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Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow

Yıl 2023, Cilt: 7 Sayı: 1, 108 - 112, 30.06.2023

Nazmiye Bitgen Özge Göktepe Münevver Baran Eren Kaan İpek Arzu Yay

https://doi.org/10.32571/ijct.1186924

Öz

Nonylphenols are endocrine disrupting toxic compounds and are widely used. For this reason, our study aimed to investigate the genotoxic effect of nonylphenols applied at different doses on mouse bone marrow cells. Groups were classified as control group, the sham administered only group, low dose, medium dose and high dose nonylphenol administered group. After euthanasia, polychromatic erythrocyte/Normochromatic erythrocyte ratio and micronuclear polychromatic erythrocyte count were determined in femur bone marrow cells and analyzed to detect DNA damage. While polychromatic erythrocyte/Normochromatic erythrocyte ratio was found to be lower in the groups treated with different doses of nonylphenol, especially in the group treated with high-dose nonylphenol, this decrease was not statistically significant. When the micronucleated polychromatic erythrocyte values were examined, it was observed that there was a statistically significant increase, especially in the medium and high dose groups compared to the control. High-dose nonylphenol has a toxic effect and may have a long-term genotoxic effect such as cancer development by interacting with genotoxic agents.

Anahtar Kelimeler

Nonylphenol genotoxicity micronucleus.

Destekleyen Kurum

Erciyes University Scientific Research Projects Coordination Unit.

Proje Numarası

TCD-2021-11459

Kaynakça

  • Ozdemir, F.; Kayaaltı, Z.; Dilek, K. A. Marmara Pharm. J. 2015, 19(3), 246-251.
  • Zemheri, F.; Cevdet, U. Marmara Üniv. Fen Bilim. Derg. 2018, 30(1), 71-76.
  • Urriola-Muñoz, P.; Li, X.; Maretzky, T.; McIlwain, D.R.; Mak, T.W.; Reyes, J.G.; Blobel, C.P.; Moreno, D. J. Cell. Physiol. 2018, 233(3), 2247-2256.
  • Abou Khalil, N. S.; Abd‐Elkareem, M.; Sayed, A. H. Aquac. Nutr. 2017, 23(6), 1467-1474.
  • Dobrzyńska, M. M. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2014, 772, 14-19.
  • Vazquez-Duhalt, R.; Marquez-Rocha, F.; Ponce, E.; Licea, A.F.; Vaiana, M.T. Appl. Ecol. Environ. Res. 2005, 4:1-25.
  • Wu, F.; Lin, L.; Qiu, J.W.; Chen, H.; Weng, S.; Luan, T. Aquat. Toxicol. 2014, 155, 43-51.
  • Shirdel, I.; Mohammad, R.K. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 183-184, 28-35.
  • Fenech, M.; Chang, W. P.; Kirsch-Volders, M.; Holland, N.; Bonassi, S.; Zeiger, E. Mut. Res. 2003, 534, 65-75.
  • Baršienė, J.; Dedonytė, V.; Rybakovas, A.; Andreikėnaitė, L.; Andersen, O. K. Aquat. Toxicol. 2006, 78, 99-104.
  • Lambert, I.B.; Singer, T.M.; Boucher, S.E.; Douglas, G.R. Mutat. Res. 2005, 590, 1-280.
  • Mavourni, K.H.; Blakey, D.H.; Cimino, M.C.; Salamone, M.F.; Heddle, J.A. Mutat. Res. 1990, 239, 29-80.
  • Celik, A.; Mazmanci, B.; Camlica, Y.; Askin, A.; Comelekoglu, U. Mutat. Res. 2003, 539, 91-97.
  • Bara, M.; Bitgen, N.; Kalkan, K.T.; Goktepe, O.; Varol, S.; Yay, A.H. Dicle Tip Derg. 2022, 49(1), 36-44.
  • Aksu, P.; Doğan, A.; Gül, S.; Kanıcı, A. Kafkas Univ. Vet. Fak. Derg. 2013, 19(6), 955-961.
  • Mekkawy, I. A.; Mahmoud, U. M.; Sayed, A.H. Tissue and Cell. 2011, 43, 223-229.
  • Sharma, M.; Chadha, P. Drug Chem. Toxicol. 2017, 40(3), 320-325.

Yıl 2023, Cilt: 7 Sayı: 1, 108 - 112, 30.06.2023

Nazmiye Bitgen Özge Göktepe Münevver Baran Eren Kaan İpek Arzu Yay

https://doi.org/10.32571/ijct.1186924

Öz

Proje Numarası

TCD-2021-11459

Kaynakça

  • Ozdemir, F.; Kayaaltı, Z.; Dilek, K. A. Marmara Pharm. J. 2015, 19(3), 246-251.
  • Zemheri, F.; Cevdet, U. Marmara Üniv. Fen Bilim. Derg. 2018, 30(1), 71-76.
  • Urriola-Muñoz, P.; Li, X.; Maretzky, T.; McIlwain, D.R.; Mak, T.W.; Reyes, J.G.; Blobel, C.P.; Moreno, D. J. Cell. Physiol. 2018, 233(3), 2247-2256.
  • Abou Khalil, N. S.; Abd‐Elkareem, M.; Sayed, A. H. Aquac. Nutr. 2017, 23(6), 1467-1474.
  • Dobrzyńska, M. M. Mutat. Res. Genet. Toxicol. Environ. Mutagen. 2014, 772, 14-19.
  • Vazquez-Duhalt, R.; Marquez-Rocha, F.; Ponce, E.; Licea, A.F.; Vaiana, M.T. Appl. Ecol. Environ. Res. 2005, 4:1-25.
  • Wu, F.; Lin, L.; Qiu, J.W.; Chen, H.; Weng, S.; Luan, T. Aquat. Toxicol. 2014, 155, 43-51.
  • Shirdel, I.; Mohammad, R.K. Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2016, 183-184, 28-35.
  • Fenech, M.; Chang, W. P.; Kirsch-Volders, M.; Holland, N.; Bonassi, S.; Zeiger, E. Mut. Res. 2003, 534, 65-75.
  • Baršienė, J.; Dedonytė, V.; Rybakovas, A.; Andreikėnaitė, L.; Andersen, O. K. Aquat. Toxicol. 2006, 78, 99-104.
  • Lambert, I.B.; Singer, T.M.; Boucher, S.E.; Douglas, G.R. Mutat. Res. 2005, 590, 1-280.
  • Mavourni, K.H.; Blakey, D.H.; Cimino, M.C.; Salamone, M.F.; Heddle, J.A. Mutat. Res. 1990, 239, 29-80.
  • Celik, A.; Mazmanci, B.; Camlica, Y.; Askin, A.; Comelekoglu, U. Mutat. Res. 2003, 539, 91-97.
  • Bara, M.; Bitgen, N.; Kalkan, K.T.; Goktepe, O.; Varol, S.; Yay, A.H. Dicle Tip Derg. 2022, 49(1), 36-44.
  • Aksu, P.; Doğan, A.; Gül, S.; Kanıcı, A. Kafkas Univ. Vet. Fak. Derg. 2013, 19(6), 955-961.
  • Mekkawy, I. A.; Mahmoud, U. M.; Sayed, A.H. Tissue and Cell. 2011, 43, 223-229.
  • Sharma, M.; Chadha, P. Drug Chem. Toxicol. 2017, 40(3), 320-325.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Yapısal Biyoloji
Bölüm Makale
Yazarlar

Nazmiye Bitgen 0000-0002-6416-9230

Özge Göktepe 0000-0002-8205-2132

Münevver Baran 0000-0003-0369-1022

Eren Kaan İpek 0000-0002-8716-5347

Arzu Yay 0000-0001-8532-3543

Proje Numarası TCD-2021-11459
Erken Görünüm Tarihi 2 Ağustos 2023
Yayımlanma Tarihi 30 Haziran 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 7 Sayı: 1

Kaynak Göster

APA Bitgen, N., Göktepe, Ö., Baran, M., İpek, E. K., vd. (2023). Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology, 7(1), 108-112. https://doi.org/10.32571/ijct.1186924
AMA Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A. Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. Int. J. Chem. Technol. Haziran 2023;7(1):108-112. doi:10.32571/ijct.1186924
Chicago Bitgen, Nazmiye, Özge Göktepe, Münevver Baran, Eren Kaan İpek, ve Arzu Yay. “Evaluation of the Genotoxic Effect of Nonylphenol Applied in Different Doses on the Bone Marrow”. International Journal of Chemistry and Technology 7, sy. 1 (Haziran 2023): 108-12. https://doi.org/10.32571/ijct.1186924.
EndNote Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A (01 Haziran 2023) Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. International Journal of Chemistry and Technology 7 1 108–112.
IEEE N. Bitgen, Ö. Göktepe, M. Baran, E. K. İpek, ve A. Yay, “Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow”, Int. J. Chem. Technol., c. 7, sy. 1, ss. 108–112, 2023, doi: 10.32571/ijct.1186924.
ISNAD Bitgen, Nazmiye vd. “Evaluation of the Genotoxic Effect of Nonylphenol Applied in Different Doses on the Bone Marrow”. International Journal of Chemistry and Technology 7/1 (Haziran 2023), 108-112. https://doi.org/10.32571/ijct.1186924.
JAMA Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A. Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. Int. J. Chem. Technol. 2023;7:108–112.
MLA Bitgen, Nazmiye vd. “Evaluation of the Genotoxic Effect of Nonylphenol Applied in Different Doses on the Bone Marrow”. International Journal of Chemistry and Technology, c. 7, sy. 1, 2023, ss. 108-12, doi:10.32571/ijct.1186924.
Vancouver Bitgen N, Göktepe Ö, Baran M, İpek EK, Yay A. Evaluation of the genotoxic effect of nonylphenol applied in different doses on the bone marrow. Int. J. Chem. Technol. 2023;7(1):108-12.
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