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Role of Apolipoproteins in Neurodegenerative Diseases

Yıl 2023, Cilt: 5 Sayı: 3, 122 - 133, 31.12.2023

Pınar Kaçamak Çiğdem Elmas

https://doi.org/10.59124/guhes.1383395

Öz

Since lipids are insoluble in water, they are carried in the blood as particles called lipoproteins. Lipoproteins consisting of lipids and proteins are multicomponent complexes. The classification of lipoproteins, which are divided into several main groups such as low density lipoprotein (LDL), high density lipoprotein (HDL), very low density lipoprotein (VLDL) and chylomicrons, is based on their density, size, lipid and apolipoprotein content. Apolipoproteins are the protein component of lipoproteins that carry lipids from the blood to various tissues of the body for metabolism and utilisation. Apolipoproteins play an important role in lipid metabolism. They regulate many metabolic enzymes and interact with lipoprotein receptors. Numerous studies have shown that apolipoprotein phenotype, different allelic polymorphism and apolipoprotein gene mutation can affect metabolism and utilisation of blood lipids and consequently trigger the onset and development of atherosclerosis, hyperlipidaemia, cerebrovascular and cardiovascular diseases. Furthermore, apolipoproteins have been associated with neurodegenerative diseases and different apolipoprotein polymorphisms have been evaluated as risk factors or protective agents in different neurodegenerative diseases. This review presents evidence from some studies linking apolipoproteins with Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration disease.

Anahtar Kelimeler

Alzheimer's disease Apolipoprotein Multiple sclerosis Neurodegeneration Parkinson's disease

Etik Beyan

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Destekleyen Kurum

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Proje Numarası

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Kaynakça

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Yıl 2023, Cilt: 5 Sayı: 3, 122 - 133, 31.12.2023

Pınar Kaçamak Çiğdem Elmas

https://doi.org/10.59124/guhes.1383395

Öz

Proje Numarası

-

Kaynakça

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  • Thompson, A. G., Talbot, K., & Turner, M. R. (2022). Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery & Psychiatry, 93(1), 75-81. https://doi.org/10.1136/jnnp-2021-327133
  • Tóth, M. E., Dukay, B., Hoyk, Z., & Sántha, M. (2020). Cerebrovascular changes and neurodegeneration related to hyperlipidemia: characteristics of the human ApoB-100 transgenic mice. Current Pharmaceutical Design, 26(13), 1486-1494. https://doi.org/10.2174/1381612826666200218101818
  • Tsuang, D., Leverenz, J. B., Lopez, O. L., Hamilton, R. L., Bennett, D. A., Schneider, J. A., Buchman, A. S., Larson, E. B., Crane, P. K., Kaye, J. A., Kramer, P., Woltjer, R., Trojanowski, J. O., Weintraub, D., Chen-Plotkin, A. S., Irwin, D. J., Rick, J., Schellenberg, G. D., Watson, G. S., … & Zabetian, C. P. (2013). APOE ϵ4 increases risk for dementia in pure synucleinopathies. JAMA neurology, 70(2), 223-228. https://doi.org/10.1001/jamaneurol.2013.600
  • Turan, T. N., Makki, A. A., Tsappidi, S., Cotsonis, G., Lynn, M. J., Cloft, H. J., & Chimowitz, M. I. (2010). Risk factors associated with severity and location of intracranial arterial stenosis. Stroke, 41(8), 1636-1640. https://doi.org/10.1161/STROKEAHA.110.584672
  • van Luijn, M. M., van Meurs, M., Stoop, M. P., Verbraak, E., Wierenga-Wolf, A. F., Melief, M. J., Kreft, K. L., Verdijk, R. M., ’t Hart, B. A., Luider, T. M., Laman, J. D., & Hintzen, R. Q. (2016). Elevated expression of the cerebrospinal fluid disease markers chromogranin a and clusterin in astrocytes of multiple sclerosis white matter lesions. Journal of Neuropathology & Experimental Neurology, 75(1), 86-98. https://doi.org/10.1093/jnen/nlv004
  • Vitali, C., Wellington, C. L., & Calabresi, L. (2014). HDL and cholesterol handling in the brain. Cardiovascular research, 103(3), 405-413. https://doi.org/10.1093/cvr/cvu148
  • Waldner, A., Dassati, S., Redl, B., Smania, N., & Gandolfi, M. (2018). Apolipoprotein D concentration in human plasma during aging and in Parkinson’s disease: a cross-sectional study. Parkinson’s Disease, 2018. https://doi.org/10.1155/2018/3751516
  • Wang, L., Sapuri-Butti, A. R., Aung, H. H., Parikh, A. N., & Rutledge, J. C. (2008). Triglyceride-rich lipoprotein lipolysis increases aggregation of endothelial cell membrane microdomains and produces reactive oxygen species. American Journal of Physiology-Heart and Circulatory Physiology, 295(1), H237-H244. https://doi.org/10.1152/ajpheart.01366.2007
  • Wei, Q., Wang, H., Tian, Y., Xu, F., Chen, X., & Wang, K. (2013). Reduced serum levels of triglyceride, very low density lipoprotein cholesterol and apolipoprotein B in Parkinson’s disease patients. PLoS One, 8(9), e75743. https://doi.org/10.1371/journal.pone.0075743
  • Weinstock-Guttman, B., Zivadinov, R., Mahfooz, N., Carl, E., Drake, A., Schneider, J., Teter, B., Hussein, S., Mehta, B., Weiskopf, M., Durfee, J., Bergsland, N., & Ramanathan, M. (2011). Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis. Journal of neuroinflammation, 8(1), 1-7. https://doi.org/10.1186/1742-2094-8-127
  • Wisniewski, T., Golabek, A. A., Kida, E., Wisniewski, K. E., & Frangione, B. (1995). Conformational mimicry in Alzheimer's disease. Role of apolipoproteins in amyloidogenesis. The American journal of pathology, 147(2), 238. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1869828/pdf/amjpathol00044-0015.pdf
  • Zhang, X., & Alzheimer’s Disease Neuroimaging Initiative. (2020). Higher plasma APOC-III was associated with a slower reduction of β-amyloid levels in cerebrospinal fluid among older individuals without dementia. Neuropsychiatric Disease and Treatment, 1139-1144. https://doi.org/10.2147/NDT.S238985
  • Zhang, X., Yin, X., Yu, H., Liu, X., Yang, F., Yao, J., Jin, H., & Yang, P. (2012). Quantitative proteomic analysis of serum proteins in patients with Parkinson’s disease using an isobaric tag for relative and absolute quantification labeling, two-dimensional liquid chromatography, and tandem mass spectrometry. Analyst, 137(2), 490-495. https://doi.org/10.1039/c1an15551b
  • Zlokovic, B. V., Martel, C. L., Matsubara, E., McComb, J. G., Zheng, G., McCluskey, R. T., Frangione, B., & Ghiso, J. (1996). Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proceedings of the National Academy of Sciences, 93(9), 4229-4234. https://doi.org/10.1073/pnas.93.9.4229
Toplam 80 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Makaleler
Yazarlar

Pınar Kaçamak 0000-0001-5650-9664

Çiğdem Elmas 0000-0002-8857-0918

Proje Numarası -
Yayımlanma Tarihi 31 Aralık 2023
Gönderilme Tarihi 30 Ekim 2023
Kabul Tarihi 27 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 5 Sayı: 3

Kaynak Göster

APA Kaçamak, P., & Elmas, Ç. (2023). Role of Apolipoproteins in Neurodegenerative Diseases. Journal of Gazi University Health Sciences Institute, 5(3), 122-133. https://doi.org/10.59124/guhes.1383395
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