • Yasuda, E., Serata, M., Sako, T. (2008). Suppressive effect on activation of macrophages by Lactobacillus casei strain shirota genes determining the synthesis of cell wall-associated polysaccharides. Applied and Environmental Microbiology, 74(15), 4746-4755. https://doi.org/10.1128/AEM.00412-08
Toplam 104 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Yapısal Biyoloji , Gıda Mühendisliği
Bölüm Review Articles
Yazarlar

Dicle Dilara Akpınar 0000-0002-8318-169X

Burcu Kaplan Türköz 0000-0003-3040-3321

Yayımlanma Tarihi 1 Ekim 2019
Gönderilme Tarihi 6 Şubat 2019
Yayımlandığı Sayı Yıl 2019

Kaynak Göster

APA Akpınar, D. D., & Kaplan Türköz, B. (2019). PROBİYOTİK- İNSAN BAĞIŞIKLIK SİSTEMİ ETKİLEŞİMLERİ. Food and Health, 5(4), 265-280. https://doi.org/10.3153/FH19027

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