Araştırma Makalesi
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Monosit-lenfosit oranı, prostat kanserinin başka bir göstergesi olabilir mi?

Yıl 2023, Cilt: 3 Sayı: 1, 16 - 24, 27.04.2023
https://doi.org/10.58961/hmj.1202211

Öz

Amaç: PSA'nın nispeten düşük duyarlılığı ve özgüllüğü nedeniyle tanı verimliliğini artırmak için ucuz, invaziv olmayan ve özellikle klinik önemli prostat kanserini tanıyabilen belirteçlere ihtiyaç vardır. MLR’nin prostat kanserinin bir biyobelirteci olarak potansiyel rolü olup olmadığının değerlendirilmesi amaçlanmıştır.
Çalışma planı: 1 Ocak 2017 ile 31 Aralık 2021 tarihleri arasında prostat biyopsisi alınan hastaların yaşı, işlem öncesinde lenfosit, monosit sayısı gibi hemogram parametreleri, free-total PSA değerleri, patoloji sonuçları kayıt altına alındı. Patoloji sonucu prostat kanseri (PCa) gelenlerin, Gleason Skoru 3+4 ve üzeri olan hastalar klinik anlamlı prostat kanseri (csPCa) olarak tanımlanırken, diğer PCa’li hastalar klinik anlamlı olmayan prostat kanseri (non-csPCa) olarak tanımlandı.
Bulgular: Çalışmaya dahil edilen 510 hastanın 164’ünün patolojisi PCa, 346’sının sonucu non-PCa olarak raporlandı. Monosit sayıları PCa’li grupta non-PCa gruptan daha yüksek bulundu. (sırasıyla; 0,61±0,33 ve 0,53±0,19, p=0.002) MLR de PCa grubunda daha yüksek bulundu. (sırasıyla; 0.35±0.29 ve 0.26±0.13, p<0.001) Tanı anındaki yaş, total PSA, monosit sayısı, MLR, PCa grubunda istatistiksel anlamlı olarak daha yüksek bulunurken, free/total PSA oranı (f/tPSA) bu grupta istatistiksel anlamlı daha düşük izlendi. Patolojisi PCa olarak raporlanan 164 hastalardan 69’unda (39%) csPCa bulunurken, 95’inde (61%) non-csPCa mevcuttu. Bu sub-grupların analizi yapıldığında tanı anındaki yaş, free PSA, total PSA csPCa grubunda istatistiksel anlamlı olarak daha yüksek bulunurken bu grupta f/tPSA değeri istatistiksel olarak anlamlı daha düşük bulundu. Lenfosit, monosit, MLR değerleri açısından csPCa ve non-csPCa grupları arasında istatistiksel olarak anlamlı bir fark bulunamadı.
Sonuç: Biyopsi yapılan hastalarda 0.3’ün üzerindeki MLR değeri olması halinde patolojinin PCa olarak sonuçlanması %27,4 duyarlılık ve %85,3 özgüllük ile öngörülebilir.

Proje Numarası

Yok

Kaynakça

  • 1. Huang TB, Zhu LY, Zhou GC, Ding XF. Pre-treatment red blood cell distribution width as a predictor of clinically significant prostate cancer. International urology and nephrology. 2021;53(9):1765-71.
  • 2. Fujita K, Nonomura N. Urinary biomarkers of prostate cancer. International journal of urology : official journal of the Japanese Urological Association. 2018;25(9):770-9.
  • 3. Stabile A, Giganti F, Rosenkrantz AB, Taneja SS, Villeirs G, Gill IS, et al. Multiparametric MRI for prostate cancer diagnosis: current status and future directions. Nature reviews Urology. 2020;17(1):41-61.
  • 4. Cho MC, Yoo S, Choo MS, Son H, Jeong H. Lymphocyte-to-monocyte ratio is a predictor of clinically significant prostate cancer at prostate biopsy. The Prostate. 2021;81(16):1278-86.
  • 5. Başer A, Aydın C, Çelikörs B, Başer HY, Baykam MM, Alkış O. PSA seviyesi 4-10 ng/mL olan hastalarda alt üriner sistem semptomları patoloji sonucunu ön görebilir mi? Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2020;53(2):81-4.
  • 6. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: a cancer journal for clinicians. 2018;68(1):7-30. 7. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet (London, England). 2001;357(9255):539-45.
  • 8. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-7.
  • 9. Fujita K, Imamura R, Tanigawa G, Nakagawa M, Hayashi T, Kishimoto N, et al. Low serum neutrophil count predicts a positive prostate biopsy. Prostate cancer and prostatic diseases. 2012;15(4):386-90.
  • 10. Caruso C, Balistreri CR, Candore G, Carruba G, Colonna-Romano G, Di Bona D, et al. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach. Cancer immunology, immunotherapy : CII. 2009;58(12):1919-33.
  • 11. Hayashi T, Fujita K, Tanigawa G, Kawashima A, Nagahara A, Ujike T, et al. Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer. Oncotarget. 2017;8(21):35255-61. 12. Xu Z, Zhang J, Zhong Y, Mai Y, Huang D, Wei W, et al. Predictive value of the monocyte-to-lymphocyte ratio in the diagnosis of prostate cancer. Medicine. 2021;100(38):e27244.
  • 13. Augier S, Ciucci T, Luci C, Carle GF, Blin-Wakkach C, Wakkach A. Inflammatory blood monocytes contribute to tumor development and represent a privileged target to improve host immunosurveillance. Journal of immunology (Baltimore, Md : 1950). 2010;185(12):7165-73.
  • 14. Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nature reviews Immunology. 2009;9(3):162-74.
  • 15. Wang L, Long W, Li PF, Lin YB, Liang Y. An Elevated Peripheral Blood Monocyte-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Primary Pulmonary Lymphoepithelioma-Like Carcinoma. PloS one. 2015;10(5):e0126269.
  • 16. Nishijima TF, Muss HB, Shachar SS, Tamura K, Takamatsu Y. Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: A systematic review and meta-analysis. Cancer treatment reviews. 2015;41(10):971-8.
  • 17. Lindholm PF, Sivapurapu N, Jovanovic B, Kajdacsy-Balla A. Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-kappaB Activity. Journal of clinical & cellular immunology. 2015;6(2).
  • 18. Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L. The origin and function of tumor-associated macrophages. Immunology today. 1992;13(7):265-70.
  • 19. Nonomura N, Takayama H, Nakayama M, Nakai Y, Kawashima A, Mukai M, et al. Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. BJU international. 2011;107(12):1918-22.
  • 20. Weitzmann MN, Ofotokun I. Physiological and pathophysiological bone turnover - role of the immune system. Nature reviews Endocrinology. 2016;12(9):518-32.
  • 21. Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, et al. Diagnostic value of blood parameters for community-acquired pneumonia. International immunopharmacology. 2018;64:10-5.
  • 22. Kawahara T, Fukui S, Sakamaki K, Ito Y, Ito H, Kobayashi N, et al. Neutrophil-to-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy. Oncotarget. 2015;6(31):32169-76.
  • 23. Gokcen K, Dundar G, Gulbahar H, Gokce G, Gultekin EY. Can routine peripheral blood counts like neutrophil-to-lymphocyte ratio be beneficial in prediagnosis of testicular cancer and its stages? Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2018;23:64.
  • 24. Baser A. Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? Journal of Urological Surgery. 2020;7(4):271-6.
  • 25. Yeldir N, Yildiz E, Dündar G. Gleason score correlation between prostate needle biopsy and radical prostatectomy materials. Turkish Journal of Pathology. 2019;35(3):185-92.

Can the monocyte-to-lymphocyte ratio be another predictor of prostate cancer?

Yıl 2023, Cilt: 3 Sayı: 1, 16 - 24, 27.04.2023
https://doi.org/10.58961/hmj.1202211

Öz

Introduction: This study aimed to evaluate whether monocyte-lymphocyte-ratio (MLR) had a potential role as a biomarker of prostate cancer (PCa).
Methods: For patients who underwent a prostate biopsy between January 1, 2017, and December 31, 2021, age, hemogram parameters, free-total PSA values, and pathology results were recorded. Patients with a pathology result of PCa and those with a Gleason score of 3+4 and above were defined as having clinically significant PCa (csPCa), while other PCa cases were defined as having clinically non-significant PCa (non-csPCa).
Results: The pathology result was reported as PCa in 164 of the 510 patients included in the study and non-PCa in 346. The monocyte count was found to be higher in the PCa group than in the non-PCa group (0.61±0.33 and 0.53±0.19, respectively; p=0.002). MLR was also significantly higher in the PCa group (0.35±0.29 and 0.26±0.13, respectively; p<0.001). Of 164 patients whose pathology was reported as PCa, 69 (39%) had csPCa and 95 (61%) had non-csPCa. When these PCa subgroups were analyzed, age at diagnosis, free PSA, and total PSA were found to be statistically significantly higher in the csPCa group, while the f/tPSA value was statistically significantly lower in this group. There was no statistically significant difference between the csPCa and non-csPCa groups in terms of the lymphocyte and monocyte counts, and MLR.
Conclusions: In patients undergoing a biopsy, an MLR value above 0.3 can predict the pathology result being reported as PCa at a sensitivity of 27.4% and specificity of 85.3%.

Destekleyen Kurum

Yok

Proje Numarası

Yok

Teşekkür

We are grateful to Prof. Guven Ozkaya for his contribution to the statistical analysis. We also thank our colleagues who performed transrectal ultrasound-guided prostate biopsies. The first author also thanks Prof. Dr. Gökhan Gökçe and Prof. Dr. Murat Demirbaş for their academic guidance.

Kaynakça

  • 1. Huang TB, Zhu LY, Zhou GC, Ding XF. Pre-treatment red blood cell distribution width as a predictor of clinically significant prostate cancer. International urology and nephrology. 2021;53(9):1765-71.
  • 2. Fujita K, Nonomura N. Urinary biomarkers of prostate cancer. International journal of urology : official journal of the Japanese Urological Association. 2018;25(9):770-9.
  • 3. Stabile A, Giganti F, Rosenkrantz AB, Taneja SS, Villeirs G, Gill IS, et al. Multiparametric MRI for prostate cancer diagnosis: current status and future directions. Nature reviews Urology. 2020;17(1):41-61.
  • 4. Cho MC, Yoo S, Choo MS, Son H, Jeong H. Lymphocyte-to-monocyte ratio is a predictor of clinically significant prostate cancer at prostate biopsy. The Prostate. 2021;81(16):1278-86.
  • 5. Başer A, Aydın C, Çelikörs B, Başer HY, Baykam MM, Alkış O. PSA seviyesi 4-10 ng/mL olan hastalarda alt üriner sistem semptomları patoloji sonucunu ön görebilir mi? Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2020;53(2):81-4.
  • 6. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA: a cancer journal for clinicians. 2018;68(1):7-30. 7. Balkwill F, Mantovani A. Inflammation and cancer: back to Virchow? Lancet (London, England). 2001;357(9255):539-45.
  • 8. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420(6917):860-7.
  • 9. Fujita K, Imamura R, Tanigawa G, Nakagawa M, Hayashi T, Kishimoto N, et al. Low serum neutrophil count predicts a positive prostate biopsy. Prostate cancer and prostatic diseases. 2012;15(4):386-90.
  • 10. Caruso C, Balistreri CR, Candore G, Carruba G, Colonna-Romano G, Di Bona D, et al. Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach. Cancer immunology, immunotherapy : CII. 2009;58(12):1919-33.
  • 11. Hayashi T, Fujita K, Tanigawa G, Kawashima A, Nagahara A, Ujike T, et al. Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer. Oncotarget. 2017;8(21):35255-61. 12. Xu Z, Zhang J, Zhong Y, Mai Y, Huang D, Wei W, et al. Predictive value of the monocyte-to-lymphocyte ratio in the diagnosis of prostate cancer. Medicine. 2021;100(38):e27244.
  • 13. Augier S, Ciucci T, Luci C, Carle GF, Blin-Wakkach C, Wakkach A. Inflammatory blood monocytes contribute to tumor development and represent a privileged target to improve host immunosurveillance. Journal of immunology (Baltimore, Md : 1950). 2010;185(12):7165-73.
  • 14. Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nature reviews Immunology. 2009;9(3):162-74.
  • 15. Wang L, Long W, Li PF, Lin YB, Liang Y. An Elevated Peripheral Blood Monocyte-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Primary Pulmonary Lymphoepithelioma-Like Carcinoma. PloS one. 2015;10(5):e0126269.
  • 16. Nishijima TF, Muss HB, Shachar SS, Tamura K, Takamatsu Y. Prognostic value of lymphocyte-to-monocyte ratio in patients with solid tumors: A systematic review and meta-analysis. Cancer treatment reviews. 2015;41(10):971-8.
  • 17. Lindholm PF, Sivapurapu N, Jovanovic B, Kajdacsy-Balla A. Monocyte-Induced Prostate Cancer Cell Invasion is Mediated by Chemokine ligand 2 and Nuclear Factor-kappaB Activity. Journal of clinical & cellular immunology. 2015;6(2).
  • 18. Mantovani A, Bottazzi B, Colotta F, Sozzani S, Ruco L. The origin and function of tumor-associated macrophages. Immunology today. 1992;13(7):265-70.
  • 19. Nonomura N, Takayama H, Nakayama M, Nakai Y, Kawashima A, Mukai M, et al. Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer. BJU international. 2011;107(12):1918-22.
  • 20. Weitzmann MN, Ofotokun I. Physiological and pathophysiological bone turnover - role of the immune system. Nature reviews Endocrinology. 2016;12(9):518-32.
  • 21. Huang Y, Liu A, Liang L, Jiang J, Luo H, Deng W, et al. Diagnostic value of blood parameters for community-acquired pneumonia. International immunopharmacology. 2018;64:10-5.
  • 22. Kawahara T, Fukui S, Sakamaki K, Ito Y, Ito H, Kobayashi N, et al. Neutrophil-to-lymphocyte ratio predicts prostatic carcinoma in men undergoing needle biopsy. Oncotarget. 2015;6(31):32169-76.
  • 23. Gokcen K, Dundar G, Gulbahar H, Gokce G, Gultekin EY. Can routine peripheral blood counts like neutrophil-to-lymphocyte ratio be beneficial in prediagnosis of testicular cancer and its stages? Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences. 2018;23:64.
  • 24. Baser A. Does the Decrease in Neutrophil-lymphocyte Ratio after BCG Treatment Be a Prognostic Marker for NMIBC? Journal of Urological Surgery. 2020;7(4):271-6.
  • 25. Yeldir N, Yildiz E, Dündar G. Gleason score correlation between prostate needle biopsy and radical prostatectomy materials. Turkish Journal of Pathology. 2019;35(3):185-92.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Üroloji
Bölüm Araştırma Makaleleri
Yazarlar

Gökçe Dündar 0000-0001-9799-9700

Anıl Erkan 0000-0003-3130-9046

Proje Numarası Yok
Yayımlanma Tarihi 27 Nisan 2023
Gönderilme Tarihi 10 Kasım 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 3 Sayı: 1

Kaynak Göster

Vancouver Dündar G, Erkan A. Can the monocyte-to-lymphocyte ratio be another predictor of prostate cancer?. HTD / HMJ. 2023;3(1):16-24.

e-ISSN: 2791-9935