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The aim of this in vitro study was assessment of the cytotoxic level of 6-O-desmethylnaproxen. A mouse connective tissue fibroblast cell line, L929 was exposed to naproxen and 6-O-desmethylnaproxen in different concentrations for 24- and 48- hours. Cell viability was tested by MTT, while apoptosis was determined by AO/PI double staining method. The control group was free from any agent (DMEM only) and accepted as 100% cell viability. The IC50 results indicated that the inhibition of 50% cell viability was resulted by the highest concentration of 6-O-desmethylnaproxen (0.7 µg/mL) while none of naproxen concentration was caused 50% cell dead. Consequently, to avoid the unacceptable side effects of naproxen metabolites that evacuated by urine; further studies should be conducted to determine the accumulation of naproxen metabolites.
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Birincil Dil | İngilizce |
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Konular | Mühendislik |
Bölüm | Articles |
Yazarlar | |
Proje Numarası | Yok |
Yayımlanma Tarihi | 1 Ocak 2021 |
Kabul Tarihi | 8 Ekim 2020 |
Yayımlandığı Sayı | Yıl 2021 Cilt: 49 Sayı: 1 |
HACETTEPE JOURNAL OF BIOLOGY AND CHEMİSTRY
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