Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

Mahmut Gür; Merve Zurnacı; Eda Altınöz; Nesrin Şener; Çiğdem Şahin; Merve Şenturan; İzzet Şener; Muhammet Çavuş; Ergin Murat Altuner

doi:10.17350/HJSE19030000297

Araştırma Makalesi

Yıl 2023, Cilt: 10 Sayı: 2, 99 - 116, 30.06.2023

Mahmut Gür Merve Zurnacı Eda Altınöz Nesrin Şener Çiğdem Şahin Merve Şenturan İzzet Şener Muhammet Çavuş Ergin Murat Altuner

https://doi.org/10.17350/HJSE19030000297

Öz

Destekleyen Kurum

Bilimsel Araştırma Projeleri Koordinasyon Birimi

Proje Numarası

KÜ-BAP01/2019-3

Kaynakça

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Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations

Yıl 2023, Cilt: 10 Sayı: 2, 99 - 116, 30.06.2023

Mahmut Gür Merve Zurnacı Eda Altınöz Nesrin Şener Çiğdem Şahin Merve Şenturan İzzet Şener Muhammet Çavuş Ergin Murat Altuner

https://doi.org/10.17350/HJSE19030000297

Öz

In this study, 1,3,4-thiadiazole derivatives were obtained from the reaction of benzophenone-4,4'-dicarboxylic acid and N-substitute-thiosemicarbazide compounds with each other. After the synthesis of the final products, some biological properties of these compounds such as antibiofilm, antimicrobial and efflux pump inhibiting efficiencies were evaluated. According to the MBC/MFC test, all the activities were found to be bacteriostatic, also, especially the biofilm inhibition activity of C1 against K. pneumoniae is noteworthy. In addition, C4 was observed to exhibit efflux pump inhibition activity in E. coli, whereas C2 and C3 in K. pneumoniae. The absorption and emission values of the molecules were obtained and electrochemical studies were performed. In addition; absorption, metabolism, distribution, excretion and toxicity (ADMET) scores were predicted using the pharmacokinetic properties of all 1,3,4-thiadiazole compounds. Finally, the electrochemical stabilities of the synthesized molecules have been analyzed by using cyclic voltammetry in 0.1 M TBAPF6 in DMSO as a supporting electrolyte.

Anahtar Kelimeler

Efflux pump inhibition, antibiofilm, antibacterial, ADMET, QSAR

Proje Numarası

KÜ-BAP01/2019-3

Kaynakça

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Toplam 92 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Çevresel ve Sürdürülebilir Süreçler
Bölüm	Research Article
Yazarlar	Mahmut Gür 0000-0001-9942-6324 Merve Zurnacı 0000-0002-2928-3492 Eda Altınöz 0000-0003-1277-2019 Nesrin Şener 0000-0001-5370-6048 Çiğdem Şahin 0000-0002-3370-2434 Merve Şenturan 0000-0003-2700-7088 İzzet Şener 0000-0003-0540-7523 Muhammet Çavuş 0000-0002-3721-0883 Ergin Murat Altuner 0000-0001-5351-8071
Proje Numarası	KÜ-BAP01/2019-3
Yayımlanma Tarihi	30 Haziran 2023
Gönderilme Tarihi	20 Ekim 2022
Yayımlandığı Sayı	Yıl 2023 Cilt: 10 Sayı: 2

Kaynak Göster

Vancouver	Gür M, Zurnacı M, Altınöz E, Şener N, Şahin Ç, Şenturan M, Şener İ, Çavuş M, Altuner EM. Novel 1,3,4-Thiadiazole Derivatives as Antibiofilm, Antimicrobial, Efflux Pump Inhibiting Agents and Their ADMET Characterizations. Hittite J Sci Eng. 2023;10(2):99-116.

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