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Yıl 2022, Cilt: 4 Sayı: 2, 107 - 124, 31.08.2022

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  • Al-Hendy, A., & Salama, S. A. (2006). Ethnic distribution of estrogen receptor-α polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. Fertility and Sterility, 86(3), 686–693. https://doi.org/10.1016/j.fertnstert.2006.01.052
  • Baird, D. D., & Dunson, D. B. (2003). Why is parity protective for uterine fibroids? Epidemiology, 14(2), 247–250. https://doi.org/10.1097/00001648-200303000-00021
  • Baird, D. D., Dunson, D. B., Hill, M. C., Cousins, D., & Schectman, J. M. (2007). Association of physical activity with development of uterine leiomyoma. American Journal of Epidemiology, 165(2), 157–163. https://doi.org/10.1093/aje/kwj363
  • Borahay, M. A., Al Hendy, A., Kilic, G. S., & Boehning, D. (2015). Signaling pathways in leiomyoma: Understanding pathobiology and implications for therapy. Molecular Medicine, 21, 242–256. https://doi.org/10.2119/molmed.2014.00053
  • Borahay, M. A., Asoglu, M. R., Mas, A., Adam, S., Kilic, G. S., & Al-Hendy, A. (2017). Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications. Reproductive Sciences, 24(9), 1235–1244. https://doi.org/10.1177/1933719116678686
  • Boynton-Jarrett, R., Rich-Edwards, J. W., Jun, H. J., Hibert, E. N., & Wright, R. J. (2011). Abuse in childhood and risk of uterine leiomyoma: The role of emotional support in biologic resilience. Epidemiology, 22(1), 6–14. https://doi.org/10.1097/EDE.0b013e3181ffb172
  • Brasky, T. M., Bethea, T. N., Wesselink, A. K., Wegienka, G. R., Baird, D. D., & Wise, L. A. (2020). Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study. American Journal of Epidemiology, 189(12), 1538–1546. https://doi.org/10.1093/aje/kwaa097
  • Bulman, J. C., Ascher, S. M., & Spies, J. B. (2012). Current concepts in uterine fibroid embolization. Radiographics, 32(6), 1735–1750. https://doi.org/10.1148/rg.326125514
  • Chiaffarino, F., Ricci, E., Cipriani, S., Chiantera, V., & Parazzini, F. (2016). Cigarette smoking and risk of uterine myoma: Systematic review and meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology, 197, 63–71. https://doi.org/10.1016/j.ejogrb.2015.11.023
  • Ciebiera, M., Włodarczyk, M., Wrzosek, M., Męczekalski, B., Nowicka, G., Łukaszuk, K., … Jakiel, G. (2017). Role of transforming growth factor β in uterine fibroid biology. International Journal of Molecular Sciences, Vol. 18, pp. 1–16. https://doi.org/10.3390/ijms18112435
  • Davis, B. J., Risinger, J. I., Chandramouli, G. V. R., Bushel, P. R., Baird, D. D., & Peddada, S. D. (2013). Gene Expression in Uterine Leiomyoma from Tumors Likely to Be Growing (from Black Women over 35) and Tumors Likely to Be Non-Growing (from White Women over 35). PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0063909
  • Donnez, J., Courtoy, G. E., Donnez, O., & Dolmans, M. M. (2018). Ulipristal acetate for the management of large uterine fibroids associated with heavy bleeding: a review. Reproductive BioMedicine Online, 37(2), 216–223. https://doi.org/10.1016/j.rbmo.2018.04.040
  • Donnez, J., & Dolmans, M. M. (2016). Uterine fibroid management: From the present to the future. Human Reproduction Update, 22(6), 665–686. https://doi.org/10.1093/humupd/dmw023
  • Duhan, N. (2011). Current and emerging treatments for uterine myoma - An update. International Journal of Women’s Health, 3(1), 231–242. https://doi.org/10.2147/ijwh.s15710
  • Farris, M., Bastianelli, C., Rosato, E., Brosens, I., & Benagiano, G. (2019, January 23). Uterine fibroids: An update on current and emerging medical treatment options. Therapeutics and Clinical Risk Management, Vol. 15, pp. 157–178. Dove Press. https://doi.org/10.2147/TCRM.S147318
  • Flake, G. P., Andersen, J., & Dixon, D. (2003). Etiology and pathogenesis of uterine leiomyomas: A review. Environmental Health Perspectives, Vol. 111, pp. 1037–1054. https://doi.org/10.1289/ehp.5787
  • Frydenberg, H., Flote, V. G., Larsson, I. M., Barrett, E. S., Furberg, A. S., Ursin, G., … Thune, I. (2015). Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women. Breast Cancer Research, 17(1), 1–12. https://doi.org/10.1186/s13058-015-0620-1
  • Gupta, J. K., Sinha, A., Lumsden, M. A., & Hickey, M. (2014). Uterine artery embolization for symptomatic uterine fibroids. Cochrane Database of Systematic Reviews, 2014(12). https://doi.org/10.1002/14651858.CD005073.pub4
  • Halder, S. K., Goodwin, J. S., & Al-Hendy, A. (2011). 1,25-Dihydroxyvitamin D3 reduces TGF-β3-induced fibrosis-related gene expression in human uterine leiomyoma cells. Journal of Clinical Endocrinology and Metabolism, 96(4), 754–762. https://doi.org/10.1210/jc.2010-2131
  • Halder, S. K., Osteen, K. G., & Al-Hendy, A. (2013). 1,25-Dihydroxyvitamin D3 Reduces Extracellular Matrix-Associated Protein Expression in Human Uterine Fibroid Cells1. Biology of Reproduction, 89(6), 1–13. https://doi.org/10.1095/biolreprod.113.107714
  • He, Y., Zeng, Q., Dong, S., Qin, L., Li, G., & Wang, P. (2013). Associations between uterine fibroids and lifestyles including diet, physical activity and stress: A case-control study in China. Asia Pacific Journal of Clinical Nutrition, 22(1), 109–117. https://doi.org/10.6133/apjcn.2013.22.1.07
  • Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., … Giudice, L. C. (2016). Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis. Reproductive Sciences, 23(10), 1289–1303. https://doi.org/10.1177/1933719116650758
  • Holdsworth-Carson, S. J., Zaitseva, M., Vollenhoven, B. J., & Rogers, P. A. W. (2014). Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues. Molecular Human Reproduction, 20(3), 250–259. https://doi.org/10.1093/molehr/gat083
  • Islam, M. S., Ciavattini, A., Petraglia, F., Castellucci, M., & Ciarmela, P. (2018). Extracellular matrix in uterine leiomyoma pathogenesis: A potential target for future therapeutics. Human Reproduction Update, 24(1), 59–85. https://doi.org/10.1093/humupd/dmx032
  • Islam, M. S., Protic, O., Giannubilo, S. R., Toti, P., Tranquilli, A. L., Petraglia, F., … Ciarmela, P. (2013). Uterine leiomyoma: Available medical treatments and new possible therapeutic options. Journal of Clinical Endocrinology and Metabolism, 98(3), 921–934. https://doi.org/10.1210/jc.2012-3237
  • Islam, M. S., Protic, O., Stortoni, P., Grechi, G., Lamanna, P., Petraglia, F., … Ciarmela, P. (2013). Complex networks of multiple factors in the pathogenesis of uterine leiomyoma. Fertility and Sterility, 100(1), 178–193. https://doi.org/10.1016/j.fertnstert.2013.03.007
  • Iwahashi, M., & Muragaki, Y. (2011). Increased type i and v collagen expression in uterine leiomyomas during the menstrual cycle. Fertility and Sterility, 95(6), 2137–2139. https://doi.org/10.1016/j.fertnstert.2010.12.028
  • Jacoby, V. L., Fujimoto, V. Y., Giudice, L. C., Kuppermann, M., & Washington, A. E. (2010). Racial and ethnic disparities in benign gynecologic conditions and associated surgeries. American Journal of Obstetrics and Gynecology, 202(6), 514–521. https://doi.org/10.1016/j.ajog.2010.02.039
  • Jayes, F. L., Liu, B., Feng, L., Aviles-Espinoza, N., Leikin, S., & Leppert, P. C. (2019). Evidence of biomechanical and collagen heterogeneity in uterine fibroids. PLoS ONE, 14(4), 1–16. https://doi.org/10.1371/journal.pone.0215646
  • Joseph, D. S., Malik, M., Nurudeen, S., & Catherino, W. H. (2010). Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor β-3. Fertility and Sterility, 93(5), 1500–1508. https://doi.org/10.1016/j.fertnstert.2009.01.081
  • Khalid, A., Qureshi, H. J., Nazir, S., & Lone, K. P. (2017). Effect of second hand smoke exposure on serum estradiol and progesterone levels in women having first trimester spontaneous abortions. Pakistan Journal of Medical and Health Sciences, 11(1), 163–167.
  • Khan, A. T., Shehmar, M., & Gupta, J. K. (2014). Uterine fibroids: Current perspectives. International Journal of Women’s Health, 6(1), 95–114. https://doi.org/10.2147/IJWH.S51083
  • Lam, S. J., Best, S., & Kumar, S. (2014). The impact of fibroid characteristics on pregnancy outcome. American Journal of Obstetrics and Gynecology, 211(4), 395.e1-395.e5. https://doi.org/10.1016/j.ajog.2014.03.066
  • Laughlin, S. K., Herring, A. H., Savitz, D. A., Olshan, A. F., Fielding, J. R., Hartmann, K. E., & Baird, D. D. (2010). Pregnancy-related fibroid reduction. Fertility and Sterility, 94(6), 2421–2423. https://doi.org/10.1016/j.fertnstert.2010.03.035
  • Laughlin, S. K., Schroeder, J. C., & Baird, D. D. (2010). New directions in the epidemiology of uterine fibroids. Seminars in Reproductive Medicine, 28(3), 204–217. https://doi.org/10.1055/s-0030-1251477
  • Laughlin, S. K., & Stewart, E. A. (2011). Uterine leiomyomas: Individualizing the approach to a heterogeneous condition. Obstetrics and Gynecology, 117(2 PART 1), 396–403. https://doi.org/10.1097/AOG.0b013e31820780e3
  • Leppert, P. C., Baginski, T., Prupas, C., Catherino, W. H., Pletcher, S., & Segars, J. H. (2004). Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. Fertility and Sterility, 82(SUPPL. 3), 1182–1187. https://doi.org/10.1016/j.fertnstert.2004.04.030
  • Leppert, P. C., Jayes, F. L., & Segars, J. H. (2014). The Extracellular Matrix Contributes to Mechanotransduction in Uterine Fibroids. Obstetrics and Gynecology International, 2014, 1–12. https://doi.org/10.1155/2014/783289
  • Lethaby, A., & Vollenhoven, B. (2015). Fibroids (uterine myomatosis, leiomyomas). BMJ Clinical Evidence, 2015(November 2006), 1–26.
  • Levy, B. S. (2020). Modern Management of Uterine Fibroids. In M. Metwally & T.-C. Li (Eds.), Acta Obstetricia et Gynecologica Scandinavica (Vol. 87). Cambridge University Press. https://doi.org/https://doi.org/10.1017/9781108332798
  • Lucero, J., Harlow, B. L., Barbieri, R. L., Sluss, P., & Cramer, D. W. (2001). Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertility and Sterility, 76(4), 723–729. https://doi.org/10.1016/S0015-0282(01)02005-2
  • Lumsden, M. A., Hamoodi, I., Gupta, J., & Hickey, M. (2015). Fibroids: Diagnosis and management. BMJ (Online), 351. https://doi.org/10.1136/bmj.h4887
  • Malik, M., Segars, J., & Catherino, W. H. (2012). Integrin β1 regulates leiomyoma cytoskeletal integrity and growth. Matrix Biology, 31(7–8), 389–397. https://doi.org/10.1016/j.matbio.2012.09.005
  • Marshall, L. M., Spiegelman, D., Goldman, M. B., Manson, J. A. E., Colditz, G. A., Barbieri, R. L., … Hunter, D. J. (1998). A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertility and Sterility, 70(3), 432–439. https://doi.org/10.1016/S0015-0282(98)00208-8
  • Mas, A., Cervello, I., Gil-Sanchis, C., & Simón, C. (2014). Current understanding of somatic stem cells in leiomyoma formation. Fertility and Sterility, 102(3), 613–620. https://doi.org/10.1016/j.fertnstert.2014.04.051
  • Medikare, V., Kandukuri, L. R., Ananthapur, V., Deenadayal, M., & Nallari, P. (2011). The genetic bases of uterine fibroids; a review. Journal of Reproduction and Infertility, 12(3), 181–191.
  • Moore, K. R., Cole, S. R., Dittmer, D. P., Schoenbach, V. J., Smith, J. S., & Baird, D. D. (2015). Self-reported reproductive tract infections and ultrasound diagnosed uterine fibroids in African-American Women. Journal of Women’s Health, 24(6), 489–495. https://doi.org/10.1089/jwh.2014.5051
  • Moro, E., Esposti, E. D., Borghese, G., Manzara, F., Zanello, M., Raimondo, D., … Seracchioli, R. (2019). The impact of hormonal replacement treatment in postmenopausal women with uterine fibroids: A state-of-the-art review of the literature. Medicina (Lithuania), 55(9). https://doi.org/10.3390/medicina55090549
  • Nagata, C., Nakamura, K., Oba, S., Hayashi, M., Takeda, N., & Yasuda, K. (2009). Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women. British Journal of Nutrition, 101(10), 1427–1431. https://doi.org/10.1017/S0007114508083566
  • Nivethithai, P., Sr, N., & Bv, R. (2010). APTI Uterine Fibroids : A Review. 3(1), 6–11.
  • Omar, M. K., Yang, Q., Laknaur, A., & Al-Hendy, A. (2016). Myometrial progesterone hyper-responsivness is associated with increased risk for the development of human uterine fibroids. Fertility and Sterility, 106(3), e96. https://doi.org/10.1016/j.fertnstert.2016.07.280
  • Ono, M., Qiang, W., Serna, V. A., Yin, P., Coon, J. S., Navarro, A., … Bulun, S. E. (2012). Role of stem cells in human uterine leiomyoma growth. PLoS ONE, 7(5). https://doi.org/10.1371/journal.pone.0036935
  • Paffoni, A., Somigliana, E., Vigano’, P., Benaglia, L., Cardellicchio, L., Pagliardini, L., … Fedele, L. (2013). Vitamin D status in women with uterine leiomyomas. Journal of Clinical Endocrinology and Metabolism, 98(8), 1374–1378. https://doi.org/10.1210/jc.2013-1777
  • Palomba, S., Orio, F., Russo, T., Falbo, A., Tolino, A., Lombardi, G., … Zullo, F. (2005). Antiproliferative and proapoptotic effects of raloxifene on uterine leiomyomas in postmenopausal women. Fertility and Sterility, 84(1), 154–161. https://doi.org/10.1016/j.fertnstert.2004.12.058
  • Pan, Q., Luo, X., & Chegini, N. (2007). Genomic and proteomic profiling I: Leiomyomas in African Americans and Caucasians. Reproductive Biology and Endocrinology, 5, 1–15. https://doi.org/10.1186/1477-7827-5-34
  • Parazzini, F., Negri, E., La Vecchia, C., Rabaiotti, M., Luchini, L., Villa, A., & Fedele, L. (1996). Uterine myomas and smoking: Results from an Italian study. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 41(5), 316–320. Retrieved from https://europepmc.org/article/med/8725755
  • Parker, W. H. (2007). Etiology, symptomatology, and diagnosis of uterine myomas. Fertility and Sterility, 87(4), 725–736. https://doi.org/10.1016/j.fertnstert.2007.01.093
  • Pascual Botia, C., Camarasa, S. C., Raga Baixauli, F., & Sanchez, A. C. (2017). Uterine Fibroids Review: Understanding their Origins to Better Understand their Future Treatments. Journal of Tumor Research, 03(03). https://doi.org/10.35248/2684-1258.17.3.130
  • Perrine Susan. (2005). 基因的改变NIH Public Access. Bone, 23(1), 1–7. https://doi.org/10.1038/jid.2014.371
  • Premkumar, A., Venzon, D. J., Avila, N., Johnson, D. V., Remaley, A. T., Forman, M. R., … Stratton, P. (2007). Gynecologic and hormonal effects of raloxifene in premenopausal women. Fertility and Sterility, 88(6), 1637–1644. https://doi.org/10.1016/j.fertnstert.2007.01.095
  • Reis, F. M., Bloise, E., & Ortiga-Carvalho, T. M. (2016). Hormones and pathogenesis of uterine fibroids. Best Practice and Research: Clinical Obstetrics and Gynaecology, 34(November), 13–24. https://doi.org/10.1016/j.bpobgyn.2015.11.015
  • Ritchie, J., & Nelson, A. L. (2017). Severe Anemia from Heavy Menstrual Bleeding Requires Heightened Attention. Clinics in Mother and Child Health, 14(1), 1–2. https://doi.org/10.4172/2090-7214.1000256
  • Sabry, M., Halder, S. K., Ait Allah, A. S. A., Roshdy, E., Rajaratnam, V., & Al-Hendy, A. (2013). Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: A cross-sectional observational study. International Journal of Women’s Health, 5(1), 93–100. https://doi.org/10.2147/IJWH.S38800
  • Samadi, A. R., Lee, N. C., Dana Flanders, W., Boring, J. R., & Parris, E. B. (1996). Risk factors for self-reported uterine fibroids: A case-control study. American Journal of Public Health, 86(6), 858–862. https://doi.org/10.2105/AJPH.86.6.858
  • Seshadri, S., El-Toukhy, T., Douiri, A., Jayaprakasan, K., & Khalaf, Y. (2015). Diagnostic accuracy of saline infusion sonography in the evaluation of uterine cavity abnormalities prior to assisted reproductive techniques: A systematic review and meta-analyses. Human Reproduction Update, 21(2), 262–274. https://doi.org/10.1093/humupd/dmu057
  • Sharan, C., Halder, S. K., Thota, C., Jaleel, T., Nair, S., & Al-Hendy, A. (2011). Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertility and Sterility, 95(1), 247–253. https://doi.org/10.1016/j.fertnstert.2010.07.1041
  • Sinclair, D. C., Mastroyannis, A., & Taylor, H. S. (2011). Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3. Journal of Clinical Endocrinology and Metabolism, 96(2), 412–421. https://doi.org/10.1210/jc.2010-1450
  • Sommer, E. M., Balkwill, A., Reeves, G., Green, J., Beral, D. V., & Coffey, K. (2015). Effects of obesity and hormone therapy on surgically-confirmed fibroids in postmenopausal women. European Journal of Epidemiology, 30(6), 493–499. https://doi.org/10.1007/s10654-015-0016-7
  • Sparic, R., Mirkovic, L., Malvasi, A., & Tinelli, A. (2016). Epidemiology of uterine myomas: A review. International Journal of Fertility and Sterility, 9(4), 424–435. https://doi.org/10.22074/ijfs.2015.4599
  • Stewart, E. A., Cookson, C. L., Gandolfo, R. A., & Schulze-Rath, R. (2017). Epidemiology of uterine fibroids: a systematic review. BJOG: An International Journal of Obstetrics and Gynaecology, 124(10), 1501–1512. https://doi.org/10.1111/1471-0528.14640
  • Stewart, Elizabeth A., & Nowak, R. A. (1996). Leiomyoma-related bleeding: A classic hypothesis updated for the molecular era. Human Reproduction Update, 2(4), 295–306. https://doi.org/10.1093/humupd/2.4.295
  • Taran, F. A., Brown, H. L., & Stewart, E. A. (2010). Racial diversity in uterine leiomyoma clinical studies. Fertility and Sterility, 94(4), 1500–1503. https://doi.org/10.1016/j.fertnstert.2009.08.037
  • Thorne, J. T., Segal, T. R., Chang, S., Jorge, S., Segars, J. H., & Leppert, P. C. (2015). Dynamic Reciprocity Between Cells and Their Microenvironment in Reproduction1. Biology of Reproduction, 92(1), 1–10. https://doi.org/10.1095/biolreprod.114.121368
  • Tinelli, A., Vinciguerra, M., Malvasi, A., Andjić, M., Babović, I., & Sparić, R. (2021). Uterine fibroids and diet. International Journal of Environmental Research and Public Health, Vol. 18, pp. 1–15. https://doi.org/10.3390/ijerph18031066
  • Välimäki, N., Kuisma, H., Pasanen, A., Heikinheimo, O., Sjöberg, J., Bützow, R., … Aaltonen, L. A. (2018). Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability. ELife, 7, 1–50. https://doi.org/10.7554/eLife.37110
  • Vessey, M. P. (1986). Risk factors for uterine fibroids: Reduced risk associated with oral contraceptives. British Medical Journal (Clinical Research Ed.), 293(6543), 359–362. https://doi.org/10.1136/bmj.293.6543.359
  • Vitner, D., Filmer, S., Goldstein, I., Khatib, N., & Weiner, Z. (2013). A comparison between ultrasonography and hysteroscopy in the diagnosis of uterine pathology. European Journal of Obstetrics and Gynecology and Reproductive Biology, 171(1), 143–145. https://doi.org/10.1016/j.ejogrb.2013.08.024
  • Wang, Y., Feng, G., Wang, J., Zhou, Y., Liu, Y., Shi, Y., … Li, Z. (2015). Differential effects of tumor necrosis factor-α on matrix metalloproteinase-2 expression in human myometrial and uterine leiomyoma smooth muscle cells. Human Reproduction, 30(1), 61–70. https://doi.org/10.1093/humrep/deu300
  • Williams, A. R. W. (2017). Uterine fibroids – what’s new? F1000Research, 6, 2109. https://doi.org/10.12688/f1000research.12172.1
  • Windham, G. C., Mitchell, P., Anderson, M., & Lasley, B. L. (2005). Cigarette smoking and effects on hormone function in premenopausal women. Environmental Health Perspectives, 113(10), 1285–1290. https://doi.org/10.1289/ehp.7899
  • Wise, L. A., & Laughlin-tommaso, S. K. (2016). Epidemiology of Uterine Fibroids. Clinical Obstetrics & Gynecology, 59(1), 2–24. https://doi.org/10.1097/grf.0000000000000164
  • Wise, L. A., Palmer, J. R., Harlow, B. L., Spiegelman, D., Stewart, E. A., Adams-Campbell, L. L., & Rosenberg, L. (2004). Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women’s Health Study. Human Reproduction, 19(8), 1746–1754. https://doi.org/10.1093/humrep/deh309
  • Wise, L. A., Palmer, J. R., Harlow, B. L., Spigelman, D., Stewart, E. A., Adams-Campbell, L. L., & Rosenberg, L. (2004). Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study. American Journal of Epidemiology, 159(2), 113–123. https://doi.org/10.1093/aje/kwh016
  • Wise, L. A., Palmer, J. R., Ruiz-Narvaez, E., Reich, D. E., & Rosenberg, L. (2013). Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry? American Journal of Epidemiology, 178(7), 1114–1119. https://doi.org/10.1093/aje/kwt091
  • Wynn, T. A., & Wynn, T. A. (2007). Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases Find the latest version : Review series introduction Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Journal Of Clinical Investigation, 117(3), 524–529. https://doi.org/10.1172/JCI31487.524
  • Yan, L., Ding, L., Li, C., Wang, Y., Tang, R., & Chen, Z. J. (2014). Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment: A retrospective cohort study. Fertility and Sterility, 101(3), 716-721.e6. https://doi.org/10.1016/j.fertnstert.2013.11.023

Current Understanding of Pathogenesis, Histopathology, Diagnosis, and Treatment Options of Uterine Fibroids-Review

Yıl 2022, Cilt: 4 Sayı: 2, 107 - 124, 31.08.2022

Öz

Uterine fibroids are the most common benign monoclonal tumors of the uterus..They are associated with a significant morbidity rate and affect women mainly during their reproductive age. These tumors are usually asymptomatic however, they may present as heavy or prolonged menstrual bleeding, abnormal uterine bleeding, consequent anaemia, pelvic pain, infertility, and/or recurrent abortions. Despite many factors playing a role in the development and incidence of these common tumors namely; modifications in growth factor expression, abnormalities in the vascular system, and tissue reaction to injury and even genetics, a clear understanding of the pathogenesis of uterine fibroids is yet to be achieved. However, there has been significant progress made towards understanding their origin witnessed in recent years which has provided more options for the treatment of uterine fibroids including medical, surgical, and radiological interventions. This article briefly reviews the current knowledge of pathology, histology, and diagnosis of uterine fibroids while highlighting their treatment options.

Kaynakça

  • Al-Hendy, A., & Salama, S. A. (2006). Ethnic distribution of estrogen receptor-α polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. Fertility and Sterility, 86(3), 686–693. https://doi.org/10.1016/j.fertnstert.2006.01.052
  • Baird, D. D., & Dunson, D. B. (2003). Why is parity protective for uterine fibroids? Epidemiology, 14(2), 247–250. https://doi.org/10.1097/00001648-200303000-00021
  • Baird, D. D., Dunson, D. B., Hill, M. C., Cousins, D., & Schectman, J. M. (2007). Association of physical activity with development of uterine leiomyoma. American Journal of Epidemiology, 165(2), 157–163. https://doi.org/10.1093/aje/kwj363
  • Borahay, M. A., Al Hendy, A., Kilic, G. S., & Boehning, D. (2015). Signaling pathways in leiomyoma: Understanding pathobiology and implications for therapy. Molecular Medicine, 21, 242–256. https://doi.org/10.2119/molmed.2014.00053
  • Borahay, M. A., Asoglu, M. R., Mas, A., Adam, S., Kilic, G. S., & Al-Hendy, A. (2017). Estrogen Receptors and Signaling in Fibroids: Role in Pathobiology and Therapeutic Implications. Reproductive Sciences, 24(9), 1235–1244. https://doi.org/10.1177/1933719116678686
  • Boynton-Jarrett, R., Rich-Edwards, J. W., Jun, H. J., Hibert, E. N., & Wright, R. J. (2011). Abuse in childhood and risk of uterine leiomyoma: The role of emotional support in biologic resilience. Epidemiology, 22(1), 6–14. https://doi.org/10.1097/EDE.0b013e3181ffb172
  • Brasky, T. M., Bethea, T. N., Wesselink, A. K., Wegienka, G. R., Baird, D. D., & Wise, L. A. (2020). Dietary Fat Intake and Risk of Uterine Leiomyomata: A Prospective Ultrasound Study. American Journal of Epidemiology, 189(12), 1538–1546. https://doi.org/10.1093/aje/kwaa097
  • Bulman, J. C., Ascher, S. M., & Spies, J. B. (2012). Current concepts in uterine fibroid embolization. Radiographics, 32(6), 1735–1750. https://doi.org/10.1148/rg.326125514
  • Chiaffarino, F., Ricci, E., Cipriani, S., Chiantera, V., & Parazzini, F. (2016). Cigarette smoking and risk of uterine myoma: Systematic review and meta-analysis. European Journal of Obstetrics and Gynecology and Reproductive Biology, 197, 63–71. https://doi.org/10.1016/j.ejogrb.2015.11.023
  • Ciebiera, M., Włodarczyk, M., Wrzosek, M., Męczekalski, B., Nowicka, G., Łukaszuk, K., … Jakiel, G. (2017). Role of transforming growth factor β in uterine fibroid biology. International Journal of Molecular Sciences, Vol. 18, pp. 1–16. https://doi.org/10.3390/ijms18112435
  • Davis, B. J., Risinger, J. I., Chandramouli, G. V. R., Bushel, P. R., Baird, D. D., & Peddada, S. D. (2013). Gene Expression in Uterine Leiomyoma from Tumors Likely to Be Growing (from Black Women over 35) and Tumors Likely to Be Non-Growing (from White Women over 35). PLoS ONE, 8(6). https://doi.org/10.1371/journal.pone.0063909
  • Donnez, J., Courtoy, G. E., Donnez, O., & Dolmans, M. M. (2018). Ulipristal acetate for the management of large uterine fibroids associated with heavy bleeding: a review. Reproductive BioMedicine Online, 37(2), 216–223. https://doi.org/10.1016/j.rbmo.2018.04.040
  • Donnez, J., & Dolmans, M. M. (2016). Uterine fibroid management: From the present to the future. Human Reproduction Update, 22(6), 665–686. https://doi.org/10.1093/humupd/dmw023
  • Duhan, N. (2011). Current and emerging treatments for uterine myoma - An update. International Journal of Women’s Health, 3(1), 231–242. https://doi.org/10.2147/ijwh.s15710
  • Farris, M., Bastianelli, C., Rosato, E., Brosens, I., & Benagiano, G. (2019, January 23). Uterine fibroids: An update on current and emerging medical treatment options. Therapeutics and Clinical Risk Management, Vol. 15, pp. 157–178. Dove Press. https://doi.org/10.2147/TCRM.S147318
  • Flake, G. P., Andersen, J., & Dixon, D. (2003). Etiology and pathogenesis of uterine leiomyomas: A review. Environmental Health Perspectives, Vol. 111, pp. 1037–1054. https://doi.org/10.1289/ehp.5787
  • Frydenberg, H., Flote, V. G., Larsson, I. M., Barrett, E. S., Furberg, A. S., Ursin, G., … Thune, I. (2015). Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women. Breast Cancer Research, 17(1), 1–12. https://doi.org/10.1186/s13058-015-0620-1
  • Gupta, J. K., Sinha, A., Lumsden, M. A., & Hickey, M. (2014). Uterine artery embolization for symptomatic uterine fibroids. Cochrane Database of Systematic Reviews, 2014(12). https://doi.org/10.1002/14651858.CD005073.pub4
  • Halder, S. K., Goodwin, J. S., & Al-Hendy, A. (2011). 1,25-Dihydroxyvitamin D3 reduces TGF-β3-induced fibrosis-related gene expression in human uterine leiomyoma cells. Journal of Clinical Endocrinology and Metabolism, 96(4), 754–762. https://doi.org/10.1210/jc.2010-2131
  • Halder, S. K., Osteen, K. G., & Al-Hendy, A. (2013). 1,25-Dihydroxyvitamin D3 Reduces Extracellular Matrix-Associated Protein Expression in Human Uterine Fibroid Cells1. Biology of Reproduction, 89(6), 1–13. https://doi.org/10.1095/biolreprod.113.107714
  • He, Y., Zeng, Q., Dong, S., Qin, L., Li, G., & Wang, P. (2013). Associations between uterine fibroids and lifestyles including diet, physical activity and stress: A case-control study in China. Asia Pacific Journal of Clinical Nutrition, 22(1), 109–117. https://doi.org/10.6133/apjcn.2013.22.1.07
  • Herndon, C. N., Aghajanova, L., Balayan, S., Erikson, D., Barragan, F., Goldfien, G., … Giudice, L. C. (2016). Global Transcriptome Abnormalities of the Eutopic Endometrium from Women with Adenomyosis. Reproductive Sciences, 23(10), 1289–1303. https://doi.org/10.1177/1933719116650758
  • Holdsworth-Carson, S. J., Zaitseva, M., Vollenhoven, B. J., & Rogers, P. A. W. (2014). Clonality of smooth muscle and fibroblast cell populations isolated from human fibroid and myometrial tissues. Molecular Human Reproduction, 20(3), 250–259. https://doi.org/10.1093/molehr/gat083
  • Islam, M. S., Ciavattini, A., Petraglia, F., Castellucci, M., & Ciarmela, P. (2018). Extracellular matrix in uterine leiomyoma pathogenesis: A potential target for future therapeutics. Human Reproduction Update, 24(1), 59–85. https://doi.org/10.1093/humupd/dmx032
  • Islam, M. S., Protic, O., Giannubilo, S. R., Toti, P., Tranquilli, A. L., Petraglia, F., … Ciarmela, P. (2013). Uterine leiomyoma: Available medical treatments and new possible therapeutic options. Journal of Clinical Endocrinology and Metabolism, 98(3), 921–934. https://doi.org/10.1210/jc.2012-3237
  • Islam, M. S., Protic, O., Stortoni, P., Grechi, G., Lamanna, P., Petraglia, F., … Ciarmela, P. (2013). Complex networks of multiple factors in the pathogenesis of uterine leiomyoma. Fertility and Sterility, 100(1), 178–193. https://doi.org/10.1016/j.fertnstert.2013.03.007
  • Iwahashi, M., & Muragaki, Y. (2011). Increased type i and v collagen expression in uterine leiomyomas during the menstrual cycle. Fertility and Sterility, 95(6), 2137–2139. https://doi.org/10.1016/j.fertnstert.2010.12.028
  • Jacoby, V. L., Fujimoto, V. Y., Giudice, L. C., Kuppermann, M., & Washington, A. E. (2010). Racial and ethnic disparities in benign gynecologic conditions and associated surgeries. American Journal of Obstetrics and Gynecology, 202(6), 514–521. https://doi.org/10.1016/j.ajog.2010.02.039
  • Jayes, F. L., Liu, B., Feng, L., Aviles-Espinoza, N., Leikin, S., & Leppert, P. C. (2019). Evidence of biomechanical and collagen heterogeneity in uterine fibroids. PLoS ONE, 14(4), 1–16. https://doi.org/10.1371/journal.pone.0215646
  • Joseph, D. S., Malik, M., Nurudeen, S., & Catherino, W. H. (2010). Myometrial cells undergo fibrotic transformation under the influence of transforming growth factor β-3. Fertility and Sterility, 93(5), 1500–1508. https://doi.org/10.1016/j.fertnstert.2009.01.081
  • Khalid, A., Qureshi, H. J., Nazir, S., & Lone, K. P. (2017). Effect of second hand smoke exposure on serum estradiol and progesterone levels in women having first trimester spontaneous abortions. Pakistan Journal of Medical and Health Sciences, 11(1), 163–167.
  • Khan, A. T., Shehmar, M., & Gupta, J. K. (2014). Uterine fibroids: Current perspectives. International Journal of Women’s Health, 6(1), 95–114. https://doi.org/10.2147/IJWH.S51083
  • Lam, S. J., Best, S., & Kumar, S. (2014). The impact of fibroid characteristics on pregnancy outcome. American Journal of Obstetrics and Gynecology, 211(4), 395.e1-395.e5. https://doi.org/10.1016/j.ajog.2014.03.066
  • Laughlin, S. K., Herring, A. H., Savitz, D. A., Olshan, A. F., Fielding, J. R., Hartmann, K. E., & Baird, D. D. (2010). Pregnancy-related fibroid reduction. Fertility and Sterility, 94(6), 2421–2423. https://doi.org/10.1016/j.fertnstert.2010.03.035
  • Laughlin, S. K., Schroeder, J. C., & Baird, D. D. (2010). New directions in the epidemiology of uterine fibroids. Seminars in Reproductive Medicine, 28(3), 204–217. https://doi.org/10.1055/s-0030-1251477
  • Laughlin, S. K., & Stewart, E. A. (2011). Uterine leiomyomas: Individualizing the approach to a heterogeneous condition. Obstetrics and Gynecology, 117(2 PART 1), 396–403. https://doi.org/10.1097/AOG.0b013e31820780e3
  • Leppert, P. C., Baginski, T., Prupas, C., Catherino, W. H., Pletcher, S., & Segars, J. H. (2004). Comparative ultrastructure of collagen fibrils in uterine leiomyomas and normal myometrium. Fertility and Sterility, 82(SUPPL. 3), 1182–1187. https://doi.org/10.1016/j.fertnstert.2004.04.030
  • Leppert, P. C., Jayes, F. L., & Segars, J. H. (2014). The Extracellular Matrix Contributes to Mechanotransduction in Uterine Fibroids. Obstetrics and Gynecology International, 2014, 1–12. https://doi.org/10.1155/2014/783289
  • Lethaby, A., & Vollenhoven, B. (2015). Fibroids (uterine myomatosis, leiomyomas). BMJ Clinical Evidence, 2015(November 2006), 1–26.
  • Levy, B. S. (2020). Modern Management of Uterine Fibroids. In M. Metwally & T.-C. Li (Eds.), Acta Obstetricia et Gynecologica Scandinavica (Vol. 87). Cambridge University Press. https://doi.org/https://doi.org/10.1017/9781108332798
  • Lucero, J., Harlow, B. L., Barbieri, R. L., Sluss, P., & Cramer, D. W. (2001). Early follicular phase hormone levels in relation to patterns of alcohol, tobacco, and coffee use. Fertility and Sterility, 76(4), 723–729. https://doi.org/10.1016/S0015-0282(01)02005-2
  • Lumsden, M. A., Hamoodi, I., Gupta, J., & Hickey, M. (2015). Fibroids: Diagnosis and management. BMJ (Online), 351. https://doi.org/10.1136/bmj.h4887
  • Malik, M., Segars, J., & Catherino, W. H. (2012). Integrin β1 regulates leiomyoma cytoskeletal integrity and growth. Matrix Biology, 31(7–8), 389–397. https://doi.org/10.1016/j.matbio.2012.09.005
  • Marshall, L. M., Spiegelman, D., Goldman, M. B., Manson, J. A. E., Colditz, G. A., Barbieri, R. L., … Hunter, D. J. (1998). A prospective study of reproductive factors and oral contraceptive use in relation to the risk of uterine leiomyomata. Fertility and Sterility, 70(3), 432–439. https://doi.org/10.1016/S0015-0282(98)00208-8
  • Mas, A., Cervello, I., Gil-Sanchis, C., & Simón, C. (2014). Current understanding of somatic stem cells in leiomyoma formation. Fertility and Sterility, 102(3), 613–620. https://doi.org/10.1016/j.fertnstert.2014.04.051
  • Medikare, V., Kandukuri, L. R., Ananthapur, V., Deenadayal, M., & Nallari, P. (2011). The genetic bases of uterine fibroids; a review. Journal of Reproduction and Infertility, 12(3), 181–191.
  • Moore, K. R., Cole, S. R., Dittmer, D. P., Schoenbach, V. J., Smith, J. S., & Baird, D. D. (2015). Self-reported reproductive tract infections and ultrasound diagnosed uterine fibroids in African-American Women. Journal of Women’s Health, 24(6), 489–495. https://doi.org/10.1089/jwh.2014.5051
  • Moro, E., Esposti, E. D., Borghese, G., Manzara, F., Zanello, M., Raimondo, D., … Seracchioli, R. (2019). The impact of hormonal replacement treatment in postmenopausal women with uterine fibroids: A state-of-the-art review of the literature. Medicina (Lithuania), 55(9). https://doi.org/10.3390/medicina55090549
  • Nagata, C., Nakamura, K., Oba, S., Hayashi, M., Takeda, N., & Yasuda, K. (2009). Association of intakes of fat, dietary fibre, soya isoflavones and alcohol with uterine fibroids in Japanese women. British Journal of Nutrition, 101(10), 1427–1431. https://doi.org/10.1017/S0007114508083566
  • Nivethithai, P., Sr, N., & Bv, R. (2010). APTI Uterine Fibroids : A Review. 3(1), 6–11.
  • Omar, M. K., Yang, Q., Laknaur, A., & Al-Hendy, A. (2016). Myometrial progesterone hyper-responsivness is associated with increased risk for the development of human uterine fibroids. Fertility and Sterility, 106(3), e96. https://doi.org/10.1016/j.fertnstert.2016.07.280
  • Ono, M., Qiang, W., Serna, V. A., Yin, P., Coon, J. S., Navarro, A., … Bulun, S. E. (2012). Role of stem cells in human uterine leiomyoma growth. PLoS ONE, 7(5). https://doi.org/10.1371/journal.pone.0036935
  • Paffoni, A., Somigliana, E., Vigano’, P., Benaglia, L., Cardellicchio, L., Pagliardini, L., … Fedele, L. (2013). Vitamin D status in women with uterine leiomyomas. Journal of Clinical Endocrinology and Metabolism, 98(8), 1374–1378. https://doi.org/10.1210/jc.2013-1777
  • Palomba, S., Orio, F., Russo, T., Falbo, A., Tolino, A., Lombardi, G., … Zullo, F. (2005). Antiproliferative and proapoptotic effects of raloxifene on uterine leiomyomas in postmenopausal women. Fertility and Sterility, 84(1), 154–161. https://doi.org/10.1016/j.fertnstert.2004.12.058
  • Pan, Q., Luo, X., & Chegini, N. (2007). Genomic and proteomic profiling I: Leiomyomas in African Americans and Caucasians. Reproductive Biology and Endocrinology, 5, 1–15. https://doi.org/10.1186/1477-7827-5-34
  • Parazzini, F., Negri, E., La Vecchia, C., Rabaiotti, M., Luchini, L., Villa, A., & Fedele, L. (1996). Uterine myomas and smoking: Results from an Italian study. Journal of Reproductive Medicine for the Obstetrician and Gynecologist, 41(5), 316–320. Retrieved from https://europepmc.org/article/med/8725755
  • Parker, W. H. (2007). Etiology, symptomatology, and diagnosis of uterine myomas. Fertility and Sterility, 87(4), 725–736. https://doi.org/10.1016/j.fertnstert.2007.01.093
  • Pascual Botia, C., Camarasa, S. C., Raga Baixauli, F., & Sanchez, A. C. (2017). Uterine Fibroids Review: Understanding their Origins to Better Understand their Future Treatments. Journal of Tumor Research, 03(03). https://doi.org/10.35248/2684-1258.17.3.130
  • Perrine Susan. (2005). 基因的改变NIH Public Access. Bone, 23(1), 1–7. https://doi.org/10.1038/jid.2014.371
  • Premkumar, A., Venzon, D. J., Avila, N., Johnson, D. V., Remaley, A. T., Forman, M. R., … Stratton, P. (2007). Gynecologic and hormonal effects of raloxifene in premenopausal women. Fertility and Sterility, 88(6), 1637–1644. https://doi.org/10.1016/j.fertnstert.2007.01.095
  • Reis, F. M., Bloise, E., & Ortiga-Carvalho, T. M. (2016). Hormones and pathogenesis of uterine fibroids. Best Practice and Research: Clinical Obstetrics and Gynaecology, 34(November), 13–24. https://doi.org/10.1016/j.bpobgyn.2015.11.015
  • Ritchie, J., & Nelson, A. L. (2017). Severe Anemia from Heavy Menstrual Bleeding Requires Heightened Attention. Clinics in Mother and Child Health, 14(1), 1–2. https://doi.org/10.4172/2090-7214.1000256
  • Sabry, M., Halder, S. K., Ait Allah, A. S. A., Roshdy, E., Rajaratnam, V., & Al-Hendy, A. (2013). Serum vitamin D3 level inversely correlates with uterine fibroid volume in different ethnic groups: A cross-sectional observational study. International Journal of Women’s Health, 5(1), 93–100. https://doi.org/10.2147/IJWH.S38800
  • Samadi, A. R., Lee, N. C., Dana Flanders, W., Boring, J. R., & Parris, E. B. (1996). Risk factors for self-reported uterine fibroids: A case-control study. American Journal of Public Health, 86(6), 858–862. https://doi.org/10.2105/AJPH.86.6.858
  • Seshadri, S., El-Toukhy, T., Douiri, A., Jayaprakasan, K., & Khalaf, Y. (2015). Diagnostic accuracy of saline infusion sonography in the evaluation of uterine cavity abnormalities prior to assisted reproductive techniques: A systematic review and meta-analyses. Human Reproduction Update, 21(2), 262–274. https://doi.org/10.1093/humupd/dmu057
  • Sharan, C., Halder, S. K., Thota, C., Jaleel, T., Nair, S., & Al-Hendy, A. (2011). Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. Fertility and Sterility, 95(1), 247–253. https://doi.org/10.1016/j.fertnstert.2010.07.1041
  • Sinclair, D. C., Mastroyannis, A., & Taylor, H. S. (2011). Leiomyoma simultaneously impair endometrial BMP-2-mediated decidualization and anticoagulant expression through secretion of TGF-β3. Journal of Clinical Endocrinology and Metabolism, 96(2), 412–421. https://doi.org/10.1210/jc.2010-1450
  • Sommer, E. M., Balkwill, A., Reeves, G., Green, J., Beral, D. V., & Coffey, K. (2015). Effects of obesity and hormone therapy on surgically-confirmed fibroids in postmenopausal women. European Journal of Epidemiology, 30(6), 493–499. https://doi.org/10.1007/s10654-015-0016-7
  • Sparic, R., Mirkovic, L., Malvasi, A., & Tinelli, A. (2016). Epidemiology of uterine myomas: A review. International Journal of Fertility and Sterility, 9(4), 424–435. https://doi.org/10.22074/ijfs.2015.4599
  • Stewart, E. A., Cookson, C. L., Gandolfo, R. A., & Schulze-Rath, R. (2017). Epidemiology of uterine fibroids: a systematic review. BJOG: An International Journal of Obstetrics and Gynaecology, 124(10), 1501–1512. https://doi.org/10.1111/1471-0528.14640
  • Stewart, Elizabeth A., & Nowak, R. A. (1996). Leiomyoma-related bleeding: A classic hypothesis updated for the molecular era. Human Reproduction Update, 2(4), 295–306. https://doi.org/10.1093/humupd/2.4.295
  • Taran, F. A., Brown, H. L., & Stewart, E. A. (2010). Racial diversity in uterine leiomyoma clinical studies. Fertility and Sterility, 94(4), 1500–1503. https://doi.org/10.1016/j.fertnstert.2009.08.037
  • Thorne, J. T., Segal, T. R., Chang, S., Jorge, S., Segars, J. H., & Leppert, P. C. (2015). Dynamic Reciprocity Between Cells and Their Microenvironment in Reproduction1. Biology of Reproduction, 92(1), 1–10. https://doi.org/10.1095/biolreprod.114.121368
  • Tinelli, A., Vinciguerra, M., Malvasi, A., Andjić, M., Babović, I., & Sparić, R. (2021). Uterine fibroids and diet. International Journal of Environmental Research and Public Health, Vol. 18, pp. 1–15. https://doi.org/10.3390/ijerph18031066
  • Välimäki, N., Kuisma, H., Pasanen, A., Heikinheimo, O., Sjöberg, J., Bützow, R., … Aaltonen, L. A. (2018). Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability. ELife, 7, 1–50. https://doi.org/10.7554/eLife.37110
  • Vessey, M. P. (1986). Risk factors for uterine fibroids: Reduced risk associated with oral contraceptives. British Medical Journal (Clinical Research Ed.), 293(6543), 359–362. https://doi.org/10.1136/bmj.293.6543.359
  • Vitner, D., Filmer, S., Goldstein, I., Khatib, N., & Weiner, Z. (2013). A comparison between ultrasonography and hysteroscopy in the diagnosis of uterine pathology. European Journal of Obstetrics and Gynecology and Reproductive Biology, 171(1), 143–145. https://doi.org/10.1016/j.ejogrb.2013.08.024
  • Wang, Y., Feng, G., Wang, J., Zhou, Y., Liu, Y., Shi, Y., … Li, Z. (2015). Differential effects of tumor necrosis factor-α on matrix metalloproteinase-2 expression in human myometrial and uterine leiomyoma smooth muscle cells. Human Reproduction, 30(1), 61–70. https://doi.org/10.1093/humrep/deu300
  • Williams, A. R. W. (2017). Uterine fibroids – what’s new? F1000Research, 6, 2109. https://doi.org/10.12688/f1000research.12172.1
  • Windham, G. C., Mitchell, P., Anderson, M., & Lasley, B. L. (2005). Cigarette smoking and effects on hormone function in premenopausal women. Environmental Health Perspectives, 113(10), 1285–1290. https://doi.org/10.1289/ehp.7899
  • Wise, L. A., & Laughlin-tommaso, S. K. (2016). Epidemiology of Uterine Fibroids. Clinical Obstetrics & Gynecology, 59(1), 2–24. https://doi.org/10.1097/grf.0000000000000164
  • Wise, L. A., Palmer, J. R., Harlow, B. L., Spiegelman, D., Stewart, E. A., Adams-Campbell, L. L., & Rosenberg, L. (2004). Risk of uterine leiomyomata in relation to tobacco, alcohol and caffeine consumption in the Black Women’s Health Study. Human Reproduction, 19(8), 1746–1754. https://doi.org/10.1093/humrep/deh309
  • Wise, L. A., Palmer, J. R., Harlow, B. L., Spigelman, D., Stewart, E. A., Adams-Campbell, L. L., & Rosenberg, L. (2004). Reproductive Factors, Hormonal Contraception, and Risk of Uterine Leiomyomata in African-American Women: A Prospective Study. American Journal of Epidemiology, 159(2), 113–123. https://doi.org/10.1093/aje/kwh016
  • Wise, L. A., Palmer, J. R., Ruiz-Narvaez, E., Reich, D. E., & Rosenberg, L. (2013). Is the observed association between dairy intake and fibroids in African Americans explained by genetic ancestry? American Journal of Epidemiology, 178(7), 1114–1119. https://doi.org/10.1093/aje/kwt091
  • Wynn, T. A., & Wynn, T. A. (2007). Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases Find the latest version : Review series introduction Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. Journal Of Clinical Investigation, 117(3), 524–529. https://doi.org/10.1172/JCI31487.524
  • Yan, L., Ding, L., Li, C., Wang, Y., Tang, R., & Chen, Z. J. (2014). Effect of fibroids not distorting the endometrial cavity on the outcome of in vitro fertilization treatment: A retrospective cohort study. Fertility and Sterility, 101(3), 716-721.e6. https://doi.org/10.1016/j.fertnstert.2013.11.023
Toplam 86 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Makaleler
Yazarlar

Nagwa Bugumaa Abubaker Alemarı 0000-0002-9304-9924

Gülnur Take 0000-0002-4321-4709

Yayımlanma Tarihi 31 Ağustos 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 4 Sayı: 2

Kaynak Göster

APA Alemarı, N. B. A., & Take, G. (2022). Current Understanding of Pathogenesis, Histopathology, Diagnosis, and Treatment Options of Uterine Fibroids-Review. Journal of Gazi University Health Sciences Institute, 4(2), 107-124.