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The Role of Dietary Supplements and Lifestyle Changes in Reducing Polycystic Ovary Syndrome Complications

Yıl 2021, Cilt: 8 Sayı: 3, 453 - 465, 31.12.2021

Halime Selen Burcu Yeşilkaya

Öz

Polycystic ovary syndrome (PCOS) is a heterogeneous disease characterized by metabolic and endocrine disorders, especially in women of reproductive age, and the criteria of "oligo-ovulation or anovulation", "clinical or biochemical findings of hyperandrogenism" and "polycystic ovaries" are used for diagnosis. PCOS is associated with inflammatory diseases such as obesity, Type 2 DM, cardiovascular disease and insulin resistance. Studies have shown that monounsaturated fatty acids (omega 9), polyunsaturated fatty acids omega 3, vitamin D, vitamin E, curcumin, cinnamon, fennel and flaxseed supplements, high-protein diets and exercise can reduce the complications of PCOS and can be effective in the treatment of PCOS. . In this review, nutritional supplements and lifestyle changes that can be made in the reduction or treatment of PCOS complications will be examined with scientific reality.

Anahtar Kelimeler

PCOS Unsatured dietary fats Exercise

Destekleyen Kurum

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Proje Numarası

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Teşekkür

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Kaynakça

  • Referans1 Abedini, M., Ghasemi-Tahrani, H., Tarrahi, M.J., & Amani, R. (2020). The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: a randomized controlled trial. Phytotherapy Research, 1-10.
  • Referans2 Amato, P., & Simpson, J.L. (2004). The genetics of polycystic ovary syndrome. Best Practice & Research: Clinical Obstetrics & Gynaecology, 18(5), 707-718.
  • Referans3 Amer, S.A.K. (2009). Polycystic ovarian syndrome: diagnosis and management of related infertility. Obstetrics, Gynaecology and Reproductive Medicine, 19(10), 263-70.
  • Referans4 Atiomo, W.U., El-Mahdi, E., & Hardiman, P. (2003). Familial associations in women with polycystic ovary syndrome. Fertility and Sterility, 80(1), 143-145.
  • Referans5 Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Futterweit, W. ve diğerleri. (2006). Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. The Journal of Clinical Endocrinology & Metabolism, 91, 4237-4245.
  • Referans6 Borzoei, A., Rafraf, M., Niromanesh, S., Farzadi, L., Narimani, F., & Doostan, F. (2018). Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome. Journal of Traditional and Complementary Medicine, 8, 128-133.
  • Referans7 Bozdağ, G., Mumuşoğlu, S., Zengin, D., Karabulut, E., & Yıldız, O. (2016) The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction, 31(12): 2841-2855.
  • Referans8 Diamanti-Kandarakis, E., & Dunaif, A. (2012). Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine Reviews, 33(6), 981-1030.
  • Referans9 Dong, J.Y., Zhang, Z.L., Wang, P.Y., & Qin, L.Q. (2013). Effects of high-protein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: meta-analysis of randomised controlled trials. British Journal of Nutrition, 110(5), 781-789.
  • Referans10 Ebrahimi, F.A., Samimi, M., Foroozanfard, F., Jamilian, M., Akbari, H., Rahmani, E. ve diğerleri (2017). The effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology & Diabetes, 125(06), 353-359.
  • Referans11 Emami, N., Alizadeh, A., Moini, A., Yaghmaei, P., & Shahhosseini, M. (2020). Differences in fatty acid profiles and desaturation indices of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS. Adipocyte, 9(1), 16-23.
  • Referans12 Eslamian, Gh., & Hekmatdoost, A. (2019). Nutrient patterns and risk of polycystic ovary syndrome. Journal of Reproduction & Infertility, 20(3), 161-168.
  • Referans13 Glueck, C.J., Goldenberg, N., & Wang, P. (2009). Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism, 22, 815-826.
  • Referans14 Haidari, F., Banaei-Jahromi, N., Zakerkish, M., & Ahmadi, K. (2020). The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Nutrition Journal, 19, 8.
  • Referans15 Hart, R., Hickey, M., & Franks, S. (2004). Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Practice & Research: Clinical Obstetrics & Gynaecology, 18(5), 671-683.
  • Referans16 Heydarpoura, F., Hematib, N., Hadic, A., Moradid, S., Mohammadie, E., & Farzaeif, M.H. (2020). Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: a systematic review and meta-analysis. Journal of Ethnopharmacology, 254, 112741.
  • Referans17 Hosseini Marnani, E., Ghadiri-Anari, A., Ramezani-Jolfaie, N., Mohammadi, M., Abdollahi, N., Namayandeh, S.M. ve diğerleri. (2020). Effect of fennel supplementation along with high-protein, low-carbohydrate weight-loss diet on insulin resistance and percentage of fat and muscle mass in overweight/obese women with polycystic ovary syndrome. Journal of Functional Foods, 67, 103848.
  • Referans18 Jamilian, M., Foroozanfard, F., Kavossian, E., Aghadavod, E., Shafabakhsh, R., Hoseini, A. ve diğerleri. (2020). Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition ESPEN, 36, 128-133.
  • Referans19 Jamilian, M., Samimi, M., Mirhosseini, N., Afshar Ebrahimi, F., Aghadavod, E., Talaee, R. ve diğerleri. (2018). The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. Journal of Affective Disorders, 238, 32-38.
  • Referans20 Järvelä, I.Y., Sladkevicius, P., Kelly, S., Ojha, K., Campbell, S., & Nargund, G. (2003). Quantification of ovarian power doppler signal with three-dimensional ultrasonography to predict response during in vitro fertilization. Obstetrics & Gynecology, 102(4), 816-822.
  • Referans21 Kalgaonkar, S., Almario, R.U., Gurusinghe, D., Garamendi, E.M., Buchan, W., Kim, K. ve diğerleri. (2011). Differential effects of walnuts vs almonds on improving metabolic and endocrine parameters in PCOS. European Journal of Clinical Nutrition, 65, 386-393.
  • Referans22 Larsen, T.M., Dalskov, S.M., Van Baak, M., Jebb, S.A., Papadaki, A., Pfeiffer, A.F. ve diğerleri. (2010). Diets with high or low protein content and glycemic index for weight-loss maintenance. New England Journal of Medicine, 363(22), 2102-2113.
  • Referans23 McGrath, K.C., McRobb, L.S., & Heather, A.K. (2008). Androgen therapy and atherosclerotic cardiovascular disease. Vascular Health and Risk Management, 4(1), 11-21.
  • Referans24 Mehrabani, H.H., Salehpour, S., Amiri, Z., Farahani, S.J., Meyer, B.J., & Tahbaz, F. (2012). Beneficial effects of a high-protein, low-glycemic-load hypocaloric diet in overweight and obese women with polycystic ovary syndrome: a randomized controlled intervention study. Journal of the American College of Nutrition, 31(2), 117-125.
  • Referans25 Mohammadi, S., Kayedpoor, P., Karimzadeh-Bardei, L., & Nabiuni, M. (2017). The effect of curcumin on TNF-α, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state. Journal of Reproduction & Infertility, 18(4), 352-360.
  • Referans26 Moran, L.J., Hutchison, S.K., Norman, R.J., & Teede, H.J. (2011). Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Systematic Review, 2(CD007506).
  • Referans27 Moran, L.J., Ko, H., Misso, M., Marsh, K., Noakes, M., & Talbot, M. (2013). Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. Journal of The Academy of Nutrition and Dietetics, 113(4), 520-545.
  • Referans28 Mu, Y., Cheng, D., Yin, T-L., & Yang, J. (2020). Vitamin D and polycystic ovary syndrome: a narrative review. Reproductive Sciences, Doi: https://doi.org/10.1007/s43032-020-00369-2
  • Referans29 Nadjarzadeh, A., Dehghani-Firouzabadi, R., Daneshbodi, H., Lotfi, M.H., Vaziri, N., & Mozaffari-Khosravi, H. (2015). Effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome. Journal of Reproduction & Infertility, 16(4), 212-220.
  • Referans30 Oner, G., & Muderris, I.I. (2013). Efficacy of omega-3 in the treatment of polycystic ovary syndrome. Journal of Obstetrics and Gynaecology, 33(3), 289-91.
  • Referans31 Patel, S. (2018). Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. Journal of Steroid Biochemistry and Molecular Biology, 182, 27-36.
  • Referans 32 Polak, A.M., Anna, K., Łebkowska, A., Buczynska, A., Adamski, M., Adamska-Patruno, E. ve diğerleri. (2020). The association of serum levels of leptin and ghrelin with the dietary fat content in non-obese women with polycystic ovary syndrome. Nutrients, 12, 2753.
  • Referans33 Reddy, P.S., Begum, N., Mutha, S., & Bakshi, V. (2016). Beneficial effect of curcumin in letrozole induced polycystic ovary syndrome. Asian Pacific Journal of Reproduction, 5(2), 116-122.
  • Referans34 Repaci, A., Gambineri, A., & Pasquali, R. (2011). The role of lowgrade inflammation in the polycystic ovary syndrome. Molecular and Cellular Endocrinology, 335(1), 30-41.
  • Referans35 Rondanelli, M., Perna, S., Faliva, M., Monteferrario, F., Repaci, E., & Allieri, F. (2014). Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Archives of Gynecology and Obstetrics, 290, 1079-1092.
  • Referans36 Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group 2004 Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Human Reproduction, 19(1), 41-47.
  • Referans37 Seif Amirhoseiny, E., Ganji, A., Mosayebi, Gh., & Ghazavi, A. (2020). Immunomodulatory effect of fennel in animal model of polycystic ovarian syndrome. Journal of Arak University of Medical Sciences (JAMS), 23(1), 22-33.
  • Referans38 Stein, I., & Leventhal, M. (1935). Amenorrhea associated with bilateral polycystic ovaries. American Journal of Obstetrics and Gynecology, 29, 181-185.
  • Referans39 Szczuko, M., Skowronek, M., Zapałowska-Chwyc, M., & Starczewski, A. (2016). Quantitative assessment of nutrition in patients with polycystic ovary syndrome (PCOS). Roczniki Panstwowego Zakladu Higieny, 67(4), 419-426.
  • Referans40 Şanlı Ak, G. (2017). Polikistik over sendromu olan kadınlarda farklı diyet uygulamalarının vücut bileşimi ve bazı biyokimyasal bulgular üzerine etkisi. (Yayınlanmamış doktora tezi). Başkent Üniversitesi, Ankara.
  • Referans41 Tarkun, İ., Arslan, B.Ç., Cantürk, Z., Türemen, E., Şahin, T., & Duman, C. (2004). Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. The Journal of Clinical Endocrinology & Metabolism, 89(11), 5592-5596.
  • Referans42 Wong, J.M., Gallagher, M., Gooding, H., Feldman, H.A., Gordon, C.M., Ludwig, D.S. ve diğerleri (2015). A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents. Pediatric Obesity, 11(3), 210-220.
  • Referans43 Wu, C., Jiang, F., Wei, K., & Jiang, Z. (2018) Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats. Scientific Report, 8, 7982.
  • Referans44 Xu, X., Du, C., Zheng, Q., Peng, L., & Sun, Y. (2014). Effect of metformin on serum interleukin-6 levels in polycystic ovary syndrome: a systematic review. BMC Women’s Health, 14, 93.
  • Referans45 Zawadzki, J.K., & Dunaif, A. (1992). Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif AGJ, Haseltine F (eds). Polycystic Ovary Syndrome. Boston: Blackwell Scientific, 1992: 377-384.

Yıl 2021, Cilt: 8 Sayı: 3, 453 - 465, 31.12.2021

Halime Selen Burcu Yeşilkaya

Öz

Proje Numarası

-

Kaynakça

  • Referans1 Abedini, M., Ghasemi-Tahrani, H., Tarrahi, M.J., & Amani, R. (2020). The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: a randomized controlled trial. Phytotherapy Research, 1-10.
  • Referans2 Amato, P., & Simpson, J.L. (2004). The genetics of polycystic ovary syndrome. Best Practice & Research: Clinical Obstetrics & Gynaecology, 18(5), 707-718.
  • Referans3 Amer, S.A.K. (2009). Polycystic ovarian syndrome: diagnosis and management of related infertility. Obstetrics, Gynaecology and Reproductive Medicine, 19(10), 263-70.
  • Referans4 Atiomo, W.U., El-Mahdi, E., & Hardiman, P. (2003). Familial associations in women with polycystic ovary syndrome. Fertility and Sterility, 80(1), 143-145.
  • Referans5 Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H.F., Futterweit, W. ve diğerleri. (2006). Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. The Journal of Clinical Endocrinology & Metabolism, 91, 4237-4245.
  • Referans6 Borzoei, A., Rafraf, M., Niromanesh, S., Farzadi, L., Narimani, F., & Doostan, F. (2018). Effects of cinnamon supplementation on antioxidant status and serum lipids in women with polycystic ovary syndrome. Journal of Traditional and Complementary Medicine, 8, 128-133.
  • Referans7 Bozdağ, G., Mumuşoğlu, S., Zengin, D., Karabulut, E., & Yıldız, O. (2016) The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduction, 31(12): 2841-2855.
  • Referans8 Diamanti-Kandarakis, E., & Dunaif, A. (2012). Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocrine Reviews, 33(6), 981-1030.
  • Referans9 Dong, J.Y., Zhang, Z.L., Wang, P.Y., & Qin, L.Q. (2013). Effects of high-protein diets on body weight, glycaemic control, blood lipids and blood pressure in type 2 diabetes: meta-analysis of randomised controlled trials. British Journal of Nutrition, 110(5), 781-789.
  • Referans10 Ebrahimi, F.A., Samimi, M., Foroozanfard, F., Jamilian, M., Akbari, H., Rahmani, E. ve diğerleri (2017). The effects of omega-3 fatty acids and vitamin E co-supplementation on indices of insulin resistance and hormonal parameters in patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Experimental and Clinical Endocrinology & Diabetes, 125(06), 353-359.
  • Referans11 Emami, N., Alizadeh, A., Moini, A., Yaghmaei, P., & Shahhosseini, M. (2020). Differences in fatty acid profiles and desaturation indices of abdominal subcutaneous adipose tissue between pregnant women with and without PCOS. Adipocyte, 9(1), 16-23.
  • Referans12 Eslamian, Gh., & Hekmatdoost, A. (2019). Nutrient patterns and risk of polycystic ovary syndrome. Journal of Reproduction & Infertility, 20(3), 161-168.
  • Referans13 Glueck, C.J., Goldenberg, N., & Wang, P. (2009). Metformin-diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism, 22, 815-826.
  • Referans14 Haidari, F., Banaei-Jahromi, N., Zakerkish, M., & Ahmadi, K. (2020). The effects of flaxseed supplementation on metabolic status in women with polycystic ovary syndrome: a randomized open-labeled controlled clinical trial. Nutrition Journal, 19, 8.
  • Referans15 Hart, R., Hickey, M., & Franks, S. (2004). Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome. Best Practice & Research: Clinical Obstetrics & Gynaecology, 18(5), 671-683.
  • Referans16 Heydarpoura, F., Hematib, N., Hadic, A., Moradid, S., Mohammadie, E., & Farzaeif, M.H. (2020). Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: a systematic review and meta-analysis. Journal of Ethnopharmacology, 254, 112741.
  • Referans17 Hosseini Marnani, E., Ghadiri-Anari, A., Ramezani-Jolfaie, N., Mohammadi, M., Abdollahi, N., Namayandeh, S.M. ve diğerleri. (2020). Effect of fennel supplementation along with high-protein, low-carbohydrate weight-loss diet on insulin resistance and percentage of fat and muscle mass in overweight/obese women with polycystic ovary syndrome. Journal of Functional Foods, 67, 103848.
  • Referans18 Jamilian, M., Foroozanfard, F., Kavossian, E., Aghadavod, E., Shafabakhsh, R., Hoseini, A. ve diğerleri. (2020). Effects of curcumin on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Clinical Nutrition ESPEN, 36, 128-133.
  • Referans19 Jamilian, M., Samimi, M., Mirhosseini, N., Afshar Ebrahimi, F., Aghadavod, E., Talaee, R. ve diğerleri. (2018). The influences of vitamin D and omega-3 co-supplementation on clinical, metabolic and genetic parameters in women with polycystic ovary syndrome. Journal of Affective Disorders, 238, 32-38.
  • Referans20 Järvelä, I.Y., Sladkevicius, P., Kelly, S., Ojha, K., Campbell, S., & Nargund, G. (2003). Quantification of ovarian power doppler signal with three-dimensional ultrasonography to predict response during in vitro fertilization. Obstetrics & Gynecology, 102(4), 816-822.
  • Referans21 Kalgaonkar, S., Almario, R.U., Gurusinghe, D., Garamendi, E.M., Buchan, W., Kim, K. ve diğerleri. (2011). Differential effects of walnuts vs almonds on improving metabolic and endocrine parameters in PCOS. European Journal of Clinical Nutrition, 65, 386-393.
  • Referans22 Larsen, T.M., Dalskov, S.M., Van Baak, M., Jebb, S.A., Papadaki, A., Pfeiffer, A.F. ve diğerleri. (2010). Diets with high or low protein content and glycemic index for weight-loss maintenance. New England Journal of Medicine, 363(22), 2102-2113.
  • Referans23 McGrath, K.C., McRobb, L.S., & Heather, A.K. (2008). Androgen therapy and atherosclerotic cardiovascular disease. Vascular Health and Risk Management, 4(1), 11-21.
  • Referans24 Mehrabani, H.H., Salehpour, S., Amiri, Z., Farahani, S.J., Meyer, B.J., & Tahbaz, F. (2012). Beneficial effects of a high-protein, low-glycemic-load hypocaloric diet in overweight and obese women with polycystic ovary syndrome: a randomized controlled intervention study. Journal of the American College of Nutrition, 31(2), 117-125.
  • Referans25 Mohammadi, S., Kayedpoor, P., Karimzadeh-Bardei, L., & Nabiuni, M. (2017). The effect of curcumin on TNF-α, IL-6 and CRP expression in a model of polycystic ovary syndrome as an inflammation state. Journal of Reproduction & Infertility, 18(4), 352-360.
  • Referans26 Moran, L.J., Hutchison, S.K., Norman, R.J., & Teede, H.J. (2011). Lifestyle changes in women with polycystic ovary syndrome. Cochrane Database Systematic Review, 2(CD007506).
  • Referans27 Moran, L.J., Ko, H., Misso, M., Marsh, K., Noakes, M., & Talbot, M. (2013). Dietary composition in the treatment of polycystic ovary syndrome: a systematic review to inform evidence-based guidelines. Journal of The Academy of Nutrition and Dietetics, 113(4), 520-545.
  • Referans28 Mu, Y., Cheng, D., Yin, T-L., & Yang, J. (2020). Vitamin D and polycystic ovary syndrome: a narrative review. Reproductive Sciences, Doi: https://doi.org/10.1007/s43032-020-00369-2
  • Referans29 Nadjarzadeh, A., Dehghani-Firouzabadi, R., Daneshbodi, H., Lotfi, M.H., Vaziri, N., & Mozaffari-Khosravi, H. (2015). Effect of omega-3 supplementation on visfatin, adiponectin, and anthropometric indices in women with polycystic ovarian syndrome. Journal of Reproduction & Infertility, 16(4), 212-220.
  • Referans30 Oner, G., & Muderris, I.I. (2013). Efficacy of omega-3 in the treatment of polycystic ovary syndrome. Journal of Obstetrics and Gynaecology, 33(3), 289-91.
  • Referans31 Patel, S. (2018). Polycystic ovary syndrome (PCOS), an inflammatory, systemic, lifestyle endocrinopathy. Journal of Steroid Biochemistry and Molecular Biology, 182, 27-36.
  • Referans 32 Polak, A.M., Anna, K., Łebkowska, A., Buczynska, A., Adamski, M., Adamska-Patruno, E. ve diğerleri. (2020). The association of serum levels of leptin and ghrelin with the dietary fat content in non-obese women with polycystic ovary syndrome. Nutrients, 12, 2753.
  • Referans33 Reddy, P.S., Begum, N., Mutha, S., & Bakshi, V. (2016). Beneficial effect of curcumin in letrozole induced polycystic ovary syndrome. Asian Pacific Journal of Reproduction, 5(2), 116-122.
  • Referans34 Repaci, A., Gambineri, A., & Pasquali, R. (2011). The role of lowgrade inflammation in the polycystic ovary syndrome. Molecular and Cellular Endocrinology, 335(1), 30-41.
  • Referans35 Rondanelli, M., Perna, S., Faliva, M., Monteferrario, F., Repaci, E., & Allieri, F. (2014). Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena. Archives of Gynecology and Obstetrics, 290, 1079-1092.
  • Referans36 Rotterdam ESHRE/ASRM-sponsored PCOS Consensus Workshop Group 2004 Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Human Reproduction, 19(1), 41-47.
  • Referans37 Seif Amirhoseiny, E., Ganji, A., Mosayebi, Gh., & Ghazavi, A. (2020). Immunomodulatory effect of fennel in animal model of polycystic ovarian syndrome. Journal of Arak University of Medical Sciences (JAMS), 23(1), 22-33.
  • Referans38 Stein, I., & Leventhal, M. (1935). Amenorrhea associated with bilateral polycystic ovaries. American Journal of Obstetrics and Gynecology, 29, 181-185.
  • Referans39 Szczuko, M., Skowronek, M., Zapałowska-Chwyc, M., & Starczewski, A. (2016). Quantitative assessment of nutrition in patients with polycystic ovary syndrome (PCOS). Roczniki Panstwowego Zakladu Higieny, 67(4), 419-426.
  • Referans40 Şanlı Ak, G. (2017). Polikistik over sendromu olan kadınlarda farklı diyet uygulamalarının vücut bileşimi ve bazı biyokimyasal bulgular üzerine etkisi. (Yayınlanmamış doktora tezi). Başkent Üniversitesi, Ankara.
  • Referans41 Tarkun, İ., Arslan, B.Ç., Cantürk, Z., Türemen, E., Şahin, T., & Duman, C. (2004). Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. The Journal of Clinical Endocrinology & Metabolism, 89(11), 5592-5596.
  • Referans42 Wong, J.M., Gallagher, M., Gooding, H., Feldman, H.A., Gordon, C.M., Ludwig, D.S. ve diğerleri (2015). A randomized pilot study of dietary treatments for polycystic ovary syndrome in adolescents. Pediatric Obesity, 11(3), 210-220.
  • Referans43 Wu, C., Jiang, F., Wei, K., & Jiang, Z. (2018) Exercise activates the PI3K-AKT signal pathway by decreasing the expression of 5α-reductase type 1 in PCOS rats. Scientific Report, 8, 7982.
  • Referans44 Xu, X., Du, C., Zheng, Q., Peng, L., & Sun, Y. (2014). Effect of metformin on serum interleukin-6 levels in polycystic ovary syndrome: a systematic review. BMC Women’s Health, 14, 93.
  • Referans45 Zawadzki, J.K., & Dunaif, A. (1992). Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif AGJ, Haseltine F (eds). Polycystic Ovary Syndrome. Boston: Blackwell Scientific, 1992: 377-384.
Toplam 45 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Halime Selen 0000-0002-3705-0875

Burcu Yeşilkaya 0000-0001-9986-6119

Proje Numarası -
Erken Görünüm Tarihi 25 Eylül 2021
Yayımlanma Tarihi 31 Aralık 2021
Gönderilme Tarihi 19 Aralık 2020
Yayımlandığı Sayı Yıl 2021 Cilt: 8 Sayı: 3

Kaynak Göster

APA Selen, H., & Yeşilkaya, B. (2021). The Role of Dietary Supplements and Lifestyle Changes in Reducing Polycystic Ovary Syndrome Complications. Hacettepe University Faculty of Health Sciences Journal, 8(3), 453-465. https://doi.org/10.21020/husbfd.842922