Araştırma Makalesi
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Yıl 2017, Cilt: 3 Sayı: 2, 29 - 35, 01.10.2017

Öz

Kaynakça

  • [1] Sanders, M. E. “Impact of probiotics on colonizing microbiota of the gut,” Journal of clinical Gastroenterology, vol. 45, pp.115-119, 2011.
  • [2] Derrien M, van Baarlen P, Hooiveld G, Norin E, Muller M, de Vos WM. “Modulation of mucosal immune response, tolerance and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila,” Frontiers in cellular and Infection Microbiology, vol. 2, pp.166, 2011.
  • [3] Reid G, Younes JA, Van der Mei Hc, Gloor GB, Knight R, Busscher HJ. “Microbiota restoration: natural and supplemented recovery of human microbial communities,” Nature Reviews Microbiology, vol. 9, pp.27–38, 2011.
  • [4] Derrien, M., Belzer, c., & de Vos, W. M. “Akkermansia muciniphila and its role in regulating host functions,” Microbial pathogenesis, vol. 106, pp.171-181, 2017.
  • [5] Derrien, M., Vaughan, E. E., Plugge, c. M., & de Vos, W. M. “Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium,” International Journal Of Systematic And Evolutionary Microbiology, vol.54, pp.1469- 1476, 2004
  • [6] Belzer, c., & De Vos, W. M. “Microbes inside—from diversity to function: the case of Akkermansia,” The ISME Journal, vol. 6, pp.1449, 2012.
  • [7] Hemarajata, P., & Versalovic, J. “Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation,” Therapeutic Advances in Gastroenterology, vol. 6, pp.39-51, 2013.
  • [8] Sekirov, I., Russell, S. L., Antunes, L. c. M., & Finlay, B. B. “Gut microbiota in health and disease,” Physiological Reviews, vol. 90, pp.859- 904, 2010
  • [9] Mändar, R., & Mikelsaar, M. “Transmission of mother’s microflora to the newborn at birth,” Neonatology, 69(1), 30-35, 1996. [10] O’Hara, A. M., & Shanahan, F. “The gut flora as a forgotten organ,” EMBO reports, vol. 7, pp.688-693, 2006.
  • [11] Vajro, P., Paolella, G., & Fasano, A. “Microbiota and gut-liver axis: a mini-review on their influences on obesity and obesity related liver disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 56(5), pp.461, 2013
  • [12] Jandhyala, S. M., Talukdar, R., Subramanyam, c., Vuyyuru, H., Sasikala, M., & Reddy, D. N. “Role of the normal gut microbiota,” World Journal of Gastroenterology: WJG, vol. 21(29), pp.8787, 2015.
  • [13] Shen, J. “Mechanism of Triglyceride Lowering Action of Akkermansia muciniphila and Fenugreek in a Genetic Induced Hyperlipidemia,” 2016.
  • [14] Everard, A., Belzer, c., Geurts, L., Ouwerkerk, J. P., Druart, c., Bindels, L. B., ... & De Vos, W. M. “cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity,” Proceedings of the National Academy of Sciences, vol. 110(22), pp.9066-9071, 2013.
  • [15] Derrien, M., Belzer, c., & de Vos, W. M. “Akkermansia muciniphila and its role in regulating host functions,” Microbial Pathogenesis, vol. 106, pp.171-181, 2017.
  • [16] Ellekilde, M., Krych, L., Hansen, c. H. F., Hufeldt, M. R., Dahl, K., Hansen, L. H., ... & Hansen, A. K. “characterization of the gut microbiota in leptin deficient obese mice–correlation to inflammatory and diabetic parameters,” Research in Veterinary Science, vol. 96, pp.241-250, 2014.
  • [17] collado, M. c., Meriluoto, J., & Salminen, S. “Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus” Letters in Applied Microbiology, vol. 45, pp.454-460, 2007.
  • [18] Varankovich, N. V., Nickerson, M. T., & Korber, D. R. “Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases,” Frontiers in Microbiology, vol. 6, pp.685, 2015.
  • [19] Murphy, E. A., Velazquez, K. T., & Herbert, K. M. “Influence of High-Fat-Diet on Gut Microbiota: A Driving Force for chronic Disease Risk,” current Opinion İn clinical Nutrition And Metabolic care, vol. 18, pp.515, 2015.
  • [20] Wang, J. H., Bose, S., Kim, G. c., Hong, S. U., Kim, J. H., Kim, J. E., & Kim, H. (2014). Flos Lonicera ameliorates obesity and associated endotoxemia in rats through modulation of gut permeability and intestinal microbiota. Plos One, vol. 9(1), e86117.
  • [21] Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., ... & Delzenne, N. M. “Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. diabetes,” vol. 60(11), pp.2775-2786, 2011.
  • [22] Org, E., Parks, B. W., Joo, J. W. J., Emert, B., Schwartzman, W., Kang, E. Y., ... & Drake, T. A. “Genetic and environmental control of host-gut microbiota interactions,” Genome Research, vol. 25(10), pp.1558-1569, 2015.
  • [23] Shin, N. R., Lee, J. c., Lee, H. Y., Kim, M. S., Whon, T. W., Lee, M. S., & Bae, J. W. “An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice,” Gut, vol. 63(5), pp.727-735, 2014.
  • [24] Li, J., Lin, S., Vanhoutte, P. M., Woo, c. W., & Xu, A. “Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-/- mice,” circulation, cIRcULATIONAHA-vol. 133, pp.2434-2446, 2016.

AKKERMANSIA MUCINIPHILA; ,FUNCTIONAL AND PROBIOTIC PROPERTIES IN THE GASTROINTESTINAL TRACT

Yıl 2017, Cilt: 3 Sayı: 2, 29 - 35, 01.10.2017

Öz

The development of microbial communities in the human gastrointestinal tract begins immediately after
birth. Human gut microbiota is comprised of the millions of bacterial microbial communities that are
effective in protecting the health of the host organism and share the common site with the host. At the same
time, the mucus layer formed by the epithelial cells surrounding the intestinal surface protects intestines
against intestinal external factors and meets the microbiota’s need for nutrition. It was found recently that
one of the intestinal bacteria isolated from human fecal samples, Akkermansia muciniphila, meets the need
for nutrition of itself and other bacteria by grafting to the mucus layer and providing the monomer by
degrading mucin which is the main component of mucus. Akkermansia muciniphila, which has positive
effects on human gut microbiota, decreases in microbiota in the presence of certain chronic diseases.
Recent studies have shown that decreasing amounts of Akkermansia muciniphila was also found in the
feces samples of individuals with chronic diseases such as obesity and diabetes, and as well as found in the
gastrointestinal tract, too.

Kaynakça

  • [1] Sanders, M. E. “Impact of probiotics on colonizing microbiota of the gut,” Journal of clinical Gastroenterology, vol. 45, pp.115-119, 2011.
  • [2] Derrien M, van Baarlen P, Hooiveld G, Norin E, Muller M, de Vos WM. “Modulation of mucosal immune response, tolerance and proliferation in mice colonized by the mucin-degrader Akkermansia muciniphila,” Frontiers in cellular and Infection Microbiology, vol. 2, pp.166, 2011.
  • [3] Reid G, Younes JA, Van der Mei Hc, Gloor GB, Knight R, Busscher HJ. “Microbiota restoration: natural and supplemented recovery of human microbial communities,” Nature Reviews Microbiology, vol. 9, pp.27–38, 2011.
  • [4] Derrien, M., Belzer, c., & de Vos, W. M. “Akkermansia muciniphila and its role in regulating host functions,” Microbial pathogenesis, vol. 106, pp.171-181, 2017.
  • [5] Derrien, M., Vaughan, E. E., Plugge, c. M., & de Vos, W. M. “Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium,” International Journal Of Systematic And Evolutionary Microbiology, vol.54, pp.1469- 1476, 2004
  • [6] Belzer, c., & De Vos, W. M. “Microbes inside—from diversity to function: the case of Akkermansia,” The ISME Journal, vol. 6, pp.1449, 2012.
  • [7] Hemarajata, P., & Versalovic, J. “Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation,” Therapeutic Advances in Gastroenterology, vol. 6, pp.39-51, 2013.
  • [8] Sekirov, I., Russell, S. L., Antunes, L. c. M., & Finlay, B. B. “Gut microbiota in health and disease,” Physiological Reviews, vol. 90, pp.859- 904, 2010
  • [9] Mändar, R., & Mikelsaar, M. “Transmission of mother’s microflora to the newborn at birth,” Neonatology, 69(1), 30-35, 1996. [10] O’Hara, A. M., & Shanahan, F. “The gut flora as a forgotten organ,” EMBO reports, vol. 7, pp.688-693, 2006.
  • [11] Vajro, P., Paolella, G., & Fasano, A. “Microbiota and gut-liver axis: a mini-review on their influences on obesity and obesity related liver disease,” Journal of Pediatric Gastroenterology and Nutrition, vol. 56(5), pp.461, 2013
  • [12] Jandhyala, S. M., Talukdar, R., Subramanyam, c., Vuyyuru, H., Sasikala, M., & Reddy, D. N. “Role of the normal gut microbiota,” World Journal of Gastroenterology: WJG, vol. 21(29), pp.8787, 2015.
  • [13] Shen, J. “Mechanism of Triglyceride Lowering Action of Akkermansia muciniphila and Fenugreek in a Genetic Induced Hyperlipidemia,” 2016.
  • [14] Everard, A., Belzer, c., Geurts, L., Ouwerkerk, J. P., Druart, c., Bindels, L. B., ... & De Vos, W. M. “cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity,” Proceedings of the National Academy of Sciences, vol. 110(22), pp.9066-9071, 2013.
  • [15] Derrien, M., Belzer, c., & de Vos, W. M. “Akkermansia muciniphila and its role in regulating host functions,” Microbial Pathogenesis, vol. 106, pp.171-181, 2017.
  • [16] Ellekilde, M., Krych, L., Hansen, c. H. F., Hufeldt, M. R., Dahl, K., Hansen, L. H., ... & Hansen, A. K. “characterization of the gut microbiota in leptin deficient obese mice–correlation to inflammatory and diabetic parameters,” Research in Veterinary Science, vol. 96, pp.241-250, 2014.
  • [17] collado, M. c., Meriluoto, J., & Salminen, S. “Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus” Letters in Applied Microbiology, vol. 45, pp.454-460, 2007.
  • [18] Varankovich, N. V., Nickerson, M. T., & Korber, D. R. “Probiotic-based strategies for therapeutic and prophylactic use against multiple gastrointestinal diseases,” Frontiers in Microbiology, vol. 6, pp.685, 2015.
  • [19] Murphy, E. A., Velazquez, K. T., & Herbert, K. M. “Influence of High-Fat-Diet on Gut Microbiota: A Driving Force for chronic Disease Risk,” current Opinion İn clinical Nutrition And Metabolic care, vol. 18, pp.515, 2015.
  • [20] Wang, J. H., Bose, S., Kim, G. c., Hong, S. U., Kim, J. H., Kim, J. E., & Kim, H. (2014). Flos Lonicera ameliorates obesity and associated endotoxemia in rats through modulation of gut permeability and intestinal microbiota. Plos One, vol. 9(1), e86117.
  • [21] Everard, A., Lazarevic, V., Derrien, M., Girard, M., Muccioli, G. G., Neyrinck, A. M., ... & Delzenne, N. M. “Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. diabetes,” vol. 60(11), pp.2775-2786, 2011.
  • [22] Org, E., Parks, B. W., Joo, J. W. J., Emert, B., Schwartzman, W., Kang, E. Y., ... & Drake, T. A. “Genetic and environmental control of host-gut microbiota interactions,” Genome Research, vol. 25(10), pp.1558-1569, 2015.
  • [23] Shin, N. R., Lee, J. c., Lee, H. Y., Kim, M. S., Whon, T. W., Lee, M. S., & Bae, J. W. “An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice,” Gut, vol. 63(5), pp.727-735, 2014.
  • [24] Li, J., Lin, S., Vanhoutte, P. M., Woo, c. W., & Xu, A. “Akkermansia muciniphila protects against atherosclerosis by preventing metabolic endotoxemia-induced inflammation in Apoe-/- mice,” circulation, cIRcULATIONAHA-vol. 133, pp.2434-2446, 2016.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Gıda Mühendisliği
Bölüm Research Articles
Yazarlar

Murat Doğan

Merve Öztağ Bu kişi benim

Hilal Demirkesen Bıçak Bu kişi benim

Yayımlanma Tarihi 1 Ekim 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 3 Sayı: 2

Kaynak Göster

APA Doğan, M., Öztağ, M., & Demirkesen Bıçak, H. (2017). AKKERMANSIA MUCINIPHILA; ,FUNCTIONAL AND PROBIOTIC PROPERTIES IN THE GASTROINTESTINAL TRACT. International Journal of Food Engineering Research, 3(2), 29-35.

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